PharmaCoNets of Valproic-acid (SPCN: 21.10 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Valproic-acidhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Valproic-acidhsa00071Fatty acid degradation2.45E-023P11310, P28332, P33121ACADM, ADH6, ACSL1More
Valproic-acidhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Valproic-acidhsa00250Alanine, aspartate and glutamate metabolism4.51E-021P51649ALDH5A1More
Valproic-acidhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Valproic-acidhsa00531Glycosaminoglycan degradation3.03E-021P15586GNSMore
Valproic-acidhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Valproic-acidhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Valproic-acidhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Valproic-acidhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Valproic-acidhsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Valproic-acidhsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Valproic-acidhsa01200Carbon metabolism4.29E-024P04406, O14521, Q9P2R7, Q02252GAPDH, SDHD, SUCLA2, ALDH6A1More
Valproic-acidhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Valproic-acidhsa01524Platinum drug resistance4.58E-034P04637, P48023, Q16772, P09211TP53, FASLG, GSTA3, GSTP1More
Valproic-acidhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Valproic-acidhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Valproic-acidhsa03040Spliceosome6.29E-037Q14562, O43143, O75940, O75494, Q07955, Q13243, O75643DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS5, ASCC3L1More
Valproic-acidhsa04012ErbB signaling pathway3.69E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Valproic-acidhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Valproic-acidhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Valproic-acidhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Valproic-acidhsa04068FoxO signaling pathway6.45E-032P48023, Q96BR1FASLG, SGK3More
Valproic-acidhsa04070Phosphatidylinositol signaling system2.11E-024P19174, P0DP23, P49619, P27987PLCG1, CALM1, DGKG, ITPKBMore
Valproic-acidhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Valproic-acidhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Valproic-acidhsa04151PI3K-Akt signaling pathway4.21E-033P48023, P04637, Q96BR1FASLG, TP53, SGK3More
Valproic-acidhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Valproic-acidhsa04360Axon guidance4.39E-024P16333, P20827, O95631, P19174NCK1, EFNA1, NTN1, PLCG1More
Valproic-acidhsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Valproic-acidhsa04612Antigen processing and presentation8.21E-035P26715, P26717, Q07444, Q13241, P01732KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Valproic-acidhsa04613Neutrophil extracellular trap formation4.62E-026P19174, P11215, Q93077, P62807, O60814, P14598PLCG1, ITGAM, HIST1H2AC, HIST1H2BC, H2BC12, NCF1More
Valproic-acidhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Valproic-acidhsa04650Natural killer cell mediated cytotoxicity2.45E-0713P19174, P06239, O60880, P20963, P42338, P48023, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, FASLG, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1More
Valproic-acidhsa04658Th1 and Th2 cell differentiation6.40E-0810Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3More
Valproic-acidhsa04659Th17 cell differentiation1.02E-0510Q04759, P19174, P06239, P14784, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Valproic-acidhsa04660T cell receptor signaling pathway1.19E-0511Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Valproic-acidhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Valproic-acidhsa04722Neurotrophin signaling pathway2.27E-022P48023, P04637FASLG, TP53More
Valproic-acidhsa04744Phototransduction7.59E-032P62873, P0DP23GNB1, CALM1More
Valproic-acidhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Valproic-acidhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Valproic-acidhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Valproic-acidhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Valproic-acidhsa04974Protein digestion and absorption1.52E-021P02452COL1A1More
Valproic-acidhsa05034Alcoholism2.05E-025P0DP23, P62873, Q93077, P62807, O60814CALM1, GNB1, HIST1H2AC, HIST1H2BC, H2BC12More
Valproic-acidhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Valproic-acidhsa05133Pertussis2.63E-022P10145, P0C0L4IL8, C4AMore
Valproic-acidhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Valproic-acidhsa05140Leishmaniasis3.52E-024P14598, P11215, P42224, P29350NCF1, ITGAM, STAT1, PTPN6More
Valproic-acidhsa05146Amoebiasis2.37E-059P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Valproic-acidhsa05160Hepatitis C3.81E-022P04637, P48023TP53, FASLGMore
Valproic-acidhsa05164Influenza A3.48E-022Q9GZY0, P48023NXF2; NXF2B, FASLGMore
Valproic-acidhsa05168Herpes simplex virus 1 infection4.54E-034P04637, Q9GZY0, P48023, P98182TP53, NXF2; NXF2B, FASLG, ZNF200More
Valproic-acidhsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Valproic-acidhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Valproic-acidhsa05214Glioma3.69E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Valproic-acidhsa05219Bladder cancer4.51E-021P04637TP53More
Valproic-acidhsa05231Choline metabolism in cancer4.95E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Valproic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.32E-048P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQMore
Valproic-acidhsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More

Community members of Valproic-acid (SDC: 2.74)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
HDAC2Q92769IC5062000