PharmaCoNets of Valine (SPCN: 52.48 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Valinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Valinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Valinehsa00280Valine, leucine and isoleucine degradation3.29E-021P05166PCCBMore
Valinehsa00500Starch and sucrose metabolism1.72E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Valinehsa00604Glycosphingolipid biosynthesis - ganglio series4.90E-021Q9H4F1ST6GALNAC4More
Valinehsa00640Propanoate metabolism1.66E-021P05166PCCBMore
Valinehsa00730Thiamine metabolism1.44E-032P05186, P24666ALPL, ACP1More
Valinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Valinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Valinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Valinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Valinehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Valinehsa03013RNA transport1.58E-0211O14980, P52298, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, TACC3More
Valinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Valinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Valinehsa04012ErbB signaling pathway1.26E-022P21860, Q13557ERBB3, CAMK2DMore
Valinehsa04020Calcium signaling pathway2.63E-022Q13557, P21860CAMK2D, ERBB3More
Valinehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Valinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Valinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Valinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Valinehsa04071Sphingolipid signaling pathway2.58E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q02156EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, PRKCEMore
Valinehsa04072Phospholipase D signaling pathway5.37E-038P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNASMore
Valinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Valinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Valinehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Valinehsa04146Peroxisome4.63E-025O96011, P56589, Q9UKG9, O75521, P33121PEX11B, PEX3, CROT, ECI2, ACSL1More
Valinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Valinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Valinehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Valinehsa04270Vascular smooth muscle contraction4.59E-021Q02156PRKCEMore
Valinehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Valinehsa04340Hedgehog signaling pathway3.10E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Valinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Valinehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Valinehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Valinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Valinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Valinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Valinehsa04640Hematopoietic cell lineage1.54E-039P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7More
Valinehsa04650Natural killer cell mediated cytotoxicity4.15E-0410P19174, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3BMore
Valinehsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Valinehsa04658Th1 and Th2 cell differentiation8.66E-0611Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, TBX21, IL2RB, HLA-DOB, RUNX3More
Valinehsa04659Th17 cell differentiation3.15E-0511Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, CD3E, CD3G, CD247More
Valinehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Valinehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Valinehsa04666Fc gamma R-mediated phagocytosis4.59E-021Q02156PRKCEMore
Valinehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Valinehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Valinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Valinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Valinehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Valinehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Valinehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Valinehsa04750Inflammatory mediator regulation of TRP channels2.25E-036P14778, Q02156, P19174, P42338, P24723, Q04759IL1R1, PRKCE, PLCG1, PIK3CB, PRKCH, PRKCQMore
Valinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Valinehsa04925Aldosterone synthesis and secretion3.62E-021Q02156PRKCEMore
Valinehsa04930Type II diabetes mellitus9.93E-031Q02156PRKCEMore
Valinehsa04931Insulin resistance2.64E-021Q02156PRKCEMore
Valinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Valinehsa04933AGE-RAGE signaling pathway in diabetic complications2.31E-021Q02156PRKCEMore
Valinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Valinehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Valinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Valinehsa04974Protein digestion and absorption9.93E-031Q7Z2H8SLC36A1More
Valinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Valinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Valinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Valinehsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Valinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Valinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Valinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Valinehsa05140Leishmaniasis3.50E-038O75015, P13765, O60603, P01375, P29350, Q16539, P51617, Q15080FCGR3B, HLA-DOB, TLR2, TNF, PTPN6, MAPK14, IRAK1, NCF4More
Valinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Valinehsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Valinehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Valinehsa05150Staphylococcus aureus infection2.69E-026P21730, P21462, O75015, P13765, Q16581, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4More
Valinehsa05152Tuberculosis1.69E-029O75015, P48382, O60603, P01375, P10415, P13765, Q9UDY8, Q16539, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, MALT1, MAPK14, IRAK1More
Valinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Valinehsa05163Human cytomegalovirus infection2.55E-0310P01375, P62873, P61586, P49841, P14778, P25025, Q16539, P63092, O00463, P61769TNF, GNB1, RHOA, GSK3B, IL1R1, CXCR2, MAPK14, GNAS, TRAF5, B2MMore
Valinehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Valinehsa05205Proteoglycans in cancer3.74E-033Q13557, P21860, Q03135CAMK2D, ERBB3, CAV1More
Valinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Valinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Valinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.52E-0511P42338, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4More
Valinehsa05310Asthma2.57E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Valinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Valinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Valinehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Valinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Valinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Valine (SDC: 4.29)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P05166PCCBPropionylNoneCoA carboxylase beta chain, mitochondrialReported00.25870.01330.24670.4028
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q7Z2H8SLC36A1ProtonNonecoupled amino acid transporter 1Predicted00.20740.034800.1732
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q9HCC0MCCC2MethylcrotonoylNoneCoA carboxylase beta chain, mitochondrialPredicted00.12380.00880.17750.257
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)