PharmaCoNets

PharmaCoNets of Valdecoxib (S_PCN: 205.92 )

Valdecoxib regulated-network (S_DN: 22.65)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Valdecoxib

hsa00020

Citrate cycle (TCA cycle)

6.05E-03

Q9P2R7, P40925, O14521

SUCLA2, MDH1, SDHD

Valdecoxib

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Valdecoxib

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Valdecoxib

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Valdecoxib

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Valdecoxib

hsa00380

Tryptophan metabolism

1.33E-02

P46952, P51648

HAAO, ALDH3A2

Valdecoxib

hsa00500

Starch and sucrose metabolism

5.75E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Valdecoxib

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Valdecoxib

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Valdecoxib

hsa00520

Amino sugar and nucleotide sugar metabolism

3.76E-02

Q13231

CHIT1

Valdecoxib

hsa00531

Glycosaminoglycan degradation

1.05E-03

P15586, P34059

GNS, GALNS

Valdecoxib

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

3.30E-02

Q9Y2C2

UST

Valdecoxib

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Valdecoxib

hsa00562

Inositol phosphate metabolism

1.91E-02

P27987, Q13572, Q96PE3

ITPKB, ITPK1, INPP4A

Valdecoxib

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Valdecoxib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Valdecoxib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Valdecoxib

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Valdecoxib

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Valdecoxib

hsa00730

Thiamine metabolism

1.06E-04

P05186, P24666

ALPL, ACP1

Valdecoxib

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Valdecoxib

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Valdecoxib

hsa00970

Aminoacyl-tRNA biosynthesis

6.41E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Valdecoxib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Valdecoxib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Valdecoxib

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Valdecoxib

hsa01200

Carbon metabolism

1.01E-03

P51854, P04406, P37837, P40925, O14521, Q9P2R7, P60891, Q02252

TKTL1, GAPDH, TALDO1, MDH1, SDHD, SUCLA2, PRPS1, ALDH6A1

Valdecoxib

hsa01210

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Valdecoxib

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Valdecoxib

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Valdecoxib

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Valdecoxib

hsa01524

Platinum drug resistance

4.78E-02

P31751

AKT2

Valdecoxib

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Valdecoxib

hsa03013

RNA transport

4.36E-03

P62826, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, O75822, P78345, P20042, Q9Y6A5, Q14232

RAN, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3J, RPP38, EIF2S2, TACC3, EIF2B1

Valdecoxib

hsa03015

mRNA surveillance pathway

4.42E-02

O60942, O43148, P52298, Q53GS7

RNGTT, RNMT, NCBP2, GLE1

Valdecoxib

hsa03020

RNA polymerase

8.48E-06

P30876, P24928, P62487, Q9GZM3, P52435

POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J

Valdecoxib

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Valdecoxib

hsa03040

Spliceosome

2.94E-06

O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O43395, O75643

DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, PRPF3, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	-0.812
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P25963	NFKBIA	NF-kappa-B inhibitor alpha	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.839
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P25963	NFKBIA	NF-kappa-B inhibitor alpha	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	-0.891
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O43395	PRPF3	U4/U6 small nuclear ribonucleoprotein Prp3	-0.747
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Valdecoxib

hsa03060

Protein export

2.29E-03

P37108, Q15005

SRP14, SPCS2

Valdecoxib

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Valdecoxib

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Valdecoxib

hsa04014

Ras signaling pathway

4.37E-03

P31751, P42338, P20827, P49767, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174

AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1

Valdecoxib

hsa04015

Rap1 signaling pathway

3.64E-04

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P31751, P0DP23, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, ITGA2B, PLCG1

Valdecoxib

hsa04020

Calcium signaling pathway

1.92E-03

P27987, Q16566, P30679, O15399, P23634, P49767

ITPKB, CAMK4, GNA15, GRIN2D, ATP2B4, VEGFC

Valdecoxib

hsa04022

cGMP-PKG signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Valdecoxib

hsa04024

cAMP signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Valdecoxib

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.71E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNF

Valdecoxib

hsa04062

Chemokine signaling pathway

6.30E-05

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P22694, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PRKACB, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.901
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.917
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P47992	XCL1	Lymphotactin	-0.797
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.797
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.743
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.737
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Valdecoxib

hsa04064

NF-kappa B signaling pathway

2.04E-11

P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.889
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.805
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Valdecoxib

hsa04071

Sphingolipid signaling pathway

1.24E-07

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Valdecoxib

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Valdecoxib

hsa04080

Neuroactive ligand-receptor interaction

1.43E-04

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2

Valdecoxib

hsa04110

Cell cycle

4.61E-04

Q9UBD5, P06493, Q14683, O75293, P30304, P33981, P42773, P01106

ORC3, CDK1, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYC

Valdecoxib

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Valdecoxib

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Valdecoxib

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Valdecoxib

hsa04140

Autophagy - animal

2.63E-05

Q9Y4H2, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759

IRS2, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.719
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.865
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9H1Y0	ATG5	Autophagy protein 5	-0.726
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9H1Y0	ATG5	Autophagy protein 5	0.762
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Valdecoxib

hsa04142

Lysosome

8.21E-05

P43234, P06865, P15586, P22304, P34059, P38571, Q13510, P07602, Q9NRA2, P49281, P61916

CTSO, HEXA, GNS, IDS, GALNS, LIPA, ASAH1, PSAP, SLC17A5, SLC11A2, NPC2

Valdecoxib

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Valdecoxib

hsa04145

Phagosome

1.66E-05

O75015, P63261, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P13765

FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P33260	CYP2C18	Cytochrome P450 2C18	P63261	ACTG1	Actin, cytoplasmic 2	0.845
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P33260	CYP2C18	Cytochrome P450 2C18	Q15080	NCF4	Neutrophil cytosol factor 4	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P33260	CYP2C18	Cytochrome P450 2C18	P14598	NCF1	Neutrophil cytosol factor 1	-0.815
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P33260	CYP2C18	Cytochrome P450 2C18	Q13509	TUBB3	Tubulin beta-3 chain	-0.816
P33260	CYP2C18	Cytochrome P450 2C18	P68371	TUBB2C	Tubulin beta-4B chain	-0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P78380	OLR1	Oxidized low-density lipoprotein receptor 1	-0.702
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35443	THBS4	Thrombospondin-4	-0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Valdecoxib

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Valdecoxib

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Valdecoxib

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Valdecoxib

hsa04210

Apoptosis

2.35E-03

Q13315, P04637, P10415, O76075, P24522, Q16548, P43234, Q14643, P63261

ATM, TP53, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1, ACTG1

Valdecoxib

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Valdecoxib

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Valdecoxib

hsa04216

Ferroptosis

1.45E-02

P04637, P49281

TP53, SLC11A2

Valdecoxib

hsa04217

Necroptosis

3.20E-06

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, Q14765, P01584, P07384, P0C0S5, Q6FI13, Q99878, P10415, Q9H444, O43633, O75351

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT4, IL1B, CAPN1, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, VPS4B

Valdecoxib

hsa04218

Cellular senescence

2.09E-03

P01106, P31751, O75293, P30304, P06493, P0DP23

MYC, AKT2, GADD45B, CDC25A, CDK1, CALM1

Valdecoxib

hsa04261

Adrenergic signaling in cardiomyocytes

2.83E-03

P07550, P22694, P31751, P18848, Q13362, P0DP23

ADRB2, PRKACB, AKT2, ATF4, PPP2R5C, CALM1

Valdecoxib

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Valdecoxib

hsa04340

Hedgehog signaling pathway

2.62E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Valdecoxib

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Valdecoxib

hsa04370

VEGF signaling pathway

3.03E-04

P16298, P31751, Q05397, Q02750

PPP3CB, AKT2, PTK2, MAP2K1

Valdecoxib

hsa04371

Apelin signaling pathway

8.81E-05

P63218, P50151, Q8WYR1, P31751, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNG5, GNG10, PIK3R5, AKT2, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Valdecoxib

hsa04380

Osteoclast differentiation

6.24E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Valdecoxib

hsa04390

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Valdecoxib

hsa04510

Focal adhesion

4.64E-02

O75369, Q15942, Q13489, P10415, P49767, P63261

FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1

Valdecoxib

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Valdecoxib

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Valdecoxib

hsa04530

Tight junction

3.02E-06

Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN

Valdecoxib

hsa04610

Complement and coagulation cascades

1.22E-05

P25116, P09871, P0C0L4

F2R, C1S, C4A

Valdecoxib

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Valdecoxib

hsa04612

Antigen processing and presentation

8.25E-07

P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P48382	RFX5	DNA-binding protein RFX5	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Valdecoxib

hsa04613

Neutrophil extracellular trap formation

1.53E-08

P17252, P16109, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Valdecoxib

hsa04614

Renin-angiotensin system

2.52E-02

P50052

AGTR2

Valdecoxib

hsa04620

Toll-like receptor signaling pathway

4.81E-03

Q13546, P01568, P31751

RIPK1, IFNA21, AKT2

Valdecoxib

hsa04621

NOD-like receptor signaling pathway

3.65E-05

Q16539, Q14643, P01568, P21796, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, IFNA21, VDAC1, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.705
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P10599	TXN	Thioredoxin	0.847
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9H1Y0	ATG5	Autophagy protein 5	-0.726
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.964
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.72
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P12838	DEFA4	Neutrophil defensin 4	0.842
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858

Valdecoxib

hsa04622

RIG-I-like receptor signaling pathway

1.02E-03

P01568, Q9NQC7, Q13546

IFNA21, CYLD, RIPK1

Valdecoxib

hsa04623

Cytosolic DNA-sensing pathway

4.94E-06

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Valdecoxib

hsa04625

C-type lectin receptor signaling pathway

2.27E-04

Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Valdecoxib

hsa04640

Hematopoietic cell lineage

1.26E-06

P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603

ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13612	ITGA4	Integrin alpha-4	-0.88
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P27930	IL1R2	Interleukin-1 receptor type 2	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P15144	ANPEP	Aminopeptidase N	0.764
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P15144	ANPEP	Aminopeptidase N	-0.757
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P11836	MS4A1	B-lymphocyte antigen CD20	-0.717
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25063	CD24	Signal transducer CD24	0.717
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P25063	CD24	Signal transducer CD24	-0.839
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.783
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09603	CSF1	Macrophage colony-stimulating factor 1	0.713

Valdecoxib

hsa04650

Natural killer cell mediated cytotoxicity

9.51E-13

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P78314	SH3BP2	SH3 domain-binding protein 2	0.769
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P78314	SH3BP2	SH3 domain-binding protein 2	0.718
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.848
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.764
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.846
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.931
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.803
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.855
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Valdecoxib

hsa04657

IL-17 signaling pathway

6.36E-07

P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P04141, P80188, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P25963	NFKBIA	NF-kappa-B inhibitor alpha	1
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.818
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P25963	NFKBIA	NF-kappa-B inhibitor alpha	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.839
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.759
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P06702	S100A9	Protein S100-A9	0.877

Valdecoxib

hsa04658

Th1 and Th2 cell differentiation

1.51E-14

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.756
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.769
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Valdecoxib

hsa04659

Th17 cell differentiation

2.06E-10

Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Valdecoxib

hsa04660

T cell receptor signaling pathway

1.10E-10

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.824
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.847
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.783
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.858
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Valdecoxib

hsa04662

B cell receptor signaling pathway

3.64E-03

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Valdecoxib

hsa04664

Fc epsilon RI signaling pathway

7.42E-04

P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Valdecoxib

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Valdecoxib

hsa04668

TNF signaling pathway

2.12E-03

P01375, O00463, Q16539, P18848, P19875, P20749, P14780

TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9

Valdecoxib

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Valdecoxib

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Valdecoxib

hsa04722

Neurotrophin signaling pathway

1.26E-03

P31751, P49841, O43524, P48023, P0DP23

AKT2, GSK3B, FOXO3, FASLG, CALM1

Valdecoxib

hsa04723

Retrograde endocannabinoid signaling

4.40E-02

Q14643, P63218, P50151, P22694, Q16539

ITPR1, GNG5, GNG10, PRKACB, MAPK14

Valdecoxib

hsa04724

Glutamatergic synapse

3.40E-02

O15399, P63218, Q9NSB8

GRIN2D, GNG5, HOMER2

Valdecoxib

hsa04728

Dopaminergic synapse

3.23E-03

P31751, P0DP23

AKT2, CALM1

Valdecoxib

hsa04730

Long-term depression

2.54E-02

Q14344, P07948

GNA13, LYN

Valdecoxib

hsa04740

Olfactory transduction

9.46E-04

Q9H255, P0DP23

OR51E2, CALM1

Valdecoxib

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Valdecoxib

hsa04744

Phototransduction

1.81E-02

P0DP23

CALM1

Valdecoxib

hsa04750

Inflammatory mediator regulation of TRP channels

4.47E-05

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM1

Valdecoxib

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Valdecoxib

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Valdecoxib

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Valdecoxib

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Valdecoxib

hsa04915

Estrogen signaling pathway

3.76E-03

Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1

Valdecoxib

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Valdecoxib

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Valdecoxib

hsa04920

Adipocytokine signaling pathway

4.19E-02

P31751

AKT2

Valdecoxib

hsa04922

Glucagon signaling pathway

3.14E-03

P22694, P06737, Q12778, P31751, P0DP23, Q14643

PRKACB, PYGL, FOXO1, AKT2, CALM1, ITPR1

Valdecoxib

hsa04923

Regulation of lipolysis in adipocytes

3.88E-03

P07550, P42338, Q9Y4H2, P31751

ADRB2, PIK3CB, IRS2, AKT2

Valdecoxib

hsa04924

Renin secretion

1.92E-04

P22694, P07550, Q14643, P0DP23

PRKACB, ADRB2, ITPR1, CALM1

Valdecoxib

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Valdecoxib

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Valdecoxib

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Valdecoxib

hsa04929

GnRH secretion

1.81E-02

P31751

AKT2

Valdecoxib

hsa04932

Non-alcoholic fatty liver disease

5.61E-06

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Valdecoxib

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Valdecoxib

hsa04940

Type I diabetes mellitus

2.61E-03

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Valdecoxib

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Valdecoxib

hsa04966

Collecting duct acid secretion

2.17E-03

P00918

CA2

Valdecoxib

hsa04970

Salivary secretion

5.38E-04

P07550, Q08828, P51828, P22694, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP

Valdecoxib

hsa04971

Gastric acid secretion

1.04E-02

Q08828, P15311, P0DP23

ADCY1, VIL2, CALM1

Valdecoxib

hsa04973

Carbohydrate digestion and absorption

4.61E-03

O43451, P42338, P31751

MGAM, PIK3CB, AKT2

Valdecoxib

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Valdecoxib

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Valdecoxib

hsa05010

Alzheimer disease

8.59E-04

Q00535, P0DP23, P31751

CDK5, CALM1, AKT2

Valdecoxib

hsa05016

Huntington disease

1.00E-04

O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, Q9NYC9, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, DNAH9, ERN1, PSMB4, PSMD12

Valdecoxib

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Valdecoxib

hsa05022

Pathways of neurodegeneration - multiple diseases

9.02E-04

O15399, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, Q16539, P07384, Q00535, P04628, Q08752, P0DP23

GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, MAPK14, CAPN1, CDK5, WNT1, PPID, CALM1

Valdecoxib

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Valdecoxib

hsa05031

Amphetamine addiction

6.98E-03

P0DP23, P22694, P18848, Q13547

CALM1, PRKACB, ATF4, HDAC1

Valdecoxib

hsa05033

Nicotine addiction

2.54E-02

P28472, O15399

GABRB3, GRIN2D

Valdecoxib

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Valdecoxib

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Valdecoxib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.00E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Valdecoxib

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Valdecoxib

hsa05131

Shigellosis

3.15E-02

P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796

TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1

Valdecoxib

hsa05132

Salmonella infection

3.09E-04

P63261, Q13546, Q13489, P10415, O75369, Q13561, O60282, Q13509, P68371

ACTG1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, KIF5C, TUBB3, TUBB2C

Valdecoxib

hsa05133

Pertussis

1.45E-04

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Valdecoxib

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Valdecoxib

hsa05140

Leishmaniasis

4.87E-06

P13612, O75015, P14598, P13765, O60603, P01375, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74

Valdecoxib

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Valdecoxib

hsa05144

Malaria

3.40E-07

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Valdecoxib

hsa05146

Amoebiasis

2.83E-09

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P27930	IL1R2	Interleukin-1 receptor type 2	0.906
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P05089	ARG1	Arginase-1	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P12814	ACTN1	Alpha-actinin-1	0.788
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P08311	CTSG	Cathepsin G	0.76
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866

Valdecoxib

hsa05150

Staphylococcus aureus infection

1.28E-05

P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Valdecoxib

hsa05152

Tuberculosis

7.94E-03

P0DP23, O75015, P48382, O60603, P01375, P31751, P10415, P13765, P49913, Q9UDY8, P51617

CALM1, FCGR3B, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Valdecoxib

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Valdecoxib

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Valdecoxib

hsa05163

Human cytomegalovirus infection

8.39E-06

P31751, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

AKT2, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.743
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.737
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.702
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734

Valdecoxib

hsa05167

Kaposi sarcoma-associated herpesvirus infection

9.52E-04

P31751, P62879, P16298, Q02750, P0DP23, P0CG47

AKT2, GNB2, PPP3CB, MAP2K1, CALM1, UBB

Valdecoxib

hsa05168

Herpes simplex virus 1 infection

1.17E-02

Q9UKJ0, Q06124, P01568, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415

PILRB, PTPN11, IFNA21, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2

Valdecoxib

hsa05169

Epstein-Barr virus infection

3.53E-03

P13765, Q13547, O00463, Q16539, P07948, Q13761, P24522, P01375, O60603, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, RUNX3, GADD45A, TNF, TLR2, OAS2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13547	HDAC1	Histone deacetylase 1	-0.795
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q13547	HDAC1	Histone deacetylase 1	-0.727
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.769
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.805
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.72
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Valdecoxib

hsa05170

Human immunodeficiency virus 1 infection

3.09E-04

P31751, Q02750, P62879, P16298, P0DP23, Q05397, P20333

AKT2, MAP2K1, GNB2, PPP3CB, CALM1, PTK2, TNFRSF1B

Valdecoxib

hsa05200

Pathways in cancer

1.81E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P31751, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, AKT2, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Valdecoxib

hsa05202

Transcriptional misregulation in cancer

1.39E-06

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Valdecoxib

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Valdecoxib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Valdecoxib

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Valdecoxib

hsa05211

Renal cell carcinoma

2.01E-03

Q06124, Q99814, P31751

PTPN11, EPAS1, AKT2

Valdecoxib

hsa05212

Pancreatic cancer

1.07E-03

P42338, P31751, P84022, Q13485, P04637, P24522, O75293

PIK3CB, AKT2, SMAD3, SMAD4, TP53, GADD45A, GADD45B

Valdecoxib

hsa05213

Endometrial cancer

3.59E-04

O15169, P31751, Q02750, P04637, P24522

AXIN1, AKT2, MAP2K1, TP53, GADD45A

Valdecoxib

hsa05214

Glioma

2.31E-04

P0DP23, P31751, P04637, P24522

CALM1, AKT2, TP53, GADD45A

Valdecoxib

hsa05216

Thyroid cancer

1.28E-03

P01106, P04637, P24522, O75293

MYC, TP53, GADD45A, GADD45B

Valdecoxib

hsa05217

Basal cell carcinoma

2.60E-02

P04637, P24522

TP53, GADD45A

Valdecoxib

hsa05218

Melanoma

1.19E-03

P04637, P31751, P24522

TP53, AKT2, GADD45A

Valdecoxib

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Valdecoxib

hsa05220

Chronic myeloid leukemia

1.88E-04

Q06124, P04637, Q13547, Q13485, P84022, P31751, P42338, P24522, O75293

PTPN11, TP53, HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, GADD45A, GADD45B

Valdecoxib

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Valdecoxib

hsa05222

Small cell lung cancer

4.78E-02

P31751

AKT2

Valdecoxib

hsa05223

Non-small cell lung cancer

8.38E-05

P31751, P10826, Q9HC35, P04637, P24522, O75293

AKT2, RARB, EML4, TP53, GADD45A, GADD45B

Valdecoxib

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Valdecoxib

hsa05225

Hepatocellular carcinoma

4.54E-02

P04637, P24522, P63261

TP53, GADD45A, ACTG1

Valdecoxib

hsa05226

Gastric cancer

4.72E-03

Q02750, P31751, O15169

MAP2K1, AKT2, AXIN1

Valdecoxib

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Valdecoxib

hsa05231

Choline metabolism in cancer

2.60E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Valdecoxib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9.65E-08

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.824
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719

Valdecoxib

hsa05310

Asthma

1.57E-06

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Valdecoxib

hsa05321

Inflammatory bowel disease

1.37E-12

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.756
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713

Valdecoxib

hsa05322

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Valdecoxib

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Valdecoxib

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Valdecoxib

hsa05332

Graft-versus-host disease

6.41E-10

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.846
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838

Valdecoxib

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Valdecoxib

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Valdecoxib

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Valdecoxib

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Valdecoxib

hsa05418

Fluid shear stress and atherosclerosis

1.27E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1

Community members of Valdecoxib (S_DC: 9.09)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CA2

Carbonic anhydrase 2

Reported

0.1125

0.2215

2.2778

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

Q99814

EPAS1

Endothelial PAS domainNonecontaining protein 1

Predicted

0.2322

0.062

0.2491

0.4892

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P33260

CYP2C18

Cytochrome P450 2C18

Predicted

0.0239

0.0756

0.1528

0.316

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

P25963

NFKBIA

NFNonekappaNoneB inhibitor alpha

Predicted

0.1048

0.0295

1.1114

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

P22894

MMP8

Neutrophil collagenase

Predicted

0.1061

0.357

0.767

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

Q16875

PFKFB3

6NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3

Predicted

0.0462

0.0886

0.2342

0.4345

Q08881

ITK

TyrosineNoneprotein kinase ITK/TSK

Predicted

0.1635

0.5545

0.422

1.6127

O15294

OGT

UDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunit

Predicted

0.2739

0.0602

0.1021

0.3594

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

O75460

ERN1

Serine/threonineNoneprotein kinase/endoribonuclease IRE1

Predicted

0.6806

0.2944

0.557

1.4862

O75493

CA11

Carbonic anhydraseNonerelated protein 11

Predicted

0.0745

0.0612

0.1597

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

PharmaCoNets of Valdecoxib (SPCN: 205.92 )

Valdecoxib regulated-network (SDN: 22.65)

Community members of Valdecoxib (SDC: 9.09)

PharmaCoNets of Valdecoxib (S_PCN: 205.92 )

Valdecoxib regulated-network (S_DN: 22.65)

Community members of Valdecoxib (S_DC: 9.09)