PharmaCoNets

PharmaCoNets of Upadacitinib (S_PCN: 18.91 )

Upadacitinib regulated-network (S_DN: 4.36)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Upadacitinib

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Upadacitinib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Upadacitinib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Upadacitinib

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Upadacitinib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Upadacitinib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Upadacitinib

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Upadacitinib

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Upadacitinib

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Upadacitinib

hsa04064

NF-kappa B signaling pathway

2.28E-03

O00463, P14778, P01584, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7

TRAF5, IL1R1, IL1B, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD

Upadacitinib

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Upadacitinib

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Upadacitinib

hsa04213

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Upadacitinib

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Upadacitinib

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Upadacitinib

hsa04613

Neutrophil extracellular trap formation

1.73E-02

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Upadacitinib

hsa04623

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Upadacitinib

hsa04657

IL-17 signaling pathway

4.55E-02

O00463, Q16539, P49841, P09341, P14780

TRAF5, MAPK14, GSK3B, CXCL1, MMP9

Upadacitinib

hsa04750

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Upadacitinib

hsa04915

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Upadacitinib

hsa04932

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Upadacitinib

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Upadacitinib

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Upadacitinib

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Upadacitinib

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Upadacitinib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Upadacitinib

hsa05134

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Upadacitinib

hsa05140

Leishmaniasis

2.69E-02

O75015, P13765, O60603, P49006, Q16539

FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14

Upadacitinib

hsa05146

Amoebiasis

4.55E-02

P09341, P14778, P27930, O60603, P05089

CXCL1, IL1R1, IL1R2, TLR2, ARG1

Upadacitinib

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Upadacitinib

hsa05163

Human cytomegalovirus infection

3.41E-03

Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Upadacitinib

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Upadacitinib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Upadacitinib

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Upadacitinib

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Upadacitinib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.55E-02

O95267, P09693, O60603, Q16539, P01730

RASGRP1, CD3G, TLR2, MAPK14, CD4

Upadacitinib

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Upadacitinib

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Upadacitinib (S_DC: 4.34)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

JAK1

TyrosineNoneprotein kinase JAK1

Reported

0.5546

0.9211

3.1195

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

PharmaCoNets of Upadacitinib (SPCN: 18.91 )

Upadacitinib regulated-network (SDN: 4.36)

Community members of Upadacitinib (SDC: 4.34)

PharmaCoNets of Upadacitinib (S_PCN: 18.91 )

Upadacitinib regulated-network (S_DN: 4.36)

Community members of Upadacitinib (S_DC: 4.34)