PharmaCoNets of Ubrogepant (SPCN: 17.64 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ubrogepanthsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ubrogepanthsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Ubrogepanthsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Ubrogepanthsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ubrogepanthsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ubrogepanthsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Ubrogepanthsa00630Glyoxylate and dicarboxylate metabolism4.46E-032P40925, P15104MDH1, GLULMore
Ubrogepanthsa00730Thiamine metabolism1.15E-032Q9Y6K8, P24666AK5, ACP1More
Ubrogepanthsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Ubrogepanthsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Ubrogepanthsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Ubrogepanthsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Ubrogepanthsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Ubrogepanthsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Ubrogepanthsa03040Spliceosome2.96E-025O60508, P08579, Q07955, Q01130, Q9Y2W2CDC40, SNRPB2, SFRS1, SFRS2, WBP11More
Ubrogepanthsa03050Proteasome4.83E-021P55036PSMD4More
Ubrogepanthsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Ubrogepanthsa04014Ras signaling pathway2.54E-025P42338, P20827, P49767, Q13009, P50151PIK3CB, EFNA1, VEGFC, TIAM1, GNG10More
Ubrogepanthsa04151PI3K-Akt signaling pathway1.14E-028P42338, P43657, P20827, P49767, P50151, O15335, Q13751, P14784PIK3CB, P2RY5, EFNA1, VEGFC, GNG10, CHAD, LAMB3, IL2RBMore
Ubrogepanthsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Ubrogepanthsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Ubrogepanthsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Ubrogepanthsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Ubrogepanthsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Ubrogepanthsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ubrogepanthsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Ubrogepanthsa04650Natural killer cell mediated cytotoxicity1.25E-028P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Ubrogepanthsa04662B cell receptor signaling pathway9.78E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Ubrogepanthsa04664Fc epsilon RI signaling pathway1.82E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Ubrogepanthsa04724Glutamatergic synapse3.24E-023P43003, P50151, P15104SLC1A3, GNG10, GLULMore
Ubrogepanthsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Ubrogepanthsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ubrogepanthsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Ubrogepanthsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Ubrogepanthsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Ubrogepanthsa05145Toxoplasmosis3.96E-022P28068, Q16787HLA-DMB, LAMA3More
Ubrogepanthsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Ubrogepanthsa05165Human papillomavirus infection2.01E-023Q16787, Q02930, Q13315LAMA3, CREB5, ATMMore
Ubrogepanthsa05166Human T-cell leukemia virus 1 infection2.91E-023Q02930, P28068, Q13315CREB5, HLA-DMB, ATMMore
Ubrogepanthsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Ubrogepanthsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ubrogepanthsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Ubrogepant (SDC: 4.42)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)