PharmaCoNets of Trovafloxacin (SPCN: 9.58 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trovafloxacinhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Trovafloxacinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Trovafloxacinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Trovafloxacinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Trovafloxacinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Trovafloxacinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Trovafloxacinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Trovafloxacinhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Trovafloxacinhsa03050Proteasome4.83E-021P55036PSMD4More
Trovafloxacinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Trovafloxacinhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Trovafloxacinhsa04020Calcium signaling pathway3.61E-024Q96DU7, Q08828, Q13557, P21860ITPKC, ADCY1, CAMK2D, ERBB3More
Trovafloxacinhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Trovafloxacinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Trovafloxacinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Trovafloxacinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trovafloxacinhsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Trovafloxacinhsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Trovafloxacinhsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Trovafloxacinhsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Trovafloxacinhsa04932Non-alcoholic fatty liver disease4.44E-024Q12933, P01584, P12074, O15239TRAF2, IL1B, COX6A1, NDUFA1More
Trovafloxacinhsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Trovafloxacinhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Trovafloxacinhsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Trovafloxacinhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Trovafloxacinhsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Trovafloxacinhsa05022Pathways of neurodegeneration - multiple diseases9.10E-039O15239, P12074, P05496, Q12933, O15169, P01584, Q13557, P62987, P43686NDUFA1, COX6A1, ATP5G1, TRAF2, AXIN1, IL1B, CAMK2D, UBA52, PSMC4More
Trovafloxacinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trovafloxacinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Trovafloxacinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Trovafloxacinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Trovafloxacinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Trovafloxacin (SDC: 3.08)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)