PharmaCoNets of Tropisetron (SPCN: 195.54 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tropisetronhsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Tropisetronhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Tropisetronhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Tropisetronhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tropisetronhsa00220Arginine biosynthesis5.12E-032P05089, P49448ARG1, GLUD2More
Tropisetronhsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Tropisetronhsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Tropisetronhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Tropisetronhsa00500Starch and sucrose metabolism9.19E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Tropisetronhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Tropisetronhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Tropisetronhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Tropisetronhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Tropisetronhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Tropisetronhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Tropisetronhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Tropisetronhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tropisetronhsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Tropisetronhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Tropisetronhsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Tropisetronhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Tropisetronhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Tropisetronhsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Tropisetronhsa00983Drug metabolism - other enzymes8.59E-044P32320, P05164, Q16772, P09211CDA, MPO, GSTA3, GSTP1More
Tropisetronhsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Tropisetronhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Tropisetronhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Tropisetronhsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Tropisetronhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Tropisetronhsa01522Endocrine resistance2.16E-021P04049RAF1More
Tropisetronhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Tropisetronhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tropisetronhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Tropisetronhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Tropisetronhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tropisetronhsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Tropisetronhsa03060Protein export3.28E-021Q15070OXA1LMore
Tropisetronhsa03410Base excision repair7.59E-031P27695APEX1More
Tropisetronhsa03430Mismatch repair4.38E-021P20585MSH3More
Tropisetronhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Tropisetronhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Tropisetronhsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Tropisetronhsa04014Ras signaling pathway3.65E-021P04049RAF1More
Tropisetronhsa04015Rap1 signaling pathway5.18E-043P04049, P06213, O00522RAF1, INSR, KRIT1More
Tropisetronhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Tropisetronhsa04024cAMP signaling pathway1.02E-025P42338, P0DP23, P04049, Q13370, Q13009PIK3CB, CALM1, RAF1, PDE3B, TIAM1More
Tropisetronhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Tropisetronhsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Tropisetronhsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Tropisetronhsa04064NF-kappa B signaling pathway2.66E-0616O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Tropisetronhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Tropisetronhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Tropisetronhsa04071Sphingolipid signaling pathway1.79E-046P04049, P21453, Q9H228, P01375, Q13362, Q9UQC2RAF1, S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Tropisetronhsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Tropisetronhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Tropisetronhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Tropisetronhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Tropisetronhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Tropisetronhsa04140Autophagy - animal2.82E-021P04049RAF1More
Tropisetronhsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Tropisetronhsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Tropisetronhsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Tropisetronhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Tropisetronhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Tropisetronhsa04218Cellular senescence2.49E-021P04049RAF1More
Tropisetronhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Tropisetronhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Tropisetronhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Tropisetronhsa04360Axon guidance5.32E-035P20827, O95631, P42338, P23528, P04049EFNA1, NTN1, PIK3CB, CFL1, RAF1More
Tropisetronhsa04370VEGF signaling pathway1.79E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Tropisetronhsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Tropisetronhsa04380Osteoclast differentiation9.58E-0513Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Tropisetronhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Tropisetronhsa04510Focal adhesion3.48E-021P04049RAF1More
Tropisetronhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Tropisetronhsa04540Gap junction1.33E-021P04049RAF1More
Tropisetronhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Tropisetronhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Tropisetronhsa04612Antigen processing and presentation9.02E-058P13765, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Tropisetronhsa04613Neutrophil extracellular trap formation1.39E-0420P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Tropisetronhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Tropisetronhsa04625C-type lectin receptor signaling pathway2.21E-0410Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Tropisetronhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Tropisetronhsa04640Hematopoietic cell lineage6.03E-0615P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Tropisetronhsa04650Natural killer cell mediated cytotoxicity3.47E-1018P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Tropisetronhsa04657IL-17 signaling pathway2.40E-069O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Tropisetronhsa04658Th1 and Th2 cell differentiation3.66E-1015Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Tropisetronhsa04659Th17 cell differentiation2.44E-0918Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Tropisetronhsa04660T cell receptor signaling pathway8.29E-0816P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Tropisetronhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Tropisetronhsa04664Fc epsilon RI signaling pathway7.50E-034P01375, Q16539, Q9UQC2, P04049TNF, MAPK14, GAB2, RAF1More
Tropisetronhsa04666Fc gamma R-mediated phagocytosis1.31E-024P42338, P04049, P23528, P14598PIK3CB, RAF1, CFL1, NCF1More
Tropisetronhsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Tropisetronhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tropisetronhsa04720Long-term potentiation2.17E-034P16298, P51812, Q02750, P04049PPP3CB, RPS6KA3, MAP2K1, RAF1More
Tropisetronhsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Tropisetronhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Tropisetronhsa04730Long-term depression1.16E-021P04049RAF1More
Tropisetronhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Tropisetronhsa04742Taste transduction1.01E-021P30939HTR1FMore
Tropisetronhsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Tropisetronhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Tropisetronhsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Tropisetronhsa04912GnRH signaling pathway2.74E-027P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1More
Tropisetronhsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Tropisetronhsa04914Progesterone-mediated oocyte maturation9.67E-047Q17RY0, P42338, Q13370, P08238, P51812, Q02750, P04049CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Tropisetronhsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Tropisetronhsa04916Melanogenesis1.33E-021P04049RAF1More
Tropisetronhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Tropisetronhsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Tropisetronhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Tropisetronhsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Tropisetronhsa04924Renin secretion2.98E-034P22694, P07550, Q13370, P0DP23PRKACB, ADRB2, PDE3B, CALM1More
Tropisetronhsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Tropisetronhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Tropisetronhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Tropisetronhsa04929GnRH secretion4.98E-031P04049RAF1More
Tropisetronhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Tropisetronhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Tropisetronhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Tropisetronhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Tropisetronhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tropisetronhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Tropisetronhsa04964Proximal tubule bicarbonate reclamation4.03E-032P00918, P49448CA2, GLUD2More
Tropisetronhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Tropisetronhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Tropisetronhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Tropisetronhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Tropisetronhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tropisetronhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tropisetronhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Tropisetronhsa05034Alcoholism2.78E-045P04049, Q93077, P62807, O60814, P68431RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tropisetronhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Tropisetronhsa05132Salmonella infection4.98E-021P04049RAF1More
Tropisetronhsa05133Pertussis3.51E-021P0C0L4C4AMore
Tropisetronhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Tropisetronhsa05140Leishmaniasis1.93E-0310P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Tropisetronhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Tropisetronhsa05144Malaria1.74E-036P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Tropisetronhsa05146Amoebiasis6.99E-0814P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Tropisetronhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Tropisetronhsa05152Tuberculosis3.98E-021P04049RAF1More
Tropisetronhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Tropisetronhsa05161Hepatitis B1.99E-021P04049RAF1More
Tropisetronhsa05163Human cytomegalovirus infection4.07E-039P04049, P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463RAF1, TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Tropisetronhsa05164Influenza A3.65E-021P04049RAF1More
Tropisetronhsa05167Kaposi sarcoma-associated herpesvirus infection4.57E-035P62879, P16298, P04049, Q02750, P0CG47GNB2, PPP3CB, RAF1, MAP2K1, UBBMore
Tropisetronhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Tropisetronhsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Tropisetronhsa05170Human immunodeficiency virus 1 infection1.31E-036P04049, Q02750, P62879, P16298, Q05397, P20333RAF1, MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Tropisetronhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Tropisetronhsa05202Transcriptional misregulation in cancer6.59E-0315P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Tropisetronhsa05203Viral carcinogenesis6.22E-035Q12933, P42229, Q15283, P62807, O60814TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12More
Tropisetronhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Tropisetronhsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Tropisetronhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Tropisetronhsa05210Colorectal cancer1.66E-021P04049RAF1More
Tropisetronhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Tropisetronhsa05212Pancreatic cancer2.44E-034P42338, P04049, P42224, O75293PIK3CB, RAF1, STAT1, GADD45BMore
Tropisetronhsa05213Endometrial cancer4.26E-033O15169, Q02750, P04049AXIN1, MAP2K1, RAF1More
Tropisetronhsa05214Glioma1.88E-034P0DP23, P04049, P42338, O75293CALM1, RAF1, PIK3CB, GADD45BMore
Tropisetronhsa05215Prostate cancer1.33E-021P04049RAF1More
Tropisetronhsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Tropisetronhsa05218Melanoma6.63E-031P04049RAF1More
Tropisetronhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Tropisetronhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Tropisetronhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Tropisetronhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Tropisetronhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Tropisetronhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Tropisetronhsa05226Gastric cancer3.26E-033P04049, Q02750, O15169RAF1, MAP2K1, AXIN1More
Tropisetronhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Tropisetronhsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Tropisetronhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.99E-0613P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Tropisetronhsa05321Inflammatory bowel disease7.47E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Tropisetronhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tropisetronhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tropisetronhsa05332Graft-versus-host disease9.47E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Tropisetronhsa05340Primary immunodeficiency2.53E-036P01730, P01732, P11912, P16871, P07766, P06239CD4, CD8A, CD79A, IL7R, CD3E, LCKMore
Tropisetronhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Tropisetronhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Tropisetronhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Tropisetronhsa05418Fluid shear stress and atherosclerosis1.56E-0512Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Tropisetron (SDC: 8.88)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q14790CASP8CaspaseNone8Predicted10.150.055811.1867
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)