PharmaCoNets of Tropicamide (SPCN: 56.72 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tropicamidehsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Tropicamidehsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Tropicamidehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Tropicamidehsa01522Endocrine resistance2.16E-021P04049RAF1More
Tropicamidehsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Tropicamidehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Tropicamidehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Tropicamidehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Tropicamidehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Tropicamidehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Tropicamidehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Tropicamidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Tropicamidehsa04062Chemokine signaling pathway7.67E-039P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151, P04049CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10, RAF1More
Tropicamidehsa04064NF-kappa B signaling pathway2.98E-0413P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Tropicamidehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Tropicamidehsa04071Sphingolipid signaling pathway4.86E-036P04049, P21453, Q9H228, Q13362, Q9BX95, P10415RAF1, S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Tropicamidehsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Tropicamidehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Tropicamidehsa04140Autophagy - animal2.95E-025P04049, P22694, Q14643, P10415, Q04759RAF1, PRKACB, ITPR1, BCL2, PRKCQMore
Tropicamidehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Tropicamidehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Tropicamidehsa04210Apoptosis3.76E-038Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643, P04049ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1, RAF1More
Tropicamidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Tropicamidehsa04217Necroptosis1.93E-024P01568, Q13489, Q13546, Q6FI13IFNA21, BIRC3, RIPK1, H2AC18; H2AC19More
Tropicamidehsa04218Cellular senescence2.49E-021P04049RAF1More
Tropicamidehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Tropicamidehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Tropicamidehsa04360Axon guidance2.49E-021P04049RAF1More
Tropicamidehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Tropicamidehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Tropicamidehsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Tropicamidehsa04510Focal adhesion3.48E-021P04049RAF1More
Tropicamidehsa04540Gap junction1.33E-021P04049RAF1More
Tropicamidehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Tropicamidehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Tropicamidehsa04613Neutrophil extracellular trap formation5.26E-039P04049, O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730RAF1, TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Tropicamidehsa04623Cytosolic DNA-sensing pathway5.29E-032P01568, Q13546IFNA21, RIPK1More
Tropicamidehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Tropicamidehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Tropicamidehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Tropicamidehsa04650Natural killer cell mediated cytotoxicity2.45E-0511P19174, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, P26717, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Tropicamidehsa04658Th1 and Th2 cell differentiation7.66E-0712Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Tropicamidehsa04659Th17 cell differentiation8.48E-0511Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Tropicamidehsa04660T cell receptor signaling pathway6.65E-0613Q9UDY8, Q04759, P42338, P10747, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049MALT1, PRKCQ, PIK3CB, CD28, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1More
Tropicamidehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Tropicamidehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Tropicamidehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Tropicamidehsa04720Long-term potentiation1.66E-021P04049RAF1More
Tropicamidehsa04722Neurotrophin signaling pathway2.32E-021P04049RAF1More
Tropicamidehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Tropicamidehsa04730Long-term depression1.16E-021P04049RAF1More
Tropicamidehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Tropicamidehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Tropicamidehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Tropicamidehsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Tropicamidehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Tropicamidehsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Tropicamidehsa04916Melanogenesis1.33E-021P04049RAF1More
Tropicamidehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Tropicamidehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Tropicamidehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Tropicamidehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Tropicamidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Tropicamidehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Tropicamidehsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Tropicamidehsa04928Parathyroid hormone synthesis, secretion and action1.60E-025Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Tropicamidehsa04929GnRH secretion4.98E-031P04049RAF1More
Tropicamidehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Tropicamidehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Tropicamidehsa05034Alcoholism2.49E-021P04049RAF1More
Tropicamidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Tropicamidehsa05132Salmonella infection6.26E-047P04049, Q9UJU2, Q13546, Q13489, Q13561, Q13509, P68371RAF1, LEF1, RIPK1, BIRC3, DCTN2, TUBB3, TUBB2CMore
Tropicamidehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Tropicamidehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Tropicamidehsa05152Tuberculosis3.98E-021P04049RAF1More
Tropicamidehsa05160Hepatitis C1.99E-021P04049RAF1More
Tropicamidehsa05161Hepatitis B1.99E-021P04049RAF1More
Tropicamidehsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Tropicamidehsa05164Influenza A3.65E-021P04049RAF1More
Tropicamidehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Tropicamidehsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Tropicamidehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Tropicamidehsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Tropicamidehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Tropicamidehsa05210Colorectal cancer1.66E-021P04049RAF1More
Tropicamidehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Tropicamidehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Tropicamidehsa05213Endometrial cancer9.95E-031P04049RAF1More
Tropicamidehsa05214Glioma9.95E-031P04049RAF1More
Tropicamidehsa05215Prostate cancer1.33E-021P04049RAF1More
Tropicamidehsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Tropicamidehsa05218Melanoma6.63E-031P04049RAF1More
Tropicamidehsa05219Bladder cancer4.98E-031P04049RAF1More
Tropicamidehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Tropicamidehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Tropicamidehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Tropicamidehsa05224Breast cancer1.49E-021P04049RAF1More
Tropicamidehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Tropicamidehsa05226Gastric cancer8.29E-031P04049RAF1More
Tropicamidehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Tropicamidehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Tropicamidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.14E-0410P42338, P19174, P07766, P20963, P09693, P06239, P04049, O60603, P10747, Q04759PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, CD28, PRKCQMore
Tropicamidehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Tropicamidehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Tropicamidehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More

Community members of Tropicamide (SDC: 4.06)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)