PharmaCoNets of Troglitazone (SPCN: 7.04 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Troglitazonehsa00040Pentose and glucuronate interconversions2.33E-042P15121, P14550AKR1B1, AKR1A1More
Troglitazonehsa00061Fatty acid biosynthesis1.52E-031Q9UKU0ACSL6More
Troglitazonehsa00071Fatty acid degradation4.55E-031Q9UKU0ACSL6More
Troglitazonehsa00220Arginine biosynthesis1.50E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Troglitazonehsa00280Valine, leucine and isoleucine degradation3.30E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Troglitazonehsa00520Amino sugar and nucleotide sugar metabolism7.87E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Troglitazonehsa00561Glycerolipid metabolism2.62E-022P15121, P14550AKR1B1, AKR1A1More
Troglitazonehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Troglitazonehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Troglitazonehsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Troglitazonehsa00983Drug metabolism - other enzymes1.63E-022P20839, Q16772IMPDH1, GSTA3More
Troglitazonehsa01100Metabolic pathways5.84E-0344P35790, P05089, Q16772, Q9UJ14, P30041, P15104, O14986, P48426, Q14642, Q96DU7, P07195, Q08828, Q02153, P20839, O94777, Q16875, O43286, O43451, P15121, Q86XP1, O95861, P14550, Q14739, Q9UHK6, P11511, Q86VZ5, Q08477, P15907, Q9UNP4, Q9H4F1, P32321, P60891, P49448, P15586, P00352, Q9BPW9, P43490, P46976, P05166, P13073, P05496, O15239, O15047, Q9NVH6CHKA, ARG1, GSTA3, GGTL3, PRDX6, GLUL, PIP5K1B, PIP4K2A, INPP5A, ITPKC, LDHB, ADCY1, GUCY1B3, IMPDH1, DPM2, PFKFB3, B4GALT5, MGAM, AKR1B1, DGKH, BPNT1, AKR1A1, LBR, AMACR, CYP19A1, SGMS1, CYP4F3, ST6GAL1, ST3GAL5, ST6GALNAC4, DCTD, PRPS1, GLUD2, GNS, ALDH1A1, DHRS9, PBEF1, GYG1, PCCB, COX4I1, ATP5G1, NDUFA1, SETD1A, TMLHEMore
Troglitazonehsa01212Fatty acid metabolism7.59E-031Q9UKU0ACSL6More
Troglitazonehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Troglitazonehsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Troglitazonehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Troglitazonehsa03320PPAR signaling pathway4.38E-033Q6PCB7, Q9UKU0, Q9UNU6SLC27A1, ACSL6, CYP8B1More
Troglitazonehsa04060Cytokine-cytokine receptor interaction4.33E-0211P27930, P14778, P01584, Q13651, Q9HBE5, Q9UBD3, P47992, P09341, P32248, P18510, P01730IL1R2, IL1R1, IL1B, IL10RA, IL21R, XCL2, XCL1, CXCL1, CCR7, IL1RN, CD4More
Troglitazonehsa04071Sphingolipid signaling pathway2.08E-026P17252, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Troglitazonehsa04114Oocyte meiosis4.51E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Troglitazonehsa04146Peroxisome1.37E-021Q9UKU0ACSL6More
Troglitazonehsa04151PI3K-Akt signaling pathway2.51E-0216P21860, P43657, P01106, P27348, O14944, Q9GZP0, P07900, P62873, P50151, P13612, P26012, P24821, Q16363, P22105, Q99941, P18848ERBB3, P2RY5, MYC, YWHAQ, EREG, PDGFD, HSP90AA1, GNB1, GNG10, ITGA4, ITGB8, TNC, LAMA4, TNXB, CREBL1, ATF4More
Troglitazonehsa04216Ferroptosis1.52E-021Q9UKU0ACSL6More
Troglitazonehsa04370VEGF signaling pathway2.47E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Troglitazonehsa04512ECM-receptor interaction4.68E-025Q16363, P24821, P22105, P13612, P26012LAMA4, TNC, TNXB, ITGA4, ITGB8More
Troglitazonehsa04613Neutrophil extracellular trap formation2.33E-0212P17252, O60603, P05164, P08246, Q6FI13, P68431, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Troglitazonehsa04640Hematopoietic cell lineage6.74E-0310P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P13765, P01584ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, HLA-DOB, IL1BMore
Troglitazonehsa04650Natural killer cell mediated cytotoxicity3.08E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Troglitazonehsa04658Th1 and Th2 cell differentiation3.62E-0411Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P46531, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, NOTCH1, HLA-DOB, RUNX3More
Troglitazonehsa04659Th17 cell differentiation8.31E-0513Q04759, P01730, P06239, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07900, P07766, P09693, P20963PRKCQ, CD4, LCK, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, HSP90AA1, CD3E, CD3G, CD247More
Troglitazonehsa04660T cell receptor signaling pathway4.36E-0310Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Troglitazonehsa04666Fc gamma R-mediated phagocytosis2.66E-025O75015, P06396, O14494, Q9UQC2, P17252FCGR3B, GSN, PLPP1, GAB2, PRKCAMore
Troglitazonehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Troglitazonehsa04714Thermogenesis3.64E-021Q9UKU0ACSL6More
Troglitazonehsa04720Long-term potentiation2.35E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Troglitazonehsa04750Inflammatory mediator regulation of TRP channels3.28E-026P14778, P01584, Q08828, Q13557, P24723, Q04759IL1R1, IL1B, ADCY1, CAMK2D, PRKCH, PRKCQMore
Troglitazonehsa04912GnRH signaling pathway3.30E-024P17252, Q16539, Q9Y6R4, Q14643PRKCA, MAPK14, MAP3K4, ITPR1More
Troglitazonehsa04914Progesterone-mediated oocyte maturation7.70E-034Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Troglitazonehsa04920Adipocytokine signaling pathway4.85E-033Q9UKU0, Q9Y478, Q96RR4ACSL6, PRKAB1, CAMKK2More
Troglitazonehsa04934Cushing syndrome2.63E-026Q99941, P18848, Q08828, O15169, Q13557, O00170CREBL1, ATF4, ADCY1, AXIN1, CAMK2D, AIPMore
Troglitazonehsa05135Yersinia infection2.58E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Troglitazonehsa05146Amoebiasis7.62E-039P01584, Q16363, P09341, P14778, P27930, P05089, Q08828, P12814, P08311IL1B, LAMA4, CXCL1, IL1R1, IL1R2, ARG1, ADCY1, ACTN1, CTSGMore
Troglitazonehsa05170Human immunodeficiency virus 1 infection4.37E-024Q02750, P62879, P16298, Q05397MAP2K1, GNB2, PPP3CB, PTK2More
Troglitazonehsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Troglitazonehsa05202Transcriptional misregulation in cancer1.75E-0212Q15532, P14780, P27930, Q16548, Q13489, Q13077, P35226, P05164, P08246, P41182, P68431, P24522SS18, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, GADD45AMore
Troglitazonehsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Troglitazonehsa05217Basal cell carcinoma3.30E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Troglitazonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.83E-027O95267, P07766, P20963, P09693, P06239, Q04759, P01730RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Troglitazonehsa05321Inflammatory bowel disease4.68E-025P13765, Q9UL17, P23771, P01584, Q9HBE5HLA-DOB, TBX21, GATA3, IL1B, IL21RMore
Troglitazonehsa05340Primary immunodeficiency3.99E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Troglitazonehsa05415Diabetic cardiomyopathy3.07E-027P17252, Q15080, Q16718, O14521, Q16539, P49841, P14780PRKCA, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9More

Community members of Troglitazone (SDC: 1.16)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09211GSTP1Glutathione SNonetransferase PReported00.32040.35230.45661.3213
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P33121ACSL1LongNonechainNonefattyNoneacidNoneNoneCoA ligase 1Predicted00.03730.01320.27090.3161
Q9UKU0ACSL6LongNonechainNonefattyNoneacidNoneNoneCoA ligase 6Predicted00.45810.01110.27090.5222
P10588NR2F6Nuclear receptor subfamily 2 group F member 6Predicted00.39230.06800.3321
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
P30740SERPINB1Leukocyte elastase inhibitorPredicted10.57720.013700.3159
Q16772GSTA3Glutathione SNonetransferase A3Predicted00.46240.03360.4250.7234
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)