PharmaCoNets of Trimipramine (SPCN: 185.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trimipraminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Trimipraminehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Trimipraminehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Trimipraminehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Trimipraminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Trimipraminehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Trimipraminehsa00230Purine metabolism4.93E-021P21589NT5EMore
Trimipraminehsa00240Pyrimidine metabolism3.20E-032P21589, P04183NT5E, TK1More
Trimipraminehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Trimipraminehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Trimipraminehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Trimipraminehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Trimipraminehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Trimipraminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Trimipraminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Trimipraminehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Trimipraminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Trimipraminehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Trimipraminehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Trimipraminehsa00760Nicotinate and nicotinamide metabolism6.37E-041P21589NT5EMore
Trimipraminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Trimipraminehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Trimipraminehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Trimipraminehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Trimipraminehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Trimipraminehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Trimipraminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Trimipraminehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Trimipraminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Trimipraminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Trimipraminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Trimipraminehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Trimipraminehsa01522Endocrine resistance2.16E-021P04049RAF1More
Trimipraminehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Trimipraminehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Trimipraminehsa03010Ribosome1.08E-0411P62753, P25398, P32969, P40429, P62829, Q07020, P18077, P36578, P27635, P05386, P62249RPS6, RPS12, RPL9, RPL13A, RPL23, RPL18, RPL35A, RPL4, RPL10, RPLP1, RPS16More
Trimipraminehsa03013RNA transport4.92E-0310P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Trimipraminehsa03020RNA polymerase1.27E-043P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Trimipraminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Trimipraminehsa03050Proteasome1.21E-021P28074PSMB5More
Trimipraminehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Trimipraminehsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Trimipraminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Trimipraminehsa03430Mismatch repair4.38E-021P20585MSH3More
Trimipraminehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Trimipraminehsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Trimipraminehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Trimipraminehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Trimipraminehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Trimipraminehsa04015Rap1 signaling pathway3.75E-047P04049, P06213, P25116, Q8TEU7, O00522, P08514, P17252RAF1, INSR, F2R, RAPGEF6, KRIT1, ITGA2B, PRKCAMore
Trimipraminehsa04022cGMP-PKG signaling pathway6.45E-035P04049, P18848, Q8WYR1, P05141, P0DP24RAF1, ATF4, PIK3R5, SLC25A5, CALM2More
Trimipraminehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Trimipraminehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Trimipraminehsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Trimipraminehsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Trimipraminehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Trimipraminehsa04071Sphingolipid signaling pathway1.10E-0610P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Trimipraminehsa04072Phospholipase D signaling pathway7.52E-043P04049, Q92529, Q14344RAF1, SHC3, GNA13More
Trimipraminehsa04080Neuroactive ligand-receptor interaction1.02E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Trimipraminehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Trimipraminehsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Trimipraminehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Trimipraminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Trimipraminehsa04140Autophagy - animal2.82E-021P04049RAF1More
Trimipraminehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Trimipraminehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Trimipraminehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Trimipraminehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Trimipraminehsa04151PI3K-Akt signaling pathway1.24E-0315P62753, P43657, O43521, P27348, P09603, Q9GZP0, Q8WYR1, P63218, P50151, P13612, O15335, Q13751, P18848, O00141, Q6ZUJ8RPS6, P2RY5, BCL2L11, YWHAQ, CSF1, PDGFD, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMB3, ATF4, SGK, PIK3AP1More
Trimipraminehsa04210Apoptosis5.34E-0515Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643, P04049ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1, RAF1More
Trimipraminehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Trimipraminehsa04217Necroptosis8.10E-0711P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557, Q9H444TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2D, CHMP4BMore
Trimipraminehsa04218Cellular senescence8.08E-035P01106, P04049, O75293, P30304, P06493MYC, RAF1, GADD45B, CDC25A, CDK1More
Trimipraminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Trimipraminehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Trimipraminehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Trimipraminehsa04360Axon guidance2.49E-021P04049RAF1More
Trimipraminehsa04370VEGF signaling pathway2.77E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Trimipraminehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Trimipraminehsa04510Focal adhesion3.48E-021P04049RAF1More
Trimipraminehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Trimipraminehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Trimipraminehsa04540Gap junction1.33E-021P04049RAF1More
Trimipraminehsa04550Signaling pathways regulating pluripotency of stem cells9.61E-034Q13873, P04049, Q02750, Q86SE9BMPR2, RAF1, MAP2K1, PCGF5More
Trimipraminehsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Trimipraminehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Trimipraminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Trimipraminehsa04613Neutrophil extracellular trap formation1.84E-0926P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Trimipraminehsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Trimipraminehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Trimipraminehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Trimipraminehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Trimipraminehsa04650Natural killer cell mediated cytotoxicity5.84E-0611P16298, P50591, P01375, P20963, Q02750, P04049, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Trimipraminehsa04657IL-17 signaling pathway5.66E-0510P07900, O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Trimipraminehsa04660T cell receptor signaling pathway8.18E-038P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P04049TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, RAF1More
Trimipraminehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Trimipraminehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Trimipraminehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Trimipraminehsa04668TNF signaling pathway2.79E-0411P01375, O00463, Q13489, P25963, P18848, P19875, P01584, P20749, Q13077, P14780, P20333TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, TNFRSF1BMore
Trimipraminehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Trimipraminehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Trimipraminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Trimipraminehsa04720Long-term potentiation4.88E-034P16298, P51812, Q02750, P04049PPP3CB, RPS6KA3, MAP2K1, RAF1More
Trimipraminehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Trimipraminehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Trimipraminehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Trimipraminehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Trimipraminehsa04730Long-term depression1.26E-033Q14344, P04049, P07948GNA13, RAF1, LYNMore
Trimipraminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Trimipraminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Trimipraminehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Trimipraminehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Trimipraminehsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Trimipraminehsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Trimipraminehsa04914Progesterone-mediated oocyte maturation1.91E-035Q17RY0, Q9Y6D9, P51812, Q02750, P04049CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Trimipraminehsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Trimipraminehsa04916Melanogenesis1.33E-021P04049RAF1More
Trimipraminehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Trimipraminehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Trimipraminehsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Trimipraminehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Trimipraminehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Trimipraminehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Trimipraminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Trimipraminehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Trimipraminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Trimipraminehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Trimipraminehsa04929GnRH secretion4.98E-031P04049RAF1More
Trimipraminehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Trimipraminehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Trimipraminehsa04932Non-alcoholic fatty liver disease4.65E-0711P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Trimipraminehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Trimipraminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Trimipraminehsa04960Aldosterone-regulated sodium reabsorption2.32E-032P06213, P48048INSR, KCNJ1More
Trimipraminehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Trimipraminehsa04966Collecting duct acid secretion1.38E-032P02730, P00918SLC4A1, CA2More
Trimipraminehsa04970Salivary secretion2.82E-035P07550, P22694, Q14643, P17252, P49913ADRB2, PRKACB, ITPR1, PRKCA, CAMPMore
Trimipraminehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Trimipraminehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Trimipraminehsa05010Alzheimer disease4.88E-0312P13073, O15399, Q9NZJ5, O75460, P0DP24, Q13564, P01584, P18848, Q71U36, P09603, P05141, P21796COX4I1, GRIN2D, EIF2AK3, ERN1, CALM2, APPBP1, IL1B, ATF4, TUBA1A, CSF1, SLC25A5, VDAC1More
Trimipraminehsa05012Parkinson disease2.77E-037O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2DMore
Trimipraminehsa05016Huntington disease4.33E-037O15239, P13073, P24928, P30876, P62487, P05141, O75460NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1More
Trimipraminehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Trimipraminehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Trimipraminehsa05022Pathways of neurodegeneration - multiple diseases9.19E-0515P49841, O15239, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2, CAMK2DMore
Trimipraminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Trimipraminehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Trimipraminehsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trimipraminehsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Trimipraminehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Trimipraminehsa05132Salmonella infection1.81E-0212P51617, P25963, P01375, P04049, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, RAF1, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Trimipraminehsa05133Pertussis4.24E-031P0C0L4C4AMore
Trimipraminehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Trimipraminehsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Trimipraminehsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Trimipraminehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Trimipraminehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Trimipraminehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Trimipraminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Trimipraminehsa05152Tuberculosis1.41E-0210P04049, Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617RAF1, TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Trimipraminehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Trimipraminehsa05161Hepatitis B4.82E-039P17252, P04049, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, RAF1, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Trimipraminehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Trimipraminehsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Trimipraminehsa05164Influenza A3.65E-021P04049RAF1More
Trimipraminehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Trimipraminehsa05170Human immunodeficiency virus 1 infection2.93E-0414P04049, P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5RAF1, TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Trimipraminehsa05171Coronavirus disease - COVID-196.98E-0512P01584, P62753, P25398, P62249, P40429, P36578, P32969, P27635, Q07020, P18077, P05386, P62829IL1B, RPS6, RPS12, RPS16, RPL13A, RPL4, RPL9, RPL10, RPL18, RPL35A, RPLP1, RPL23More
Trimipraminehsa05202Transcriptional misregulation in cancer1.61E-0620Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Trimipraminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Trimipraminehsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Trimipraminehsa05205Proteoglycans in cancer1.38E-0310Q12955, P04049, Q14247, P14780, P17252, P01375, P23588, Q13635, P22694, P08962ANK3, RAF1, CTTN, MMP9, PRKCA, TNF, EIF4B, PTCH1, PRKACB, CD63More
Trimipraminehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Trimipraminehsa05210Colorectal cancer1.66E-021P04049RAF1More
Trimipraminehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Trimipraminehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Trimipraminehsa05213Endometrial cancer9.95E-031P04049RAF1More
Trimipraminehsa05214Glioma9.95E-031P04049RAF1More
Trimipraminehsa05215Prostate cancer1.33E-021P04049RAF1More
Trimipraminehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Trimipraminehsa05218Melanoma9.63E-044P09619, Q9GZP0, Q02750, P04049PDGFRB, PDGFD, MAP2K1, RAF1More
Trimipraminehsa05219Bladder cancer4.98E-031P04049RAF1More
Trimipraminehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Trimipraminehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Trimipraminehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Trimipraminehsa05223Non-small cell lung cancer6.95E-044P10826, P04049, Q9HC35, O75293RARB, RAF1, EML4, GADD45BMore
Trimipraminehsa05224Breast cancer1.49E-021P04049RAF1More
Trimipraminehsa05225Hepatocellular carcinoma6.30E-043P04049, Q92529, P51531RAF1, SHC3, SMARCA2More
Trimipraminehsa05226Gastric cancer8.29E-031P04049RAF1More
Trimipraminehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Trimipraminehsa05231Choline metabolism in cancer1.49E-035Q02750, P04049, P09619, Q9GZP0, O15245MAP2K1, RAF1, PDGFRB, PDGFD, SLC22A1More
Trimipraminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.21E-035P07766, P06239, P04049, Q9HC35, P01730CD3E, LCK, RAF1, EML4, CD4More
Trimipraminehsa05310Asthma1.70E-034P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Trimipraminehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Trimipraminehsa05321Inflammatory bowel disease7.13E-046O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Trimipraminehsa05322Systemic lupus erythematosus1.52E-0514P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Trimipraminehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Trimipraminehsa05332Graft-versus-host disease2.32E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Trimipraminehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Trimipraminehsa05412Arrhythmogenic right ventricular cardiomyopathy2.60E-046Q8IZS8, P54284, P14923, P08514, P13612, Q9UJU2CACNA2D3, CACNB3, JUP, ITGA2B, ITGA4, LEF1More
Trimipraminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Trimipraminehsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Trimipraminehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Trimipramine (SDC: 7.45)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645Ki149