PharmaCoNets of Trimetrexate (SPCN: 49.54 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trimetrexatehsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Trimetrexatehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Trimetrexatehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Trimetrexatehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Trimetrexatehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Trimetrexatehsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Trimetrexatehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Trimetrexatehsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Trimetrexatehsa04062Chemokine signaling pathway4.01E-0413P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITKMore
Trimetrexatehsa04064NF-kappa B signaling pathway6.63E-0516P10415, Q13489, O00463, P14778, P29965, P19174, Q04759, Q9UDY8, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643BCL2, BIRC3, TRAF5, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Trimetrexatehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Trimetrexatehsa04071Sphingolipid signaling pathway4.49E-024P17252, Q13362, Q9BX95, P10415PRKCA, PPP2R5C, SGPP1, BCL2More
Trimetrexatehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Trimetrexatehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Trimetrexatehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Trimetrexatehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Trimetrexatehsa04217Necroptosis9.14E-037P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPIDMore
Trimetrexatehsa04261Adrenergic signaling in cardiomyocytes2.84E-025P09493, Q13362, P0DP23, P17252, P10415TPM1, PPP2R5C, CALM1, PRKCA, BCL2More
Trimetrexatehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Trimetrexatehsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Trimetrexatehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Trimetrexatehsa04613Neutrophil extracellular trap formation3.58E-028P17252, O60603, P08246, Q6FI13, P68431, P14598, Q15080, P21462PRKCA, TLR2, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Trimetrexatehsa04640Hematopoietic cell lineage1.03E-0511P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Trimetrexatehsa04650Natural killer cell mediated cytotoxicity2.48E-0510P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Trimetrexatehsa04658Th1 and Th2 cell differentiation2.82E-1012Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Trimetrexatehsa04659Th17 cell differentiation2.90E-0812Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Trimetrexatehsa04660T cell receptor signaling pathway1.03E-0511Q04759, P42338, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, PIK3CB, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Trimetrexatehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Trimetrexatehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Trimetrexatehsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Trimetrexatehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Trimetrexatehsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Trimetrexatehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Trimetrexatehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Trimetrexatehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Trimetrexatehsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Trimetrexatehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Trimetrexatehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Trimetrexatehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Trimetrexatehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Trimetrexatehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Trimetrexatehsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Trimetrexatehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Trimetrexatehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Trimetrexatehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Trimetrexatehsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Trimetrexatehsa05022Pathways of neurodegeneration - multiple diseases4.48E-0310Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1More
Trimetrexatehsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Trimetrexatehsa05120Epithelial cell signaling in Helicobacter pylori infection5.80E-057Q99437, P09341, P19875, P19174, P25024, P25025, P41240ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSKMore
Trimetrexatehsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Trimetrexatehsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Trimetrexatehsa05133Pertussis3.51E-021P0C0L4C4AMore
Trimetrexatehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Trimetrexatehsa05140Leishmaniasis2.17E-036P14598, P42224, P13765, O60603, P29350, Q15080NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4More
Trimetrexatehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Trimetrexatehsa05146Amoebiasis8.66E-069P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Trimetrexatehsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Trimetrexatehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Trimetrexatehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Trimetrexatehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Trimetrexatehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Trimetrexatehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Trimetrexatehsa05200Pathways in cancer8.04E-0315P17301, P42224, Q9UJU2, P17252, P20585, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P62879, P0DP23, P01568ITGA2, STAT1, LEF1, PRKCA, MSH3, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GNB2, CALM1, IFNA21More
Trimetrexatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.33E-048P42338, P19174, P07766, P20963, P09693, P06239, Q04759, P01730PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Trimetrexatehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Trimetrexatehsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trimetrexatehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Trimetrexatehsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Trimetrexatehsa05332Graft-versus-host disease3.93E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Trimetrexatehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Trimetrexatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Trimetrexatehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Trimetrexatehsa05415Diabetic cardiomyopathy3.55E-025P17252, P14598, Q15080, Q16718, O14521PRKCA, NCF1, NCF4, NDUFA5, SDHDMore
Trimetrexatehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Trimetrexate (SDC: 4.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00374DHFRDihydrofolate reductaseReported00.3380.18680.22630.7688
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DHFRP00374IC501.4
DHFRP00374IC501.5
DHFRP00374IC502.6
DHFRP00374Ki1.4
DHFRP00374Ki13
DHFRP00374Ki83