| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Trimethoprim | hsa00040 | Pentose and glucuronate interconversions | 3.53E-02 | 1 | O60701 | UGDH | More | | | Trimethoprim | hsa00520 | Amino sugar and nucleotide sugar metabolism | 6.13E-03 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Trimethoprim | hsa00591 | Linoleic acid metabolism | 1.78E-02 | 1 | P11712 | CYP2C9 | More | | | Trimethoprim | hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 3.60E-03 | 2 | P06865, O75752 | HEXA, B3GALNT1 | More | | | Trimethoprim | hsa00670 | One carbon pool by folate | 3.62E-02 | 1 | P00374 | DHFR | More | | | Trimethoprim | hsa00740 | Riboflavin metabolism | 3.53E-02 | 1 | P24666 | ACP1 | More | | | Trimethoprim | hsa00790 | Folate biosynthesis | 3.62E-02 | 1 | P00374 | DHFR | More | | | Trimethoprim | hsa03020 | RNA polymerase | 3.00E-02 | 3 | P30876, P24928, P62487 | POLR2B, POLR2A, POLR2G | More | | | Trimethoprim | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Trimethoprim | hsa04064 | NF-kappa B signaling pathway | 2.35E-02 | 4 | P01584, P63279, Q8NHW4, Q9NQC7 | IL1B, UBE2I, CCL4L2, CYLD | More | | | Trimethoprim | hsa04071 | Sphingolipid signaling pathway | 1.94E-02 | 6 | P21453, Q9H228, P01375, Q13362, Q9BX95, P10415 | S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2 | More | | | Trimethoprim | hsa04114 | Oocyte meiosis | 1.92E-02 | 4 | Q9Y6D9, P51812, Q02750, Q14738 | MAD1L1, RPS6KA3, MAP2K1, PPP2R5D | More | | | Trimethoprim | hsa04140 | Autophagy - animal | 3.72E-02 | 5 | P22694, Q14643, P10415, Q9H1Y0, Q04759 | PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Trimethoprim | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Trimethoprim | hsa04144 | Endocytosis | 1.67E-02 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | | Trimethoprim | hsa04213 | Longevity regulating pathway - multiple species | 3.14E-03 | 5 | Q9Y4H2, Q08828, P51828, P0DMV8, Q13547 | IRS2, ADCY1, ADCY7, HSPA1A, HDAC1 | More | | | Trimethoprim | hsa04270 | Vascular smooth muscle contraction | 6.96E-03 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Trimethoprim | hsa04520 | Adherens junction | 2.70E-02 | 2 | P37173, P24666 | TGFBR2, ACP1 | More | | | Trimethoprim | hsa04612 | Antigen processing and presentation | 2.84E-02 | 7 | P13765, P48382, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Trimethoprim | hsa04613 | Neutrophil extracellular trap formation | 2.07E-03 | 16 | P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P58876, Q16778, O60814, Q15080, P20160, P08311, P49913, P21730, P21462 | ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1 | More | | | Trimethoprim | hsa04623 | Cytosolic DNA-sensing pathway | 1.65E-02 | 2 | P01584, Q8NHW4 | IL1B, CCL4L2 | More | | | Trimethoprim | hsa04640 | Hematopoietic cell lineage | 3.58E-02 | 8 | P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375 | ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF | More | | | Trimethoprim | hsa04658 | Th1 and Th2 cell differentiation | 1.48E-02 | 7 | Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765 | PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOB | More | | | Trimethoprim | hsa04660 | T cell receptor signaling pathway | 3.19E-03 | 10 | P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191 | TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB | More | | | Trimethoprim | hsa04672 | Intestinal immune network for IgA production | 1.66E-02 | 3 | P10747, P13765, P13612 | CD28, HLA-DOB, ITGA4 | More | | | Trimethoprim | hsa04726 | Serotonergic synapse | 2.37E-02 | 2 | P31645, P11712 | SLC6A4, CYP2C9 | More | | | Trimethoprim | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.01E-02 | 4 | P01584, Q08828, P51828, P0DP23 | IL1B, ADCY1, ADCY7, CALM1 | More | | | Trimethoprim | hsa04914 | Progesterone-mediated oocyte maturation | 3.88E-02 | 3 | Q9Y6D9, P51812, Q02750 | MAD1L1, RPS6KA3, MAP2K1 | More | | | Trimethoprim | hsa04915 | Estrogen signaling pathway | 3.17E-02 | 5 | Q08828, P51828, P0DMV8, P0DP23, Q15788 | ADCY1, ADCY7, HSPA1A, CALM1, NCOA1 | More | | | Trimethoprim | hsa04919 | Thyroid hormone signaling pathway | 2.44E-02 | 3 | Q02750, Q15788, P08237 | MAP2K1, NCOA1, PFKM | More | | | Trimethoprim | hsa04924 | Renin secretion | 3.64E-02 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Trimethoprim | hsa04927 | Cortisol synthesis and secretion | 1.66E-02 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Trimethoprim | hsa04932 | Non-alcoholic fatty liver disease | 1.39E-02 | 6 | O43521, O75460, P01584, P13073, P12074, O95298 | BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2 | More | | | Trimethoprim | hsa04940 | Type I diabetes mellitus | 3.64E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Trimethoprim | hsa04970 | Salivary secretion | 5.33E-03 | 7 | P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMP | More | | | Trimethoprim | hsa04976 | Bile secretion | 4.78E-02 | 3 | Q08828, P51828, Q14032 | ADCY1, ADCY7, BAAT | More | | | Trimethoprim | hsa05016 | Huntington disease | 2.46E-02 | 9 | O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12 | More | | | Trimethoprim | hsa05034 | Alcoholism | 1.30E-04 | 6 | Q13547, P62879, Q9BTM1, P58876, Q16778, O60814 | HDAC1, GNB2, H2AFJ, H2BC5, HIST2H2BE, H2BC12 | More | | | Trimethoprim | hsa05134 | Legionellosis | 2.82E-02 | 3 | P01584, Q9NR31, P0DMV8 | IL1B, SAR1A, HSPA1A | More | | | Trimethoprim | hsa05144 | Malaria | 4.92E-02 | 4 | O60603, P01375, P35443, P26718 | TLR2, TNF, THBS4, KLRK1 | More | | | Trimethoprim | hsa05146 | Amoebiasis | 1.48E-02 | 7 | P09341, P27930, P01375, O60603, P05089, P22694, P08311 | CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG | More | | | Trimethoprim | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Trimethoprim | hsa05163 | Human cytomegalovirus infection | 3.31E-02 | 7 | P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651 | CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA | More | | | Trimethoprim | hsa05200 | Pathways in cancer | 4.70E-02 | 3 | P17301, P20585, P62879 | ITGA2, MSH3, GNB2 | More | | | Trimethoprim | hsa05202 | Transcriptional misregulation in cancer | 4.59E-03 | 13 | P14780, P27930, Q15744, Q16548, P11215, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522 | MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A | More | | | Trimethoprim | hsa05203 | Viral carcinogenesis | 6.44E-03 | 4 | Q13547, P58876, Q16778, O60814 | HDAC1, H2BC5, HIST2H2BE, H2BC12 | More | | | Trimethoprim | hsa05310 | Asthma | 1.66E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Trimethoprim | hsa05321 | Inflammatory bowel disease | 1.14E-03 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Trimethoprim | hsa05322 | Systemic lupus erythematosus | 1.18E-02 | 3 | P58876, Q16778, O60814 | H2BC5, HIST2H2BE, H2BC12 | More | | | Trimethoprim | hsa05323 | Rheumatoid arthritis | 1.58E-02 | 5 | P01375, P13765, P10747, P09341, O60603 | TNF, HLA-DOB, CD28, CXCL1, TLR2 | More | | | Trimethoprim | hsa05332 | Graft-versus-host disease | 2.03E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Trimethoprim | hsa05415 | Diabetic cardiomyopathy | 4.23E-02 | 2 | O14521, P37173 | SDHD, TGFBR2 | More | |
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