PharmaCoNets

PharmaCoNets of Trimebutine (S_PCN: 48.68 )

Trimebutine regulated-network (S_DN: 11.40)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Trimebutine

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Trimebutine

hsa00190

Oxidative phosphorylation

1.00E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Trimebutine

hsa00500

Starch and sucrose metabolism

9.22E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Trimebutine

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Trimebutine

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Trimebutine

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Trimebutine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

1.34E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Trimebutine

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Trimebutine

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Trimebutine

hsa00970

Aminoacyl-tRNA biosynthesis

9.22E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Trimebutine

hsa01210

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Trimebutine

hsa03008

Ribosome biogenesis in eukaryotes

4.42E-02

Q9NYH9, P78345, Q9BVP2

UTP6, RPP38, GNL3

Trimebutine

hsa03013

RNA transport

2.29E-04

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1

Trimebutine

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Trimebutine

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Trimebutine

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Trimebutine

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Trimebutine

hsa04062

Chemokine signaling pathway

1.43E-04

P25024, P25025, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Trimebutine

hsa04064

NF-kappa B signaling pathway

4.92E-02

P10415, P51617, Q13546, Q9UDY8, Q13077, P24522

BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45A

Trimebutine

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Trimebutine

hsa04071

Sphingolipid signaling pathway

2.68E-04

P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415

PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2

Trimebutine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Trimebutine

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Trimebutine

hsa04217

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Trimebutine

hsa04261

Adrenergic signaling in cardiomyocytes

3.44E-02

Q16537, P0DP23, P17252, P10415, P20020

PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Trimebutine

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Trimebutine

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Trimebutine

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Trimebutine

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Trimebutine

hsa04390

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Trimebutine

hsa04530

Tight junction

4.35E-02

P63261, Q92974

ACTG1, ARHGEF2

Trimebutine

hsa04610

Complement and coagulation cascades

4.69E-03

P0C0L4

C4A

Trimebutine

hsa04612

Antigen processing and presentation

1.68E-04

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897

Trimebutine

hsa04613

Neutrophil extracellular trap formation

2.39E-03

P17252, O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, P33778, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, H2BC3, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Trimebutine

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Trimebutine

hsa04621

NOD-like receptor signaling pathway

1.90E-03

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Trimebutine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Trimebutine

hsa04650

Natural killer cell mediated cytotoxicity

3.20E-06

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Trimebutine

hsa04657

IL-17 signaling pathway

3.91E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Trimebutine

hsa04658

Th1 and Th2 cell differentiation

1.12E-02

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Trimebutine

hsa04659

Th17 cell differentiation

1.70E-02

P19174, P14784, P14778, P84022, Q13485, P08238, P07766

PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3E

Trimebutine

hsa04660

T cell receptor signaling pathway

2.26E-05

P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Trimebutine

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Trimebutine

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Trimebutine

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Trimebutine

hsa04720

Long-term potentiation

4.42E-02

P17252, P0DP23, Q14643

PRKCA, CALM1, ITPR1

Trimebutine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Trimebutine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Trimebutine

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Trimebutine

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Trimebutine

hsa04925

Aldosterone synthesis and secretion

1.54E-02

Q14643, P0DP23, P17252, P20020

ITPR1, CALM1, PRKCA, ATP2B1

Trimebutine

hsa04932

Non-alcoholic fatty liver disease

2.74E-02

P01375, P49841, P48023

TNF, GSK3B, FASLG

Trimebutine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Trimebutine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Trimebutine

hsa04966

Collecting duct acid secretion

3.15E-02

P02730, Q9Y666

SLC4A1, SLC12A7

Trimebutine

hsa04970

Salivary secretion

1.00E-02

Q14643, P20020, P17252, P0DP23

ITPR1, ATP2B1, PRKCA, CALM1

Trimebutine

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Trimebutine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.11E-02

Q16539, P25024, P25025, P07948

MAPK14, CXCR1, CXCR2, LYN

Trimebutine

hsa05132

Salmonella infection

1.02E-03

P51617, Q9UJU2, Q13546, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509

IRAK1, LEF1, RIPK1, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3

Trimebutine

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Trimebutine

hsa05140

Leishmaniasis

4.86E-05

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Trimebutine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Trimebutine

hsa05144

Malaria

1.36E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Trimebutine

hsa05146

Amoebiasis

3.91E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Trimebutine

hsa05150

Staphylococcus aureus infection

2.88E-04

P0C0L4, P21730, P21462, O75015, P13646, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Trimebutine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Trimebutine

hsa05163

Human cytomegalovirus infection

1.72E-02

P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463

TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Trimebutine

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Trimebutine

hsa05169

Epstein-Barr virus infection

2.54E-02

Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693

HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3G

Trimebutine

hsa05170

Human immunodeficiency virus 1 infection

6.54E-03

P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5

CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2

Trimebutine

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Trimebutine

hsa05202

Transcriptional misregulation in cancer

3.00E-02

P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Trimebutine

hsa05212

Pancreatic cancer

9.39E-03

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Trimebutine

hsa05214

Glioma

9.32E-04

P09619, P0DP23, P17252, Q02750, P04637, P24522

PDGFRB, CALM1, PRKCA, MAP2K1, TP53, GADD45A

Trimebutine

hsa05216

Thyroid cancer

1.85E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Trimebutine

hsa05217

Basal cell carcinoma

4.42E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Trimebutine

hsa05218

Melanoma

1.34E-02

P09619, Q02750

PDGFRB, MAP2K1

Trimebutine

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Trimebutine

hsa05230

Central carbon metabolism in cancer

4.10E-02

P09619, Q02750

PDGFRB, MAP2K1

Trimebutine

hsa05310

Asthma

2.81E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Trimebutine

hsa05321

Inflammatory bowel disease

3.16E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Trimebutine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Trimebutine

hsa05332

Graft-versus-host disease

4.38E-03

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Trimebutine

hsa05415

Diabetic cardiomyopathy

1.07E-02

P17252, P14598, Q15080, Q16718, O14521, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH

Trimebutine

hsa05418

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Trimebutine (S_DC: 4.27)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CACNB3

VoltageNonedependent LNonetype calcium channel subunit betaNone3

Reported

0.1026

0.1539

0.3291

0.6881

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

PharmaCoNets of Trimebutine (SPCN: 48.68 )

Trimebutine regulated-network (SDN: 11.40)

Community members of Trimebutine (SDC: 4.27)

PharmaCoNets of Trimebutine (S_PCN: 48.68 )

Trimebutine regulated-network (S_DN: 11.40)

Community members of Trimebutine (S_DC: 4.27)