PharmaCoNets of Trilostane (SPCN: 35.06 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trilostanehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Trilostanehsa00030Pentose phosphate pathway3.67E-033P60891, P11413, P37837PRPS1, G6PD, TALDO1More
Trilostanehsa00190Oxidative phosphorylation2.11E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Trilostanehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Trilostanehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Trilostanehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Trilostanehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Trilostanehsa01230Biosynthesis of amino acids3.27E-035P51854, P60891, Q99707, P50213, P37837TKTL1, PRPS1, MTR, IDH3A, TALDO1More
Trilostanehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Trilostanehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Trilostanehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Trilostanehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Trilostanehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Trilostanehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Trilostanehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Trilostanehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Trilostanehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Trilostanehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Trilostanehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Trilostanehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Trilostanehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Trilostanehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Trilostanehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Trilostanehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Trilostanehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Trilostanehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Trilostanehsa04650Natural killer cell mediated cytotoxicity1.30E-0411P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3More
Trilostanehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Trilostanehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Trilostanehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Trilostanehsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Trilostanehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Trilostanehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Trilostanehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Trilostanehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Trilostanehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Trilostanehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Trilostanehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Trilostanehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Trilostanehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Trilostanehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Trilostanehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Trilostanehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Trilostanehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Trilostanehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Trilostanehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Trilostanehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Trilostanehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Trilostanehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Trilostanehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Trilostanehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Trilostanehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Trilostanehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Trilostanehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Trilostanehsa05415Diabetic cardiomyopathy4.92E-035Q16718, O14521, Q16539, P49841, P11413NDUFA5, SDHD, MAPK14, GSK3B, G6PDMore

Community members of Trilostane (SDC: 4.92)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)