PharmaCoNets of Triflusal (SPCN: 6.13 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Triflusalhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Triflusalhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Triflusalhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Triflusalhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Triflusalhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Triflusalhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Triflusalhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Triflusalhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Triflusalhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Triflusalhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Triflusalhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Triflusalhsa04610Complement and coagulation cascades6.67E-043P25116, P0C0L4, P10909F2R, C4A, CLUMore
Triflusalhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Triflusalhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Triflusalhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Triflusalhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Triflusalhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Triflusalhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Triflusalhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Triflusalhsa05133Pertussis4.20E-021P0C0L4C4AMore
Triflusalhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Triflusalhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Triflusalhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Triflusal (SDC: 2.21)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)