PharmaCoNets of Trifluridine (SPCN: 4.50 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trifluridinehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Trifluridinehsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Trifluridinehsa00240Pyrimidine metabolism6.80E-075P31350, P21589, P32320, P04183, P04818RRM2, NT5E, CDA, TK1, TYMSMore
Trifluridinehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Trifluridinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Trifluridinehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Trifluridinehsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Trifluridinehsa04064NF-kappa B signaling pathway1.98E-037P10415, P51617, Q04759, Q9UDY8, Q13315, P24522, P09341BCL2, IRAK1, PRKCQ, MALT1, ATM, GADD45A, CXCL1More
Trifluridinehsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Trifluridinehsa04115p53 signaling pathway1.85E-046P24522, Q13315, P31350, P06493, O95067, P10415GADD45A, ATM, RRM2, CDK1, CCNB2, BCL2More
Trifluridinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Trifluridinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Trifluridinehsa05152Tuberculosis1.95E-025P48382, P10415, P13765, Q9UDY8, P51617RFX5, BCL2, HLA-DOB, MALT1, IRAK1More
Trifluridinehsa05202Transcriptional misregulation in cancer3.11E-027Q13315, P14923, Q15744, P05164, P08246, Q9C0K0, P24522ATM, JUP, CEBPE, MPO, ELA2, BCL11B, GADD45AMore
Trifluridinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Trifluridinehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Trifluridinehsa05310Asthma3.01E-022P13765, P12724HLA-DOB, RNASE3More
Trifluridinehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Trifluridine (SDC: 1.74)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04818TYMSThymidylate synthaseReported10.45530.27060.18930.9582
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)