PharmaCoNets of Triflupromazine (SPCN: 54.07 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Triflupromazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Triflupromazinehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Triflupromazinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Triflupromazinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Triflupromazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Triflupromazinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Triflupromazinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Triflupromazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Triflupromazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Triflupromazinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Triflupromazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Triflupromazinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Triflupromazinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Triflupromazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Triflupromazinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Triflupromazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Triflupromazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Triflupromazinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Triflupromazinehsa03010Ribosome1.08E-0411P62753, P25398, P32969, P40429, P62829, Q07020, P18077, P36578, P27635, P05386, P62249RPS6, RPS12, RPL9, RPL13A, RPL23, RPL18, RPL35A, RPL4, RPL10, RPLP1, RPS16More
Triflupromazinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Triflupromazinehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Triflupromazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Triflupromazinehsa04071Sphingolipid signaling pathway6.19E-058P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Triflupromazinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Triflupromazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Triflupromazinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Triflupromazinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Triflupromazinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Triflupromazinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Triflupromazinehsa04217Necroptosis4.24E-0510P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Triflupromazinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Triflupromazinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Triflupromazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Triflupromazinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Triflupromazinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Triflupromazinehsa04613Neutrophil extracellular trap formation2.22E-0622P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Triflupromazinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Triflupromazinehsa04657IL-17 signaling pathway5.66E-0510P07900, O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Triflupromazinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Triflupromazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Triflupromazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Triflupromazinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Triflupromazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Triflupromazinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Triflupromazinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Triflupromazinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Triflupromazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Triflupromazinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Triflupromazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Triflupromazinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Triflupromazinehsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Triflupromazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Triflupromazinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Triflupromazinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Triflupromazinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Triflupromazinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Triflupromazinehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Triflupromazinehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Triflupromazinehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Triflupromazinehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Triflupromazinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Triflupromazinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Triflupromazinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Triflupromazinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Triflupromazinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Triflupromazinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Triflupromazinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Triflupromazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Triflupromazinehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Triflupromazinehsa05171Coronavirus disease - COVID-196.98E-0512P01584, P62753, P25398, P62249, P40429, P36578, P32969, P27635, Q07020, P18077, P05386, P62829IL1B, RPS6, RPS12, RPS16, RPL13A, RPL4, RPL9, RPL10, RPL18, RPL35A, RPLP1, RPL23More
Triflupromazinehsa05202Transcriptional misregulation in cancer1.62E-0315Q15532, P41732, P14780, P27930, P14923, Q16548, P11215, Q13077, O15550, P35226, P05164, P08246, Q13547, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, ELA2, HDAC1, LYL1, GADD45AMore
Triflupromazinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Triflupromazinehsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Triflupromazinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Triflupromazinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Triflupromazinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Triflupromazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Triflupromazinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Triflupromazinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Triflupromazinehsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore

Community members of Triflupromazine (SDC: 5.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki2.8