PharmaCoNets of Trifluoperazine (SPCN: 76.31 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trifluoperazinehsa00030Pentose phosphate pathway1.76E-044P60891, P51854, P04075, P37837PRPS1, TKTL1, ALDOA, TALDO1More
Trifluoperazinehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Trifluoperazinehsa00220Arginine biosynthesis1.79E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Trifluoperazinehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Trifluoperazinehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Trifluoperazinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Trifluoperazinehsa00430Taurine and hypotaurine metabolism4.49E-021Q14032BAATMore
Trifluoperazinehsa00500Starch and sucrose metabolism4.66E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Trifluoperazinehsa00512Mucin type O-glycan biosynthesis2.11E-022O95395, Q8N4A0GCNT3, GALNT4More
Trifluoperazinehsa00514Other types of O-glycan biosynthesis3.37E-022P15907, Q8N4A0ST6GAL1, GALNT4More
Trifluoperazinehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Trifluoperazinehsa00564Glycerophospholipid metabolism3.93E-023P49619, O14494, Q3LIE5DGKG, PLPP1, ADPRMMore
Trifluoperazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Trifluoperazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Trifluoperazinehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Trifluoperazinehsa00730Thiamine metabolism4.15E-022P05186, P24666ALPL, ACP1More
Trifluoperazinehsa00760Nicotinate and nicotinamide metabolism2.11E-022P43490, Q13423PBEF1, NNTMore
Trifluoperazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Trifluoperazinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Trifluoperazinehsa00910Nitrogen metabolism1.79E-033P22748, P15104, P49448CA4, GLUL, GLUD2More
Trifluoperazinehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Trifluoperazinehsa00970Aminoacyl-tRNA biosynthesis8.37E-043O95363, P54136, P14868FARS2, RARS1, DARSMore
Trifluoperazinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Trifluoperazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Trifluoperazinehsa01100Metabolic pathways3.95E-0223Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Trifluoperazinehsa01200Carbon metabolism4.76E-037P51854, P04406, P37837, O14521, Q9P2R7, P60891, Q02252TKTL1, GAPDH, TALDO1, SDHD, SUCLA2, PRPS1, ALDH6A1More
Trifluoperazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Trifluoperazinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Trifluoperazinehsa01524Platinum drug resistance6.70E-036P10415, Q13489, O15392, P78417, P11388, P43246BCL2, BIRC3, BIRC5, GSTO1, TOP2A, MSH2More
Trifluoperazinehsa02010ABC transporters2.66E-032P45844, Q99758ABCG1, ABCA3More
Trifluoperazinehsa03010Ribosome1.24E-0315P62753, P39019, P42677, P40429, P62906, P62917, Q07020, P61513, Q02878, P63173, P36578, P27635, P05386, P62249, P23396RPS6, RPS19, RPS27, RPL13A, RPL10A, RPL8, RPL18, RPL37A, RPL6, RPL38, RPL4, RPL10, RPLP1, RPS16, RPS3More
Trifluoperazinehsa03013RNA transport4.79E-022P62826, P63279RAN, UBE2IMore
Trifluoperazinehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Trifluoperazinehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Trifluoperazinehsa03040Spliceosome1.22E-0819Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, O43395, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, PRPF3, MAGOHMore
Trifluoperazinehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Trifluoperazinehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Trifluoperazinehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Trifluoperazinehsa04014Ras signaling pathway2.65E-039P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Trifluoperazinehsa04015Rap1 signaling pathway5.41E-039P20827, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1More
Trifluoperazinehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Trifluoperazinehsa04024cAMP signaling pathway3.01E-039Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1More
Trifluoperazinehsa04060Cytokine-cytokine receptor interaction4.07E-0314P32927, P27930, P01584, P61073, P25024, P25025, Q9UBD3, P47992, P20333, P01375, P09341, Q99731, P18510, Q93038CSF2RB, IL1R2, IL1B, CXCR4, CXCR1, CXCR2, XCL2, XCL1, TNFRSF1B, TNF, CXCL1, CCL19, IL1RN, TNFRSF25More
Trifluoperazinehsa04061Viral protein interaction with cytokine and cytokine receptor3.95E-039Q99731, P09341, P25024, P25025, P61073, P47992, Q9UBD3, P20333, P01375CCL19, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, TNFRSF1B, TNFMore
Trifluoperazinehsa04062Chemokine signaling pathway2.66E-0316P51684, P25024, P25025, Q8NHW4, P07948, P19174, P62873, P63218, P50151, Q08828, P51828, Q13009, P14598, P42224, P31751, P49841CCR6, CXCR1, CXCR2, CCL4L2, LYN, PLCG1, GNB1, GNG5, GNG10, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2, GSK3BMore
Trifluoperazinehsa04064NF-kappa B signaling pathway1.34E-0518P10415, Q13489, P51617, O00463, P01584, P01375, P29965, P19174, Q04759, Q16548, P06239, P63279, P24522, O75293, Q8NHW4, P09341, Q99731, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, IL1B, TNF, CD40LG, PLCG1, PRKCQ, BCL2A1, LCK, UBE2I, GADD45A, GADD45B, CCL4L2, CXCL1, CCL19, CYLDMore
Trifluoperazinehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Trifluoperazinehsa04071Sphingolipid signaling pathway1.60E-039P17252, P21453, Q9H228, P01375, Q13510, Q13362, P10415, Q9UQC2, P01042PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, BCL2, GAB2, KNG1More
Trifluoperazinehsa04072Phospholipase D signaling pathway2.03E-028P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Trifluoperazinehsa04080Neuroactive ligand-receptor interaction8.52E-049P28472, P21453, Q9H228, P43657, Q01726, P21730, P14416, P07550, P35318GABRB3, S1PR1, EDG8, P2RY5, MC1R, C5AR1, DRD2, ADRB2, ADMMore
Trifluoperazinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Trifluoperazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Trifluoperazinehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Trifluoperazinehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Trifluoperazinehsa04145Phagosome1.34E-0310P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, O60603, P01889, P10321ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2, HLA-B, HLA-CMore
Trifluoperazinehsa04146Peroxisome7.06E-032Q14032, P00441BAAT, SOD1More
Trifluoperazinehsa04151PI3K-Akt signaling pathway6.57E-0426P43657, O43521, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8P2RY5, BCL2L11, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1More
Trifluoperazinehsa04210Apoptosis6.18E-033P07384, P60709, P63261CAPN1, ACTB, ACTG1More
Trifluoperazinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Trifluoperazinehsa04216Ferroptosis2.75E-023P04637, Q9H1Y0, P33121TP53, ATG5, ACSL1More
Trifluoperazinehsa04217Necroptosis2.92E-0919P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Trifluoperazinehsa04218Cellular senescence3.20E-036P01106, O75293, P30304, P06493, P01889, P10321MYC, GADD45B, CDC25A, CDK1, HLA-B, HLA-CMore
Trifluoperazinehsa04261Adrenergic signaling in cardiomyocytes4.46E-0713P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Trifluoperazinehsa04360Axon guidance8.44E-048P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1More
Trifluoperazinehsa04371Apelin signaling pathway3.08E-027P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Trifluoperazinehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Trifluoperazinehsa04390Hippo signaling pathway1.37E-035P60709, P63261, Q13485, O15105, O43623ACTB, ACTG1, SMAD4, SMAD7, SNAI2More
Trifluoperazinehsa04510Focal adhesion3.76E-027P16144, O75369, Q15942, P17252, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFCMore
Trifluoperazinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Trifluoperazinehsa04514Cell adhesion molecules2.20E-022P01889, P10321HLA-B, HLA-CMore
Trifluoperazinehsa04520Adherens junction2.08E-034Q13485, O43623, P60709, P63261SMAD4, SNAI2, ACTB, ACTG1More
Trifluoperazinehsa04530Tight junction6.83E-046P60709, P63261, P16989, P56750, Q14247, P60660ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6More
Trifluoperazinehsa04540Gap junction4.08E-025P17252, Q13509, P68371, Q08828, P51828PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7More
Trifluoperazinehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa04612Antigen processing and presentation1.07E-0610P04233, Q14953, P26715, P26717, Q13241, P01732, P01889, P10321, Q06323, P01375CD74, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, HLA-B, HLA-C, PSME1, TNFMore
Trifluoperazinehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trifluoperazinehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Trifluoperazinehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Trifluoperazinehsa04623Cytosolic DNA-sensing pathway4.25E-022P01568, Q8NHW4IFNA21, CCL4L2More
Trifluoperazinehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Trifluoperazinehsa04640Hematopoietic cell lineage4.98E-045P08514, P21926, P07766, P01730, P09564ITGA2B, CD9, CD3E, CD4, CD7More
Trifluoperazinehsa04650Natural killer cell mediated cytotoxicity1.28E-0613P01375, P06239, O60880, P20963, Q29983, P10321, P01889, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Trifluoperazinehsa04657IL-17 signaling pathway3.48E-038O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Trifluoperazinehsa04658Th1 and Th2 cell differentiation5.20E-039Q04759, P20963, P06239, Q14765, P23771, Q9UL17, P46531, Q9UM47, Q13761PRKCQ, CD247, LCK, STAT4, GATA3, TBX21, NOTCH1, NOTCH3, RUNX3More
Trifluoperazinehsa04660T cell receptor signaling pathway1.66E-029P01375, Q04759, O95267, Q08881, Q9NQU5, P20963, P01732, Q13191, P06239TNF, PRKCQ, RASGRP1, ITK, PAK6, CD247, CD8A, CBLB, LCKMore
Trifluoperazinehsa04662B cell receptor signaling pathway3.04E-036P25963, P49841, P20023, P60033, P07948, Q8N149NFKBIA, GSK3B, CR2, CD81, LYN, LILRA2More
Trifluoperazinehsa04664Fc epsilon RI signaling pathway4.19E-023Q16539, P07948, P09917MAPK14, LYN, ALOX5More
Trifluoperazinehsa04666Fc gamma R-mediated phagocytosis2.78E-026P08575, P19174, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCAMore
Trifluoperazinehsa04668TNF signaling pathway3.38E-039P01375, O00463, P18848, P09341, P19875, P01584, P20749, P14780, P20333TNF, TRAF5, ATF4, CXCL1, CXCL2, IL1B, BCL3, MMP9, TNFRSF1BMore
Trifluoperazinehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa04713Circadian entrainment5.61E-057O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7More
Trifluoperazinehsa04714Thermogenesis3.64E-044P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Trifluoperazinehsa04720Long-term potentiation3.26E-036P17252, Q13557, P0DP23, P18848, O15399, Q08828PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1More
Trifluoperazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Trifluoperazinehsa04724Glutamatergic synapse7.25E-0610P48058, O15399, P43003, Q08828, P51828, P17252, P62873, P63218, P50151, P15104GRIA4, GRIN2D, SLC1A3, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLULMore
Trifluoperazinehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Trifluoperazinehsa04727GABAergic synapse3.01E-038Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCAMore
Trifluoperazinehsa04728Dopaminergic synapse2.96E-025P14416, P63218, P50151, P49841, Q16539DRD2, GNG5, GNG10, GSK3B, MAPK14More
Trifluoperazinehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Trifluoperazinehsa04740Olfactory transduction5.88E-034P62873, Q9H255, Q13557, P0DP23GNB1, OR51E2, CAMK2D, CALM1More
Trifluoperazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Trifluoperazinehsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Trifluoperazinehsa04750Inflammatory mediator regulation of TRP channels4.32E-058P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1More
Trifluoperazinehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Trifluoperazinehsa04912GnRH signaling pathway2.85E-025P17252, Q08828, P18848, Q13557, P0DP23PRKCA, ADCY1, ATF4, CAMK2D, CALM1More
Trifluoperazinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Trifluoperazinehsa04914Progesterone-mediated oocyte maturation3.26E-026Q08828, P51828, P31751, Q13370, Q9UJX4, P08238ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1More
Trifluoperazinehsa04915Estrogen signaling pathway3.28E-039P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Trifluoperazinehsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Trifluoperazinehsa04923Regulation of lipolysis in adipocytes2.12E-024Q08828, P51828, Q13370, P31751ADCY1, ADCY7, PDE3B, AKT2More
Trifluoperazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Trifluoperazinehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Trifluoperazinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Trifluoperazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Trifluoperazinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Trifluoperazinehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Trifluoperazinehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Trifluoperazinehsa04940Type I diabetes mellitus5.99E-044P48023, P01889, P10321, P01375FASLG, HLA-B, HLA-C, TNFMore
Trifluoperazinehsa04964Proximal tubule bicarbonate reclamation4.33E-022P22748, P49448CA4, GLUD2More
Trifluoperazinehsa04970Salivary secretion9.40E-058P07550, Q08828, P51828, P22694, P23634, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM1, CAMPMore
Trifluoperazinehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa04972Pancreatic secretion1.92E-035P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Trifluoperazinehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Trifluoperazinehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Trifluoperazinehsa05017Spinocerebellar ataxia3.80E-038P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12More
Trifluoperazinehsa05031Amphetamine addiction3.62E-037O15399, P0DP23, Q13557, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1More
Trifluoperazinehsa05032Morphine addiction1.94E-039Q08828, P51828, P62873, P63218, P50151, Q13370, Q07343, P17252, P43250ADCY1, ADCY7, GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6More
Trifluoperazinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trifluoperazinehsa05100Bacterial invasion of epithelial cells1.02E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa05120Epithelial cell signaling in Helicobacter pylori infection8.53E-034Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Trifluoperazinehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Trifluoperazinehsa05132Salmonella infection3.99E-0413P51617, P01584, P08238, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Trifluoperazinehsa05133Pertussis3.94E-045P0DP23, P01584, P23528, P09871, P51617CALM1, IL1B, CFL1, C1S, IRAK1More
Trifluoperazinehsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Trifluoperazinehsa05140Leishmaniasis1.92E-038O75015, P14598, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Trifluoperazinehsa05143African trypanosomiasis3.02E-047P01375, P01584, P69905, P68871, P48023, P17252, P01042TNF, IL1B, HBA2, HBB, FASLG, PRKCA, KNG1More
Trifluoperazinehsa05144Malaria1.50E-035P60033, P01375, P35443, P01584, P26718CD81, TNF, THBS4, IL1B, KLRK1More
Trifluoperazinehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Trifluoperazinehsa05146Amoebiasis2.31E-0310P01584, P09341, P19875, P27930, P01375, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Trifluoperazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Trifluoperazinehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Trifluoperazinehsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Trifluoperazinehsa05163Human cytomegalovirus infection1.71E-0421P31751, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P61769, P01568AKT2, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, B2M, IFNA21More
Trifluoperazinehsa05164Influenza A7.10E-033P48551, P60709, P63261IFNAR2, ACTB, ACTG1More
Trifluoperazinehsa05165Human papillomavirus infection5.90E-033P01889, P10321, O14745HLA-B, HLA-C, SLC9A3R1More
Trifluoperazinehsa05167Kaposi sarcoma-associated herpesvirus infection1.22E-033P01889, P10321, Q29983HLA-B, HLA-C, MICAMore
Trifluoperazinehsa05168Herpes simplex virus 1 infection2.41E-0621P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, P04233, Q13489, P51617, P01889, P10321, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, CD74, BIRC3, IRAK1, HLA-B, HLA-C, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Trifluoperazinehsa05169Epstein-Barr virus infection2.87E-022P01889, P10321HLA-B, HLA-CMore
Trifluoperazinehsa05170Human immunodeficiency virus 1 infection7.86E-0614P31751, P01889, P10321, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5AKT2, HLA-B, HLA-C, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2More
Trifluoperazinehsa05171Coronavirus disease - COVID-194.10E-0318P01375, P01584, P23396, P62753, P62249, P39019, P42677, P40429, P62906, P36578, Q02878, P62917, P27635, Q07020, P61513, P63173, P05386, P21730TNF, IL1B, RPS3, RPS6, RPS16, RPS19, RPS27, RPL13A, RPL10A, RPL4, RPL6, RPL8, RPL10, RPL18, RPL37A, RPL38, RPLP1, C5AR1More
Trifluoperazinehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Trifluoperazinehsa05202Transcriptional misregulation in cancer4.61E-0312P01106, P27930, P11215, P35226, O60583, P04141, P59665, P59666, P42773, Q13547, P12980, O75293MYC, IL1R2, ITGAM, BMI1, CCNT2, CSF2, DEFA1; DEFA1B, DEFA3, CDKN2C, HDAC1, LYL1, GADD45BMore
Trifluoperazinehsa05203Viral carcinogenesis6.56E-058Q13547, Q15283, P01889, P10321, P58876, P62807, Q16778, O60814HDAC1, RASA2, HLA-B, HLA-C, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Trifluoperazinehsa05204Chemical carcinogenesis4.02E-055P00325, P09211, P78417, P11712, P33260ADH1B, GSTP1, GSTO1, CYP2C9, CYP2C18More
Trifluoperazinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Trifluoperazinehsa05206MicroRNAs in cancer6.16E-038P15311, P01106, P26358, Q9UM47, P35226, Q96EB6, P63279, P19174VIL2, MYC, DNMT1, NOTCH3, BMI1, SIRT1, UBE2I, PLCG1More
Trifluoperazinehsa05212Pancreatic cancer5.55E-036P31751, Q15311, P23458, P42224, Q13485, O75293AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Trifluoperazinehsa05214Glioma1.87E-056P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Trifluoperazinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Trifluoperazinehsa05219Bladder cancer4.15E-022P14780, P04637MMP9, TP53More
Trifluoperazinehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Trifluoperazinehsa05224Breast cancer4.92E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Trifluoperazinehsa05225Hepatocellular carcinoma4.07E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Trifluoperazinehsa05320Autoimmune thyroid disease3.49E-032P01889, P10321HLA-B, HLA-CMore
Trifluoperazinehsa05321Inflammatory bowel disease2.06E-035P01375, Q14765, Q9UL17, P23771, P01584TNF, STAT4, TBX21, GATA3, IL1BMore
Trifluoperazinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trifluoperazinehsa05330Allograft rejection5.99E-044P01889, P10321, P48023, P01375HLA-B, HLA-C, FASLG, TNFMore
Trifluoperazinehsa05332Graft-versus-host disease3.48E-056P48023, P01889, P10321, P01375, P26715, Q13241FASLG, HLA-B, HLA-C, TNF, KLRC1, KLRD1More
Trifluoperazinehsa05340Primary immunodeficiency8.85E-054P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Trifluoperazinehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-035P23229, P16144, P60709, P63261, P35609ITGA6, ITGB4, ACTB, ACTG1, ACTN2More
Trifluoperazinehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Trifluoperazinehsa05416Viral myocarditis1.06E-044P01889, P10321, P60709, P63261HLA-B, HLA-C, ACTB, ACTG1More
Trifluoperazinehsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Trifluoperazine (SDC: 3.18)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
P42857NSG1Neuronal vesicle traffickingNoneassociated protein 1Predicted10.03240.005100.0264
P33764S100A3Protein S100NoneA3Predicted00.12250.020200.1016
P25815S100PProtein S100NonePPredicted00.48450.029400.301
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
P60903S100A10Protein S100NoneA10Predicted00.25010.02120.23330.4008
P80511S100A12Protein S100NoneA12Predicted10.47670.030900.3002
P06702S100A9Protein S100NoneA9Predicted10.04390.02560.12470.1978
P05109S100A8Protein S100NoneA8Predicted10.26720.02330.12470.305
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki0.96
DRD2P14416Ki1.1
DRD2P14416Ki1.3