PharmaCoNets of Triclocarban (SPCN: 12.46 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Triclocarbanhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Triclocarbanhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Triclocarbanhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Triclocarbanhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Triclocarbanhsa00630Glyoxylate and dicarboxylate metabolism4.46E-032P40925, P15104MDH1, GLULMore
Triclocarbanhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Triclocarbanhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Triclocarbanhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Triclocarbanhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Triclocarbanhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Triclocarbanhsa03040Spliceosome2.96E-025O60508, P08579, Q07955, Q01130, Q9Y2W2CDC40, SNRPB2, SFRS1, SFRS2, WBP11More
Triclocarbanhsa04014Ras signaling pathway2.54E-025P42338, P20827, P49767, Q13009, P50151PIK3CB, EFNA1, VEGFC, TIAM1, GNG10More
Triclocarbanhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Triclocarbanhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Triclocarbanhsa04151PI3K-Akt signaling pathway1.14E-028P42338, P43657, P20827, P49767, P50151, O15335, Q13751, P14784PIK3CB, P2RY5, EFNA1, VEGFC, GNG10, CHAD, LAMB3, IL2RBMore
Triclocarbanhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Triclocarbanhsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Triclocarbanhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Triclocarbanhsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Triclocarbanhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Triclocarbanhsa04662B cell receptor signaling pathway9.78E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Triclocarbanhsa04664Fc epsilon RI signaling pathway1.82E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Triclocarbanhsa04724Glutamatergic synapse3.24E-023P43003, P50151, P15104SLC1A3, GNG10, GLULMore
Triclocarbanhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Triclocarbanhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Triclocarbanhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Triclocarbanhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Triclocarbanhsa05133Pertussis4.20E-021P0C0L4C4AMore
Triclocarbanhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Triclocarbanhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Triclocarbanhsa05144Malaria2.23E-047P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Triclocarbanhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Triclocarbanhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Triclocarbanhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Triclocarban (SDC: 3.14)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)