PharmaCoNets

PharmaCoNets of Triclabendazole (S_PCN: 57.07 )

Triclabendazole regulated-network (S_DN: 16.99)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Triclabendazole

hsa00010

Glycolysis / Gluconeogenesis

1.79E-03

P06733, P04406

ENO1, GAPDH

Triclabendazole

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Triclabendazole

hsa00220

Arginine biosynthesis

4.97E-04

P15104, P49448

GLUL, GLUD2

Triclabendazole

hsa00250

Alanine, aspartate and glutamate metabolism

1.20E-03

P49448, P15104

GLUD2, GLUL

Triclabendazole

hsa00270

Cysteine and methionine metabolism

3.03E-02

P17707, P40926

AMD1, MDH2

Triclabendazole

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Triclabendazole

hsa00500

Starch and sucrose metabolism

7.13E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Triclabendazole

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Triclabendazole

hsa00630

Glyoxylate and dicarboxylate metabolism

1.23E-04

P40925, P15104

MDH1, GLUL

Triclabendazole

hsa00730

Thiamine metabolism

3.83E-02

P05186, P24666

ALPL, ACP1

Triclabendazole

hsa00790

Folate biosynthesis

3.23E-03

P05186, P07101, P42330

ALPL, TH, AKR1C3

Triclabendazole

hsa00910

Nitrogen metabolism

1.20E-03

P15104, P49448

GLUL, GLUD2

Triclabendazole

hsa00970

Aminoacyl-tRNA biosynthesis

1.17E-02

O95363, P14868, Q15046

FARS2, DARS, KARS

Triclabendazole

hsa01200

Carbon metabolism

4.10E-03

P04406, P06733

GAPDH, ENO1

Triclabendazole

hsa01230

Biosynthesis of amino acids

1.77E-05

P04406, P06733, P15104, P37837

GAPDH, ENO1, GLUL, TALDO1

Triclabendazole

hsa03013

RNA transport

1.53E-07

P62826, Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P11940, Q13310, P20042, Q14232

RAN, RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, PABPC1, PABPC4, EIF2S2, EIF2B1

Triclabendazole

hsa03015

mRNA surveillance pathway

1.03E-02

P11940, Q13310, Q13362, Q15287, Q9UBU9

PABPC1, PABPC4, PPP2R5C, RNPS1, NXF1

Triclabendazole

hsa03020

RNA polymerase

3.60E-02

P61218

POLR2F

Triclabendazole

hsa03040

Spliceosome

2.74E-07

Q14562, O43143, O60508, P17844, P08579, Q15427, P51991, P38159, P61978, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, HNRPA3, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P27348	YWHAQ	14-3-3 protein theta	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P27348	YWHAQ	14-3-3 protein theta	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.715
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P27348	YWHAQ	14-3-3 protein theta	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P27348	YWHAQ	14-3-3 protein theta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P27348	YWHAQ	14-3-3 protein theta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78

Triclabendazole

hsa03050

Proteasome

4.78E-02

P62195

PSMC5

Triclabendazole

hsa03060

Protein export

7.45E-04

P37108, Q15005

SRP14, SPCS2

Triclabendazole

hsa04012

ErbB signaling pathway

1.66E-03

P21860, P16333, Q13557, P19174, O14944, P42338, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYC

Triclabendazole

hsa04014

Ras signaling pathway

9.85E-06

P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Triclabendazole

hsa04015

Rap1 signaling pathway

4.83E-03

P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174

EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1

Triclabendazole

hsa04020

Calcium signaling pathway

1.92E-06

P27987, Q96DU7, P21796, P45880, Q13557, P21860, P19174, P61073, P0DP23, P0DP24, P05141, P51828, P23634, Q9NRA1, P49767

ITPKB, ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CXCR4, CALM1, CALM2, SLC25A5, ADCY7, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.891
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P27348	YWHAQ	14-3-3 protein theta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.76
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P27348	YWHAQ	14-3-3 protein theta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.708
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P27348	YWHAQ	14-3-3 protein theta	P0DP24	CALM2	Calmodulin-2	0.777
P27348	YWHAQ	14-3-3 protein theta	P05141	SLC25A5	ADP/ATP translocase 2	0.748
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P27348	YWHAQ	14-3-3 protein theta	P51828	ADCY7	Adenylate cyclase type 7	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P27348	YWHAQ	14-3-3 protein theta	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.779
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778

Triclabendazole

hsa04022

cGMP-PKG signaling pathway

1.66E-03

Q99941, P18848, P23634, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, ADCY7, SLC25A5, VDAC2, CALM2

Triclabendazole

hsa04060

Cytokine-cytokine receptor interaction

3.68E-03

P27930, P14778, P25025, Q9UBD3, P47992, P02775, P09341, P32248, P18510, P01730

IL1R2, IL1R1, CXCR2, XCL2, XCL1, PPBP, CXCL1, CCR7, IL1RN, CD4

Triclabendazole

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.82E-03

P32248, P09341, P02775, P25025, P47992, Q9UBD3

CCR7, CXCL1, PPBP, CXCR2, XCL1, XCL2

Triclabendazole

hsa04062

Chemokine signaling pathway

1.91E-06

P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963

LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Triclabendazole

hsa04066

HIF-1 signaling pathway

2.46E-03

P04406, P06733

GAPDH, ENO1

Triclabendazole

hsa04070

Phosphatidylinositol signaling system

8.72E-04

P19174, P0DP23, P42338, P23743, P27987

PLCG1, CALM1, PIK3CB, DGKA, ITPKB

Triclabendazole

hsa04072

Phospholipase D signaling pathway

4.67E-02

P42338, P19174, Q14344, P23743, Q9NRA1

PIK3CB, PLCG1, GNA13, DGKA, PDGFC

Triclabendazole

hsa04114

Oocyte meiosis

1.39E-03

P51812, Q02750, Q13557, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362

RPS6KA3, MAP2K1, CAMK2D, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C

Triclabendazole

hsa04141

Protein processing in endoplasmic reticulum

6.40E-05

P18848, P30101, Q15437, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27348	YWHAQ	14-3-3 protein theta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.827
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P27348	YWHAQ	14-3-3 protein theta	Q15437	SEC23B	Protein transport protein Sec23B	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P27348	YWHAQ	14-3-3 protein theta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.711
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P27348	YWHAQ	14-3-3 protein theta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.828
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P27348	YWHAQ	14-3-3 protein theta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P27348	YWHAQ	14-3-3 protein theta	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.833
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P27348	YWHAQ	14-3-3 protein theta	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9H173	SIL1	Nucleotide exchange factor SIL1	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9UNL2	SSR3	Translocon-associated protein subunit gamma	-0.706

Triclabendazole

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Triclabendazole

hsa04145

Phagosome

2.53E-03

P11215, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P25774

ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, CTSS

Triclabendazole

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Triclabendazole

hsa04151

PI3K-Akt signaling pathway

7.63E-04

P42338, P43657, P01106, P09603, P20827, Q9NRA1, P49767, Q9GZP0, P08238, P62873, P63218, P50151, P13612, O15335, Q13751, P14784, P01568

PIK3CB, P2RY5, MYC, CSF1, EFNA1, PDGFC, VEGFC, PDGFD, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701

Triclabendazole

hsa04210

Apoptosis

1.95E-02

P04637, O76075, P24522, Q16548, P43234, Q14643, P63261

TP53, DFFB, GADD45A, BCL2A1, CTSO, ITPR1, ACTG1

Triclabendazole

hsa04261

Adrenergic signaling in cardiomyocytes

2.39E-04

P51828, Q99941, P18848, Q13362, P0DP24, Q13557, P23634

ADCY7, CREBL1, ATF4, PPP2R5C, CALM2, CAMK2D, ATP2B4

Triclabendazole

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Triclabendazole

hsa04360

Axon guidance

2.87E-02

P16333, P20827, O95631, P42338, P19174

NCK1, EFNA1, NTN1, PIK3CB, PLCG1

Triclabendazole

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Triclabendazole

hsa04371

Apelin signaling pathway

6.35E-06

P62873, P63218, P50151, Q13370, Q14814, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, SMAD3, CALM1

Triclabendazole

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Triclabendazole

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Triclabendazole

hsa04612

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Triclabendazole

hsa04613

Neutrophil extracellular trap formation

2.76E-02

P42338, P19174, P11215, Q13547, P62807, Q93079, P21796, P14598

PIK3CB, PLCG1, ITGAM, HDAC1, HIST1H2BC, H2BC9, VDAC1, NCF1

Triclabendazole

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Triclabendazole

hsa04623

Cytosolic DNA-sensing pathway

7.85E-04

P01568, P25963, P61218

IFNA21, NFKBIA, POLR2F

Triclabendazole

hsa04625

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Triclabendazole

hsa04640

Hematopoietic cell lineage

2.18E-02

P14778, P27930, P11836, P09693, P01730, P13765

IL1R1, IL1R2, MS4A1, CD3G, CD4, HLA-DOB

Triclabendazole

hsa04650

Natural killer cell mediated cytotoxicity

1.22E-04

P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Triclabendazole

hsa04658

Th1 and Th2 cell differentiation

3.08E-06

P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Triclabendazole

hsa04659

Th17 cell differentiation

2.25E-07

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P43234	CTSO	Cathepsin O	Q04759	PRKCQ	Protein kinase C theta type	0.71
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P43234	CTSO	Cathepsin O	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P43234	CTSO	Cathepsin O	P01730	CD4	T-cell surface glycoprotein CD4	0.793
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P43234	CTSO	Cathepsin O	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.775
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P43234	CTSO	Cathepsin O	P14778	IL1R1	Interleukin-1 receptor type 1	-0.758
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P43234	CTSO	Cathepsin O	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.858
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P43234	CTSO	Cathepsin O	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.824
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Triclabendazole

hsa04660

T cell receptor signaling pathway

1.81E-02

O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Triclabendazole

hsa04662

B cell receptor signaling pathway

1.12E-02

P25963, P42338, P07948, P21854, Q8N149

NFKBIA, PIK3CB, LYN, CD72, LILRA2

Triclabendazole

hsa04664

Fc epsilon RI signaling pathway

2.35E-04

P04141, P42338, P07948, P19174, P09917

CSF2, PIK3CB, LYN, PLCG1, ALOX5

Triclabendazole

hsa04666

Fc gamma R-mediated phagocytosis

2.92E-02

P07948, P42338, P19174, P14598

LYN, PIK3CB, PLCG1, NCF1

Triclabendazole

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Triclabendazole

hsa04713

Circadian entrainment

2.25E-03

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Triclabendazole

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Triclabendazole

hsa04724

Glutamatergic synapse

3.48E-05

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Triclabendazole

hsa04725

Cholinergic synapse

2.92E-02

P62873, P63218, P50151, P42338

GNB1, GNG5, GNG10, PIK3CB

Triclabendazole

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Triclabendazole

hsa04727

GABAergic synapse

5.37E-06

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Triclabendazole

hsa04728

Dopaminergic synapse

1.90E-02

Q99941, P18848, Q13557, Q13362, P0DP24

CREBL1, ATF4, CAMK2D, PPP2R5C, CALM2

Triclabendazole

hsa04730

Long-term depression

3.34E-03

Q14344, P07948

GNA13, LYN

Triclabendazole

hsa04744

Phototransduction

1.23E-04

P62873, P0DP23

GNB1, CALM1

Triclabendazole

hsa04750

Inflammatory mediator regulation of TRP channels

1.55E-05

P14778, P01584, P51828, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP23, P0DP24

IL1R1, IL1B, ADCY7, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM1, CALM2

Triclabendazole

hsa04810

Regulation of actin cytoskeleton

2.61E-02

P12814, Q13009, P42338, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC

Triclabendazole

hsa04911

Insulin secretion

2.01E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Triclabendazole

hsa04912

GnRH signaling pathway

2.85E-02

P51828, P18848, Q13557, P0DP24

ADCY7, ATF4, CAMK2D, CALM2

Triclabendazole

hsa04914

Progesterone-mediated oocyte maturation

4.29E-03

Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Triclabendazole

hsa04915

Estrogen signaling pathway

1.66E-03

Q99941, P18848, P51828, P07900, P11142, P0DP24

CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, CALM2

Triclabendazole

hsa04916

Melanogenesis

4.19E-02

Q13557, P0DP24, P51828

CAMK2D, CALM2, ADCY7

Triclabendazole

hsa04918

Thyroid hormone synthesis

2.06E-02

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Triclabendazole

hsa04925

Aldosterone synthesis and secretion

5.00E-06

Q99941, P18848, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY7, CALM2, CAMK2D, ATP2B4

Triclabendazole

hsa04926

Relaxin signaling pathway

8.74E-03

P25963, P42338, P62873, P63218, P50151, P49767

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC

Triclabendazole

hsa04927

Cortisol synthesis and secretion

2.83E-02

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Triclabendazole

hsa04932

Non-alcoholic fatty liver disease

5.18E-03

P18848, O75460, P01584, P13073, P12074, P19404

ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFV2

Triclabendazole

hsa04934

Cushing syndrome

1.46E-04

Q99941, P18848, P51828, O15169, Q13557

CREBL1, ATF4, ADCY7, AXIN1, CAMK2D

Triclabendazole

hsa04970

Salivary secretion

2.83E-02

P51828, P23634, P0DP24

ADCY7, ATP2B4, CALM2

Triclabendazole

hsa04971

Gastric acid secretion

1.57E-03

P51828, P15311, P0DP24, Q13557

ADCY7, VIL2, CALM2, CAMK2D

Triclabendazole

hsa05010

Alzheimer disease

1.18E-03

Q92542, P05496, P12074, O15399, Q9NZJ5, O75460, P04406, Q13564, P01584, Q71U36, O15169, P09603, P21796, P45880, P62195

NCSTN, ATP5G1, COX6A1, GRIN2D, EIF2AK3, ERN1, GAPDH, APPBP1, IL1B, TUBA1A, AXIN1, CSF1, VDAC1, VDAC2, PSMC5

Triclabendazole

hsa05012

Parkinson disease

1.18E-04

P19404, P13073, P12074, P05141, P21796, P60604, O75460, P18848, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371

NDUFV2, COX4I1, COX6A1, SLC25A5, VDAC1, UBE2G2, ERN1, ATF4, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2C

Triclabendazole

hsa05014

Amyotrophic lateral sclerosis

2.00E-02

P19404, P13073, P12074, O75460, P18848, Q8TEV9, P51991, P22626, Q9UBU9

NDUFV2, COX4I1, COX6A1, ERN1, ATF4, SMCR8, HNRPA3, HNRNPA2B1, NXF1

Triclabendazole

hsa05016

Huntington disease

1.54E-02

P61218, P62195

POLR2F, PSMC5

Triclabendazole

hsa05020

Prion disease

2.89E-03

P01584, P46531, P11142, P19404, P05496, P13073, P12074, P18848, P05141, P45880, Q99941

IL1B, NOTCH1, HSPA8, NDUFV2, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC2, CREBL1

Triclabendazole

hsa05022

Pathways of neurodegeneration - multiple diseases

2.36E-02

P19404, P13073, P12074, Q8TEV9, O75460, P18848, P05141, P01584, P0DP24, Q13557

NDUFV2, COX4I1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, IL1B, CALM2, CAMK2D

Triclabendazole

hsa05031

Amphetamine addiction

5.59E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Triclabendazole

hsa05032

Morphine addiction

1.77E-05

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Triclabendazole

hsa05034

Alcoholism

6.32E-03

Q13547, P0DP23, P62873, P63218, P50151, P62807, Q93079

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2BC, H2BC9

Triclabendazole

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Triclabendazole

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.08E-02

P25963, Q13488, P19174, P07948

NFKBIA, TCIRG1, PLCG1, LYN

Triclabendazole

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Triclabendazole

hsa05131

Shigellosis

4.96E-02

P14778, Q16539, Q04759, Q9NQL2, P63261, Q14643, P04637

IL1R1, MAPK14, PRKCQ, RRAGD, ACTG1, ITPR1, TP53

Triclabendazole

hsa05132

Salmonella infection

1.95E-03

P25963, P08238, P01106, P42338, O75369, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, MYC, PIK3CB, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41

Triclabendazole

hsa05134

Legionellosis

1.58E-03

P01584, P25963, Q9NR31, P11215, P68104, P11142

IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA8

Triclabendazole

hsa05140

Leishmaniasis

4.82E-02

P14598, P11215, P42224, P25963

NCF1, ITGAM, STAT1, NFKBIA

Triclabendazole

hsa05144

Malaria

1.20E-03

P60033, O60603, P35443, P26718

CD81, TLR2, THBS4, KLRK1

Triclabendazole

hsa05152

Tuberculosis

4.16E-02

Q99437, P25774

ATP6V0B, CTSS

Triclabendazole

hsa05162

Measles

1.84E-02

P01568, P25963, P42224, P14784, P07766, P42338, P11142

IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8

Triclabendazole

hsa05163

Human cytomegalovirus infection

3.84E-06

P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568

PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21

Triclabendazole

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.48E-09

P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P04141, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CSF2, CALM1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Triclabendazole

hsa05168

Herpes simplex virus 1 infection

5.29E-03

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189

Triclabendazole

hsa05169

Epstein-Barr virus infection

2.24E-04

P13765, P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, O60603, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TLR2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q13547	HDAC1	Histone deacetylase 1	-0.727
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Triclabendazole

hsa05170

Human immunodeficiency virus 1 infection

2.74E-06

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Triclabendazole

hsa05200

Pathways in cancer

1.45E-05

P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, P20585, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, MSH3, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43246	MSH2	DNA mismatch repair protein Msh2	0.887
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717

Triclabendazole

hsa05202

Transcriptional misregulation in cancer

4.08E-02

Q15532, P27930, Q16548, O15550, P04637, P05164, Q9C0K0, P24522

SS18, IL1R2, BCL2A1, UTX, TP53, MPO, BCL11B, GADD45A

Triclabendazole

hsa05203

Viral carcinogenesis

4.34E-04

Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q7KZF4, Q13547, P12814, P25963, P61978, P62807, Q93079

CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, SND1, HDAC1, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9

Triclabendazole

hsa05206

MicroRNAs in cancer

4.00E-04

P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174

CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1

Triclabendazole

hsa05212

Pancreatic cancer

4.75E-02

P42224, P84022, O75293

STAT1, SMAD3, GADD45B

Triclabendazole

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Triclabendazole

hsa05214

Glioma

1.54E-03

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Triclabendazole

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Triclabendazole

hsa05220

Chronic myeloid leukemia

2.17E-02

Q13547, P01106, P25963, P42338, O75293

HDAC1, MYC, NFKBIA, PIK3CB, GADD45B

Triclabendazole

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Triclabendazole

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Triclabendazole

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.94E-03

P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q16539

NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, MAPK14

Triclabendazole

hsa05418

Fluid shear stress and atherosclerosis

3.59E-02

Q16539, P63261, P04637, P14778, P27930

MAPK14, ACTG1, TP53, IL1R1, IL1R2

Community members of Triclabendazole (S_DC: 3.36)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P06733

ENO1

AlphaNoneenolase

Predicted

0.4744

0.0115

0.2922

0.5525

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P27348

YWHAQ

14None3None3 protein theta

Predicted

0.336

0.0037

0.5612

0.7365

P43234

CTSO

Cathepsin O

Predicted

0.3771

0.0049

0.3008

0.4991

PharmaCoNets of Triclabendazole (SPCN: 57.07 )

Triclabendazole regulated-network (SDN: 16.99)

Community members of Triclabendazole (SDC: 3.36)

PharmaCoNets of Triclabendazole (S_PCN: 57.07 )

Triclabendazole regulated-network (S_DN: 16.99)

Community members of Triclabendazole (S_DC: 3.36)