PharmaCoNets of Triamterene (SPCN: 68.76 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Triamterenehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Triamterenehsa00220Arginine biosynthesis1.05E-032P15104, P49448GLUL, GLUD2More
Triamterenehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Triamterenehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Triamterenehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Triamterenehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Triamterenehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Triamterenehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Triamterenehsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Triamterenehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Triamterenehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Triamterenehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Triamterenehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Triamterenehsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Triamterenehsa03013RNA transport1.16E-039P62826, O14893, Q9UBU9, P63279, P68104, Q14240, Q9BZI7, Q14232, Q06787RAN, GEMIN2, NXF1, UBE2I, EEF1A1, EIF4A2, UPF3B, EIF2B1, FMR1More
Triamterenehsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Triamterenehsa03020RNA polymerase4.09E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Triamterenehsa03430Mismatch repair4.38E-021P20585MSH3More
Triamterenehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Triamterenehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Triamterenehsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Triamterenehsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Triamterenehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Triamterenehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Triamterenehsa04061Viral protein interaction with cytokine and cytokine receptor4.54E-022Q8NHW4, Q13651CCL4L2, IL10RAMore
Triamterenehsa04064NF-kappa B signaling pathway4.10E-034P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Triamterenehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Triamterenehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Triamterenehsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Triamterenehsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Triamterenehsa04114Oocyte meiosis4.41E-036P0DP23, Q08828, P51828, Q13362, Q14738, P08069CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Triamterenehsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Triamterenehsa04140Autophagy - animal4.41E-036P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Triamterenehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Triamterenehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Triamterenehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Triamterenehsa04211Longevity regulating pathway5.00E-035P31751, P08069, Q08828, P51828, P18848AKT2, IGF1R, ADCY1, ADCY7, ATF4More
Triamterenehsa04213Longevity regulating pathway - multiple species1.06E-024P31751, P08069, Q08828, P51828AKT2, IGF1R, ADCY1, ADCY7More
Triamterenehsa04217Necroptosis1.44E-035Q9NQC7, P07900, P15104, P01584, Q9H444CYLD, HSP90AA1, GLUL, IL1B, CHMP4BMore
Triamterenehsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Triamterenehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Triamterenehsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Triamterenehsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Triamterenehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Triamterenehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Triamterenehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Triamterenehsa04520Adherens junction8.29E-031P08069IGF1RMore
Triamterenehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Triamterenehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Triamterenehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Triamterenehsa04621NOD-like receptor signaling pathway2.92E-023P01584, P07900, P43490IL1B, HSP90AA1, PBEF1More
Triamterenehsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Triamterenehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Triamterenehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Triamterenehsa04657IL-17 signaling pathway7.99E-047P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Triamterenehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Triamterenehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Triamterenehsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Triamterenehsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Triamterenehsa04720Long-term potentiation4.54E-023P0DP23, P18848, Q08828CALM1, ATF4, ADCY1More
Triamterenehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Triamterenehsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Triamterenehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Triamterenehsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Triamterenehsa04730Long-term depression1.34E-023Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Triamterenehsa04742Taste transduction3.91E-021P17612PRKACAMore
Triamterenehsa04750Inflammatory mediator regulation of TRP channels9.86E-034P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Triamterenehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Triamterenehsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Triamterenehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Triamterenehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Triamterenehsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Triamterenehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Triamterenehsa04923Regulation of lipolysis in adipocytes7.59E-044Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Triamterenehsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Triamterenehsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Triamterenehsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Triamterenehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Triamterenehsa04932Non-alcoholic fatty liver disease9.81E-047P31751, P18848, O75460, P01584, P12074, O15239, O95298AKT2, ATF4, ERN1, IL1B, COX6A1, NDUFA1, NDUFC2More
Triamterenehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Triamterenehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Triamterenehsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Triamterenehsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Triamterenehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Triamterenehsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Triamterenehsa05010Alzheimer disease7.09E-0415O95298, O15399, Q00535, Q9NZJ5, O75460, P0DP23, Q13564, P01584, P18848, Q71U36, P09603, P31751, P05141, P21796, P28070NDUFC2, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, ATF4, TUBA1A, CSF1, AKT2, SLC25A5, VDAC1, PSMB4More
Triamterenehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Triamterenehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Triamterenehsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Triamterenehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Triamterenehsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Triamterenehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Triamterenehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Triamterenehsa05163Human cytomegalovirus infection1.64E-0515P31751, P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463AKT2, TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Triamterenehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Triamterenehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Triamterenehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Triamterenehsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Triamterenehsa05200Pathways in cancer4.70E-023P17301, P20585, P62879ITGA2, MSH3, GNB2More
Triamterenehsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Triamterenehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Triamterenehsa05212Pancreatic cancer2.40E-023P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Triamterenehsa05214Glioma9.95E-031P08069IGF1RMore
Triamterenehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Triamterenehsa05218Melanoma6.63E-031P08069IGF1RMore
Triamterenehsa05224Breast cancer1.49E-021P08069IGF1RMore
Triamterenehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Triamterenehsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Triamterenehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Triamterene (SDC: 4.99)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)