PharmaCoNets

PharmaCoNets of Tretinoin (S_PCN: 20.36 )

Tretinoin regulated-network (S_DN: 9.98)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Alitretinoin

hsa00310

Lysine degradation

4.97E-02

Q9NVH6, O15047

TMLHE, SETD1A

Alitretinoin

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Alitretinoin

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Alitretinoin

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

2.03E-02

Q9Y2C2

UST

Alitretinoin

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Alitretinoin

hsa00561

Glycerolipid metabolism

7.73E-03

Q8NEB5, P14550, Q86XP1

PPAPDC1B, AKR1A1, DGKH

Alitretinoin

hsa00591

Linoleic acid metabolism

4.96E-02

P11712

CYP2C9

Alitretinoin

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Alitretinoin

hsa00620

Pyruvate metabolism

4.97E-02

P40926, P14550

MDH2, AKR1A1

Alitretinoin

hsa00900

Terpenoid backbone biosynthesis

3.03E-03

Q9UHG3

PCYOX1

Alitretinoin

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Alitretinoin

hsa00980

Metabolism of xenobiotics by cytochrome P450

3.03E-03

Q16772

GSTA3

Alitretinoin

hsa00982

Drug metabolism - cytochrome P450

3.03E-03

Q16772

GSTA3

Alitretinoin

hsa00983

Drug metabolism - other enzymes

2.64E-03

P04183, P20839, P32320, P05164, Q16772

TK1, IMPDH1, CDA, MPO, GSTA3

Alitretinoin

hsa01240

Biosynthesis of cofactors

3.29E-02

P13716, P14618

ALAD, PKM2

Alitretinoin

hsa01522

Endocrine resistance

5.97E-03

P14780, P22694, P10415, Q13323

MMP9, PRKACB, BCL2, BIK

Alitretinoin

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Alitretinoin

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Alitretinoin

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Alitretinoin

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Alitretinoin

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Alitretinoin

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Alitretinoin

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.65E-02

P09341, P19875, Q13651, P14784, P01375

CXCL1, CXCL2, IL10RA, IL2RB, TNF

Alitretinoin

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Alitretinoin

hsa04064

NF-kappa B signaling pathway

5.05E-04

P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341

BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1

Alitretinoin

hsa04080

Neuroactive ligand-receptor interaction

4.90E-03

P08311, Q15722, P21453, Q9H228, O00398, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	0.728
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q15722	LTB4R	Leukotriene B4 receptor 1	0.781
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.706
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P21462	FPR1	fMet-Leu-Phe receptor	0.834
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.835
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P07550	ADRB2	Beta-2 adrenergic receptor	-0.846
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.719

Alitretinoin

hsa04114

Oocyte meiosis

4.51E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863

Alitretinoin

hsa04120

Ubiquitin mediated proteolysis

3.92E-02

Q969M7, Q86TM6, Q16763, O95071

UBE2F, SYVN1, UBE2S, UBR5

Alitretinoin

hsa04130

SNARE interactions in vesicular transport

4.96E-02

O15155

BET1

Alitretinoin

hsa04137

Mitophagy - animal

2.73E-02

Q96CV9, Q14596, P18848

OPTN, NBR1, ATF4

Alitretinoin

hsa04140

Autophagy - animal

5.97E-03

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Alitretinoin

hsa04142

Lysosome

4.41E-02

P10619, P49281

CTSA, SLC11A2

Alitretinoin

hsa04150

mTOR signaling pathway

1.59E-02

P23588, P04628

EIF4B, WNT1

Alitretinoin

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Alitretinoin

hsa04210

Apoptosis

2.31E-02

Q13315, P10415, P01375, P24522, Q16548, Q13077, P18848, Q14643

ATM, BCL2, TNF, GADD45A, BCL2A1, TRAF1, ATF4, ITPR1

Alitretinoin

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Alitretinoin

hsa04330

Notch signaling pathway

7.73E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Alitretinoin

hsa04340

Hedgehog signaling pathway

1.19E-03

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Alitretinoin

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Alitretinoin

hsa04370

VEGF signaling pathway

2.47E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Alitretinoin

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725

Alitretinoin

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Alitretinoin

hsa04540

Gap junction

2.86E-02

P22694, P68371, Q14643

PRKACB, TUBB2C, ITPR1

Alitretinoin

hsa04550

Signaling pathways regulating pluripotency of stem cells

4.41E-02

P04628, Q02535

WNT1, ID3

Alitretinoin

hsa04612

Antigen processing and presentation

5.03E-03

P13765, P48382, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P48382	RFX5	DNA-binding protein RFX5	-0.892
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.836
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.836
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13241	KLRD1	Natural killer cells antigen CD94	-0.789
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P48382	RFX5	DNA-binding protein RFX5	-0.75
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q13241	KLRD1	Natural killer cells antigen CD94	-0.826
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.701
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.76
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01375	TNF	Tumor necrosis factor	0.821

Alitretinoin

hsa04613

Neutrophil extracellular trap formation

4.02E-02

P05164, P08246, Q9UM07, Q15080, P20160, P08311, P49913, P21730, P21462

MPO, ELA2, PADI4, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Alitretinoin

hsa04621

NOD-like receptor signaling pathway

2.31E-02

Q14643, P43490, O00463, P10415, P01375, P09341, P49913, P12838

ITPR1, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4

Alitretinoin

hsa04622

RIG-I-like receptor signaling pathway

2.65E-02

Q12933, P10145

TRAF2, IL8

Alitretinoin

hsa04625

C-type lectin receptor signaling pathway

2.81E-02

P20749, Q9UDY8, Q14643, P01375, Q13191

BCL3, MALT1, ITPR1, TNF, CBLB

Alitretinoin

hsa04650

Natural killer cell mediated cytotoxicity

2.12E-06

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, Q07444, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01375	TNF	Tumor necrosis factor	0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.734
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.808
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13241	KLRD1	Natural killer cells antigen CD94	-0.78
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13241	KLRD1	Natural killer cells antigen CD94	-0.789
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.778
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.84
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	O14931	NCR3	Natural cytotoxicity triggering receptor 3	-0.746
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.836
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q07444	KLRC3	NKG2-E type II integral membrane protein	-0.822
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.836
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01375	TNF	Tumor necrosis factor	0.821
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.727
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q13241	KLRD1	Natural killer cells antigen CD94	-0.826
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.801
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.764
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.854

Alitretinoin

hsa04657

IL-17 signaling pathway

4.73E-02

O00463, P09341, P14780, P80188, P01375

TRAF5, CXCL1, MMP9, LCN2, TNF

Alitretinoin

hsa04658

Th1 and Th2 cell differentiation

2.82E-06

Q04759, P07766, P20963, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.731
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.865
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9UL17	TBX21	T-box transcription factor TBX21	-0.813
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UL17	TBX21	T-box transcription factor TBX21	-0.746
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13761	RUNX3	Runt-related transcription factor 3	-0.887
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73

Alitretinoin

hsa04659

Th17 cell differentiation

1.91E-06

P25963, Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P20963

NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9HBE5	IL21R	Interleukin-21 receptor	-0.715
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9HBE5	IL21R	Interleukin-21 receptor	-0.799
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9UL17	TBX21	T-box transcription factor TBX21	-0.813
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UL17	TBX21	T-box transcription factor TBX21	-0.746
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797

Alitretinoin

hsa04660

T cell receptor signaling pathway

6.24E-05

P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P01732, Q13191, P06239

TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01375	TNF	Tumor necrosis factor	0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.715
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.714
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.869
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.706
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.756
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.848
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.701
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771

Alitretinoin

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Alitretinoin

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Alitretinoin

hsa04668

TNF signaling pathway

5.03E-03

P01375, O00463, P18848, P09341, P20749, Q13077, P14780

TNF, TRAF5, ATF4, CXCL1, BCL3, TRAF1, MMP9

Alitretinoin

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Alitretinoin

hsa04720

Long-term potentiation

2.35E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Alitretinoin

hsa04725

Cholinergic synapse

3.47E-03

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Alitretinoin

hsa04727

GABAergic synapse

2.73E-02

P63218, P50151, P28472

GNG5, GNG10, GABRB3

Alitretinoin

hsa04913

Ovarian steroidogenesis

2.72E-02

P42330, P22694

AKR1C3, PRKACB

Alitretinoin

hsa04914

Progesterone-mediated oocyte maturation

7.70E-03

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Alitretinoin

hsa04915

Estrogen signaling pathway

2.07E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Alitretinoin

hsa04918

Thyroid hormone synthesis

2.75E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Alitretinoin

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Alitretinoin

hsa04922

Glucagon signaling pathway

4.66E-02

P14618, P06737

PKM2, PYGL

Alitretinoin

hsa04924

Renin secretion

3.09E-03

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Alitretinoin

hsa04927

Cortisol synthesis and secretion

3.58E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Alitretinoin

hsa04928

Parathyroid hormone synthesis, secretion and action

4.51E-04

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.744
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.813
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.796
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723

Alitretinoin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Alitretinoin

hsa04934

Cushing syndrome

4.74E-02

Q14643, P22694, P04628

ITPR1, PRKACB, WNT1

Alitretinoin

hsa04970

Salivary secretion

2.11E-02

P07550, P22694, Q14643

ADRB2, PRKACB, ITPR1

Alitretinoin

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Alitretinoin

hsa05034

Alcoholism

3.50E-02

P62873, Q93077, O60814, P68431

GNB1, HIST1H2AC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Alitretinoin

hsa05132

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75369	FLNB	Filamin-B	-0.863
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13561	DCTN2	Dynactin subunit 2	-0.818
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13509	TUBB3	Tubulin beta-3 chain	-0.815
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.744

Alitretinoin

hsa05134

Legionellosis

3.83E-02

P01375, P09341, P19875

TNF, CXCL1, CXCL2

Alitretinoin

hsa05135

Yersinia infection

2.58E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Alitretinoin

hsa05140

Leishmaniasis

3.39E-02

P11215, P42224, P29350

ITGAM, STAT1, PTPN6

Alitretinoin

hsa05142

Chagas disease

2.90E-02

P01375, P30679, P07766, P20963

TNF, GNA15, CD3E, CD247

Alitretinoin

hsa05144

Malaria

3.83E-02

P60033, P01375, P26718

CD81, TNF, KLRK1

Alitretinoin

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Alitretinoin

hsa05146

Amoebiasis

9.40E-05

P09341, P19875, P01375, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSG

Alitretinoin

hsa05150

Staphylococcus aureus infection

1.47E-02

P21730, P21462, P13765, P12838, P49913

C5AR1, FPR1, HLA-DOB, DEFA4, CAMP

Alitretinoin

hsa05152

Tuberculosis

4.32E-02

P48382, P01375, P10415, P13765, P49913, Q9UDY8

RFX5, TNF, BCL2, HLA-DOB, CAMP, MALT1

Alitretinoin

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Alitretinoin

hsa05170

Human immunodeficiency virus 1 infection

4.37E-02

Q02750, P62879, P16298, Q05397

MAP2K1, GNB2, PPP3CB, PTK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889

Alitretinoin

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Alitretinoin

hsa05202

Transcriptional misregulation in cancer

2.51E-02

Q13315, P14780, Q15744, Q16548, Q13077, P05164, P12838, P08246, Q9C0K0, P24522

ATM, MMP9, CEBPE, BCL2A1, TRAF1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Alitretinoin

hsa05204

Chemical carcinogenesis

3.03E-03

Q16772

GSTA3

Alitretinoin

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Alitretinoin

hsa05212

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Alitretinoin

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Alitretinoin

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Alitretinoin

hsa05225

Hepatocellular carcinoma

1.21E-02

P04628, Q92922, Q9NPI1

WNT1, SMARCC1, BRD7

Alitretinoin

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Alitretinoin

hsa05310

Asthma

5.45E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Alitretinoin

hsa05321

Inflammatory bowel disease

2.88E-06

P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Alitretinoin

hsa05322

Systemic lupus erythematosus

1.98E-02

P29965, Q93077, O60814, P68431

CD40LG, HIST1H2AC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Alitretinoin

hsa05332

Graft-versus-host disease

5.67E-03

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Alitretinoin

hsa05418

Fluid shear stress and atherosclerosis

4.21E-03

Q16772, P51636

GSTA3, CAV2

Isotretinoin

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Isotretinoin

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Isotretinoin

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Isotretinoin

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Isotretinoin

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Isotretinoin

hsa01522

Endocrine resistance

4.74E-02

P22694, P10415, Q13323

PRKACB, BCL2, BIK

Isotretinoin

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Isotretinoin

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Isotretinoin

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Isotretinoin

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Isotretinoin

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Isotretinoin

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Isotretinoin

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Isotretinoin

hsa04080

Neuroactive ligand-receptor interaction

4.90E-03

P08311, Q15722, P21453, Q9H228, O00398, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	0.728
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q15722	LTB4R	Leukotriene B4 receptor 1	0.781
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.706
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P21462	FPR1	fMet-Leu-Phe receptor	0.834
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.835
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P07550	ADRB2	Beta-2 adrenergic receptor	-0.846
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.719

Isotretinoin

hsa04114

Oocyte meiosis

4.51E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863

Isotretinoin

hsa04140

Autophagy - animal

4.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Isotretinoin

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Isotretinoin

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Isotretinoin

hsa04340

Hedgehog signaling pathway

9.74E-03

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Isotretinoin

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Isotretinoin

hsa04370

VEGF signaling pathway

2.47E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Isotretinoin

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725

Isotretinoin

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Isotretinoin

hsa04540

Gap junction

2.86E-02

P22694, P68371, Q14643

PRKACB, TUBB2C, ITPR1

Isotretinoin

hsa04650

Natural killer cell mediated cytotoxicity

3.08E-02

P16298, P50591, Q02750

PPP3CB, TNFSF10, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01375	TNF	Tumor necrosis factor	0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.734
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.808
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13241	KLRD1	Natural killer cells antigen CD94	-0.78
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13241	KLRD1	Natural killer cells antigen CD94	-0.789
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.778
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.84
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	O14931	NCR3	Natural cytotoxicity triggering receptor 3	-0.746
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.836
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q07444	KLRC3	NKG2-E type II integral membrane protein	-0.822
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.836
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01375	TNF	Tumor necrosis factor	0.821
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.727
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q13241	KLRD1	Natural killer cells antigen CD94	-0.826
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.801
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.764
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.854

Isotretinoin

hsa04659

Th17 cell differentiation

2.08E-03

P25963, P19174, P14784, P14778, P84022, Q13485, P08238, P07766

NFKBIA, PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3E

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9HBE5	IL21R	Interleukin-21 receptor	-0.715
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9HBE5	IL21R	Interleukin-21 receptor	-0.799
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9UL17	TBX21	T-box transcription factor TBX21	-0.813
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UL17	TBX21	T-box transcription factor TBX21	-0.746
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797

Isotretinoin

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Isotretinoin

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Isotretinoin

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Isotretinoin

hsa04720

Long-term potentiation

2.35E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Isotretinoin

hsa04725

Cholinergic synapse

3.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Isotretinoin

hsa04913

Ovarian steroidogenesis

2.72E-02

P42330, P22694

AKR1C3, PRKACB

Isotretinoin

hsa04914

Progesterone-mediated oocyte maturation

7.70E-03

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Isotretinoin

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Isotretinoin

hsa04924

Renin secretion

3.09E-03

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Isotretinoin

hsa04927

Cortisol synthesis and secretion

2.72E-02

Q14643, P22694

ITPR1, PRKACB

Isotretinoin

hsa04928

Parathyroid hormone synthesis, secretion and action

1.02E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.744
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.813
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.796
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723

Isotretinoin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Isotretinoin

hsa04934

Cushing syndrome

4.74E-02

Q14643, P22694, P04628

ITPR1, PRKACB, WNT1

Isotretinoin

hsa04970

Salivary secretion

2.11E-02

P07550, P22694, Q14643

ADRB2, PRKACB, ITPR1

Isotretinoin

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Isotretinoin

hsa05132

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75369	FLNB	Filamin-B	-0.863
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13561	DCTN2	Dynactin subunit 2	-0.818
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13509	TUBB3	Tubulin beta-3 chain	-0.815
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.744

Isotretinoin

hsa05135

Yersinia infection

2.58E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Isotretinoin

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Isotretinoin

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Isotretinoin

hsa05170

Human immunodeficiency virus 1 infection

4.37E-02

Q02750, P62879, P16298, Q05397

MAP2K1, GNB2, PPP3CB, PTK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889

Isotretinoin

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Isotretinoin

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Isotretinoin

hsa05212

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Isotretinoin

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Isotretinoin

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Isotretinoin

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Tretinoin

hsa00030

Pentose phosphate pathway

2.32E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Tretinoin

hsa00040

Pentose and glucuronate interconversions

2.31E-02

Q9UEF7, O60701

KL, UGDH

Tretinoin

hsa00190

Oxidative phosphorylation

2.74E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Tretinoin

hsa00220

Arginine biosynthesis

1.43E-02

P05089, P49448

ARG1, GLUD2

Tretinoin

hsa00250

Alanine, aspartate and glutamate metabolism

4.51E-02

P51649

ALDH5A1

Tretinoin

hsa00280

Valine, leucine and isoleucine degradation

2.20E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Tretinoin

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Tretinoin

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Tretinoin

hsa00531

Glycosaminoglycan degradation

3.03E-02

P15586

GNS

Tretinoin

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Tretinoin

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Tretinoin

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Tretinoin

hsa01522

Endocrine resistance

4.74E-02

P22694, P10415, Q13323

PRKACB, BCL2, BIK

Tretinoin

hsa01524

Platinum drug resistance

1.01E-03

P04637, O15392, P48023, P11388

TP53, BIRC5, FASLG, TOP2A

Tretinoin

hsa03013

RNA transport

2.60E-03

Q09161, O14893, Q9H307, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114

NCBP1, GEMIN2, PNN, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1

Tretinoin

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Tretinoin

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Tretinoin

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Tretinoin

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Tretinoin

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Tretinoin

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Tretinoin

hsa04068

FoxO signaling pathway

6.45E-03

P48023, Q96BR1

FASLG, SGK3

Tretinoin

hsa04080

Neuroactive ligand-receptor interaction

6.57E-04

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550, P35318

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	0.728
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q15722	LTB4R	Leukotriene B4 receptor 1	0.781
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.706
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P21462	FPR1	fMet-Leu-Phe receptor	0.834
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.835
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P07550	ADRB2	Beta-2 adrenergic receptor	-0.846
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.719

Tretinoin

hsa04114

Oocyte meiosis

4.51E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.832
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.87
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.863

Tretinoin

hsa04140

Autophagy - animal

4.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Tretinoin

hsa04151

PI3K-Akt signaling pathway

2.80E-03

P42338, P43657, P48023, P04637, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, Q96BR1, P30281

PIK3CB, P2RY5, FASLG, TP53, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, SGK3, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Tretinoin

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Tretinoin

hsa04340

Hedgehog signaling pathway

9.74E-03

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Tretinoin

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Tretinoin

hsa04370

VEGF signaling pathway

2.47E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Tretinoin

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725

Tretinoin

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Tretinoin

hsa04540

Gap junction

2.86E-02

P22694, P68371, Q14643

PRKACB, TUBB2C, ITPR1

Tretinoin

hsa04612

Antigen processing and presentation

2.22E-04

P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375

RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P48382	RFX5	DNA-binding protein RFX5	-0.892
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.836
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.836
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13241	KLRD1	Natural killer cells antigen CD94	-0.789
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P48382	RFX5	DNA-binding protein RFX5	-0.75
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q13241	KLRD1	Natural killer cells antigen CD94	-0.826
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.701
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.76
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01375	TNF	Tumor necrosis factor	0.821

Tretinoin

hsa04614

Renin-angiotensin system

2.52E-02

P50052

AGTR2

Tretinoin

hsa04622

RIG-I-like receptor signaling pathway

3.49E-02

P01568, P25963, Q9H1Y0, Q13546

IFNA21, NFKBIA, ATG5, RIPK1

Tretinoin

hsa04623

Cytosolic DNA-sensing pathway

3.47E-03

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Tretinoin

hsa04650

Natural killer cell mediated cytotoxicity

4.16E-07

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, P48023, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, FASLG, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01375	TNF	Tumor necrosis factor	0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.734
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.808
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13241	KLRD1	Natural killer cells antigen CD94	-0.78
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13241	KLRD1	Natural killer cells antigen CD94	-0.789
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.778
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.84
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	O14931	NCR3	Natural cytotoxicity triggering receptor 3	-0.746
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.836
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q07444	KLRC3	NKG2-E type II integral membrane protein	-0.822
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.836
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P01375	TNF	Tumor necrosis factor	0.821
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.727
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13241	KLRD1	Natural killer cells antigen CD94	0.78
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Q13241	KLRD1	Natural killer cells antigen CD94	-0.826
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.767
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.801
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.818
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.764
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26717	KLRC2	NKG2-C type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.854
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.829
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.726
O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.854

Tretinoin

hsa04658

Th1 and Th2 cell differentiation

7.09E-05

Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761

PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.731
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.865
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9UL17	TBX21	T-box transcription factor TBX21	-0.813
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UL17	TBX21	T-box transcription factor TBX21	-0.746
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13761	RUNX3	Runt-related transcription factor 3	-0.887
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q13761	RUNX3	Runt-related transcription factor 3	0.73

Tretinoin

hsa04659

Th17 cell differentiation

2.27E-05

P25963, Q04759, P19174, P06239, P14784, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9HBE5	IL21R	Interleukin-21 receptor	-0.715
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9HBE5	IL21R	Interleukin-21 receptor	-0.799
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q9UL17	TBX21	T-box transcription factor TBX21	-0.813
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UL17	TBX21	T-box transcription factor TBX21	-0.746
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797

Tretinoin

hsa04660

T cell receptor signaling pathway

8.49E-04

Q04759, O95267, Q08881, P20963, P09693, P01732, P06239

PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01375	TNF	Tumor necrosis factor	0.756
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01375	TNF	Tumor necrosis factor	0.831
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.715
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q04759	PRKCQ	Protein kinase C theta type	-0.794
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q04759	PRKCQ	Protein kinase C theta type	-0.897
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.714
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.869
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.716
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.904
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.818
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.706
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.756
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.848
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.701
P31997	CEACAM8	Carcinoembryonic antigen-related cell adhesion molecule 8	P06239	LCK	Tyrosine-protein kinase Lck	-0.76
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771

Tretinoin

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Tretinoin

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Tretinoin

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Tretinoin

hsa04720

Long-term potentiation

2.35E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Tretinoin

hsa04722

Neurotrophin signaling pathway

2.27E-02

P48023, P04637

FASLG, TP53

Tretinoin

hsa04725

Cholinergic synapse

3.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Tretinoin

hsa04744

Phototransduction

2.31E-02

P62873, P0DP23

GNB1, CALM1

Tretinoin

hsa04913

Ovarian steroidogenesis

2.72E-02

P42330, P22694

AKR1C3, PRKACB

Tretinoin

hsa04914

Progesterone-mediated oocyte maturation

7.70E-03

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Tretinoin

hsa04916

Melanogenesis

3.49E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Tretinoin

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Tretinoin

hsa04924

Renin secretion

1.55E-04

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Tretinoin

hsa04927

Cortisol synthesis and secretion

2.72E-02

Q14643, P22694

ITPR1, PRKACB

Tretinoin

hsa04928

Parathyroid hormone synthesis, secretion and action

1.02E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.744
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.813
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.79
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.796
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723

Tretinoin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Tretinoin

hsa04934

Cushing syndrome

4.74E-02

Q14643, P22694, P04628

ITPR1, PRKACB, WNT1

Tretinoin

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P48048

KCNJ1

Tretinoin

hsa04970

Salivary secretion

2.11E-02

P07550, P22694, Q14643

ADRB2, PRKACB, ITPR1

Tretinoin

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Tretinoin

hsa05132

Salmonella infection

3.68E-05

P25963, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P49754

NFKBIA, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.77
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75369	FLNB	Filamin-B	-0.863
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13561	DCTN2	Dynactin subunit 2	-0.818
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13509	TUBB3	Tubulin beta-3 chain	-0.815
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.744

Tretinoin

hsa05135

Yersinia infection

2.58E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Tretinoin

hsa05144

Malaria

2.21E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Tretinoin

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Tretinoin

hsa05146

Amoebiasis

2.73E-02

P09341, P05089, P12814, P08311

CXCL1, ARG1, ACTN1, CTSG

Tretinoin

hsa05152

Tuberculosis

1.14E-02

Q13488, Q15075, P0DP23, P48382, O60603, P10415, P01568, Q9UDY8

TCIRG1, EEA1, CALM1, RFX5, TLR2, BCL2, IFNA21, MALT1

Tretinoin

hsa05160

Hepatitis C

3.81E-02

P04637, P48023

TP53, FASLG

Tretinoin

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Tretinoin

hsa05164

Influenza A

3.48E-02

Q9GZY0, P48023

NXF2; NXF2B, FASLG

Tretinoin

hsa05168

Herpes simplex virus 1 infection

2.26E-03

O60603, P25963, P01568, P04637, Q9GZY0, Q07955, P48023, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, O75820, P98182, P10415

TLR2, NFKBIA, IFNA21, TP53, NXF2; NXF2B, SFRS1, FASLG, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF189, ZNF200, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P04637	TP53	Cellular tumor antigen p53	-0.723
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	-0.759
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.82
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.736
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.837
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13398	ZNF211	Zinc finger protein 211	-0.711
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P51522	ZNF83	Zinc finger protein 83	0.737
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9NR11	ZNF302	Zinc finger protein 302	0.808
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9HCX3	ZNF304	Zinc finger protein 304	0.701
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17097	ZNF7	Zinc finger protein 7	0.744
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q03923	ZNF85	Zinc finger protein 85	0.705
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O75820	ZNF189	Zinc finger protein 189	0.753
P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	P98182	ZNF200	Zinc finger protein 200	0.747
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849

Tretinoin

hsa05170

Human immunodeficiency virus 1 infection

2.56E-03

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, P01568, P25963, O60603, P10415, Q13619, Q9Y6Q5

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, IFNA21, NFKBIA, TLR2, BCL2, CUL4A, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.767
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P0DP23	CALM1	Calmodulin-1	-0.816
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P17252	PRKCA	Protein kinase C alpha type	0.74
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.787
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P01568	IFNA21	Interferon alpha-21	0.828
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.761
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	O60603	TLR2	Toll-like receptor 2	-0.831
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	P10415	BCL2	Apoptosis regulator Bcl-2	0.849
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q13619	CUL4A	Cullin-4A	0.706
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.889

Tretinoin

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Tretinoin

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Tretinoin

hsa05212

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Tretinoin

hsa05219

Bladder cancer

4.51E-02

P04637

TP53

Tretinoin

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Tretinoin

hsa05222

Small cell lung cancer

1.82E-03

P10826, Q13489, P10415, P25963, Q13077, O75293

RARB, BIRC3, BCL2, NFKBIA, TRAF1, GADD45B

Tretinoin

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Tretinoin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.88E-03

O95267, P20963, P09693, P06239, Q04759

RASGRP1, CD247, CD3G, LCK, PRKCQ

Tretinoin

hsa05321

Inflammatory bowel disease

2.21E-02

O60603, P01375, Q14765, Q9UL17

TLR2, TNF, STAT4, TBX21

Tretinoin

hsa05322

Systemic lupus erythematosus

1.57E-02

P08311, P62807, Q16778, P12814

CTSG, HIST1H2BC, HIST2H2BE, ACTN1

Tretinoin

hsa05332

Graft-versus-host disease

7.62E-03

P10747, P01375, P26715, Q13241

CD28, TNF, KLRC1, KLRD1

Community members of Tretinoin (S_DC: 2.04)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ALDH1A1

Aldehyde dehydrogenase 1A1

Reported

0.3208

0.2925

0.1543

0.8998

P10826

RARB

Retinoic acid receptor beta

Reported

0.0094

0.3466

0.3005

0.9983

P31025

LCN1

LipocalinNone1

Reported

0.0084

0.0067

0.0175

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P10588

NR2F6

Nuclear receptor subfamily 2 group F member 6

Predicted

0.3923

0.068

0.3321

P51649

ALDH5A1

SuccinateNonesemialdehyde dehydrogenase, mitochondrial

Predicted

0.173

0.0778

0.152

0.394

Q02252

ALDH6A1

MethylmalonateNonesemialdehyde dehydrogenase [acylating], mitochondrial

Predicted

0.4334

0.0148

0.2428

0.4891

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

O14874

BCKDK

[3NonemethylNone2Noneoxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Predicted

0.1618

0.002

0.0849

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Gene name	UniProt_ID	Bioactivity	Value (nM)
RARB	P10826	IC50	7
RARB	P10826	Ki	0.5
RARB	P10826	Ki	0.7
RARB	P10826	Ki	11
RARB	P10826	Kd	7
RARB	P10826	Kd	97
RARB	P10826	Kd	100
RARB	P10826	IC50	0.9
RARB	P10826	IC50	0.94
RARB	P10826	IC50	13
RARB	P10826	Ki	0.4
RARB	P10826	Ki	0.5
RARB	P10826	Ki	4.1
RARB	P10826	Kd	0.4
RARB	P10826	Kd	7
RARB	P10826	Kd	11

PharmaCoNets of Tretinoin (SPCN: 20.36 )

Tretinoin regulated-network (SDN: 9.98)

Community members of Tretinoin (SDC: 2.04)

PharmaCoNets of Tretinoin (S_PCN: 20.36 )

Tretinoin regulated-network (S_DN: 9.98)

Community members of Tretinoin (S_DC: 2.04)