PharmaCoNets of Tranylcypromine (SPCN: 38.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tranylcyprominehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tranylcyprominehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Tranylcyprominehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Tranylcyprominehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Tranylcyprominehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Tranylcyprominehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tranylcyprominehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tranylcyprominehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Tranylcyprominehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tranylcyprominehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Tranylcyprominehsa03015mRNA surveillance pathway2.95E-023O94913, Q9H307, Q13148PCF11, PNN, TARDBPMore
Tranylcyprominehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tranylcyprominehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Tranylcyprominehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Tranylcyprominehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Tranylcyprominehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Tranylcyprominehsa04064NF-kappa B signaling pathway2.21E-0412Q13489, O00463, Q13546, P14778, Q04759, Q9UDY8, P07948, P06239, P24522, P09341, Q06643, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, PRKCQ, MALT1, LYN, LCK, GADD45A, CXCL1, LTB, EDARMore
Tranylcyprominehsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Tranylcyprominehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Tranylcyprominehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Tranylcyprominehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Tranylcyprominehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Tranylcyprominehsa04217Necroptosis2.34E-0513P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Tranylcyprominehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Tranylcyprominehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Tranylcyprominehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Tranylcyprominehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Tranylcyprominehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Tranylcyprominehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Tranylcyprominehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Tranylcyprominehsa04623Cytosolic DNA-sensing pathway2.63E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Tranylcyprominehsa04640Hematopoietic cell lineage1.60E-0410P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Tranylcyprominehsa04650Natural killer cell mediated cytotoxicity3.08E-038P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Tranylcyprominehsa04658Th1 and Th2 cell differentiation2.44E-0711Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Tranylcyprominehsa04659Th17 cell differentiation4.63E-0611Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Tranylcyprominehsa04660T cell receptor signaling pathway8.91E-049Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Tranylcyprominehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tranylcyprominehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Tranylcyprominehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tranylcyprominehsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Tranylcyprominehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Tranylcyprominehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tranylcyprominehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tranylcyprominehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Tranylcyprominehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Tranylcyprominehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tranylcyprominehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tranylcyprominehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tranylcyprominehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Tranylcyprominehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Tranylcyprominehsa05133Pertussis4.20E-021P0C0L4C4AMore
Tranylcyprominehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Tranylcyprominehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Tranylcyprominehsa05144Malaria6.79E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Tranylcyprominehsa05146Amoebiasis9.73E-036P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Tranylcyprominehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tranylcyprominehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Tranylcyprominehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Tranylcyprominehsa05205Proteoglycans in cancer4.43E-023P63261, P04637, Q06124ACTG1, TP53, PTPN11More
Tranylcyprominehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Tranylcyprominehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Tranylcyprominehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Tranylcyprominehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Tranylcyprominehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.73E-036P07766, P20963, P09693, P06239, Q04759, P01730CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Tranylcyprominehsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Tranylcyprominehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tranylcyprominehsa05332Graft-versus-host disease1.96E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Tranylcyprominehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Tranylcyprominehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Tranylcyprominehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Tranylcypromine (SDC: 4.28)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)