PharmaCoNets of Trandolapril (SPCN: 35.97 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trandolaprilhsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Trandolaprilhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Trandolaprilhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Trandolaprilhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Trandolaprilhsa00670One carbon pool by folate1.32E-021P00374DHFRMore
Trandolaprilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Trandolaprilhsa00790Folate biosynthesis1.32E-021P00374DHFRMore
Trandolaprilhsa01523Antifolate resistance1.98E-021P00374DHFRMore
Trandolaprilhsa01524Platinum drug resistance4.57E-021P20585MSH3More
Trandolaprilhsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Trandolaprilhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Trandolaprilhsa03430Mismatch repair3.93E-021P20585MSH3More
Trandolaprilhsa04015Rap1 signaling pathway2.05E-034P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Trandolaprilhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Trandolaprilhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Trandolaprilhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Trandolaprilhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Trandolaprilhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Trandolaprilhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Trandolaprilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Trandolaprilhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Trandolaprilhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Trandolaprilhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Trandolaprilhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Trandolaprilhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Trandolaprilhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Trandolaprilhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Trandolaprilhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Trandolaprilhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Trandolaprilhsa04611Platelet activation7.40E-065P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Trandolaprilhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Trandolaprilhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Trandolaprilhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Trandolaprilhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Trandolaprilhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Trandolaprilhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Trandolaprilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Trandolaprilhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Trandolaprilhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Trandolaprilhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Trandolaprilhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Trandolaprilhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Trandolaprilhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Trandolaprilhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Trandolaprilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Trandolaprilhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Trandolaprilhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Trandolaprilhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Trandolaprilhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Trandolaprilhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Trandolaprilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Trandolaprilhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Trandolaprilhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Trandolaprilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Trandolaprilhsa05200Pathways in cancer3.23E-022P17301, P20585ITGA2, MSH3More
Trandolaprilhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Trandolaprilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Trandolaprilhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Trandolaprilhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Trandolaprilhsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Trandolaprilhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Trandolaprilhsa05410Hypertrophic cardiomyopathy2.63E-021P17301ITGA2More
Trandolaprilhsa05412Arrhythmogenic right ventricular cardiomyopathy8.47E-044P14923, P17301, P08514, Q9UJU2JUP, ITGA2, ITGA2B, LEF1More
Trandolaprilhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Trandolapril (SDC: 3.69)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P17301ITGA2Integrin alphaNone2Predicted00.52210.04470.68391.0343
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)