PharmaCoNets of Trametinib (SPCN: 45.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Trametinibhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Trametinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Trametinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Trametinibhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Trametinibhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Trametinibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Trametinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Trametinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Trametinibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Trametinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Trametinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Trametinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Trametinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Trametinibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Trametinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Trametinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Trametinibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Trametinibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Trametinibhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Trametinibhsa03013RNA transport3.52E-024P52298, O14893, O14602, P78345NCBP2, GEMIN2, EIF1AY, RPP38More
Trametinibhsa04064NF-kappa B signaling pathway2.71E-0311P10415, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341BCL2, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1More
Trametinibhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Trametinibhsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Trametinibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Trametinibhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Trametinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Trametinibhsa04145Phagosome4.79E-023P14598, Q13509, P68371NCF1, TUBB3, TUBB2CMore
Trametinibhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Trametinibhsa04370VEGF signaling pathway1.29E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Trametinibhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Trametinibhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Trametinibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Trametinibhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Trametinibhsa04540Gap junction7.81E-033Q13509, P68371, Q9NRA1TUBB3, TUBB2C, PDGFCMore
Trametinibhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trametinibhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Trametinibhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Trametinibhsa04657IL-17 signaling pathway1.88E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Trametinibhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Trametinibhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Trametinibhsa04720Long-term potentiation3.73E-022Q15418, P18848RPS6KA1, ATF4More
Trametinibhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Trametinibhsa04727GABAergic synapse4.60E-022P51828, P46459ADCY7, NSFMore
Trametinibhsa04912GnRH signaling pathway3.96E-022P51828, P45985ADCY7, MAP2K4More
Trametinibhsa04914Progesterone-mediated oocyte maturation2.66E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Trametinibhsa04918Thyroid hormone synthesis4.48E-022P18848, P05543ATF4, SERPINA7More
Trametinibhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Trametinibhsa04935Growth hormone synthesis, secretion and action4.60E-022P51828, P45985ADCY7, MAP2K4More
Trametinibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Trametinibhsa05010Alzheimer disease3.57E-024P13073, P18848, P67870, P05141COX4I1, ATF4, CSNK2B, SLC25A5More
Trametinibhsa05020Prion disease3.29E-024P13073, P18848, P05141, P67870COX4I1, ATF4, SLC25A5, CSNK2BMore
Trametinibhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Trametinibhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trametinibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Trametinibhsa05130Pathogenic Escherichia coli infection4.08E-023Q15438, P35579, P55061PSCD1, MYH9, TEGTMore
Trametinibhsa05131Shigellosis1.80E-025Q13546, Q9UDY8, Q12778, Q13315, P10415RIPK1, MALT1, FOXO1, ATM, BCL2More
Trametinibhsa05132Salmonella infection4.85E-024Q13546, P10415, Q13509, P68371RIPK1, BCL2, TUBB3, TUBB2CMore
Trametinibhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Trametinibhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Trametinibhsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Trametinibhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Trametinibhsa05163Human cytomegalovirus infection3.04E-038P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Trametinibhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Trametinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Trametinibhsa05215Prostate cancer3.03E-023P10415, Q12778, Q9NRA1BCL2, FOXO1, PDGFCMore
Trametinibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Trametinibhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Trametinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Trametinibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Trametinibhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Trametinibhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Trametinibhsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Trametinib (SDC: 5.07)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Reported00.3120.512912.1819
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)