PharmaCoNets of Tramadol (SPCN: 73.46 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tramadolhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Tramadolhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Tramadolhsa00190Oxidative phosphorylation5.61E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Tramadolhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Tramadolhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Tramadolhsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Tramadolhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Tramadolhsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Tramadolhsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Tramadolhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Tramadolhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Tramadolhsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Tramadolhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Tramadolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Tramadolhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Tramadolhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Tramadolhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Tramadolhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Tramadolhsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Tramadolhsa03013RNA transport3.55E-0513O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Tramadolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tramadolhsa03040Spliceosome9.19E-0610Q14562, O43143, O60508, Q99633, P08579, P26368, Q13595, Q01130, Q9UMS4, O43447DHX8, DHX15, CDC40, PRPF18, SNRPB2, U2AF2, TRA2A, SFRS2, PRPF19, PPIHMore
Tramadolhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Tramadolhsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Tramadolhsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Tramadolhsa04020Calcium signaling pathway2.42E-0710P27987, P21796, Q16566, P17252, P30679, O15399, P25116, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, PRKCA, GNA15, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Tramadolhsa04024cAMP signaling pathway1.22E-036P42338, P0DP23, P23634, Q16566, O15399, P25116PIK3CB, CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Tramadolhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Tramadolhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Tramadolhsa04070Phosphatidylinositol signaling system2.54E-048P0DP23, Q14643, P42338, Q96PE3, O14732, Q13572, P27987, P17252CALM1, ITPR1, PIK3CB, INPP4A, IMPA2, ITPK1, ITPKB, PRKCAMore
Tramadolhsa04071Sphingolipid signaling pathway9.73E-059P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Tramadolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Tramadolhsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Tramadolhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Tramadolhsa04145Phagosome1.09E-0411P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOBMore
Tramadolhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Tramadolhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Tramadolhsa04261Adrenergic signaling in cardiomyocytes2.85E-039P07550, P22694, P18848, Q13362, Q16537, P0DP23, P17252, P10415, P20020ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Tramadolhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Tramadolhsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Tramadolhsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Tramadolhsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Tramadolhsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Tramadolhsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Tramadolhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Tramadolhsa04612Antigen processing and presentation9.45E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Tramadolhsa04613Neutrophil extracellular trap formation4.20E-0519P17252, P11215, O60603, P08246, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P33778, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, ELA2, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Tramadolhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Tramadolhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Tramadolhsa04640Hematopoietic cell lineage1.64E-032P04234, P20036CD3D, HLA-DPA1More
Tramadolhsa04650Natural killer cell mediated cytotoxicity2.62E-0711P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Tramadolhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Tramadolhsa04658Th1 and Th2 cell differentiation1.85E-032P04234, P20036CD3D, HLA-DPA1More
Tramadolhsa04659Th17 cell differentiation1.64E-032P20036, P04234HLA-DPA1, CD3DMore
Tramadolhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Tramadolhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Tramadolhsa04666Fc gamma R-mediated phagocytosis1.76E-048P07948, P42338, P23528, P49006, P06396, O14494, P14598, P17252LYN, PIK3CB, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Tramadolhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Tramadolhsa04672Intestinal immune network for IgA production1.43E-024P29965, P10747, P13765, P20036CD40LG, CD28, HLA-DOB, HLA-DPA1More
Tramadolhsa04713Circadian entrainment8.43E-034O15399, P0DP23, P63218, P50151GRIN2D, CALM1, GNG5, GNG10More
Tramadolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tramadolhsa04720Long-term potentiation1.62E-055P17252, Q16566, P0DP23, O15399, Q14643PRKCA, CAMK4, CALM1, GRIN2D, ITPR1More
Tramadolhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Tramadolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tramadolhsa04724Glutamatergic synapse4.10E-023O15399, P63218, P50151GRIN2D, GNG5, GNG10More
Tramadolhsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Tramadolhsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Tramadolhsa04728Dopaminergic synapse3.55E-038P14416, P63218, P50151, P49841, Q16539, P49407, P0DP23, O00327DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, CALM1, ARNTLMore
Tramadolhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Tramadolhsa04742Taste transduction1.01E-021P30939HTR1FMore
Tramadolhsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Tramadolhsa04750Inflammatory mediator regulation of TRP channels4.93E-021Q9Y5S1TRPV2More
Tramadolhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Tramadolhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Tramadolhsa04916Melanogenesis4.47E-034P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Tramadolhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Tramadolhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Tramadolhsa04925Aldosterone synthesis and secretion2.55E-056Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Tramadolhsa04926Relaxin signaling pathway3.93E-048P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15More
Tramadolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Tramadolhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Tramadolhsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Tramadolhsa04940Type I diabetes mellitus5.38E-033P48023, P20036, P01375FASLG, HLA-DPA1, TNFMore
Tramadolhsa04966Collecting duct acid secretion9.34E-043P02730, P00918, Q9Y666SLC4A1, CA2, SLC12A7More
Tramadolhsa04970Salivary secretion4.63E-058P07550, P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913ADRB2, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMPMore
Tramadolhsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Tramadolhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Tramadolhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tramadolhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Tramadolhsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Tramadolhsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Tramadolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tramadolhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tramadolhsa05031Amphetamine addiction1.61E-037O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1More
Tramadolhsa05034Alcoholism6.03E-049O15399, Q16566, Q13547, P0DP23, P63218, P50151, P58876, Q16778, O60814GRIN2D, CAMK4, HDAC1, CALM1, GNG5, GNG10, H2BC5, HIST2H2BE, H2BC12More
Tramadolhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Tramadolhsa05132Salmonella infection3.16E-0513P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Tramadolhsa05133Pertussis3.42E-034P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Tramadolhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Tramadolhsa05140Leishmaniasis6.62E-048P14598, P42224, O60603, P25963, P29350, P49006, P51617, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, MARCKSL1, IRAK1, NCF4More
Tramadolhsa05142Chagas disease4.93E-021P04234CD3DMore
Tramadolhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Tramadolhsa05144Malaria1.03E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Tramadolhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Tramadolhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Tramadolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tramadolhsa05163Human cytomegalovirus infection2.17E-0311P42338, P01375, P63218, P50151, P0DP23, P49841, P14778, P25025, Q16539, O00463, P30101PIK3CB, TNF, GNG5, GNG10, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3More
Tramadolhsa05166Human T-cell leukemia virus 1 infection9.87E-032P04234, P20036CD3D, HLA-DPA1More
Tramadolhsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Tramadolhsa05168Herpes simplex virus 1 infection2.31E-0417Q9UKJ0, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6, P10415PILRB, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Tramadolhsa05169Epstein-Barr virus infection1.76E-0310P20036, Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P04234, P09693HLA-DPA1, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3D, CD3GMore
Tramadolhsa05170Human immunodeficiency virus 1 infection1.77E-0518P42338, P62873, P63218, P50151, P0DP23, P17252, Q13546, O00463, P30101, Q14643, P01568, P51617, O60603, P23528, P09693, P10415, Q93034, Q9Y6Q5PIK3CB, GNB1, GNG5, GNG10, CALM1, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, TLR2, CFL1, CD3G, BCL2, CUL5, AP1M2More
Tramadolhsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Tramadolhsa05202Transcriptional misregulation in cancer4.29E-0315Q12778, Q15532, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q13547, P12980FOXO1, SS18, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1More
Tramadolhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Tramadolhsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Tramadolhsa05205Proteoglycans in cancer1.39E-0313Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Tramadolhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Tramadolhsa05214Glioma5.48E-056P0DP23, Q16566, P17252, P42338, P04637, P24522CALM1, CAMK4, PRKCA, PIK3CB, TP53, GADD45AMore
Tramadolhsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Tramadolhsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Tramadolhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Tramadolhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Tramadolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.93E-021P04234CD3DMore
Tramadolhsa05310Asthma2.71E-021P20036HLA-DPA1More
Tramadolhsa05320Autoimmune thyroid disease6.60E-035P13765, P20036, P29965, P01568, P10747HLA-DOB, HLA-DPA1, CD40LG, IFNA21, CD28More
Tramadolhsa05321Inflammatory bowel disease4.40E-034P01375, P20036, Q14765, Q9UL17TNF, HLA-DPA1, STAT4, TBX21More
Tramadolhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Tramadolhsa05330Allograft rejection5.38E-033P20036, P48023, P01375HLA-DPA1, FASLG, TNFMore
Tramadolhsa05332Graft-versus-host disease2.53E-045P20036, P48023, P01375, P26715, Q13241HLA-DPA1, FASLG, TNF, KLRC1, KLRD1More
Tramadolhsa05340Primary immunodeficiency1.81E-021P04234CD3DMore
Tramadolhsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Tramadolhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Tramadolhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Tramadolhsa05416Viral myocarditis4.49E-021P20036HLA-DPA1More
Tramadolhsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Tramadol (SDC: 3.85)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q9Y5S1TRPV2Transient receptor potential cation channel subfamily V member 2Predicted00.62910.03880.24020.6324
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC501100
SLC6A4P31645IC501493
SLC6A4P31645IC501900