PharmaCoNets of Toremifene (SPCN: 27.05 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Toremifenehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Toremifenehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Toremifenehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Toremifenehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Toremifenehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Toremifenehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Toremifenehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Toremifenehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Toremifenehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Toremifenehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Toremifenehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Toremifenehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Toremifenehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Toremifenehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Toremifenehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Toremifenehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Toremifenehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Toremifenehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Toremifenehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Toremifenehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Toremifenehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Toremifenehsa04512ECM-receptor interaction3.88E-035Q13751, P07359, P13612, P08514, O15335LAMB3, GP1BA, ITGA4, ITGA2B, CHADMore
Toremifenehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Toremifenehsa04610Complement and coagulation cascades3.52E-022P09871, P20023C1S, CR2More
Toremifenehsa04611Platelet activation5.13E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Toremifenehsa04613Neutrophil extracellular trap formation9.78E-048P16109, Q99878, Q93077, P62807, O60814, P68431, P08514, P07359SELP, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BAMore
Toremifenehsa04640Hematopoietic cell lineage2.62E-023P07359, P08514, P20023GP1BA, ITGA2B, CR2More
Toremifenehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Toremifenehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Toremifenehsa04662B cell receptor signaling pathway4.53E-033P20023, Q8WV28, P11912CR2, BLNK, CD79AMore
Toremifenehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Toremifenehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Toremifenehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Toremifenehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Toremifenehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Toremifenehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Toremifenehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Toremifenehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Toremifenehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Toremifenehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Toremifenehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Toremifenehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Toremifenehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Toremifenehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Toremifenehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Toremifenehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Toremifenehsa05150Staphylococcus aureus infection4.83E-022P09871, P16109C1S, SELPMore
Toremifenehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Toremifenehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Toremifenehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Toremifenehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Toremifenehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Toremifenehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Toremifenehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Toremifenehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Toremifenehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Toremifenehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Toremifenehsa05340Primary immunodeficiency2.93E-022P11912, Q8WV28CD79A, BLNKMore

Community members of Toremifene (SDC: 4.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
P11511CYP19A1AromatasePredicted00.815610.15882.5666
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)