PharmaCoNets of Torasemide (SPCN: 18.38 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Torasemidehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Torasemidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Torasemidehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Torasemidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Torasemidehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Torasemidehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Torasemidehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Torasemidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Torasemidehsa04064NF-kappa B signaling pathway9.70E-0312O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CYLDMore
Torasemidehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Torasemidehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Torasemidehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Torasemidehsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Torasemidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Torasemidehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Torasemidehsa04613Neutrophil extracellular trap formation1.86E-0214O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Torasemidehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Torasemidehsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Torasemidehsa04640Hematopoietic cell lineage4.31E-0210P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNF, IL1BMore
Torasemidehsa04650Natural killer cell mediated cytotoxicity3.07E-0411P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Torasemidehsa04657IL-17 signaling pathway1.92E-039O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Torasemidehsa04658Th1 and Th2 cell differentiation1.26E-0210Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1More
Torasemidehsa04659Th17 cell differentiation1.39E-0211Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P01584, P09693, P20963, P23458PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3G, CD247, JAK1More
Torasemidehsa04660T cell receptor signaling pathway1.11E-0211P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Torasemidehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Torasemidehsa04750Inflammatory mediator regulation of TRP channels1.17E-028P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2More
Torasemidehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Torasemidehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Torasemidehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Torasemidehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Torasemidehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Torasemidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Torasemidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Torasemidehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Torasemidehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Torasemidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Torasemidehsa05140Leishmaniasis2.29E-029P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4More
Torasemidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Torasemidehsa05144Malaria2.43E-048P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Torasemidehsa05146Amoebiasis4.22E-0311P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Torasemidehsa05202Transcriptional misregulation in cancer6.59E-0315P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Torasemidehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Torasemidehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Torasemidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.10E-028O95267, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14More
Torasemidehsa05321Inflammatory bowel disease7.47E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Torasemidehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Torasemidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Torasemide (SDC: 3.05)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)