PharmaCoNets of Topotecan (SPCN: 3.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Topotecanhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Topotecanhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Topotecanhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Topotecanhsa00670One carbon pool by folate2.93E-022O95954, Q99707FTCD, MTRMore
Topotecanhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Topotecanhsa00770Pantothenate and CoA biosynthesis1.94E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Topotecanhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Topotecanhsa03013RNA transport6.33E-038O14980, Q09161, P35658, P47813, Q14152, Q14240, Q06787, P51114XPO1, NCBP1, NUP214, EIF1AX, EIF3A, EIF4A2, FMR1, FXR1More
Topotecanhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Topotecanhsa03040Spliceosome3.89E-038O14776, O75940, Q09161, P09651, O75494, Q16629, O95777, O43395TCERG1, SMNDC1, NCBP1, HNRNPA1, FUSIP1, SFRS7, LSM8, PRPF3More
Topotecanhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Topotecanhsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Topotecanhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Topotecanhsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Topotecanhsa04071Sphingolipid signaling pathway2.14E-023Q13510, Q13362, Q9UQC2ASAH1, PPP2R5C, GAB2More
Topotecanhsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Topotecanhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Topotecanhsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Topotecanhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Topotecanhsa04621NOD-like receptor signaling pathway2.70E-027Q9H1Y0, Q05823, P01375, P49913, P59665, P59666, Q16513ATG5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, PKN2More
Topotecanhsa04730Long-term depression3.52E-021Q14344GNA13More
Topotecanhsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Topotecanhsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Topotecanhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Topotecanhsa04970Salivary secretion3.20E-033P51828, P23634, P0DP24ADCY7, ATP2B4, CALM2More
Topotecanhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Topotecanhsa05150Staphylococcus aureus infection3.62E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Topotecanhsa05160Hepatitis C3.16E-024P52630, P60033, Q9NZJ5, P49841STAT2, CD81, EIF2AK3, GSK3BMore
Topotecanhsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Topotecanhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore

Community members of Topotecan (SDC: 1.47)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P09651HNRNPA1Heterogeneous nuclear ribonucleoprotein A1Predicted00.21740.00550.33380.4534
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)