PharmaCoNets of Topiramate (SPCN: 20.86 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Topiramatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Topiramatehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Topiramatehsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Topiramatehsa00520Amino sugar and nucleotide sugar metabolism3.76E-021Q13231CHIT1More
Topiramatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Topiramatehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Topiramatehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Topiramatehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Topiramatehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Topiramatehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Topiramatehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Topiramatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Topiramatehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Topiramatehsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Topiramatehsa03050Proteasome1.40E-021P55036PSMD4More
Topiramatehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Topiramatehsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Topiramatehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Topiramatehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Topiramatehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Topiramatehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Topiramatehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Topiramatehsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Topiramatehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Topiramatehsa04610Complement and coagulation cascades1.12E-051P0C0L4C4AMore
Topiramatehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Topiramatehsa04614Renin-angiotensin system2.52E-021P50052AGTR2More
Topiramatehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Topiramatehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Topiramatehsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Topiramatehsa04657IL-17 signaling pathway4.98E-026O00463, Q16539, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNFMore
Topiramatehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Topiramatehsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Topiramatehsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Topiramatehsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Topiramatehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Topiramatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Topiramatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Topiramatehsa04970Salivary secretion4.78E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Topiramatehsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Topiramatehsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Topiramatehsa05032Morphine addiction1.09E-022P78334, P32298GABRE, GRK4More
Topiramatehsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Topiramatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Topiramatehsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Topiramatehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Topiramatehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Topiramatehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Topiramatehsa05150Staphylococcus aureus infection1.61E-035P0C0L4, P13646, P59665, P59666, P12838C4A, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4More
Topiramatehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Topiramatehsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Topiramatehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Topiramatehsa05200Pathways in cancer4.70E-023P17301, P20585, P62879ITGA2, MSH3, GNB2More
Topiramatehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Topiramatehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Topiramatehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Topiramatehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Topiramatehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Topiramatehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Topiramatehsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore
Topiramatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Topiramate (SDC: 3.02)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Reported10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Reported00.00560.82670.16091.8171
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
O75493CA11Carbonic anhydraseNonerelated protein 11Predicted00.07450.061200.1597
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CA2P00918IC505
CA2P00918IC502100
CA2P00918Ki5
CA2P00918Ki5
CA2P00918Ki9
CA2P00918Kd13.8
CA2P00918Kd290
CA4P22748Ki4900