PharmaCoNets of Tolnaftate (SPCN: 33.75 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tolnaftatehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Tolnaftatehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Tolnaftatehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Tolnaftatehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tolnaftatehsa00500Starch and sucrose metabolism3.85E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Tolnaftatehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Tolnaftatehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tolnaftatehsa00970Aminoacyl-tRNA biosynthesis1.17E-023O95363, P14868, Q15046FARS2, DARS, KARSMore
Tolnaftatehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Tolnaftatehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Tolnaftatehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tolnaftatehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tolnaftatehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Tolnaftatehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Tolnaftatehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Tolnaftatehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Tolnaftatehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Tolnaftatehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Tolnaftatehsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Tolnaftatehsa04612Antigen processing and presentation9.45E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Tolnaftatehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Tolnaftatehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Tolnaftatehsa04650Natural killer cell mediated cytotoxicity5.07E-0510P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Tolnaftatehsa04657IL-17 signaling pathway8.98E-047O00463, Q16539, P49841, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNFMore
Tolnaftatehsa04660T cell receptor signaling pathway1.81E-028O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Tolnaftatehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Tolnaftatehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Tolnaftatehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tolnaftatehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tolnaftatehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Tolnaftatehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Tolnaftatehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Tolnaftatehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Tolnaftatehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Tolnaftatehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tolnaftatehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Tolnaftatehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Tolnaftatehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Tolnaftatehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tolnaftatehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tolnaftatehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tolnaftatehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Tolnaftatehsa05133Pertussis3.51E-021P0C0L4C4AMore
Tolnaftatehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Tolnaftatehsa05144Malaria1.84E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Tolnaftatehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Tolnaftatehsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Tolnaftatehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tolnaftatehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Tolnaftatehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Tolnaftatehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Tolnaftatehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tolnaftatehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Tolnaftatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Tolnaftatehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Tolnaftatehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Tolnaftatehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Tolnaftate (SDC: 4.70)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)