PharmaCoNets

PharmaCoNets of Tolmetin (S_PCN: 134.84 )

Tolmetin regulated-network (S_DN: 21.68)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Tolmetin

hsa00010

Glycolysis / Gluconeogenesis

1.52E-02

P04075, P14618

ALDOA, PKM2

Tolmetin

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Tolmetin

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Tolmetin

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Tolmetin

hsa00500

Starch and sucrose metabolism

2.61E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Tolmetin

hsa00510

N-Glycan biosynthesis

1.00E-02

O94777, Q9BVK2

DPM2, ALG8

Tolmetin

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Tolmetin

hsa00561

Glycerolipid metabolism

2.03E-03

P14550, Q86XP1

AKR1A1, DGKH

Tolmetin

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3.47E-03

O94777, Q14442

DPM2, PIGH

Tolmetin

hsa00565

Ether lipid metabolism

5.94E-07

Q9Y6K0, Q8N661

CEPT1, TMEM86B

Tolmetin

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Tolmetin

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Tolmetin

hsa00600

Sphingolipid metabolism

4.47E-02

Q96G23, Q86VZ5

LASS2, SGMS1

Tolmetin

hsa00970

Aminoacyl-tRNA biosynthesis

6.28E-04

O95363, P14868, Q15046

FARS2, DARS, KARS

Tolmetin

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Tolmetin

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Tolmetin

hsa00983

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Tolmetin

hsa01100

Metabolic pathways

2.60E-06

Q9Y234, P35790, Q16772, P09211, Q9UJ14, P30041, Q6ZQY3, Q02153, P20839, P40926, O94777, Q7KZN9, Q9Y6K0, P15121, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, Q9BVK2, Q14442, P37837, Q9BQB6, Q06055, Q99437, Q9NVH6

LIPT1, CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GADL1, GUCY1B3, IMPDH1, MDH2, DPM2, COX15, CEPT1, AKR1B1, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALG8, PIGH, TALDO1, VKORC1, ATP5G2, ATP6V0B, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.738
P10145	IL8	Interleukin-8	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.766
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q6ZQY3	GADL1	Acidic amino acid decarboxylase GADL1	0.743
P10145	IL8	Interleukin-8	Q6ZQY3	GADL1	Acidic amino acid decarboxylase GADL1	0.753
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.741
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.788
P10145	IL8	Interleukin-8	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P10145	IL8	Interleukin-8	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	0.757
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.748
P10145	IL8	Interleukin-8	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.758
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.792
P10145	IL8	Interleukin-8	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.805
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	0.733
P10145	IL8	Interleukin-8	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	0.723
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.768
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P10145	IL8	Interleukin-8	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.744
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.78
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P10145	IL8	Interleukin-8	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.758
P10145	IL8	Interleukin-8	Q96G23	LASS2	Ceramide synthase 2	-0.796
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.754
P10145	IL8	Interleukin-8	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.844
P10145	IL8	Interleukin-8	Q14442	PIGH	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H	-0.752
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P37837	TALDO1	Transaldolase	0.746
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P10145	IL8	Interleukin-8	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.753
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.72
P10145	IL8	Interleukin-8	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.732
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.799
P10145	IL8	Interleukin-8	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.73

Tolmetin

hsa01200

Carbon metabolism

3.16E-02

P04075, P14618

ALDOA, PKM2

Tolmetin

hsa01230

Biosynthesis of amino acids

1.26E-02

P14618, P04075

PKM2, ALDOA

Tolmetin

hsa01240

Biosynthesis of cofactors

1.26E-02

P13716, P14618

ALAD, PKM2

Tolmetin

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Tolmetin

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Tolmetin

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Tolmetin

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Tolmetin

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Tolmetin

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Tolmetin

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Tolmetin

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Tolmetin

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Tolmetin

hsa03460

Fanconi anemia pathway

4.83E-02

Q9BXW9, P07992

FANCD2, ERCC1

Tolmetin

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Tolmetin

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Tolmetin

hsa04014

Ras signaling pathway

1.13E-02

P04049, P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

RAF1, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Tolmetin

hsa04015

Rap1 signaling pathway

5.95E-03

P04049, P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

RAF1, EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Tolmetin

hsa04022

cGMP-PKG signaling pathway

3.15E-02

P04049

RAF1

Tolmetin

hsa04024

cAMP signaling pathway

2.49E-02

P04049

RAF1

Tolmetin

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Tolmetin

hsa04062

Chemokine signaling pathway

2.48E-04

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, P04049, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, RAF1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Tolmetin

hsa04064

NF-kappa B signaling pathway

2.50E-07

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Tolmetin

hsa04066

HIF-1 signaling pathway

2.12E-02

P04075, Q15389

ALDOA, ANGPT1

Tolmetin

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Tolmetin

hsa04070

Phosphatidylinositol signaling system

1.53E-02

Q86XP1, Q96DU7

DGKH, ITPKC

Tolmetin

hsa04071

Sphingolipid signaling pathway

1.65E-04

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Tolmetin

hsa04072

Phospholipase D signaling pathway

2.31E-02

P04049, P42338, P43657, P25024, P25025, P19174

RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Tolmetin

hsa04080

Neuroactive ligand-receptor interaction

3.44E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2

Tolmetin

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Tolmetin

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Tolmetin

hsa04140

Autophagy - animal

2.95E-02

P04049, P22694, Q14643, P10415, Q04759

RAF1, PRKACB, ITPR1, BCL2, PRKCQ

Tolmetin

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Tolmetin

hsa04145

Phagosome

2.60E-03

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Tolmetin

hsa04150

mTOR signaling pathway

7.74E-03

P04049, Q02750, Q9NQL2, P51812

RAF1, MAP2K1, RRAGD, RPS6KA3

Tolmetin

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Tolmetin

hsa04210

Apoptosis

2.38E-04

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P04049

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, RAF1

Tolmetin

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Tolmetin

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Tolmetin

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Tolmetin

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Tolmetin

hsa04330

Notch signaling pathway

3.09E-02

P49768, P78504

PSEN1, JAG1

Tolmetin

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Tolmetin

hsa04360

Axon guidance

1.51E-02

P16333, P20827, O95631, P42338, P07332, P04049, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1

Tolmetin

hsa04370

VEGF signaling pathway

1.79E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Tolmetin

hsa04371

Apelin signaling pathway

4.16E-03

P63218, P50151, Q8WYR1, P04049, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, RAF1, MEF2D, GNA13, SMAD4, SMAD3

Tolmetin

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Tolmetin

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Tolmetin

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Tolmetin

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P04049

RAF1

Tolmetin

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Tolmetin

hsa04612

Antigen processing and presentation

1.93E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Tolmetin

hsa04613

Neutrophil extracellular trap formation

2.88E-06

P17252, P04049, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462

PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85

Tolmetin

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Tolmetin

hsa04625

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Tolmetin

hsa04630

JAK-STAT signaling pathway

1.49E-02

P04049

RAF1

Tolmetin

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Tolmetin

hsa04650

Natural killer cell mediated cytotoxicity

9.13E-08

P16298, P50591, P19174, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Tolmetin

hsa04657

IL-17 signaling pathway

4.87E-02

P07900, P01584

HSP90AA1, IL1B

Tolmetin

hsa04658

Th1 and Th2 cell differentiation

7.66E-07

Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Tolmetin

hsa04659

Th17 cell differentiation

5.84E-06

Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Tolmetin

hsa04660

T cell receptor signaling pathway

1.25E-07

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861

Tolmetin

hsa04662

B cell receptor signaling pathway

2.42E-03

P42338, P60033, P07948, P21854, Q8N149, P04049

PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Tolmetin

hsa04664

Fc epsilon RI signaling pathway

5.86E-03

P42338, P07948, P19174, P04049, P09917

PIK3CB, LYN, PLCG1, RAF1, ALOX5

Tolmetin

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Tolmetin

hsa04668

TNF signaling pathway

2.59E-02

P01375, O00463, Q13489, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9

Tolmetin

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Tolmetin

hsa04720

Long-term potentiation

2.17E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Tolmetin

hsa04721

Synaptic vesicle cycle

3.05E-03

Q99437, P43005

ATP6V0B, SLC1A1

Tolmetin

hsa04722

Neurotrophin signaling pathway

2.32E-02

P04049

RAF1

Tolmetin

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Tolmetin

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Tolmetin

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Tolmetin

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Tolmetin

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Tolmetin

hsa04912

GnRH signaling pathway

1.82E-02

P04049

RAF1

Tolmetin

hsa04914

Progesterone-mediated oocyte maturation

5.89E-03

Q17RY0, P51812, Q02750, P04049

CPEB4, RPS6KA3, MAP2K1, RAF1

Tolmetin

hsa04915

Estrogen signaling pathway

2.99E-02

P04049

RAF1

Tolmetin

hsa04916

Melanogenesis

1.33E-02

P04049

RAF1

Tolmetin

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Tolmetin

hsa04919

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Tolmetin

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Tolmetin

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Tolmetin

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Tolmetin

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Tolmetin

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Tolmetin

hsa04926

Relaxin signaling pathway

2.32E-02

P04049

RAF1

Tolmetin

hsa04928

Parathyroid hormone synthesis, secretion and action

1.60E-02

Q14643, P22694, P23771, P04049, P10415

ITPR1, PRKACB, GATA3, RAF1, BCL2

Tolmetin

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Tolmetin

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Tolmetin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Tolmetin

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Tolmetin

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Tolmetin

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Tolmetin

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Tolmetin

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Tolmetin

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Tolmetin

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Tolmetin

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Tolmetin

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Tolmetin

hsa05034

Alcoholism

2.78E-04

P04049, Q93077, P62807, O60814, P68431

RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Tolmetin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.53E-05

Q99437, P09341, P19875, P10145, P19174, P25024, P25025

ATP6V0B, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2

Tolmetin

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Tolmetin

hsa05132

Salmonella infection

1.81E-02

P51617, P25963, P01375, P04049, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, RAF1, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Tolmetin

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Tolmetin

hsa05134

Legionellosis

6.38E-04

P01584, P11215, P68104, P11142, P09341, P19875

IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2

Tolmetin

hsa05140

Leishmaniasis

1.18E-02

P14598, P13765, O60603, P25963, P01375, P51617, Q15080

NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4

Tolmetin

hsa05143

African trypanosomiasis

5.67E-04

P69905, P68871

HBA2, HBB

Tolmetin

hsa05144

Malaria

2.03E-04

P60033, P69905, P68871, O60603, P35443, P10145, P26718

CD81, HBA2, HBB, TLR2, THBS4, IL8, KLRK1

Tolmetin

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Tolmetin

hsa05146

Amoebiasis

2.21E-04

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1

Tolmetin

hsa05152

Tuberculosis

1.41E-02

P04049, Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

RAF1, TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Tolmetin

hsa05160

Hepatitis C

1.99E-02

P04049

RAF1

Tolmetin

hsa05161

Hepatitis B

4.82E-03

P17252, P04049, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, RAF1, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Tolmetin

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Tolmetin

hsa05163

Human cytomegalovirus infection

4.98E-02

P04049

RAF1

Tolmetin

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Tolmetin

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.57E-03

P62879, P16298, P04049, Q02750, P0CG47

GNB2, PPP3CB, RAF1, MAP2K1, UBB

Tolmetin

hsa05170

Human immunodeficiency virus 1 infection

7.33E-06

P04049, Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333

RAF1, MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Tolmetin

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Tolmetin

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Tolmetin

hsa05202

Transcriptional misregulation in cancer

1.31E-06

Q92570, Q12778, Q15532, Q13315, O94812, P58340, P10145, P14780, P14923, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

NR4A3, FOXO1, SS18, ATM, BAIAP3, MLF1, IL8, MMP9, JUP, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	Q92570	NR4A3	Nuclear receptor subfamily 4 group A member 3	-0.754
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	O94812	BAIAP3	BAI1-associated protein 3	0.73
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P58340	MLF1	Myeloid leukemia factor 1	0.7
P38919	EIF4A3	Eukaryotic initiation factor 4A-III	P10145	IL8	Interleukin-8	0.941
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Tolmetin

hsa05203

Viral carcinogenesis

6.22E-03

Q12933, P42229, Q15283, P62807, O60814

TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12

Tolmetin

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Tolmetin

hsa05205

Proteoglycans in cancer

3.48E-02

P04049

RAF1

Tolmetin

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Tolmetin

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Tolmetin

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Tolmetin

hsa05212

Pancreatic cancer

8.83E-03

P42338, P04049, P84022, Q13485, O75293

PIK3CB, RAF1, SMAD3, SMAD4, GADD45B

Tolmetin

hsa05213

Endometrial cancer

4.26E-03

O15169, Q02750, P04049

AXIN1, MAP2K1, RAF1

Tolmetin

hsa05214

Glioma

9.95E-03

P04049

RAF1

Tolmetin

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Tolmetin

hsa05218

Melanoma

6.63E-03

P04049

RAF1

Tolmetin

hsa05219

Bladder cancer

4.98E-03

P04049

RAF1

Tolmetin

hsa05220

Chronic myeloid leukemia

3.00E-03

Q13547, Q13485, P84022, P42338, P04049, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, RAF1, GADD45B

Tolmetin

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Tolmetin

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Tolmetin

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Tolmetin

hsa05224

Breast cancer

1.49E-02

P04049

RAF1

Tolmetin

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Tolmetin

hsa05226

Gastric cancer

3.26E-03

P04049, Q02750, O15169

RAF1, MAP2K1, AXIN1

Tolmetin

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Tolmetin

hsa05231

Choline metabolism in cancer

1.33E-02

P04049

RAF1

Tolmetin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.14E-04

P42338, P19174, P07766, P20963, P09693, P06239, P04049, O60603, P10747, Q04759

PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, CD28, PRKCQ

Tolmetin

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Tolmetin

hsa05321

Inflammatory bowel disease

6.27E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Tolmetin

hsa05322

Systemic lupus erythematosus

2.09E-04

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Tolmetin

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Tolmetin

hsa05332

Graft-versus-host disease

1.14E-04

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Tolmetin

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Tolmetin

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Community members of Tolmetin (S_DC: 6.22)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

IL8

InterleukinNone8

Predicted

0.1967

0.1304

1.3591

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P38919

EIF4A3

Eukaryotic initiation factor 4ANoneIII

Predicted

0.3646

0.0334

0.4886

0.7378

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P14618

PKM2

Pyruvate kinase PKM

Predicted

0.0736

0.0107

0.4594

0.5176

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

PharmaCoNets of Tolmetin (SPCN: 134.84 )

Tolmetin regulated-network (SDN: 21.68)

Community members of Tolmetin (SDC: 6.22)

PharmaCoNets of Tolmetin (S_PCN: 134.84 )

Tolmetin regulated-network (S_DN: 21.68)

Community members of Tolmetin (S_DC: 6.22)