PharmaCoNets of Tolbutamide (SPCN: 69.67 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tolbutamidehsa00010Glycolysis / Gluconeogenesis8.02E-032P07738, P19367BPGM, HK1More
Tolbutamidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tolbutamidehsa00061Fatty acid biosynthesis4.07E-021P33121ACSL1More
Tolbutamidehsa00071Fatty acid degradation2.54E-033O75521, P11766, P33121ECI2, ADH5, ACSL1More
Tolbutamidehsa00190Oxidative phosphorylation1.48E-022Q16718, O14521NDUFA5, SDHDMore
Tolbutamidehsa00260Glycine, serine and threonine metabolism2.42E-021P07738BPGMMore
Tolbutamidehsa00500Starch and sucrose metabolism6.17E-074P19367, O43451, P46976, P06737HK1, MGAM, GYG1, PYGLMore
Tolbutamidehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Tolbutamidehsa00524Neomycin, kanamycin and gentamicin biosynthesis1.21E-021P19367HK1More
Tolbutamidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tolbutamidehsa00590Arachidonic acid metabolism3.13E-032P11712, P09960CYP2C9, LTA4HMore
Tolbutamidehsa00591Linoleic acid metabolism1.63E-031P11712CYP2C9More
Tolbutamidehsa00604Glycosphingolipid biosynthesis - ganglio series3.60E-021Q9H4F1ST6GALNAC4More
Tolbutamidehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Tolbutamidehsa00730Thiamine metabolism8.11E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Tolbutamidehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Tolbutamidehsa00770Pantothenate and CoA biosynthesis3.70E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Tolbutamidehsa00970Aminoacyl-tRNA biosynthesis1.16E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Tolbutamidehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Tolbutamidehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Tolbutamidehsa01100Metabolic pathways8.59E-0436P05089, O14521, O95455, P21953, P19367, P48426, P32320, Q13370, P11766, P06280, Q16875, O43286, O43451, P07738, P11712, P05186, P24666, P23743, O60701, Q9HCC0, P33121, Q08477, P15907, Q9NY28, Q9UNP4, Q9H4F1, P09960, P37837, P32321, Q9BPW9, Q9UHY7, P43490, Q9Y2B2, P46976, P06737, Q16718ARG1, SDHD, TGDS, BCKDHB, HK1, PIP4K2A, CDA, PDE3B, ADH5, GLA, PFKFB3, B4GALT5, MGAM, BPGM, CYP2C9, ALPL, ACP1, DGKA, UGDH, MCCC2, ACSL1, CYP4F3, ST6GAL1, GALNT8, ST3GAL5, ST6GALNAC4, LTA4H, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, PIGL, GYG1, PYGL, NDUFA5More
Tolbutamidehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Tolbutamidehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Tolbutamidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Tolbutamidehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Tolbutamidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Tolbutamidehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Tolbutamidehsa03022Basal transcription factors2.17E-022O00268, Q15544TAF4, TAF11More
Tolbutamidehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Tolbutamidehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Tolbutamidehsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Tolbutamidehsa04020Calcium signaling pathway4.93E-023P17252, P25116, P20020PRKCA, F2R, ATP2B1More
Tolbutamidehsa04024cAMP signaling pathway4.93E-023P20020, Q13370, P25116ATP2B1, PDE3B, F2RMore
Tolbutamidehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Tolbutamidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Tolbutamidehsa04062Chemokine signaling pathway2.43E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Tolbutamidehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Tolbutamidehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Tolbutamidehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Tolbutamidehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Tolbutamidehsa04072Phospholipase D signaling pathway5.10E-0410P42338, Q92529, P43657, P25116, P25024, P25025, P19174, P17252, Q14344, P23743PIK3CB, SHC3, P2RY5, F2R, CXCR1, CXCR2, PLCG1, PRKCA, GNA13, DGKAMore
Tolbutamidehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Tolbutamidehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Tolbutamidehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Tolbutamidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Tolbutamidehsa04150mTOR signaling pathway1.06E-024P08069, P42338, Q13322, P49841IGF1R, PIK3CB, GRB10, GSK3BMore
Tolbutamidehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Tolbutamidehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Tolbutamidehsa04213Longevity regulating pathway - multiple species1.17E-025P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Tolbutamidehsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Tolbutamidehsa04261Adrenergic signaling in cardiomyocytes3.29E-023P09493, P17252, P20020TPM1, PRKCA, ATP2B1More
Tolbutamidehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Tolbutamidehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Tolbutamidehsa04520Adherens junction8.29E-031P08069IGF1RMore
Tolbutamidehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Tolbutamidehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Tolbutamidehsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Tolbutamidehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Tolbutamidehsa04613Neutrophil extracellular trap formation6.68E-0417O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Tolbutamidehsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Tolbutamidehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Tolbutamidehsa04650Natural killer cell mediated cytotoxicity6.78E-0713P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Tolbutamidehsa04657IL-17 signaling pathway1.19E-0410P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Tolbutamidehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Tolbutamidehsa04659Th17 cell differentiation1.76E-048Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Tolbutamidehsa04660T cell receptor signaling pathway2.21E-0514P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Tolbutamidehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Tolbutamidehsa04714Thermogenesis1.99E-023P33121, Q16718, O14521ACSL1, NDUFA5, SDHDMore
Tolbutamidehsa04726Serotonergic synapse1.64E-023P17252, P31645, P11712PRKCA, SLC6A4, CYP2C9More
Tolbutamidehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Tolbutamidehsa04730Long-term depression1.55E-032Q14344, P08069GNA13, IGF1RMore
Tolbutamidehsa04750Inflammatory mediator regulation of TRP channels7.26E-045P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Tolbutamidehsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Tolbutamidehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Tolbutamidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Tolbutamidehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Tolbutamidehsa04930Type II diabetes mellitus4.78E-021P19367HK1More
Tolbutamidehsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Tolbutamidehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Tolbutamidehsa04961Endocrine and other factor-regulated calcium reabsorption1.48E-022P20020, P17252ATP2B1, PRKCAMore
Tolbutamidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tolbutamidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Tolbutamidehsa04970Salivary secretion4.83E-022P20020, P17252ATP2B1, PRKCAMore
Tolbutamidehsa04972Pancreatic secretion1.48E-022P20020, P17252ATP2B1, PRKCAMore
Tolbutamidehsa04973Carbohydrate digestion and absorption5.89E-053O43451, P19367, P42338MGAM, HK1, PIK3CBMore
Tolbutamidehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Tolbutamidehsa05016Huntington disease2.29E-039O15239, Q16718, O14521, P13073, P30876, P62487, P05141, O00268, Q13561NDUFA1, NDUFA5, SDHD, COX4I1, POLR2B, POLR2G, SLC25A5, TAF4, DCTN2More
Tolbutamidehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Tolbutamidehsa05022Pathways of neurodegeneration - multiple diseases1.89E-0311O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, P17252, P01584, Q08752, Q13557NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, PRKCA, IL1B, PPID, CAMK2DMore
Tolbutamidehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tolbutamidehsa05120Epithelial cell signaling in Helicobacter pylori infection1.70E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Tolbutamidehsa05133Pertussis2.64E-032P0DP23, P0C0L4CALM1, C4AMore
Tolbutamidehsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Tolbutamidehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Tolbutamidehsa05140Leishmaniasis2.47E-025P13612, O75015, P01375, P49006, Q16539ITGA4, FCGR3B, TNF, MARCKSL1, MAPK14More
Tolbutamidehsa05143African trypanosomiasis1.93E-042P69905, P68871HBA2, HBBMore
Tolbutamidehsa05144Malaria2.23E-047P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Tolbutamidehsa05146Amoebiasis5.06E-059P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, ACTN1More
Tolbutamidehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Tolbutamidehsa05163Human cytomegalovirus infection1.69E-038P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Tolbutamidehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Tolbutamidehsa05202Transcriptional misregulation in cancer8.39E-0413Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P08069, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, ELA2, GADD45AMore
Tolbutamidehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Tolbutamidehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Tolbutamidehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Tolbutamidehsa05214Glioma9.95E-031P08069IGF1RMore
Tolbutamidehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Tolbutamidehsa05216Thyroid cancer3.60E-021Q13772NCOA4More
Tolbutamidehsa05218Melanoma6.63E-031P08069IGF1RMore
Tolbutamidehsa05224Breast cancer1.49E-021P08069IGF1RMore
Tolbutamidehsa05225Hepatocellular carcinoma6.30E-043Q92529, P08069, P51531SHC3, IGF1R, SMARCA2More
Tolbutamidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Tolbutamidehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tolbutamidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Tolbutamidehsa05415Diabetic cardiomyopathy2.47E-037P17252, P05141, O15239, Q16718, O14521, P13073, Q13557PRKCA, SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2DMore
Tolbutamidehsa05418Fluid shear stress and atherosclerosis2.87E-047Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Tolbutamide (SDC: 4.79)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Reported00.00420.2820.12740.6935
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P19367HK1HexokinaseNone1Predicted10.37230.01670.39970.6193
Q08752PPIDPeptidylNoneprolyl cisNonetrans isomerase DPredicted00.20150.03360.51080.6787
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)