PharmaCoNets of Tolazoline (SPCN: 90.17 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tolazolinehsa00030Pentose phosphate pathway1.13E-044P60891, P51854, P11413, P37837PRPS1, TKTL1, G6PD, TALDO1More
Tolazolinehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Tolazolinehsa00500Starch and sucrose metabolism2.15E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Tolazolinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Tolazolinehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Tolazolinehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Tolazolinehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Tolazolinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tolazolinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Tolazolinehsa00970Aminoacyl-tRNA biosynthesis5.30E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Tolazolinehsa01200Carbon metabolism2.23E-024P51854, P11413, P37837, P60891TKTL1, G6PD, TALDO1, PRPS1More
Tolazolinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Tolazolinehsa01524Platinum drug resistance4.78E-021P31751AKT2More
Tolazolinehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Tolazolinehsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Tolazolinehsa03015mRNA surveillance pathway1.37E-036Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBPMore
Tolazolinehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Tolazolinehsa04014Ras signaling pathway4.37E-0310P31751, P42338, P20827, P49767, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1More
Tolazolinehsa04015Rap1 signaling pathway2.75E-0310P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1More
Tolazolinehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Tolazolinehsa04022cGMP-PKG signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Tolazolinehsa04024cAMP signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Tolazolinehsa04061Viral protein interaction with cytokine and cytokine receptor2.91E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Tolazolinehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Tolazolinehsa04064NF-kappa B signaling pathway7.66E-0614P10415, Q13489, P25963, P51617, O00463, Q13546, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, Q9UNE0BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, EDARMore
Tolazolinehsa04071Sphingolipid signaling pathway3.74E-047P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Tolazolinehsa04080Neuroactive ligand-receptor interaction3.10E-0512P08311, P28472, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P07550, P35318CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Tolazolinehsa04114Oocyte meiosis1.25E-037P51812, Q02750, P0DP23, P16298, Q17RY0, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PPP2R5C, PPP2R5DMore
Tolazolinehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Tolazolinehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Tolazolinehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Tolazolinehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Tolazolinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Tolazolinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Tolazolinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Tolazolinehsa04210Apoptosis1.42E-0312Q13315, P04637, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P63261ATM, TP53, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, ACTG1More
Tolazolinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Tolazolinehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Tolazolinehsa04218Cellular senescence3.65E-032P31751, P0DP23AKT2, CALM1More
Tolazolinehsa04261Adrenergic signaling in cardiomyocytes3.26E-047P07550, P22694, P31751, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Tolazolinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Tolazolinehsa04370VEGF signaling pathway3.03E-044P16298, P31751, Q05397, Q02750PPP3CB, AKT2, PTK2, MAP2K1More
Tolazolinehsa04371Apelin signaling pathway9.78E-049P63218, P50151, Q8WYR1, P31751, Q14814, Q14344, Q13485, P84022, P0DP23GNG5, GNG10, PIK3R5, AKT2, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Tolazolinehsa04380Osteoclast differentiation2.11E-032Q9NQC7, P31751CYLD, AKT2More
Tolazolinehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Tolazolinehsa04612Antigen processing and presentation5.66E-058P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Tolazolinehsa04613Neutrophil extracellular trap formation5.16E-0517P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Tolazolinehsa04620Toll-like receptor signaling pathway4.81E-033Q13546, P01568, P31751RIPK1, IFNA21, AKT2More
Tolazolinehsa04621NOD-like receptor signaling pathway7.18E-0413Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4More
Tolazolinehsa04622RIG-I-like receptor signaling pathway1.02E-033P01568, Q9NQC7, Q13546IFNA21, CYLD, RIPK1More
Tolazolinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Tolazolinehsa04625C-type lectin receptor signaling pathway1.38E-053Q9NQC7, P31751, P0DP23CYLD, AKT2, CALM1More
Tolazolinehsa04650Natural killer cell mediated cytotoxicity1.55E-0612P16298, P50591, P01375, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Tolazolinehsa04657IL-17 signaling pathway1.64E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Tolazolinehsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Tolazolinehsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Tolazolinehsa04662B cell receptor signaling pathway3.64E-036P31751, P42338, P60033, P07948, P21854, Q8N149AKT2, PIK3CB, CD81, LYN, CD72, LILRA2More
Tolazolinehsa04664Fc epsilon RI signaling pathway7.18E-035P31751, P42338, P07948, P19174, P09917AKT2, PIK3CB, LYN, PLCG1, ALOX5More
Tolazolinehsa04668TNF signaling pathway2.93E-039P01375, O00463, Q13489, P25963, P18848, P19875, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9More
Tolazolinehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Tolazolinehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Tolazolinehsa04722Neurotrophin signaling pathway1.26E-035P31751, P49841, O43524, P48023, P0DP23AKT2, GSK3B, FOXO3, FASLG, CALM1More
Tolazolinehsa04728Dopaminergic synapse7.72E-044P31751, Q13362, Q14738, P0DP23AKT2, PPP2R5C, PPP2R5D, CALM1More
Tolazolinehsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Tolazolinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Tolazolinehsa04744Phototransduction1.81E-021P0DP23CALM1More
Tolazolinehsa04910Insulin signaling pathway9.82E-042P0DP23, P31751CALM1, AKT2More
Tolazolinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Tolazolinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Tolazolinehsa04915Estrogen signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Tolazolinehsa04916Melanogenesis4.78E-021P0DP23CALM1More
Tolazolinehsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Tolazolinehsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Tolazolinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Tolazolinehsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Tolazolinehsa04923Regulation of lipolysis in adipocytes3.01E-021P31751AKT2More
Tolazolinehsa04924Renin secretion6.02E-033P22694, P07550, P0DP23PRKACB, ADRB2, CALM1More
Tolazolinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Tolazolinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Tolazolinehsa04929GnRH secretion1.81E-021P31751AKT2More
Tolazolinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Tolazolinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Tolazolinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tolazolinehsa04970Salivary secretion6.99E-046P07550, P22694, Q14643, P17252, P0DP23, P49913ADRB2, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Tolazolinehsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Tolazolinehsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Tolazolinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Tolazolinehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Tolazolinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Tolazolinehsa05010Alzheimer disease8.59E-043Q00535, P0DP23, P31751CDK5, CALM1, AKT2More
Tolazolinehsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q00535, P0DP23CDK5, CALM1More
Tolazolinehsa05030Cocaine addiction4.19E-021Q00535CDK5More
Tolazolinehsa05031Amphetamine addiction6.98E-034P0DP23, P22694, P18848, Q13547CALM1, PRKACB, ATF4, HDAC1More
Tolazolinehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Tolazolinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.87E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Tolazolinehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Tolazolinehsa05132Salmonella infection2.05E-0314P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Tolazolinehsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Tolazolinehsa05140Leishmaniasis1.59E-039O75015, P14598, P13765, O60603, P25963, P01375, Q16539, P51617, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, IRAK1, NCF4More
Tolazolinehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Tolazolinehsa05144Malaria1.38E-034O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Tolazolinehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Tolazolinehsa05146Amoebiasis7.83E-0510P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Tolazolinehsa05152Tuberculosis7.36E-0311Q13488, P0DP23, P48382, O60603, P01375, P31751, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Tolazolinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tolazolinehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Tolazolinehsa05163Human cytomegalovirus infection1.21E-022P31751, P0DP23AKT2, CALM1More
Tolazolinehsa05167Kaposi sarcoma-associated herpesvirus infection1.44E-048P31751, P23458, P62879, Q13469, P16298, Q02750, P0DP23, P0CG47AKT2, JAK1, GNB2, NFATC2, PPP3CB, MAP2K1, CALM1, UBBMore
Tolazolinehsa05170Human immunodeficiency virus 1 infection2.37E-0620P31751, Q02750, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, MAP2K1, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Tolazolinehsa05200Pathways in cancer1.81E-0319Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P31751, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, AKT2, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RBMore
Tolazolinehsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Tolazolinehsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Tolazolinehsa05211Renal cell carcinoma1.47E-033Q06124, Q99814, P31751PTPN11, EPAS1, AKT2More
Tolazolinehsa05212Pancreatic cancer1.08E-049P42338, P31751, Q15311, P23458, P84022, Q13485, P04637, P24522, O75293PIK3CB, AKT2, RALBP1, JAK1, SMAD3, SMAD4, TP53, GADD45A, GADD45BMore
Tolazolinehsa05213Endometrial cancer2.88E-045O15169, P31751, Q02750, P04637, P24522AXIN1, AKT2, MAP2K1, TP53, GADD45AMore
Tolazolinehsa05214Glioma1.51E-044P0DP23, P31751, P04637, P24522CALM1, AKT2, TP53, GADD45AMore
Tolazolinehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Tolazolinehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Tolazolinehsa05218Melanoma8.68E-043P04637, P31751, P24522TP53, AKT2, GADD45AMore
Tolazolinehsa05220Chronic myeloid leukemia1.59E-049Q06124, P04637, Q13547, Q13485, P84022, P31751, P42338, P24522, O75293PTPN11, TP53, HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, GADD45A, GADD45BMore
Tolazolinehsa05221Acute myeloid leukemia4.19E-021P31751AKT2More
Tolazolinehsa05222Small cell lung cancer5.10E-037P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Tolazolinehsa05223Non-small cell lung cancer1.84E-033P31751, P04637, P24522AKT2, TP53, GADD45AMore
Tolazolinehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Tolazolinehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Tolazolinehsa05226Gastric cancer4.72E-033Q02750, P31751, O15169MAP2K1, AKT2, AXIN1More
Tolazolinehsa05230Central carbon metabolism in cancer1.25E-032P31751, P11413AKT2, G6PDMore
Tolazolinehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Tolazolinehsa05321Inflammatory bowel disease7.13E-046O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Tolazolinehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Tolazolinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tolazolinehsa05332Graft-versus-host disease2.32E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Tolazolinehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Tolazolinehsa05418Fluid shear stress and atherosclerosis6.47E-038Q16539, P31751, P10599, P14780, P01375, P14778, P27930, P0DP23MAPK14, AKT2, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1More

Community members of Tolazoline (SDC: 4.76)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)