PharmaCoNets of Tirofiban (SPCN: 13.79 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tirofibanhsa00440Phosphonate and phosphinate metabolism2.16E-021Q9Y6K0CEPT1More
Tirofibanhsa00564Glycerophospholipid metabolism2.52E-023P48651, Q9Y6K0, Q86XP1PTDSS1, CEPT1, DGKHMore
Tirofibanhsa00565Ether lipid metabolism4.27E-021Q9Y6K0CEPT1More
Tirofibanhsa00670One carbon pool by folate1.32E-021P00374DHFRMore
Tirofibanhsa00740Riboflavin metabolism2.16E-021Q969G6RFKMore
Tirofibanhsa00785Lipoic acid metabolism4.27E-021Q9Y234LIPT1More
Tirofibanhsa00790Folate biosynthesis1.32E-021P00374DHFRMore
Tirofibanhsa00983Drug metabolism - other enzymes3.10E-022P20839, Q16772IMPDH1, GSTA3More
Tirofibanhsa01100Metabolic pathways2.79E-0214Q9Y234, Q16772, Q02153, P20839, O94777, Q9Y6K0, Q86XP1, Q9UHK6, Q86VZ5, P48651, Q969G6, P14927, Q06055, Q9NVH6LIPT1, GSTA3, GUCY1B3, IMPDH1, DPM2, CEPT1, DGKH, AMACR, SGMS1, PTDSS1, RFK, UQCRB, ATP5G2, TMLHEMore
Tirofibanhsa01240Biosynthesis of cofactors1.75E-022Q969G6, Q9Y234RFK, LIPT1More
Tirofibanhsa01523Antifolate resistance1.98E-021P00374DHFRMore
Tirofibanhsa01524Platinum drug resistance4.57E-021P20585MSH3More
Tirofibanhsa03420Nucleotide excision repair4.91E-022P07992, P54727ERCC1, RAD23BMore
Tirofibanhsa03430Mismatch repair3.93E-021P20585MSH3More
Tirofibanhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Tirofibanhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Tirofibanhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Tirofibanhsa04071Sphingolipid signaling pathway4.56E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Tirofibanhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Tirofibanhsa04330Notch signaling pathway4.91E-022P49768, P78504PSEN1, JAG1More
Tirofibanhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Tirofibanhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Tirofibanhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Tirofibanhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Tirofibanhsa04520Adherens junction4.91E-022P07947, P19784YES1, CSNK2A2More
Tirofibanhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Tirofibanhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Tirofibanhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Tirofibanhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Tirofibanhsa04613Neutrophil extracellular trap formation3.61E-0213O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Tirofibanhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Tirofibanhsa04622RIG-I-like receptor signaling pathway1.63E-022Q12933, P10145TRAF2, IL8More
Tirofibanhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Tirofibanhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Tirofibanhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Tirofibanhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Tirofibanhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Tirofibanhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Tirofibanhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Tirofibanhsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Tirofibanhsa05144Malaria1.17E-023P68871, P05107, P10145HBB, ITGB2, IL8More
Tirofibanhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Tirofibanhsa05200Pathways in cancer3.23E-022P17301, P20585ITGA2, MSH3More
Tirofibanhsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Tirofibanhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Tirofibanhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Tirofibanhsa05332Graft-versus-host disease3.46E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Tirofibanhsa05410Hypertrophic cardiomyopathy2.63E-021P17301ITGA2More
Tirofibanhsa05412Arrhythmogenic right ventricular cardiomyopathy1.98E-021P17301ITGA2More

Community members of Tirofiban (SDC: 2.25)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08514ITGA2BIntegrin alphaNoneIIbReported10.07820.32480.7791.4677
P17301ITGA2Integrin alphaNone2Predicted00.52210.04470.68391.0343
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P05107ITGB2Integrin betaNone2Predicted10.19860.0080.94341.0587
P26012ITGB8Integrin betaNone8Predicted00.12270.02490.5130.6241
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ITGA2BP08514IC500.37
ITGA2BP08514IC500.37
ITGA2BP08514IC500.95
ITGA2BP08514Kd1.9
ITGA2BP08514Kd13
ITGA2BP08514Kd15