PharmaCoNets of Tipranavir (SPCN: 9.82 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tipranavirhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Tipranavirhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Tipranavirhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Tipranavirhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Tipranavirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Tipranavirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Tipranavirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Tipranavirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Tipranavirhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Tipranavirhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Tipranavirhsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Tipranavirhsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Tipranavirhsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Tipranavirhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Tipranavirhsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Tipranavirhsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Tipranavirhsa04071Sphingolipid signaling pathway2.14E-023Q13510, Q13362, Q9UQC2ASAH1, PPP2R5C, GAB2More
Tipranavirhsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Tipranavirhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Tipranavirhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Tipranavirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Tipranavirhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Tipranavirhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tipranavirhsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Tipranavirhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Tipranavirhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Tipranavirhsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Tipranavirhsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Tipranavirhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Tipranavirhsa04970Salivary secretion3.20E-033P51828, P23634, P0DP24ADCY7, ATP2B4, CALM2More
Tipranavirhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Tipranavirhsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Tipranavirhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tipranavirhsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Tipranavirhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Tipranavirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Tipranavirhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Tipranavirhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Tipranavirhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Tipranavirhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tipranavirhsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Tipranavirhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Tipranavirhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Tipranavir (SDC: 2.23)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)