| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Tioconazole | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Tioconazole | hsa00220 | Arginine biosynthesis | 1.97E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Tioconazole | hsa00250 | Alanine, aspartate and glutamate metabolism | 1.97E-02 | 2 | P49448, P15104 | GLUD2, GLUL | More | | | Tioconazole | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Tioconazole | hsa00500 | Starch and sucrose metabolism | 5.73E-04 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Tioconazole | hsa00512 | Mucin type O-glycan biosynthesis | 4.86E-02 | 2 | O95395, Q9NY28 | GCNT3, GALNT8 | More | | | Tioconazole | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Tioconazole | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Tioconazole | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.23E-04 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Tioconazole | hsa00730 | Thiamine metabolism | 5.35E-04 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Tioconazole | hsa00910 | Nitrogen metabolism | 1.97E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Tioconazole | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Tioconazole | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Tioconazole | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | | | Tioconazole | hsa03013 | RNA transport | 8.19E-04 | 7 | Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042 | RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2 | More | | | Tioconazole | hsa03040 | Spliceosome | 1.87E-06 | 13 | Q14562, O43143, O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, Q13243, P11142, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.803 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.775 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.869 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.871 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.827 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.716 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.778 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15427 | SF3B4 | Splicing factor 3B subunit 4 | 0.71 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P38159 | RBMX | RNA-binding motif protein, X chromosome | 0.733 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.784 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.866 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.835 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.908 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.928 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.876 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | 0.786 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | 0.78 |
| | Tioconazole | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | | Tioconazole | hsa03060 | Protein export | 1.43E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Tioconazole | hsa04012 | ErbB signaling pathway | 1.66E-03 | 7 | P21860, P16333, Q13557, P19174, O14944, P42338, P01106 | ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYC | More | | | Tioconazole | hsa04014 | Ras signaling pathway | 9.85E-06 | 10 | P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Tioconazole | hsa04015 | Rap1 signaling pathway | 4.83E-03 | 8 | P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174 | EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1 | More | | | Tioconazole | hsa04020 | Calcium signaling pathway | 1.09E-04 | 12 | P27987, Q96DU7, P21796, P45880, Q13557, P21860, P19174, P0DP23, P51828, P23634, Q9NRA1, P49767 | ITPKB, ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC | More | | | Tioconazole | hsa04022 | cGMP-PKG signaling pathway | 4.72E-02 | 4 | Q99941, P23634, P51828, P45880 | CREBL1, ATP2B4, ADCY7, VDAC2 | More | | | Tioconazole | hsa04062 | Chemokine signaling pathway | 1.91E-06 | 11 | P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963 | LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.852 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.782 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.775 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.746 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.785 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 |
| | Tioconazole | hsa04070 | Phosphatidylinositol signaling system | 8.72E-04 | 5 | P19174, P0DP23, P42338, P23743, P27987 | PLCG1, CALM1, PIK3CB, DGKA, ITPKB | More | | | Tioconazole | hsa04071 | Sphingolipid signaling pathway | 1.94E-02 | 3 | Q9H228, P01375, Q9UQC2 | EDG8, TNF, GAB2 | More | | | Tioconazole | hsa04072 | Phospholipase D signaling pathway | 4.67E-02 | 5 | P42338, P19174, Q14344, P23743, Q9NRA1 | PIK3CB, PLCG1, GNA13, DGKA, PDGFC | More | | | Tioconazole | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Tioconazole | hsa04141 | Protein processing in endoplasmic reticulum | 1.33E-03 | 10 | P30101, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9H173, Q9UNL2 | PDIA3, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SIL1, SSR3 | More | | | Tioconazole | hsa04145 | Phagosome | 6.51E-03 | 6 | P11215, P14598, Q71U36, Q13509, P68371, Q13488 | ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1 | More | | | Tioconazole | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Tioconazole | hsa04151 | PI3K-Akt signaling pathway | 7.63E-04 | 17 | P42338, P43657, P01106, P09603, P20827, Q9NRA1, P49767, Q9GZP0, P08238, P62873, P63218, P50151, P13612, O15335, Q13751, P14784, P01568 | PIK3CB, P2RY5, MYC, CSF1, EFNA1, PDGFC, VEGFC, PDGFD, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, CHAD, LAMB3, IL2RB, IFNA21 | More | | | Tioconazole | hsa04210 | Apoptosis | 3.58E-02 | 4 | O76075, P01375, Q9NR28, Q16548 | DFFB, TNF, DIABLO, BCL2A1 | More | | | Tioconazole | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.98E-02 | 4 | P51828, Q99941, Q13557, P23634 | ADCY7, CREBL1, CAMK2D, ATP2B4 | More | | | Tioconazole | hsa04330 | Notch signaling pathway | 4.34E-02 | 2 | Q92542, P46531 | NCSTN, NOTCH1 | More | | | Tioconazole | hsa04340 | Hedgehog signaling pathway | 3.32E-02 | 2 | P49841, P22694 | GSK3B, PRKACB | More | | | Tioconazole | hsa04360 | Axon guidance | 2.87E-02 | 5 | P16333, P20827, O95631, P42338, P19174 | NCK1, EFNA1, NTN1, PIK3CB, PLCG1 | More | | | Tioconazole | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Tioconazole | hsa04371 | Apelin signaling pathway | 6.35E-06 | 8 | P62873, P63218, P50151, Q13370, Q14814, Q14344, P84022, P0DP23 | GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, SMAD3, CALM1 | More | | | Tioconazole | hsa04512 | ECM-receptor interaction | 4.41E-02 | 3 | Q13751, P13612, O15335 | LAMB3, ITGA4, CHAD | More | | | Tioconazole | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Tioconazole | hsa04540 | Gap junction | 1.08E-02 | 4 | Q13509, P68371, Q71U36, Q9NRA1 | TUBB3, TUBB2C, TUBA1A, PDGFC | More | | | Tioconazole | hsa04613 | Neutrophil extracellular trap formation | 2.06E-03 | 11 | P42338, P19174, P11215, Q13547, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598 | PIK3CB, PLCG1, ITGAM, HDAC1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1 | More | | | Tioconazole | hsa04620 | Toll-like receptor signaling pathway | 4.00E-02 | 4 | P01568, P42224, P25963, P42338 | IFNA21, STAT1, NFKBIA, PIK3CB | More | | | Tioconazole | hsa04623 | Cytosolic DNA-sensing pathway | 1.55E-03 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Tioconazole | hsa04625 | C-type lectin receptor signaling pathway | 2.17E-02 | 5 | Q9ULY5, P42224, P25963, P42338, P0DP23 | CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1 | More | | | Tioconazole | hsa04650 | Natural killer cell mediated cytotoxicity | 3.18E-03 | 9 | P16298, P50591, P78314, P06239, O60880, P20963, Q02750, P26718, O75015 | PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRK1, FCGR3B | More | | | Tioconazole | hsa04657 | IL-17 signaling pathway | 3.31E-02 | 3 | P49841, P14780, P01375 | GSK3B, MMP9, TNF | More | | | Tioconazole | hsa04658 | Th1 and Th2 cell differentiation | 2.45E-04 | 12 | P25963, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q9UL17, P14784, P13765, Q13761 | NFKBIA, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | | Tioconazole | hsa04659 | Th17 cell differentiation | 2.25E-05 | 14 | P25963, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P84022, P08238, P07766, P09693, P20963 | NFKBIA, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, SMAD3, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 |
| | Tioconazole | hsa04662 | B cell receptor signaling pathway | 1.12E-02 | 5 | P25963, P42338, P07948, P21854, Q8N149 | NFKBIA, PIK3CB, LYN, CD72, LILRA2 | More | | | Tioconazole | hsa04664 | Fc epsilon RI signaling pathway | 2.35E-04 | 5 | P04141, P42338, P07948, P19174, P09917 | CSF2, PIK3CB, LYN, PLCG1, ALOX5 | More | | | Tioconazole | hsa04666 | Fc gamma R-mediated phagocytosis | 2.92E-02 | 4 | P07948, P42338, P19174, P14598 | LYN, PIK3CB, PLCG1, NCF1 | More | | | Tioconazole | hsa04668 | TNF signaling pathway | 4.74E-02 | 3 | Q99941, P01584, O95429 | CREBL1, IL1B, BAG4 | More | | | Tioconazole | hsa04713 | Circadian entrainment | 2.25E-03 | 4 | P0DP23, P62873, P63218, P50151 | CALM1, GNB1, GNG5, GNG10 | More | | | Tioconazole | hsa04720 | Long-term potentiation | 1.38E-02 | 3 | P16298, P51812, Q02750 | PPP3CB, RPS6KA3, MAP2K1 | More | | | Tioconazole | hsa04724 | Glutamatergic synapse | 3.48E-05 | 5 | O15399, P62873, P63218, P50151, P15104 | GRIN2D, GNB1, GNG5, GNG10, GLUL | More | | | Tioconazole | hsa04725 | Cholinergic synapse | 2.92E-02 | 4 | P62873, P63218, P50151, P42338 | GNB1, GNG5, GNG10, PIK3CB | More | | | Tioconazole | hsa04726 | Serotonergic synapse | 3.80E-02 | 4 | P62873, P63218, P50151, P09917 | GNB1, GNG5, GNG10, ALOX5 | More | | | Tioconazole | hsa04727 | GABAergic synapse | 5.37E-06 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Tioconazole | hsa04730 | Long-term depression | 3.34E-03 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Tioconazole | hsa04744 | Phototransduction | 1.23E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Tioconazole | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.11E-03 | 7 | P01584, P51828, Q13557, P19174, P42338, P24723, P0DP23 | IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, CALM1 | More | | | Tioconazole | hsa04810 | Regulation of actin cytoskeleton | 2.61E-02 | 6 | P12814, Q13009, P42338, P11215, Q14344, Q9NRA1 | ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC | More | | | Tioconazole | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | | | Tioconazole | hsa04911 | Insulin secretion | 1.48E-02 | 3 | P51828, Q99941, Q13557 | ADCY7, CREBL1, CAMK2D | More | | | Tioconazole | hsa04914 | Progesterone-mediated oocyte maturation | 4.29E-03 | 7 | Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750 | CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Tioconazole | hsa04915 | Estrogen signaling pathway | 4.72E-02 | 4 | Q99941, P51828, P07900, P11142 | CREBL1, ADCY7, HSP90AA1, HSPA8 | More | | | Tioconazole | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | | | Tioconazole | hsa04925 | Aldosterone synthesis and secretion | 5.19E-03 | 4 | Q99941, P51828, Q13557, P23634 | CREBL1, ADCY7, CAMK2D, ATP2B4 | More | | | Tioconazole | hsa04926 | Relaxin signaling pathway | 8.74E-03 | 6 | P25963, P42338, P62873, P63218, P50151, P49767 | NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC | More | | | Tioconazole | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Tioconazole | hsa04934 | Cushing syndrome | 3.48E-03 | 4 | Q99941, P51828, O15169, Q13557 | CREBL1, ADCY7, AXIN1, CAMK2D | More | | | Tioconazole | hsa04971 | Gastric acid secretion | 1.48E-02 | 3 | P51828, P15311, Q13557 | ADCY7, VIL2, CAMK2D | More | | | Tioconazole | hsa04976 | Bile secretion | 2.44E-02 | 2 | P22694, P08183 | PRKACB, ABCB1 | More | | | Tioconazole | hsa05010 | Alzheimer disease | 3.15E-03 | 13 | Q92542, P05496, P12074, O15399, Q9NZJ5, O75460, Q13564, P01584, Q71U36, O15169, P09603, P21796, P45880 | NCSTN, ATP5G1, COX6A1, GRIN2D, EIF2AK3, ERN1, APPBP1, IL1B, TUBA1A, AXIN1, CSF1, VDAC1, VDAC2 | More | | | Tioconazole | hsa05012 | Parkinson disease | 2.12E-03 | 7 | P21796, P60604, P19174, P0DP23, Q71U36, Q13509, P68371 | VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Tioconazole | hsa05020 | Prion disease | 1.81E-02 | 7 | P01584, P46531, P11142, P05496, P12074, P45880, Q99941 | IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1 | More | | | Tioconazole | hsa05032 | Morphine addiction | 1.77E-05 | 6 | P62873, P63218, P50151, Q13370, Q07343, P43250 | GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6 | More | | | Tioconazole | hsa05034 | Alcoholism | 9.92E-05 | 10 | Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431 | HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Tioconazole | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.08E-02 | 4 | P25963, Q13488, P19174, P07948 | NFKBIA, TCIRG1, PLCG1, LYN | More | | | Tioconazole | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Tioconazole | hsa05132 | Salmonella infection | 1.95E-03 | 9 | P25963, P08238, P01106, P42338, O75369, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, MYC, PIK3CB, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Tioconazole | hsa05134 | Legionellosis | 4.75E-02 | 3 | P25963, P11215, P11142 | NFKBIA, ITGAM, HSPA8 | More | | | Tioconazole | hsa05140 | Leishmaniasis | 4.82E-02 | 4 | P14598, P11215, P42224, P25963 | NCF1, ITGAM, STAT1, NFKBIA | More | | | Tioconazole | hsa05144 | Malaria | 1.44E-02 | 4 | P60033, O60603, P35443, P26718 | CD81, TLR2, THBS4, KLRK1 | More | | | Tioconazole | hsa05162 | Measles | 1.84E-02 | 7 | P01568, P25963, P42224, P14784, P07766, P42338, P11142 | IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8 | More | | | Tioconazole | hsa05163 | Human cytomegalovirus infection | 3.84E-06 | 10 | P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568 | PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21 | More | | | Tioconazole | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.48E-09 | 16 | P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P04141, P0DP23, P0CG47 | IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CSF2, CALM1, UBB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P11511 | CYP19A1 | Aromatase | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.852 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.782 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P04141 | CSF2 | Granulocyte-macrophage colony-stimulating factor | -0.79 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P11511 | CYP19A1 | Aromatase | P0CG47 | UBB | Polyubiquitin-B | -0.741 |
| | Tioconazole | hsa05168 | Herpes simplex virus 1 infection | 5.29E-03 | 10 | P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189 | More | | | Tioconazole | hsa05169 | Epstein-Barr virus infection | 2.24E-04 | 18 | P13765, P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, O60603, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TLR2, CD3E, CD3G, CD247 | More | | | Tioconazole | hsa05170 | Human immunodeficiency virus 1 infection | 2.74E-06 | 15 | P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333 | PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1B | More | | | Tioconazole | hsa05200 | Pathways in cancer | 1.45E-05 | 19 | P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, P20585, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784 | PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, MSH3, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.887 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.735 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.847 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 |
| | Tioconazole | hsa05203 | Viral carcinogenesis | 6.72E-04 | 11 | P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079, O60814 | PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9, H2BC12 | More | | | Tioconazole | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Tioconazole | hsa05206 | MicroRNAs in cancer | 4.00E-04 | 13 | P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174 | CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1 | More | | | Tioconazole | hsa05212 | Pancreatic cancer | 4.75E-02 | 3 | P42224, P84022, O75293 | STAT1, SMAD3, GADD45B | More | | | Tioconazole | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Tioconazole | hsa05214 | Glioma | 1.54E-03 | 4 | P0DP23, P42338, P19174, O75293 | CALM1, PIK3CB, PLCG1, GADD45B | More | | | Tioconazole | hsa05218 | Melanoma | 2.31E-02 | 3 | Q9NRA1, P42338, O75293 | PDGFC, PIK3CB, GADD45B | More | | | Tioconazole | hsa05220 | Chronic myeloid leukemia | 2.17E-02 | 5 | Q13547, P01106, P25963, P42338, O75293 | HDAC1, MYC, NFKBIA, PIK3CB, GADD45B | More | | | Tioconazole | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Tioconazole | hsa05231 | Choline metabolism in cancer | 2.92E-03 | 5 | P42338, Q9NRA1, Q9Y259, P19174, P23743 | PIK3CB, PDGFC, CHKB, PLCG1, DGKA | More | | | Tioconazole | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 3.94E-03 | 10 | P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q16539 | NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, MAPK14 | More | | | Tioconazole | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | |
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