PharmaCoNets of Tiludronic-acid (SPCN: 11.50 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tiludronic-acidhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tiludronic-acidhsa00190Oxidative phosphorylation2.67E-034Q16718, Q13488, Q9Y5K8, O14521NDUFA5, TCIRG1, ATP6V1D, SDHDMore
Tiludronic-acidhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Tiludronic-acidhsa00561Glycerolipid metabolism2.55E-035O14494, P14550, P06280, P23743, Q86XP1PLPP1, AKR1A1, GLA, DGKA, DGKHMore
Tiludronic-acidhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tiludronic-acidhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Tiludronic-acidhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Tiludronic-acidhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Tiludronic-acidhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Tiludronic-acidhsa04145Phagosome2.47E-027P60709, Q15075, Q15080, P14598, Q13509, Q13488, Q9Y5K8ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, ATP6V1DMore
Tiludronic-acidhsa04150mTOR signaling pathway2.32E-021Q9Y5K8ATP6V1DMore
Tiludronic-acidhsa04151PI3K-Akt signaling pathway2.22E-029Q08999, P20827, Q13362, P08238, P62873, P16144, P01568, P10415, P17252RBL2, EFNA1, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNA21, BCL2, PRKCAMore
Tiludronic-acidhsa04217Necroptosis4.64E-037P01568, Q13489, P42224, P08238, Q6FI13, P10415, O43633IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, BCL2, CHMP2AMore
Tiludronic-acidhsa04218Cellular senescence6.34E-035P30281, P10145, P01889, P10321, P12236CCND3, IL8, HLA-B, HLA-C, SLC25A6More
Tiludronic-acidhsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Tiludronic-acidhsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Tiludronic-acidhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Tiludronic-acidhsa04621NOD-like receptor signaling pathway4.52E-026P08238, P42224, P01568, P25963, Q13489, P10415HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2More
Tiludronic-acidhsa04623Cytosolic DNA-sensing pathway2.27E-022P01568, P25963IFNA21, NFKBIAMore
Tiludronic-acidhsa04630JAK-STAT signaling pathway4.82E-025P10415, P42224, P29350, P40189, P01568BCL2, STAT1, PTPN6, IL6ST, IFNA21More
Tiludronic-acidhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Tiludronic-acidhsa04721Synaptic vesicle cycle8.29E-031Q9Y5K8ATP6V1DMore
Tiludronic-acidhsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Tiludronic-acidhsa04933AGE-RAGE signaling pathway in diabetic complications3.87E-024P42224, P10415, Q12778, P17252STAT1, BCL2, FOXO1, PRKCAMore
Tiludronic-acidhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tiludronic-acidhsa04966Collecting duct acid secretion4.60E-042Q9Y5K8, P00918ATP6V1D, CA2More
Tiludronic-acidhsa05110Vibrio cholerae infection3.63E-057Q13488, Q9Y5K8, Q99437, P17252, P19174, P17612, P60709TCIRG1, ATP6V1D, ATP6V0B, PRKCA, PLCG1, PRKACA, ACTBMore
Tiludronic-acidhsa05120Epithelial cell signaling in Helicobacter pylori infection9.23E-044Q9Y5K8, Q99437, P10145, P41240ATP6V1D, ATP6V0B, IL8, CSKMore
Tiludronic-acidhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Tiludronic-acidhsa05132Salmonella infection1.94E-027P25963, P08238, Q13489, P10415, Q13561, P68371, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, DCTN2, TUBB2C, VPS41More
Tiludronic-acidhsa05133Pertussis4.20E-021P0C0L4C4AMore
Tiludronic-acidhsa05140Leishmaniasis1.26E-035P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Tiludronic-acidhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Tiludronic-acidhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Tiludronic-acidhsa05152Tuberculosis4.05E-025Q13488, P42224, P10415, P01568, Q9UDY8TCIRG1, STAT1, BCL2, IFNA21, MALT1More
Tiludronic-acidhsa05165Human papillomavirus infection5.13E-0313P16144, Q08999, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, P17612, Q13362, Q12778ITGB4, RBL2, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PRKACA, PPP2R5C, FOXO1More
Tiludronic-acidhsa05168Herpes simplex virus 1 infection8.71E-0310P25963, P01568, P42224, Q07955, Q13243, Q13489, Q13398, O75820, Q9UDV6, P10415NFKBIA, IFNA21, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF189, ZNF212, BCL2More
Tiludronic-acidhsa05170Human immunodeficiency virus 1 infection2.67E-027P62873, P17252, P01568, P25963, P23528, P10415, Q13619GNB1, PRKCA, IFNA21, NFKBIA, CFL1, BCL2, CUL4AMore
Tiludronic-acidhsa05203Viral carcinogenesis1.06E-025P30281, P06396, P01889, P10321, P17612CCND3, GSN, HLA-B, HLA-C, PRKACAMore
Tiludronic-acidhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Tiludronic-acidhsa05215Prostate cancer4.81E-024P25963, P10415, Q12778, P08238NFKBIA, BCL2, FOXO1, HSP90AB1More
Tiludronic-acidhsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Tiludronic-acidhsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Tiludronic-acidhsa05323Rheumatoid arthritis1.82E-021Q9Y5K8ATP6V1DMore
Tiludronic-acidhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Tiludronic-acidhsa05415Diabetic cardiomyopathy2.64E-036P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Tiludronic-acid (SDC: 2.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)