PharmaCoNets of Ticagrelor (SPCN: 5.70 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ticagrelorhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ticagrelorhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ticagrelorhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Ticagrelorhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Ticagrelorhsa04145Phagosome3.99E-024P05164, P78380, P35443, P13765MPO, OLR1, THBS4, HLA-DOBMore
Ticagrelorhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Ticagrelorhsa04612Antigen processing and presentation1.31E-036P13765, P26715, P26717, Q07444, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Ticagrelorhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ticagrelorhsa04640Hematopoietic cell lineage4.90E-036P25063, P07766, P01732, P09564, P13765, P09603CD24, CD3E, CD8A, CD7, HLA-DOB, CSF1More
Ticagrelorhsa04650Natural killer cell mediated cytotoxicity9.26E-069P06239, O60880, P20963, Q13241, P26718, O14931, P26717, Q07444, P26715LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1More
Ticagrelorhsa04658Th1 and Th2 cell differentiation5.90E-068Q04759, P07766, P20963, P06239, Q14765, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, LCK, STAT4, TBX21, HLA-DOB, RUNX3More
Ticagrelorhsa04659Th17 cell differentiation3.38E-047Q04759, P06239, P13765, Q9HBE5, Q9UL17, P07766, P20963PRKCQ, LCK, HLA-DOB, IL21R, TBX21, CD3E, CD247More
Ticagrelorhsa04660T cell receptor signaling pathway8.49E-047Q04759, Q08881, P07766, P20963, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD8A, CBLB, LCKMore
Ticagrelorhsa04750Inflammatory mediator regulation of TRP channels4.74E-023P22694, P24723, Q04759PRKACB, PRKCH, PRKCQMore
Ticagrelorhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Ticagrelorhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ticagrelorhsa05146Amoebiasis6.67E-046P09341, P19875, P05089, P22694, P12814, P08311CXCL1, CXCL2, ARG1, PRKACB, ACTN1, CTSGMore
Ticagrelorhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Ticagrelorhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ticagrelorhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.73E-024P07766, P20963, P06239, Q04759CD3E, CD247, LCK, PRKCQMore
Ticagrelorhsa05310Asthma2.72E-022P13765, P12724HLA-DOB, RNASE3More
Ticagrelorhsa05321Inflammatory bowel disease2.22E-034P13765, Q14765, Q9UL17, Q9HBE5HLA-DOB, STAT4, TBX21, IL21RMore
Ticagrelorhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ticagrelorhsa05323Rheumatoid arthritis3.51E-034P09603, P13765, P09341, P19875CSF1, HLA-DOB, CXCL1, CXCL2More
Ticagrelorhsa05332Graft-versus-host disease9.74E-033P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Ticagrelorhsa05340Primary immunodeficiency2.86E-023P01732, P07766, P06239CD8A, CD3E, LCKMore

Community members of Ticagrelor (SDC: 1.34)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O14626GPR171Probable GNoneprotein coupled receptor 171Predicted00.06460.018300.0689
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)