PharmaCoNets of Thioridazine (SPCN: 61.17 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Thioridazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Thioridazinehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Thioridazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Thioridazinehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Thioridazinehsa00500Starch and sucrose metabolism2.21E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Thioridazinehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Thioridazinehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Thioridazinehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Thioridazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Thioridazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Thioridazinehsa00600Sphingolipid metabolism4.77E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Thioridazinehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Thioridazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Thioridazinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Thioridazinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Thioridazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Thioridazinehsa00983Drug metabolism - other enzymes3.48E-033P04183, P32320, P05164TK1, CDA, MPOMore
Thioridazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Thioridazinehsa01230Biosynthesis of amino acids2.92E-035P51854, P60891, P05089, P15104, P37837TKTL1, PRPS1, ARG1, GLUL, TALDO1More
Thioridazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Thioridazinehsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Thioridazinehsa03013RNA transport2.12E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Thioridazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Thioridazinehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Thioridazinehsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Thioridazinehsa04060Cytokine-cytokine receptor interaction2.05E-0211P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P18510, P01730IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, IL1RN, CD4More
Thioridazinehsa04061Viral protein interaction with cytokine and cytokine receptor3.04E-026P09341, P25024, P25025, P47992, Q9UBD3, Q13651CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RAMore
Thioridazinehsa04062Chemokine signaling pathway6.90E-0310P25024, P25025, P09341, P47992, Q9UBD3, P07948, P63218, P50151, Q08881, P49841CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, ITK, GSK3BMore
Thioridazinehsa04064NF-kappa B signaling pathway1.02E-0311P10415, O00463, P14778, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, P09341BCL2, TRAF5, IL1R1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1More
Thioridazinehsa04071Sphingolipid signaling pathway1.82E-047P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Thioridazinehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Thioridazinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Thioridazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Thioridazinehsa04145Phagosome3.82E-038Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4More
Thioridazinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Thioridazinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Thioridazinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Thioridazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Thioridazinehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Thioridazinehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Thioridazinehsa04612Antigen processing and presentation2.09E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Thioridazinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Thioridazinehsa04640Hematopoietic cell lineage3.31E-039P13612, P14778, P27930, P11836, P07766, P09693, P01732, P01730, P13765ITGA4, IL1R1, IL1R2, MS4A1, CD3E, CD3G, CD8A, CD4, HLA-DOBMore
Thioridazinehsa04650Natural killer cell mediated cytotoxicity1.34E-0411P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Thioridazinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Thioridazinehsa04658Th1 and Th2 cell differentiation1.64E-0611Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21, HLA-DOB, RUNX3More
Thioridazinehsa04659Th17 cell differentiation2.83E-0511Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Thioridazinehsa04660T cell receptor signaling pathway2.18E-0512Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Thioridazinehsa04662B cell receptor signaling pathway2.57E-025P49841, P60033, P07948, P21854, Q8N149GSK3B, CD81, LYN, CD72, LILRA2More
Thioridazinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Thioridazinehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Thioridazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Thioridazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Thioridazinehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Thioridazinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Thioridazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Thioridazinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Thioridazinehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Thioridazinehsa04918Thyroid hormone synthesis2.88E-035P22694, P17252, P18848, Q14643, P27824PRKACB, PRKCA, ATF4, ITPR1, CANXMore
Thioridazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Thioridazinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Thioridazinehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Thioridazinehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Thioridazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Thioridazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Thioridazinehsa04961Endocrine and other factor-regulated calcium reabsorption2.68E-023P20020, Q9UEF7, P17252ATP2B1, KL, PRKCAMore
Thioridazinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Thioridazinehsa04972Pancreatic secretion2.68E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Thioridazinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Thioridazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Thioridazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Thioridazinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Thioridazinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Thioridazinehsa05120Epithelial cell signaling in Helicobacter pylori infection7.16E-035Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Thioridazinehsa05132Salmonella infection4.62E-0311P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Thioridazinehsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Thioridazinehsa05135Yersinia infection1.66E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Thioridazinehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Thioridazinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Thioridazinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Thioridazinehsa05152Tuberculosis1.08E-028Q13488, P48382, P25208, O60603, P10415, P01568, Q9UDY8, P51617TCIRG1, RFX5, NFYB, TLR2, BCL2, IFNA21, MALT1, IRAK1More
Thioridazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Thioridazinehsa05163Human cytomegalovirus infection8.17E-039P63218, P50151, P49841, P14778, Q13651, P25025, Q16539, O00463, P30101GNG5, GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3More
Thioridazinehsa05169Epstein-Barr virus infection1.68E-0312P13765, Q13547, O00463, Q16539, P07948, P30101, Q13761, P24522, P29728, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247More
Thioridazinehsa05170Human immunodeficiency virus 1 infection2.65E-0319P62873, P63218, P50151, P17252, Q13546, O00463, P30101, Q14643, P01568, P01730, Q16539, P51617, O60603, Q13315, P07766, P09693, P20963, P10415, Q9Y6Q5GNB1, GNG5, GNG10, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, CD4, MAPK14, IRAK1, TLR2, ATM, CD3E, CD3G, CD247, BCL2, AP1M2More
Thioridazinehsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Thioridazinehsa05202Transcriptional misregulation in cancer9.36E-0416Q12778, Q15532, Q13315, P14780, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Thioridazinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Thioridazinehsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Thioridazinehsa05205Proteoglycans in cancer3.10E-0414Q13009, Q12955, Q14643, O75369, Q14247, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, CTTN, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Thioridazinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.92E-048O95267, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Thioridazinehsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Thioridazinehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Thioridazinehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Thioridazinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Thioridazinehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Thioridazinehsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Thioridazinehsa05340Primary immunodeficiency3.99E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Thioridazinehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Thioridazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Thioridazinehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Thioridazine (SDC: 4.40)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P11169SLC2A3Solute carrier family 2, facilitated glucose transporter member 3Predicted00.13570.065800.1995
Q9UDY8MALT1MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1Predicted10.05160.1470.55920.8789
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki0.4
DRD2P14416Ki1.6
DRD2P14416Ki2.8