| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Thiabendazole | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Thiabendazole | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Thiabendazole | hsa00072 | Synthesis and degradation of ketone bodies | 2.78E-02 | 1 | Q01581 | HMGCS1 | More | | | Thiabendazole | hsa00190 | Oxidative phosphorylation | 7.32E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Thiabendazole | hsa00220 | Arginine biosynthesis | 5.61E-05 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Thiabendazole | hsa00230 | Purine metabolism | 1.81E-02 | 2 | P20839, Q02153 | IMPDH1, GUCY1B3 | More | | | Thiabendazole | hsa00250 | Alanine, aspartate and glutamate metabolism | 1.22E-02 | 2 | Q96RQ9, P15104 | IL4I1, GLUL | More | | | Thiabendazole | hsa00260 | Glycine, serine and threonine metabolism | 1.99E-02 | 1 | P22557 | ALAS2 | More | | | Thiabendazole | hsa00270 | Cysteine and methionine metabolism | 3.39E-02 | 2 | Q96RQ9, P40926 | IL4I1, MDH2 | More | | | Thiabendazole | hsa00310 | Lysine degradation | 4.57E-02 | 2 | Q96KQ7, Q02809 | EHMT2, PLOD1 | More | | | Thiabendazole | hsa00350 | Tyrosine metabolism | 3.40E-02 | 1 | P28332 | ADH6 | More | | | Thiabendazole | hsa00500 | Starch and sucrose metabolism | 3.07E-07 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Thiabendazole | hsa00561 | Glycerolipid metabolism | 1.12E-02 | 3 | Q8NEB5, P14550, Q86XP1 | PPAPDC1B, AKR1A1, DGKH | More | | | Thiabendazole | hsa00562 | Inositol phosphate metabolism | 2.00E-02 | 4 | P27987, P19174, P42338, Q02252 | ITPKB, PLCG1, PIK3CB, ALDH6A1 | More | | | Thiabendazole | hsa00565 | Ether lipid metabolism | 3.00E-03 | 1 | Q8N661 | TMEM86B | More | | | Thiabendazole | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Thiabendazole | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Thiabendazole | hsa00600 | Sphingolipid metabolism | 2.44E-02 | 2 | Q9BX95, Q06136 | SGPP1, FVT1 | More | | | Thiabendazole | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.03E-04 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Thiabendazole | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | | Thiabendazole | hsa00670 | One carbon pool by folate | 3.15E-02 | 2 | O95954, Q99707 | FTCD, MTR | More | | | Thiabendazole | hsa00730 | Thiamine metabolism | 1.06E-04 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Thiabendazole | hsa00740 | Riboflavin metabolism | 4.77E-02 | 1 | P30043 | BLVRB | More | | | Thiabendazole | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Thiabendazole | hsa00785 | Lipoic acid metabolism | 4.32E-02 | 1 | Q9Y234 | LIPT1 | More | | | Thiabendazole | hsa00790 | Folate biosynthesis | 1.04E-02 | 3 | Q92820, P05186, P42330 | GGH, ALPL, AKR1C3 | More | | | Thiabendazole | hsa00830 | Retinol metabolism | 2.51E-03 | 4 | P00325, P00352, Q9BPW9, O75911 | ADH1B, ALDH1A1, DHRS9, DHRS3 | More | | | Thiabendazole | hsa00860 | Porphyrin and chlorophyll metabolism | 3.15E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Thiabendazole | hsa00900 | Terpenoid backbone biosynthesis | 1.70E-04 | 3 | Q01581, P49354, Q9UHG3 | HMGCS1, FNTA, PCYOX1 | More | | | Thiabendazole | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.41E-04 | 3 | O95363, P54136, P14868 | FARS2, RARS1, DARS | More | | | Thiabendazole | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 8.40E-04 | 3 | P78417, P28332, P11712 | GSTO1, ADH6, CYP2C9 | More | | | Thiabendazole | hsa00982 | Drug metabolism - cytochrome P450 | 8.40E-04 | 3 | P11712, P78417, P28332 | CYP2C9, GSTO1, ADH6 | More | | | Thiabendazole | hsa00983 | Drug metabolism - other enzymes | 3.02E-03 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Thiabendazole | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | | Thiabendazole | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 2.18E-02 | 2 | P49841, Q9NRA1 | GSK3B, PDGFC | More | | | Thiabendazole | hsa01522 | Endocrine resistance | 4.55E-02 | 5 | P14780, P22694, Q9UM47, P10415, Q13323 | MMP9, PRKACB, NOTCH3, BCL2, BIK | More | | | Thiabendazole | hsa01523 | Antifolate resistance | 2.54E-03 | 4 | P41440, Q92820, P04818, P01375 | SLC19A1, GGH, TYMS, TNF | More | | | Thiabendazole | hsa02010 | ABC transporters | 2.17E-03 | 1 | Q8IZY2 | ABCA7 | More | | | Thiabendazole | hsa03010 | Ribosome | 7.34E-03 | 6 | P62753, P62829, P62888, P61927, P61513, P36578 | RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4 | More | | | Thiabendazole | hsa03013 | RNA transport | 1.41E-09 | 25 | P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114 | RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P62826 | RAN | GTP-binding nuclear protein Ran | 0.732 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | O14980 | XPO1 | Exportin-1 | 0.943 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.888 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | P49759 | CLK1 | Dual specificity protein kinase CLK1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.76 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.853 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | P61326 | MAGOH | Protein mago nashi homolog | 0.737 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.756 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.723 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.79 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q9H307 | PNN | Pinin | 0.722 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.787 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.774 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.725 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.781 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.751 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.736 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P68104 | EEF1A1 | Elongation factor 1-alpha 1 | 0.721 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.902 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.734 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P55884 | EIF3B | Eukaryotic translation initiation factor 3 subunit B | -0.731 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O15371 | EIF3D | Eukaryotic translation initiation factor 3 subunit D | 0.77 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.83 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.837 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.852 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.733 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.867 | | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.704 | | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q9BZI7 | UPF3B | Regulator of nonsense transcripts 3B | 0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.812 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q14232 | EIF2B1 | Translation initiation factor eIF-2B subunit alpha | 0.749 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.772 | | P49759 | CLK1 | Dual specificity protein kinase CLK1 | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.793 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | P51114 | FXR1 | Fragile X mental retardation syndrome-related protein 1 | 0.854 |
| | Thiabendazole | hsa03015 | mRNA surveillance pathway | 1.93E-03 | 5 | Q9BZI7, Q13362, Q14738, O94913, Q9UBU9 | UPF3B, PPP2R5C, PPP2R5D, PCF11, NXF1 | More | | | Thiabendazole | hsa03020 | RNA polymerase | 4.91E-06 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Thiabendazole | hsa03022 | Basal transcription factors | 2.41E-02 | 1 | Q12962 | TAF10 | More | | | Thiabendazole | hsa03040 | Spliceosome | 2.30E-04 | 12 | Q14562, O43143, O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, Q13243, P11142, O43447 | DHX8, DHX15, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH | More | | | Thiabendazole | hsa03060 | Protein export | 1.29E-05 | 3 | Q15070, P37108, Q15005 | OXA1L, SRP14, SPCS2 | More | | | Thiabendazole | hsa03320 | PPAR signaling pathway | 6.48E-03 | 3 | Q6PCB7, Q13418, Q9UNU6 | SLC27A1, ILK, CYP8B1 | More | | | Thiabendazole | hsa03450 | Non-homologous end-joining | 3.17E-03 | 2 | Q9NP87, P13010 | POLM, XRCC5 | More | | | Thiabendazole | hsa04012 | ErbB signaling pathway | 2.07E-04 | 8 | P21860, P16333, P17252, Q13557, P19174, O14944, P42338, P01106 | ERBB3, NCK1, PRKCA, CAMK2D, PLCG1, EREG, PIK3CB, MYC | More | | | Thiabendazole | hsa04014 | Ras signaling pathway | 7.71E-04 | 10 | P42338, P20827, P49767, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174 | PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1 | More | | | Thiabendazole | hsa04015 | Rap1 signaling pathway | 1.43E-03 | 11 | P09603, P20827, P49767, Q9GZP0, P11215, Q13009, P42338, P0DP23, Q86WV1, P17252, P19174 | CSF1, EFNA1, VEGFC, PDGFD, ITGAM, TIAM1, PIK3CB, CALM1, SKAP1, PRKCA, PLCG1 | More | | | Thiabendazole | hsa04020 | Calcium signaling pathway | 2.72E-06 | 16 | P27987, Q96DU7, Q08828, P45880, Q13557, P17252, P21860, O15399, P19174, P0DP23, P05141, P51828, P26678, P63092, P23634, P49767 | ITPKB, ITPKC, ADCY1, VDAC2, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CALM1, SLC25A5, ADCY7, PLN, GNAS, ATP2B4, VEGFC | More | | | Thiabendazole | hsa04022 | cGMP-PKG signaling pathway | 6.39E-04 | 9 | Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP23 | CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM1 | More | | | Thiabendazole | hsa04024 | cAMP signaling pathway | 4.64E-03 | 9 | Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009 | ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1 | More | | | Thiabendazole | hsa04060 | Cytokine-cytokine receptor interaction | 5.34E-03 | 11 | P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4 | More | | | Thiabendazole | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.05E-06 | 10 | Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375 | CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNF | More | | | Thiabendazole | hsa04062 | Chemokine signaling pathway | 2.78E-04 | 16 | P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963 | CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA | More | | | Thiabendazole | hsa04064 | NF-kappa B signaling pathway | 7.73E-12 | 23 | P10415, Q13489, P51617, O00463, P14778, P01584, P01375, P29965, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7 | BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, CD40LG, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P22894 | MMP8 | Neutrophil collagenase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.959 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.744 | | P05164 | MPO | Myeloperoxidase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.821 | | P22894 | MMP8 | Neutrophil collagenase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.867 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P01584 | IL1B | Interleukin-1 beta | 0.762 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | P17252 | PRKCA | Protein kinase C alpha type | P29965 | CD40LG | CD40 ligand | 0.788 | | P05164 | MPO | Myeloperoxidase | Q04759 | PRKCQ | Protein kinase C theta type | -0.88 | | P22894 | MMP8 | Neutrophil collagenase | Q04759 | PRKCQ | Protein kinase C theta type | -0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | | P05164 | MPO | Myeloperoxidase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.758 | | P22894 | MMP8 | Neutrophil collagenase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.891 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P67870 | CSNK2B | Casein kinase II subunit beta | 0.709 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P17252 | PRKCA | Protein kinase C alpha type | Q8WV28 | BLNK | B-cell linker protein | 0.838 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.702 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.727 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.727 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P05164 | MPO | Myeloperoxidase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.806 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q06643 | LTB | Lymphotoxin-beta | 0.846 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.763 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| | Thiabendazole | hsa04070 | Phosphatidylinositol signaling system | 1.09E-06 | 12 | P19174, P0DP23, Q14643, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252 | PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCA | More | | | Thiabendazole | hsa04071 | Sphingolipid signaling pathway | 1.11E-05 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | | Thiabendazole | hsa04072 | Phospholipase D signaling pathway | 2.40E-03 | 6 | P31751, O14986, Q15438, Q08828, P51828, Q16760 | AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD | More | | | Thiabendazole | hsa04080 | Neuroactive ligand-receptor interaction | 3.19E-06 | 14 | P08311, Q15722, P21453, Q9H228, P43657, O00398, Q01726, P41968, P21462, P21730, Q16581, P14416, P07550, P35318 | CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1, DRD2, ADRB2, ADM | More | | | Thiabendazole | hsa04110 | Cell cycle | 6.63E-04 | 6 | P06493, O60566, P30304, P33981, P42773, P01106 | CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC | More | | | Thiabendazole | hsa04114 | Oocyte meiosis | 1.15E-06 | 10 | Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738 | MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D | More | | | Thiabendazole | hsa04115 | p53 signaling pathway | 3.98E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Thiabendazole | hsa04120 | Ubiquitin mediated proteolysis | 7.75E-05 | 8 | Q9UBT2, Q14145, Q13042, P62837, Q15751, O95071, Q14669, P0CG47 | SAE2, KEAP1, CDC16, UBE2D2, HERC1, UBR5, TRIP12, UBB | More | | | Thiabendazole | hsa04137 | Mitophagy - animal | 9.52E-03 | 2 | Q07817, P0CG47 | BCL2L1, UBB | More | | | Thiabendazole | hsa04140 | Autophagy - animal | 5.56E-03 | 10 | P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9 | AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8 | More | | | Thiabendazole | hsa04141 | Protein processing in endoplasmic reticulum | 3.64E-02 | 5 | Q99941, O75460, P11142, Q9H3Z4, P07900 | CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1 | More | | | Thiabendazole | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Thiabendazole | hsa04144 | Endocytosis | 1.67E-02 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | | Thiabendazole | hsa04145 | Phagosome | 4.60E-07 | 10 | O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765 | FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | | Thiabendazole | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Thiabendazole | hsa04151 | PI3K-Akt signaling pathway | 1.08E-04 | 22 | P42338, P43657, P25116, P01106, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252 | PIK3CB, P2RY5, F2R, MYC, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.744 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P01106 | MYC | Myc proto-oncogene protein | -0.707 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P09603 | CSF1 | Macrophage colony-stimulating factor 1 | 0.73 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P20827 | EFNA1 | Ephrin-A1 | -0.872 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.871 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | Q9GZP0 | PDGFD | Platelet-derived growth factor D | -0.7 | | P17252 | PRKCA | Protein kinase C alpha type | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.745 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.813 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.779 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P13612 | ITGA4 | Integrin alpha-4 | -0.804 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P16144 | ITGB4 | Integrin beta-4 | -0.705 | | P17252 | PRKCA | Protein kinase C alpha type | P16144 | ITGB4 | Integrin beta-4 | 0.755 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O15335 | CHAD | Chondroadherin | -0.719 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.705 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.867 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.701 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 |
| | Thiabendazole | hsa04152 | AMPK signaling pathway | 1.83E-02 | 3 | Q96RR4, Q13362, Q14738 | CAMKK2, PPP2R5C, PPP2R5D | More | | | Thiabendazole | hsa04210 | Apoptosis | 3.77E-02 | 8 | Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643 | ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1 | More | | | Thiabendazole | hsa04211 | Longevity regulating pathway | 1.88E-02 | 4 | P31751, Q08828, P51828, P18848 | AKT2, ADCY1, ADCY7, ATF4 | More | | | Thiabendazole | hsa04213 | Longevity regulating pathway - multiple species | 3.11E-03 | 4 | P31751, Q08828, P51828, P0DMV8 | AKT2, ADCY1, ADCY7, HSPA1A | More | | | Thiabendazole | hsa04217 | Necroptosis | 9.98E-08 | 18 | P01375, P01568, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P01584, Q6FI13, Q99878, P10415, Q9H444, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, PPID | More | | | Thiabendazole | hsa04260 | Cardiac muscle contraction | 4.49E-02 | 3 | P67936, P13073, P12074 | TPM4, COX4I1, COX6A1 | More | | | Thiabendazole | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.64E-06 | 13 | P09493, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P17252, P10415, P23634 | TPM1, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4 | More | | | Thiabendazole | hsa04270 | Vascular smooth muscle contraction | 8.40E-04 | 10 | P24723, Q04759, Q14643, P0DP23, Q08828, P51828, P22694, P35579, P35749, P35318 | PRKCH, PRKCQ, ITPR1, CALM1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADM | More | | | Thiabendazole | hsa04310 | Wnt signaling pathway | 1.79E-02 | 2 | P17612, P67870 | PRKACA, CSNK2B | More | | | Thiabendazole | hsa04330 | Notch signaling pathway | 9.62E-04 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | | | Thiabendazole | hsa04340 | Hedgehog signaling pathway | 1.95E-03 | 5 | P49841, P17612, P22694, Q13635, P10415 | GSK3B, PRKACA, PRKACB, PTCH1, BCL2 | More | | | Thiabendazole | hsa04360 | Axon guidance | 2.13E-03 | 7 | P16333, P20827, O95631, P17252, P42338, P23528, P19174 | NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1 | More | | | Thiabendazole | hsa04370 | VEGF signaling pathway | 8.49E-07 | 6 | P19174, P16298, P42338, P17252, Q05397, Q02750 | PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1 | More | | | Thiabendazole | hsa04371 | Apelin signaling pathway | 3.94E-02 | 4 | P31751, Q08828, P51828, P0DP23 | AKT2, ADCY1, ADCY7, CALM1 | More | | | Thiabendazole | hsa04380 | Osteoclast differentiation | 5.27E-04 | 10 | Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149 | CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Thiabendazole | hsa04390 | Hippo signaling pathway | 5.79E-03 | 4 | P04628, Q9UJU2, O43623, Q13489 | WNT1, LEF1, SNAI2, BIRC3 | More | | | Thiabendazole | hsa04392 | Hippo signaling pathway - multiple species | 3.01E-02 | 1 | Q6V0I7 | FAT4 | More | | | Thiabendazole | hsa04510 | Focal adhesion | 7.77E-03 | 9 | P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767 | ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFC | More | | | Thiabendazole | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Thiabendazole | hsa04540 | Gap junction | 1.29E-02 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Thiabendazole | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 4.73E-02 | 3 | Q13873, Q02750, Q86SE9 | BMPR2, MAP2K1, PCGF5 | More | | | Thiabendazole | hsa04610 | Complement and coagulation cascades | 4.27E-06 | 1 | P0C0L4 | C4A | More | | | Thiabendazole | hsa04611 | Platelet activation | 2.12E-02 | 2 | Q9Y490, P17612 | TLN1, PRKACA | More | | | Thiabendazole | hsa04612 | Antigen processing and presentation | 9.91E-09 | 10 | P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNF | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P05164 | MPO | Myeloperoxidase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.85 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.734 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P48382 | RFX5 | DNA-binding protein RFX5 | -0.747 | | P05164 | MPO | Myeloperoxidase | P48382 | RFX5 | DNA-binding protein RFX5 | -0.851 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P48382 | RFX5 | DNA-binding protein RFX5 | -0.874 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | | P05164 | MPO | Myeloperoxidase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.82 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.867 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.915 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.726 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | | P05164 | MPO | Myeloperoxidase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.82 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.867 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.915 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.726 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.718 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.829 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | | P05164 | MPO | Myeloperoxidase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.775 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.941 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.78 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O43908 | KLRC4 | NKG2-F type II integral membrane protein | -0.718 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43908 | KLRC4 | NKG2-F type II integral membrane protein | -0.792 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.704 | | P05164 | MPO | Myeloperoxidase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.803 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.892 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.763 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P01375 | TNF | Tumor necrosis factor | -0.783 |
| | Thiabendazole | hsa04613 | Neutrophil extracellular trap formation | 5.63E-07 | 21 | P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05164 | MPO | Myeloperoxidase | 0.717 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | P17252 | PRKCA | Protein kinase C alpha type | P08246 | ELA2 | Neutrophil elastase | -0.735 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.736 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P22894 | MMP8 | Neutrophil collagenase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.877 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.759 | | P17252 | PRKCA | Protein kinase C alpha type | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.83 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P22894 | MMP8 | Neutrophil collagenase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.909 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P17252 | PRKCA | Protein kinase C alpha type | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.783 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.706 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P22894 | MMP8 | Neutrophil collagenase | P20160 | AZU1 | Azurocidin | 0.824 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P22894 | MMP8 | Neutrophil collagenase | P08311 | CTSG | Cathepsin G | 0.8 | | P22894 | MMP8 | Neutrophil collagenase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.7 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.923 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P22894 | MMP8 | Neutrophil collagenase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.756 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.779 | | P17252 | PRKCA | Protein kinase C alpha type | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.731 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P22894 | MMP8 | Neutrophil collagenase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.88 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O43315 | AQP9 | Aquaporin-9 | 0.918 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.839 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Thiabendazole | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | | Thiabendazole | hsa04621 | NOD-like receptor signaling pathway | 1.38E-03 | 13 | P01584, P07900, Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838 | IL1B, HSP90AA1, MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4 | More | | | Thiabendazole | hsa04622 | RIG-I-like receptor signaling pathway | 3.39E-02 | 2 | Q12933, P10145 | TRAF2, IL8 | More | | | Thiabendazole | hsa04623 | Cytosolic DNA-sensing pathway | 5.31E-10 | 6 | P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4 | IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2 | More | | | Thiabendazole | hsa04625 | C-type lectin receptor signaling pathway | 1.14E-03 | 8 | Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539 | CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14 | More | | | Thiabendazole | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | | Thiabendazole | hsa04640 | Hematopoietic cell lineage | 3.98E-07 | 15 | P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603 | ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1 | More | | | Thiabendazole | hsa04650 | Natural killer cell mediated cytotoxicity | 1.94E-13 | 15 | P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715 | PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q05397 | PTK2 | Focal adhesion kinase 1 | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.919 | | P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | Q05397 | PTK2 | Focal adhesion kinase 1 | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.849 | | P11511 | CYP19A1 | Aromatase | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.701 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P01375 | TNF | Tumor necrosis factor | -0.783 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.769 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.786 | | P06239 | LCK | Tyrosine-protein kinase Lck | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.906 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.922 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.707 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.881 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 | | Q05397 | PTK2 | Focal adhesion kinase 1 | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.898 | | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.941 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.78 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.773 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.886 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.858 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.767 | | P06239 | LCK | Tyrosine-protein kinase Lck | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.732 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.818 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.892 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.716 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.915 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.726 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.718 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.829 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.915 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.726 |
| | Thiabendazole | hsa04657 | IL-17 signaling pathway | 1.21E-06 | 9 | P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584 | HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B | More | | | Thiabendazole | hsa04658 | Th1 and Th2 cell differentiation | 8.00E-17 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q04759 | PRKCQ | Protein kinase C theta type | 0.869 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.734 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.881 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.731 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.702 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.769 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.821 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.878 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.849 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.858 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.705 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.701 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.734 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | P43250 | GRK6 | G protein-coupled receptor kinase 6 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.828 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.702 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.73 |
| | Thiabendazole | hsa04659 | Th17 cell differentiation | 1.09E-10 | 17 | P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q04759 | PRKCQ | Protein kinase C theta type | 0.869 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.734 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.769 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.841 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.734 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.748 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.858 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.705 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.878 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.849 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.731 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.812 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.881 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 |
| | Thiabendazole | hsa04660 | T cell receptor signaling pathway | 5.64E-09 | 14 | P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P01375 | TNF | Tumor necrosis factor | -0.783 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q04759 | PRKCQ | Protein kinase C theta type | 0.869 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.737 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.808 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.881 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.797 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.731 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.812 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.892 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.763 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.795 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.769 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.771 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 |
| | Thiabendazole | hsa04662 | B cell receptor signaling pathway | 1.49E-03 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Thiabendazole | hsa04664 | Fc epsilon RI signaling pathway | 1.09E-05 | 8 | P01375, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917 | TNF, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5 | More | | | Thiabendazole | hsa04666 | Fc gamma R-mediated phagocytosis | 5.03E-05 | 8 | O75015, P42338, P19174, P23528, P06396, O14494, P14598, P17252 | FCGR3B, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCA | More | | | Thiabendazole | hsa04668 | TNF signaling pathway | 2.47E-03 | 8 | P01375, O00463, Q16539, Q99941, P01584, P20749, P14780, O95429 | TNF, TRAF5, MAPK14, CREBL1, IL1B, BCL3, MMP9, BAG4 | More | | | Thiabendazole | hsa04672 | Intestinal immune network for IgA production | 1.24E-04 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Thiabendazole | hsa04710 | Circadian rhythm | 4.40E-02 | 1 | O15516 | CLOCK | More | | | Thiabendazole | hsa04713 | Circadian entrainment | 5.47E-06 | 12 | O15399, P0DP23, Q13557, Q02153, P17252, P62873, P50151, P61952, Q14643, Q08828, P51828, P63092 | GRIN2D, CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG10, GNG11, ITPR1, ADCY1, ADCY7, GNAS | More | | | Thiabendazole | hsa04720 | Long-term potentiation | 1.96E-05 | 8 | P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, Q14643 | PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, ITPR1 | More | | | Thiabendazole | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Thiabendazole | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Thiabendazole | hsa04724 | Glutamatergic synapse | 1.44E-04 | 6 | O15399, P17252, P62873, P63218, P50151, P15104 | GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL | More | | | Thiabendazole | hsa04725 | Cholinergic synapse | 1.94E-06 | 12 | Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, P42338, P31751, P10415 | ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, PIK3CB, AKT2, BCL2 | More | | | Thiabendazole | hsa04726 | Serotonergic synapse | 2.54E-02 | 5 | P17252, P62873, P50151, P33260, P09917 | PRKCA, GNB1, GNG10, CYP2C18, ALOX5 | More | | | Thiabendazole | hsa04727 | GABAergic synapse | 5.11E-04 | 5 | P62873, P63218, P50151, P15104, P17252 | GNB1, GNG5, GNG10, GLUL, PRKCA | More | | | Thiabendazole | hsa04728 | Dopaminergic synapse | 6.24E-06 | 13 | P63092, Q14643, P17252, P62873, P61952, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23, O15516 | GNAS, ITPR1, PRKCA, GNB1, GNG11, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1, CLOCK | More | | | Thiabendazole | hsa04742 | Taste transduction | 3.91E-02 | 1 | P17612 | PRKACA | More | | | Thiabendazole | hsa04744 | Phototransduction | 5.31E-06 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Thiabendazole | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.22E-04 | 5 | P01584, Q08828, P51828, Q13557, P0DP23 | IL1B, ADCY1, ADCY7, CAMK2D, CALM1 | More | | | Thiabendazole | hsa04911 | Insulin secretion | 1.10E-04 | 6 | Q08828, P51828, P63092, Q99941, P18848, Q13557 | ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2D | More | | | Thiabendazole | hsa04912 | GnRH signaling pathway | 1.52E-03 | 6 | P17252, Q08828, P51828, P18848, Q14643, P0DP23 | PRKCA, ADCY1, ADCY7, ATF4, ITPR1, CALM1 | More | | | Thiabendazole | hsa04914 | Progesterone-mediated oocyte maturation | 5.49E-05 | 9 | Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750 | CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Thiabendazole | hsa04915 | Estrogen signaling pathway | 4.79E-05 | 14 | P14780, P22694, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, Q15788, P10415 | MMP9, PRKACB, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, NCOA1, BCL2 | More | | | Thiabendazole | hsa04916 | Melanogenesis | 3.52E-04 | 8 | P0DP23, Q9UJU2, Q08828, P51828, P17252, P49841, Q01726, P04628 | CALM1, LEF1, ADCY1, ADCY7, PRKCA, GSK3B, MC1R, WNT1 | More | | | Thiabendazole | hsa04918 | Thyroid hormone synthesis | 3.50E-02 | 3 | P22694, P18848, Q14643 | PRKACB, ATF4, ITPR1 | More | | | Thiabendazole | hsa04921 | Oxytocin signaling pathway | 3.13E-02 | 3 | P0DP23, Q96RR4, Q13469 | CALM1, CAMKK2, NFATC2 | More | | | Thiabendazole | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Thiabendazole | hsa04923 | Regulation of lipolysis in adipocytes | 5.15E-03 | 3 | Q08828, P51828, P31751 | ADCY1, ADCY7, AKT2 | More | | | Thiabendazole | hsa04924 | Renin secretion | 4.33E-04 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Thiabendazole | hsa04925 | Aldosterone synthesis and secretion | 1.35E-04 | 7 | Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634 | CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4 | More | | | Thiabendazole | hsa04926 | Relaxin signaling pathway | 2.26E-05 | 12 | P31751, P25963, P42338, P62873, P63218, P50151, P18848, P49767, Q08828, P51828, P17252, P49407 | AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, ARRB1 | More | | | Thiabendazole | hsa04927 | Cortisol synthesis and secretion | 5.17E-04 | 5 | Q14643, P18848, Q08828, P51828, P22694 | ITPR1, ATF4, ADCY1, ADCY7, PRKACB | More | | | Thiabendazole | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.13E-02 | 5 | Q14643, P22694, P23771, P18848, P10415 | ITPR1, PRKACB, GATA3, ATF4, BCL2 | More | | | Thiabendazole | hsa04929 | GnRH secretion | 4.62E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | | | Thiabendazole | hsa04932 | Non-alcoholic fatty liver disease | 1.32E-07 | 12 | P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298 | AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2 | More | | | Thiabendazole | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.26E-03 | 7 | P42224, P10415, P42338, Q12778, P49767, P17252, P19174 | STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1 | More | | | Thiabendazole | hsa04934 | Cushing syndrome | 2.34E-05 | 7 | Q99941, P18848, Q08828, P51828, P63092, O15169, Q13557 | CREBL1, ATF4, ADCY1, ADCY7, GNAS, AXIN1, CAMK2D | More | | | Thiabendazole | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Thiabendazole | hsa04940 | Type I diabetes mellitus | 2.61E-03 | 4 | P10747, P48023, P13765, P01375 | CD28, FASLG, HLA-DOB, TNF | More | | | Thiabendazole | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.40E-02 | 1 | O00141 | SGK | More | | | Thiabendazole | hsa04964 | Proximal tubule bicarbonate reclamation | 2.17E-03 | 1 | P00918 | CA2 | More | | | Thiabendazole | hsa04966 | Collecting duct acid secretion | 1.26E-04 | 3 | Q13488, P00918, Q9Y666 | TCIRG1, CA2, SLC12A7 | More | | | Thiabendazole | hsa04970 | Salivary secretion | 1.89E-03 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | | | Thiabendazole | hsa04971 | Gastric acid secretion | 9.27E-05 | 5 | Q08828, P51828, P15311, P0DP23, Q13557 | ADCY1, ADCY7, VIL2, CALM1, CAMK2D | More | | | Thiabendazole | hsa04976 | Bile secretion | 2.10E-04 | 6 | O43315, Q08828, P51828, P22694, P08183, Q14032 | AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT | More | | | Thiabendazole | hsa04979 | Cholesterol metabolism | 1.61E-02 | 2 | P38571, P61916 | LIPA, NPC2 | More | | | Thiabendazole | hsa05010 | Alzheimer disease | 4.90E-06 | 24 | Q92542, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, O95197, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P45880, Q08752, P28070 | NCSTN, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PPID, PSMB4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q92542 | NCSTN | Nicastrin | 0.706 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.721 | | P17252 | PRKCA | Protein kinase C alpha type | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.811 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.822 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P05496 | ATP5G1 | ATP synthase F(0) complex subunit C1, mitochondrial | 0.733 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.778 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.754 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.847 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 0.783 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.731 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.733 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P0DP23 | CALM1 | Calmodulin-1 | 0.762 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P01584 | IL1B | Interleukin-1 beta | 0.75 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P01584 | IL1B | Interleukin-1 beta | 0.762 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | O95197 | RTN3 | Reticulon-3 | 0.702 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O15169 | AXIN1 | Axin-1 | 0.742 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P67870 | CSNK2B | Casein kinase II subunit beta | 0.709 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P45880 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | 0.708 | | P17252 | PRKCA | Protein kinase C alpha type | Q08752 | PPID | Peptidyl-prolyl cis-trans isomerase D | 0.725 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.778 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 |
| | Thiabendazole | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Thiabendazole | hsa05016 | Huntington disease | 1.76E-03 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | | | Thiabendazole | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | | Thiabendazole | hsa05020 | Prion disease | 8.68E-05 | 16 | P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q92736, Q14643, P45880, O60282, Q13509, P68371, Q99941, P14598, Q15080 | IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, ITPR1, VDAC2, KIF5C, TUBB3, TUBB2C, CREBL1, NCF1, NCF4 | More | | | Thiabendazole | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.86E-04 | 20 | Q14643, Q13509, P68371, P10415, Q16718, O95298, O14521, Q06055, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q00535, P01584, Q08752, O15020, P0DP23, P28070 | ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, NDUFC2, SDHD, ATP5G2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, IL1B, PPID, SPTBN2, CALM1, PSMB4 | More | | | Thiabendazole | hsa05031 | Amphetamine addiction | 4.88E-02 | 3 | Q13557, P63092, Q99941 | CAMK2D, GNAS, CREBL1 | More | | | Thiabendazole | hsa05032 | Morphine addiction | 4.41E-04 | 7 | P62873, P63218, P50151, Q13370, Q07343, P17252, P43250 | GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6 | More | | | Thiabendazole | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Thiabendazole | hsa05100 | Bacterial invasion of epithelial cells | 2.85E-02 | 3 | Q14141, Q05397, Q96JJ3 | SEPT6, PTK2, ELMO2 | More | | | Thiabendazole | hsa05110 | Vibrio cholerae infection | 5.33E-04 | 5 | Q13488, Q99437, P17252, P19174, P17612 | TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACA | More | | | Thiabendazole | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.32E-03 | 4 | Q16539, P09341, P25024, P25025 | MAPK14, CXCL1, CXCR1, CXCR2 | More | | | Thiabendazole | hsa05131 | Shigellosis | 2.27E-02 | 8 | P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Thiabendazole | hsa05132 | Salmonella infection | 6.53E-06 | 13 | P51617, Q9UJU2, O00471, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371 | IRAK1, LEF1, EXOC5, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C | More | | | Thiabendazole | hsa05133 | Pertussis | 3.02E-03 | 1 | P0C0L4 | C4A | More | | | Thiabendazole | hsa05134 | Legionellosis | 2.82E-02 | 3 | P01584, Q9NR31, P0DMV8 | IL1B, SAR1A, HSPA1A | More | | | Thiabendazole | hsa05135 | Yersinia infection | 3.29E-02 | 4 | Q05397, P51812, Q02750, Q96JJ3 | PTK2, RPS6KA3, MAP2K1, ELMO2 | More | | | Thiabendazole | hsa05140 | Leishmaniasis | 7.96E-08 | 12 | P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | | Thiabendazole | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Thiabendazole | hsa05144 | Malaria | 1.16E-04 | 7 | P60033, P69905, P68871, O60603, P01375, P35443, P26718 | CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | | Thiabendazole | hsa05145 | Toxoplasmosis | 1.19E-03 | 10 | P25963, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965 | NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LG | More | | | Thiabendazole | hsa05146 | Amoebiasis | 2.46E-09 | 9 | P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311 | CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.771 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.927 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.796 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.822 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.953 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.779 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.813 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P01375 | TNF | Tumor necrosis factor | 0.761 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P01375 | TNF | Tumor necrosis factor | -0.783 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.762 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P05089 | ARG1 | Arginase-1 | 0.819 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05089 | ARG1 | Arginase-1 | 0.881 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | P06239 | LCK | Tyrosine-protein kinase Lck | P05089 | ARG1 | Arginase-1 | -0.803 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P05089 | ARG1 | Arginase-1 | -0.905 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P05089 | ARG1 | Arginase-1 | -0.703 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.708 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.826 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.894 | | P06239 | LCK | Tyrosine-protein kinase Lck | P12814 | ACTN1 | Alpha-actinin-1 | -0.867 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P12814 | ACTN1 | Alpha-actinin-1 | -0.76 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.8 | | Q16769 | QPCT | Glutaminyl-peptide cyclotransferase | P08311 | CTSG | Cathepsin G | 0.715 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P06239 | LCK | Tyrosine-protein kinase Lck | P08311 | CTSG | Cathepsin G | -0.816 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P08311 | CTSG | Cathepsin G | -0.898 | | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P08311 | CTSG | Cathepsin G | -0.733 |
| | Thiabendazole | hsa05150 | Staphylococcus aureus infection | 1.34E-04 | 11 | P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P49913 | C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMP | More | | | Thiabendazole | hsa05152 | Tuberculosis | 7.25E-07 | 13 | Q13488, P0DP23, O75015, P42224, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617 | TCIRG1, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1 | More | | | Thiabendazole | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Thiabendazole | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Thiabendazole | hsa05163 | Human cytomegalovirus infection | 4.05E-09 | 25 | P31751, P42338, P01375, P25963, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568 | AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P0DP23 | CALM1 | Calmodulin-1 | 0.762 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.727 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.727 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.829 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.847 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P01584 | IL1B | Interleukin-1 beta | 0.762 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | P61073 | CXCR4 | C-X-C chemokine receptor type 4 | 0.774 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | P62942 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.769 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.739 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 |
| | Thiabendazole | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | | Thiabendazole | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Thiabendazole | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | | Thiabendazole | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 6.73E-06 | 17 | P01568, P42224, P25963, P42338, P40189, P23458, P62873, P62879, P50151, P19174, Q13469, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2 | IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, JAK1, GNB1, GNB2, GNG10, PLCG1, NFATC2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1 | More | | | Thiabendazole | hsa05168 | Herpes simplex virus 1 infection | 1.03E-03 | 17 | P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212 | More | | | Thiabendazole | hsa05169 | Epstein-Barr virus infection | 1.01E-04 | 14 | P13765, P01106, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, O75293, O60603, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q13547 | HDAC1 | Histone deacetylase 1 | -0.774 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13547 | HDAC1 | Histone deacetylase 1 | 0.811 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q13547 | HDAC1 | Histone deacetylase 1 | -0.727 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.788 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.735 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.708 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.768 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60603 | TLR2 | Toll-like receptor 2 | 0.72 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.77 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 |
| | Thiabendazole | hsa05170 | Human immunodeficiency virus 1 infection | 7.17E-08 | 23 | P42338, Q02750, P62873, P62879, P50151, P16298, P0DP23, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, P10415, Q93034, Q9Y6Q5, P20333 | PIK3CB, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, CUL5, AP1M2, TNFRSF1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P11511 | CYP19A1 | Aromatase | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0.704 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P11511 | CYP19A1 | Aromatase | Q05397 | PTK2 | Focal adhesion kinase 1 | 0.75 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.739 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P23528 | CFL1 | Cofilin-1 | -0.853 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P17252 | PRKCA | Protein kinase C alpha type | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.829 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 | | P11511 | CYP19A1 | Aromatase | P20333 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | -0.75 |
| | Thiabendazole | hsa05171 | Coronavirus disease - COVID-19 | 4.35E-03 | 14 | P01584, P25963, P42224, P01568, P62753, P36578, P62888, P61927, P61513, P62829, P40189, P42338, P19174, P17252 | IL1B, NFKBIA, STAT1, IFNA21, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23, IL6ST, PIK3CB, PLCG1, PRKCA | More | | | Thiabendazole | hsa05200 | Pathways in cancer | 3.54E-05 | 25 | Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P10826, P14923, P10415, Q13489, P49767, P14921, Q12778, P25116, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, RARB, JUP, BCL2, BIRC3, VEGFC, ETS1, FOXO1, F2R, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.705 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.743 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.802 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.841 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.73 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.785 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P17252 | PRKCA | Protein kinase C alpha type | -0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.925 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P10826 | RARB | Retinoic acid receptor beta | 0.779 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14923 | JUP | Junction plakoglobin | -0.716 | | P17252 | PRKCA | Protein kinase C alpha type | P14923 | JUP | Junction plakoglobin | 0.761 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.747 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.871 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14921 | ETS1 | Protein C-ets-1 | 0.731 | | P17252 | PRKCA | Protein kinase C alpha type | Q12778 | FOXO1 | Forkhead box protein O1 | 0.863 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.837 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.712 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | -0.703 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.919 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P0DP23 | CALM1 | Calmodulin-1 | 0.926 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P01568 | IFNA21 | Interferon alpha-21 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.865 | | O95271 | TNKS | Poly [ADP-ribose] polymerase tankyrase-1 | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.748 |
| | Thiabendazole | hsa05202 | Transcriptional misregulation in cancer | 2.25E-06 | 20 | Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P05164 | MPO | Myeloperoxidase | Q15532 | SS18 | Protein SSXT | -0.719 | | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | P05164 | MPO | Myeloperoxidase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.869 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.813 | | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P05164 | MPO | Myeloperoxidase | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.844 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.762 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | O15550 | UTX | Lysine-specific demethylase 6A | 0.763 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P05164 | MPO | Myeloperoxidase | P05164 | MPO | Myeloperoxidase | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P05164 | MPO | Myeloperoxidase | -0.867 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P05164 | MPO | Myeloperoxidase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.733 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P12838 | DEFA4 | Neutrophil defensin 4 | -0.852 | | P05164 | MPO | Myeloperoxidase | P08246 | ELA2 | Neutrophil elastase | 0.903 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P08246 | ELA2 | Neutrophil elastase | -0.742 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P05164 | MPO | Myeloperoxidase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.822 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q13547 | HDAC1 | Histone deacetylase 1 | 0.83 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P12980 | LYL1 | Protein lyl-1 | -0.73 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q92630 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.787 |
| | Thiabendazole | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Thiabendazole | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Thiabendazole | hsa05205 | Proteoglycans in cancer | 1.09E-02 | 10 | Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962 | TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63 | More | | | Thiabendazole | hsa05206 | MicroRNAs in cancer | 2.97E-03 | 6 | P15311, P21860, P61978, P46531, P63279, P22105 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB | More | | | Thiabendazole | hsa05212 | Pancreatic cancer | 2.33E-03 | 3 | P31751, Q15311, P23458 | AKT2, RALBP1, JAK1 | More | | | Thiabendazole | hsa05213 | Endometrial cancer | 4.72E-03 | 3 | O15169, Q13418, Q02750 | AXIN1, ILK, MAP2K1 | More | | | Thiabendazole | hsa05214 | Glioma | 2.73E-03 | 5 | P0DP23, P17252, P42338, P19174, O75293 | CALM1, PRKCA, PIK3CB, PLCG1, GADD45B | More | | | Thiabendazole | hsa05217 | Basal cell carcinoma | 4.31E-02 | 2 | P04628, Q9UJU2 | WNT1, LEF1 | More | | | Thiabendazole | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Thiabendazole | hsa05222 | Small cell lung cancer | 1.10E-02 | 6 | P10826, P42338, Q13751, Q13489, P25963, O75293 | RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45B | More | | | Thiabendazole | hsa05223 | Non-small cell lung cancer | 4.91E-03 | 5 | P17252, P42338, P19174, P10826, O75293 | PRKCA, PIK3CB, PLCG1, RARB, GADD45B | More | | | Thiabendazole | hsa05224 | Breast cancer | 4.75E-02 | 4 | P49841, Q92837, P04637, P24522 | GSK3B, FRAT1, TP53, GADD45A | More | | | Thiabendazole | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Thiabendazole | hsa05231 | Choline metabolism in cancer | 4.50E-04 | 8 | P31751, P42338, Q9Y259, P19174, P23743, Q16760, O14986, P17252 | AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKD, PIP5K1B, PRKCA | More | | | Thiabendazole | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 3.94E-06 | 9 | O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730 | RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4 | More | | | Thiabendazole | hsa05310 | Asthma | 1.90E-05 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Thiabendazole | hsa05320 | Autoimmune thyroid disease | 2.92E-05 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Thiabendazole | hsa05321 | Inflammatory bowel disease | 8.47E-08 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Thiabendazole | hsa05322 | Systemic lupus erythematosus | 1.43E-08 | 16 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB | More | | | Thiabendazole | hsa05323 | Rheumatoid arthritis | 1.29E-02 | 4 | P13765, Q13488, P10747, O60603 | HLA-DOB, TCIRG1, CD28, TLR2 | More | | | Thiabendazole | hsa05330 | Allograft rejection | 1.04E-03 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Thiabendazole | hsa05332 | Graft-versus-host disease | 1.80E-08 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | | Thiabendazole | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Thiabendazole | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 2.17E-03 | 1 | P54284 | CACNB3 | More | | | Thiabendazole | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Thiabendazole | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | | | Thiabendazole | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Thiabendazole | hsa05418 | Fluid shear stress and atherosclerosis | 2.60E-05 | 8 | Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2 | More | |
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