PharmaCoNets of Theophylline (SPCN: 111.95 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Theophyllinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Theophyllinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Theophyllinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Theophyllinehsa00190Oxidative phosphorylation4.21E-044Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Theophyllinehsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Theophyllinehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Theophyllinehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Theophyllinehsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Theophyllinehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Theophyllinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Theophyllinehsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Theophyllinehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Theophyllinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Theophyllinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Theophyllinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Theophyllinehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Theophyllinehsa00980Metabolism of xenobiotics by cytochrome P4504.50E-021P28332ADH6More
Theophyllinehsa00982Drug metabolism - cytochrome P4504.50E-021P28332ADH6More
Theophyllinehsa00983Drug metabolism - other enzymes4.57E-043P04183, P32320, P05164TK1, CDA, MPOMore
Theophyllinehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Theophyllinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Theophyllinehsa01230Biosynthesis of amino acids1.42E-045P51854, P60891, Q99707, P15104, P37837TKTL1, PRPS1, MTR, GLUL, TALDO1More
Theophyllinehsa01522Endocrine resistance5.79E-036P22694, Q02750, Q9UM47, P46527, P10415, Q13323PRKACB, MAP2K1, NOTCH3, CDKN1B, BCL2, BIKMore
Theophyllinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Theophyllinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Theophyllinehsa03013RNA transport1.89E-0816O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1More
Theophyllinehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Theophyllinehsa03040Spliceosome9.53E-0411Q14562, O43143, P17844, O75940, P51991, P61978, O75494, Q07955, Q01130, Q13243, P11142DHX8, DHX15, DDX5, SMNDC1, HNRPA3, HNRPK, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8More
Theophyllinehsa03050Proteasome4.83E-021P55036PSMD4More
Theophyllinehsa03060Protein export2.16E-022P37108, Q15005SRP14, SPCS2More
Theophyllinehsa03410Base excision repair7.59E-031P27695APEX1More
Theophyllinehsa03450Non-homologous end-joining1.02E-032P78527, P13010PRKDC, XRCC5More
Theophyllinehsa04014Ras signaling pathway2.21E-0312Q02750, P20827, Q15389, Q9NRA1, P49767, P17252, P21359, P0DP23, P62873, P62879, P19174, P22694MAP2K1, EFNA1, ANGPT1, PDGFC, VEGFC, PRKCA, NF1, CALM1, GNB1, GNB2, PLCG1, PRKACBMore
Theophyllinehsa04015Rap1 signaling pathway4.58E-026P20827, Q9NRA1, P49767, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1More
Theophyllinehsa04020Calcium signaling pathway2.54E-039P17252, P19174, P0DP24, P0DP23, P51828, P20020, P23634, Q9NRA1, P49767PRKCA, PLCG1, CALM2, CALM1, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Theophyllinehsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Theophyllinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Theophyllinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Theophyllinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Theophyllinehsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Theophyllinehsa04070Phosphatidylinositol signaling system4.40E-024P19174, P0DP23, P23743, P17252PLCG1, CALM1, DGKA, PRKCAMore
Theophyllinehsa04071Sphingolipid signaling pathway6.91E-046P21453, Q9H228, P01375, Q13510, Q13362, Q9UQC2S1PR1, EDG8, TNF, ASAH1, PPP2R5C, GAB2More
Theophyllinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Theophyllinehsa04080Neuroactive ligand-receptor interaction2.95E-048P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Theophyllinehsa04110Cell cycle1.35E-021P78527PRKDCMore
Theophyllinehsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Theophyllinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Theophyllinehsa04140Autophagy - animal3.14E-038Q7L523, Q96RR4, O75460, P22694, Q14643, P10415, Q96GC9, Q8TEV9RRAGA, CAMKK2, ERN1, PRKACB, ITPR1, BCL2, TMEM49, SMCR8More
Theophyllinehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Theophyllinehsa04142Lysosome3.80E-034Q99437, P08311, P25774, Q9UPM8ATP6V0B, CTSG, CTSS, AP4E1More
Theophyllinehsa04144Endocytosis1.67E-028P11142, Q9H444, Q9NZZ3, P62491, Q9Y6D6, Q14161, Q13636, Q96QK1HSPA8, CHMP4B, CHMP5, RAB11A, ARFGEF1, GIT2, RAB31, VPS35More
Theophyllinehsa04145Phagosome1.83E-027Q15080, P14598, Q13509, P68371, Q13488, Q99437, P25774NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, CTSSMore
Theophyllinehsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Theophyllinehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Theophyllinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Theophyllinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Theophyllinehsa04217Necroptosis1.36E-027P01568, P42224, P08238, Q6FI13, Q93077, O43633, Q08752IFNA21, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPIDMore
Theophyllinehsa04261Adrenergic signaling in cardiomyocytes4.86E-059P07550, P51828, P22694, Q99941, P18848, Q13362, P0DP24, Q13557, P23634ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CALM2, CAMK2D, ATP2B4More
Theophyllinehsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Theophyllinehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Theophyllinehsa04360Axon guidance2.29E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Theophyllinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Theophyllinehsa04540Gap junction8.54E-057P17252, P22694, Q13509, P68371, Q02750, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, PDGFC, ITPR1More
Theophyllinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Theophyllinehsa04612Antigen processing and presentation3.75E-048P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Theophyllinehsa04613Neutrophil extracellular trap formation4.72E-023P05164, P20160, P08311MPO, AZU1, CTSGMore
Theophyllinehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Theophyllinehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Theophyllinehsa04623Cytosolic DNA-sensing pathway3.29E-022P01568, P25963IFNA21, NFKBIAMore
Theophyllinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Theophyllinehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Theophyllinehsa04650Natural killer cell mediated cytotoxicity4.02E-0713P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Theophyllinehsa04657IL-17 signaling pathway8.78E-0512P25963, P08238, O00463, Q07955, Q16539, P49841, P19875, P14780, P04141, P80188, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9More
Theophyllinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Theophyllinehsa04659Th17 cell differentiation6.17E-0510Q04759, P19174, P06239, P14784, P14778, Q9HBE5, Q9UL17, P84022, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, IL21R, TBX21, SMAD3, CD3E, CD247More
Theophyllinehsa04660T cell receptor signaling pathway4.48E-0413P04141, P25963, Q04759, P42338, P10747, P19174, P16333, P07766, P20963, P01732, Q13191, P06239, P29350CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, PLCG1, NCK1, CD3E, CD247, CD8A, CBLB, LCK, PTPN6More
Theophyllinehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Theophyllinehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Theophyllinehsa04713Circadian entrainment3.32E-024P0DP23, P17252, P62873, O15055CALM1, PRKCA, GNB1, PER2More
Theophyllinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Theophyllinehsa04720Long-term potentiation1.09E-024P17252, P51812, P22694, Q02750PRKCA, RPS6KA3, PRKACB, MAP2K1More
Theophyllinehsa04725Cholinergic synapse1.65E-049P51828, P22694, Q14643, P17252, P62879, P18848, Q13557, P10415, Q02750ADCY7, PRKACB, ITPR1, PRKCA, GNB2, ATF4, CAMK2D, BCL2, MAP2K1More
Theophyllinehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Theophyllinehsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Theophyllinehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Theophyllinehsa04744Phototransduction1.18E-022P62873, P0DP23GNB1, CALM1More
Theophyllinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Theophyllinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Theophyllinehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Theophyllinehsa04913Ovarian steroidogenesis1.27E-032P42330, P22694AKR1C3, PRKACBMore
Theophyllinehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Theophyllinehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Theophyllinehsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Theophyllinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Theophyllinehsa04924Renin secretion2.90E-043P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Theophyllinehsa04925Aldosterone synthesis and secretion5.96E-056Q99941, P18848, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY7, CALM2, CAMK2D, ATP2B4More
Theophyllinehsa04926Relaxin signaling pathway2.06E-036Q99941, P18848, P22694, P14780, P51828, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, GNA15More
Theophyllinehsa04927Cortisol synthesis and secretion1.75E-055Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Theophyllinehsa04928Parathyroid hormone synthesis, secretion and action1.09E-0410Q14643, P51828, P22694, P23771, Q02750, P17252, Q99941, P18848, P10415, Q9Y5Q3ITPR1, ADCY7, PRKACB, GATA3, MAP2K1, PRKCA, CREBL1, ATF4, BCL2, MAFBMore
Theophyllinehsa04933AGE-RAGE signaling pathway in diabetic complications1.72E-025P42224, Q12778, P49767, P17252, P19174STAT1, FOXO1, VEGFC, PRKCA, PLCG1More
Theophyllinehsa04934Cushing syndrome2.44E-047Q14643, Q99941, P18848, P51828, P22694, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY7, PRKACB, CAMK2D, WNT1More
Theophyllinehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Theophyllinehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Theophyllinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Theophyllinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Theophyllinehsa04970Salivary secretion1.87E-068P07550, P51828, P22694, Q14643, P23634, P17252, P0DP24, P49913ADRB2, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CAMPMore
Theophyllinehsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Theophyllinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Theophyllinehsa05012Parkinson disease3.12E-026Q16718, O14521, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2CMore
Theophyllinehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Theophyllinehsa05020Prion disease3.28E-022Q92736, O60282RYR2, KIF5CMore
Theophyllinehsa05022Pathways of neurodegeneration - multiple diseases2.29E-029Q13509, P68371, Q16718, O14521, Q13561, P19174, P17252, Q08752, P0DP23TUBB3, TUBB2C, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, PPID, CALM1More
Theophyllinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Theophyllinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Theophyllinehsa05110Vibrio cholerae infection2.60E-034Q13488, Q99437, P17252, P19174TCIRG1, ATP6V0B, PRKCA, PLCG1More
Theophyllinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Theophyllinehsa05132Salmonella infection3.95E-0310P25963, P08238, O00471, P04406, O75369, Q13561, O60282, Q13509, P68371, P49754NFKBIA, HSP90AB1, EXOC5, GAPDH, FLNB, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41More
Theophyllinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Theophyllinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Theophyllinehsa05140Leishmaniasis1.72E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Theophyllinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Theophyllinehsa05144Malaria1.94E-046P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Theophyllinehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Theophyllinehsa05150Staphylococcus aureus infection1.19E-058P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Theophyllinehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Theophyllinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Theophyllinehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Theophyllinehsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Theophyllinehsa05167Kaposi sarcoma-associated herpesvirus infection5.71E-038P01568, P42224, P25963, P40189, P62873, P19174, P04141, P0DP23IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, CSF2, CALM1More
Theophyllinehsa05168Herpes simplex virus 1 infection4.15E-0312P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF140, ZNF189, ZNF212More
Theophyllinehsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Theophyllinehsa05200Pathways in cancer1.75E-0214P08238, P42224, P25963, P19174, P17252, P43246, P14923, P49767, Q12778, P62873, O75293, P0DP23, P01568, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, JUP, VEGFC, FOXO1, GNB1, GADD45B, CALM1, IFNA21, IL6STMore
Theophyllinehsa05202Transcriptional misregulation in cancer3.76E-027Q12778, Q13315, Q15744, P46527, P05164, P08246, Q9C0K0FOXO1, ATM, CEBPE, CDKN1B, MPO, ELA2, BCL11BMore
Theophyllinehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Theophyllinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Theophyllinehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Theophyllinehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Theophyllinehsa05214Glioma1.09E-024P0DP23, P17252, P19174, O75293CALM1, PRKCA, PLCG1, GADD45BMore
Theophyllinehsa05231Choline metabolism in cancer2.25E-035Q9NRA1, Q9Y259, P19174, P23743, P17252PDGFC, CHKB, PLCG1, DGKA, PRKCAMore
Theophyllinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.13E-0410P25963, P42338, P19174, P07766, P20963, P06239, P29350, P42224, P10747, Q04759NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, PTPN6, STAT1, CD28, PRKCQMore
Theophyllinehsa05310Asthma1.07E-023P13765, P29965, P12724HLA-DOB, CD40LG, RNASE3More
Theophyllinehsa05321Inflammatory bowel disease8.78E-045P01375, Q14765, Q9UL17, P84022, Q9HBE5TNF, STAT4, TBX21, SMAD3, IL21RMore
Theophyllinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Theophyllinehsa05340Primary immunodeficiency3.73E-022P11912, P16871CD79A, IL7RMore
Theophyllinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Theophyllinehsa05415Diabetic cardiomyopathy1.20E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Theophyllinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Theophylline (SDC: 5.91)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BReported00.02530.99460.222.2219
Q92769HDAC2Histone deacetylase 2Reported10.047310.9863.0097
P09874PARP1Poly [ADPNoneribose] polymerase 1Reported10.553610.44822.725
Q13231CHIT1ChitotriosidaseNone1Predicted00.03570.04290.19630.3
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
Q14790CASP8CaspaseNone8Predicted10.150.055811.1867
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
O75131CPNE3CopineNone3Predicted00.3080.004400.1628
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PDE4BQ07343IC5081000
PDE4BQ07343IC501780000
PDE4BQ07343IC50>200000
PDE4BQ07343Ki56800