PharmaCoNets of Tetryzoline (SPCN: 41.53 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tetryzolinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Tetryzolinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tetryzolinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tetryzolinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Tetryzolinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Tetryzolinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Tetryzolinehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tetryzolinehsa03015mRNA surveillance pathway1.37E-036Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBPMore
Tetryzolinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tetryzolinehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Tetryzolinehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Tetryzolinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Tetryzolinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Tetryzolinehsa04114Oocyte meiosis1.25E-037P51812, Q02750, P0DP23, P16298, Q17RY0, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PPP2R5C, PPP2R5DMore
Tetryzolinehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Tetryzolinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Tetryzolinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Tetryzolinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Tetryzolinehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Tetryzolinehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Tetryzolinehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Tetryzolinehsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Tetryzolinehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Tetryzolinehsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Tetryzolinehsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Tetryzolinehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Tetryzolinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Tetryzolinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Tetryzolinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Tetryzolinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Tetryzolinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Tetryzolinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Tetryzolinehsa04650Natural killer cell mediated cytotoxicity3.52E-0510P16298, P50591, P01375, P20963, Q02750, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Tetryzolinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Tetryzolinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Tetryzolinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tetryzolinehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Tetryzolinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tetryzolinehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Tetryzolinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Tetryzolinehsa04742Taste transduction7.70E-042P30939, P17612HTR1F, PRKACAMore
Tetryzolinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Tetryzolinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Tetryzolinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Tetryzolinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Tetryzolinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Tetryzolinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Tetryzolinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Tetryzolinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tetryzolinehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Tetryzolinehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Tetryzolinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Tetryzolinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Tetryzolinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tetryzolinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Tetryzolinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tetryzolinehsa05022Pathways of neurodegeneration - multiple diseases4.25E-038P49841, Q16718, O14521, Q06055, Q13561, Q16539, Q08752, O15020GSK3B, NDUFA5, SDHD, ATP5G2, DCTN2, MAPK14, PPID, SPTBN2More
Tetryzolinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Tetryzolinehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Tetryzolinehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Tetryzolinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Tetryzolinehsa05133Pertussis3.51E-021P0C0L4C4AMore
Tetryzolinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Tetryzolinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Tetryzolinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Tetryzolinehsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Tetryzolinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tetryzolinehsa05167Kaposi sarcoma-associated herpesvirus infection2.39E-037P23458, P62879, Q13469, P16298, Q02750, P0DP23, P0CG47JAK1, GNB2, NFATC2, PPP3CB, MAP2K1, CALM1, UBBMore
Tetryzolinehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Tetryzolinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Tetryzolinehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Tetryzolinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Tetryzolinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Tetryzolinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Tetryzolinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tetryzolinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Tetryzolinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Tetryzolinehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Tetryzolinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Tetryzoline (SDC: 4.69)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)