PharmaCoNets

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Chlortetracycline

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Chlortetracycline

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Chlortetracycline

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Chlortetracycline

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Chlortetracycline

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Chlortetracycline

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Chlortetracycline

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Chlortetracycline

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Chlortetracycline

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Chlortetracycline

hsa04015

Rap1 signaling pathway

4.78E-02

P09603, Q9GZP0, P11215, Q86WV1, P19174

CSF1, PDGFD, ITGAM, SKAP1, PLCG1

Chlortetracycline

NF-kappa B signaling pathway

9.28E-03

P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Chlortetracycline

Sphingolipid signaling pathway

4.78E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959

Chlortetracycline

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746

Chlortetracycline

Autophagy - animal

4.20E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756

Chlortetracycline

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Chlortetracycline

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797

Chlortetracycline

hsa04151

PI3K-Akt signaling pathway

1.27E-02

P43657, P01106, P09603, Q9GZP0, P63218, P50151, P13612, Q13751, P14784

P2RY5, MYC, CSF1, PDGFD, GNG5, GNG10, ITGA4, LAMB3, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701

Chlortetracycline

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Chlortetracycline

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Chlortetracycline

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Chlortetracycline

Antigen processing and presentation

1.94E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P61769	B2M	Beta-2-microglobulin	P61769	B2M	Beta-2-microglobulin	1
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	Q06323	PSME1	Proteasome activator complex subunit 1	0.707
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897

Chlortetracycline

Neutrophil extracellular trap formation

1.59E-05

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Chlortetracycline

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858

Chlortetracycline

Hematopoietic cell lineage

4.59E-03

P13612, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P09603

ITGA4, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73

Chlortetracycline

IL-17 signaling pathway

2.59E-03

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Chlortetracycline

Th1 and Th2 cell differentiation

2.06E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828

Chlortetracycline

T cell receptor signaling pathway

4.04E-05

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Chlortetracycline

hsa04664

Fc epsilon RI signaling pathway

3.15E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Chlortetracycline

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Chlortetracycline

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Chlortetracycline

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Chlortetracycline

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Chlortetracycline

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Chlortetracycline

Type I diabetes mellitus

2.91E-03

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Chlortetracycline

Salivary secretion

4.92E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Chlortetracycline

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Chlortetracycline

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Chlortetracycline

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Chlortetracycline

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Chlortetracycline

Morphine addiction

1.27E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Chlortetracycline

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P61769	B2M	Beta-2-microglobulin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.738
P61769	B2M	Beta-2-microglobulin	P0DP24	CALM2	Calmodulin-2	0.787
P61769	B2M	Beta-2-microglobulin	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Chlortetracycline

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Chlortetracycline

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963

Chlortetracycline

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Chlortetracycline

Amoebiasis

1.70E-03

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79

Chlortetracycline

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7

Chlortetracycline

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744

Chlortetracycline

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Chlortetracycline

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Chlortetracycline

Transcriptional misregulation in cancer

2.97E-04

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Chlortetracycline

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Chlortetracycline

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Chlortetracycline

Asthma

2.84E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Chlortetracycline

Inflammatory bowel disease

3.13E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751

Chlortetracycline

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725

Chlortetracycline

Rheumatoid arthritis

1.58E-02

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772

Chlortetracycline

Graft-versus-host disease

1.09E-05

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837

Chlortetracycline

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Oxytetracycline

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Oxytetracycline

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Oxytetracycline

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Oxytetracycline

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Oxytetracycline

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Oxytetracycline

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Oxytetracycline

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Oxytetracycline

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Oxytetracycline

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Oxytetracycline

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Oxytetracycline

hsa04015

Rap1 signaling pathway

4.78E-02

P09603, Q9GZP0, P11215, Q86WV1, P19174

CSF1, PDGFD, ITGAM, SKAP1, PLCG1

Oxytetracycline

NF-kappa B signaling pathway

9.28E-03

P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Oxytetracycline

Sphingolipid signaling pathway

4.78E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959

Oxytetracycline

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746

Oxytetracycline

Autophagy - animal

4.20E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756

Oxytetracycline

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Oxytetracycline

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797

Oxytetracycline

hsa04151

PI3K-Akt signaling pathway

1.27E-02

P43657, P01106, P09603, Q9GZP0, P63218, P50151, P13612, Q13751, P14784

P2RY5, MYC, CSF1, PDGFD, GNG5, GNG10, ITGA4, LAMB3, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701

Oxytetracycline

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Oxytetracycline

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Oxytetracycline

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Oxytetracycline

Antigen processing and presentation

1.94E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P61769	B2M	Beta-2-microglobulin	P61769	B2M	Beta-2-microglobulin	1
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	Q06323	PSME1	Proteasome activator complex subunit 1	0.707
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897

Oxytetracycline

Neutrophil extracellular trap formation

1.59E-05

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Oxytetracycline

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858

Oxytetracycline

Hematopoietic cell lineage

4.59E-03

P13612, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P09603

ITGA4, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73

Oxytetracycline

IL-17 signaling pathway

2.59E-03

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Oxytetracycline

Th1 and Th2 cell differentiation

2.06E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828

Oxytetracycline

T cell receptor signaling pathway

4.04E-05

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Oxytetracycline

hsa04664

Fc epsilon RI signaling pathway

3.15E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Oxytetracycline

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Oxytetracycline

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Oxytetracycline

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Oxytetracycline

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Oxytetracycline

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Oxytetracycline

Type I diabetes mellitus

2.91E-03

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Oxytetracycline

Salivary secretion

4.92E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Oxytetracycline

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Oxytetracycline

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Oxytetracycline

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Oxytetracycline

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Oxytetracycline

Morphine addiction

1.27E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Oxytetracycline

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P61769	B2M	Beta-2-microglobulin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.738
P61769	B2M	Beta-2-microglobulin	P0DP24	CALM2	Calmodulin-2	0.787
P61769	B2M	Beta-2-microglobulin	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Oxytetracycline

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Oxytetracycline

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963

Oxytetracycline

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Oxytetracycline

Amoebiasis

1.70E-03

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79

Oxytetracycline

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7

Oxytetracycline

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744

Oxytetracycline

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Oxytetracycline

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Oxytetracycline

Transcriptional misregulation in cancer

2.97E-04

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Oxytetracycline

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Oxytetracycline

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Oxytetracycline

Asthma

2.84E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Oxytetracycline

Inflammatory bowel disease

3.13E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751

Oxytetracycline

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725

Oxytetracycline

Rheumatoid arthritis

1.58E-02

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772

Oxytetracycline

Graft-versus-host disease

1.09E-05

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837

Oxytetracycline

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Rolitetracycline

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Rolitetracycline

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Rolitetracycline

hsa00600

Sphingolipid metabolism

1.34E-02

P07602, Q13510

PSAP, ASAH1

Rolitetracycline

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Rolitetracycline

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Rolitetracycline

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Rolitetracycline

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Rolitetracycline

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Rolitetracycline

hsa04020

Calcium signaling pathway

1.42E-02

Q13557, P0DP24, P05141

CAMK2D, CALM2, SLC25A5

Rolitetracycline

hsa04022

cGMP-PKG signaling pathway

2.24E-02

P18848, P05141, P0DP24

ATF4, SLC25A5, CALM2

Rolitetracycline

NF-kappa B signaling pathway

9.28E-03

P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Rolitetracycline

hsa04070

Phosphatidylinositol signaling system

4.48E-02

P0DP24, O14986

CALM2, PIP5K1B

Rolitetracycline

Sphingolipid signaling pathway

4.78E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959

Rolitetracycline

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746

Rolitetracycline

hsa04114

Oocyte meiosis

1.67E-02

Q13557, P0DP24, Q13362

CAMK2D, CALM2, PPP2R5C

Rolitetracycline

Autophagy - animal

4.20E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756

Rolitetracycline

hsa04142

Lysosome

2.91E-02

Q13510, P07602, P61916

ASAH1, PSAP, NPC2

Rolitetracycline

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797

Rolitetracycline

hsa04218

Cellular senescence

1.39E-03

P0DP24, P01889, P10321, P05141

CALM2, HLA-B, HLA-C, SLC25A5

Rolitetracycline

hsa04261

Adrenergic signaling in cardiomyocytes

2.17E-03

P18848, Q13362, P0DP24, Q13557

ATF4, PPP2R5C, CALM2, CAMK2D

Rolitetracycline

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Rolitetracycline

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Rolitetracycline

Antigen processing and presentation

8.65E-05

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P61769, P01889, P10321, Q06323, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, B2M, HLA-B, HLA-C, PSME1, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P61769	B2M	Beta-2-microglobulin	P61769	B2M	Beta-2-microglobulin	1
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	Q06323	PSME1	Proteasome activator complex subunit 1	0.707
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897

Rolitetracycline

Neutrophil extracellular trap formation

1.59E-05

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Rolitetracycline

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858

Rolitetracycline

Hematopoietic cell lineage

3.58E-02

P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73

Rolitetracycline

hsa04650

Natural killer cell mediated cytotoxicity

6.51E-03

Q29983, P10321, P01889

MICA, HLA-C, HLA-B

Rolitetracycline

IL-17 signaling pathway

3.91E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Rolitetracycline

Th1 and Th2 cell differentiation

4.81E-04

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828

Rolitetracycline

T cell receptor signaling pathway

4.04E-05

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Rolitetracycline

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Rolitetracycline

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Rolitetracycline

hsa04713

Circadian entrainment

2.91E-03

P0DP24, Q13557, P62873

CALM2, CAMK2D, GNB1

Rolitetracycline

hsa04720

Long-term potentiation

2.91E-03

Q13557, P0DP24, P18848

CAMK2D, CALM2, ATF4

Rolitetracycline

hsa04722

Neurotrophin signaling pathway

9.93E-03

P18848, Q13557, P0DP24

ATF4, CAMK2D, CALM2

Rolitetracycline

hsa04723

Retrograde endocannabinoid signaling

4.48E-02

P48169, P62873

GABRA4, GNB1

Rolitetracycline

hsa04725

Cholinergic synapse

5.11E-03

P62873, P18848, Q13557

GNB1, ATF4, CAMK2D

Rolitetracycline

hsa04728

Dopaminergic synapse

6.94E-05

P62873, P18848, Q13557, Q13362, P0DP24

GNB1, ATF4, CAMK2D, PPP2R5C, CALM2

Rolitetracycline

hsa04740

Olfactory transduction

1.10E-04

P62873, Q13557, P0DP24

GNB1, CAMK2D, CALM2

Rolitetracycline

hsa04744

Phototransduction

2.85E-03

P62873, P0DP24

GNB1, CALM2

Rolitetracycline

hsa04750

Inflammatory mediator regulation of TRP channels

4.48E-02

Q13557, P0DP24

CAMK2D, CALM2

Rolitetracycline

hsa04911

Insulin secretion

2.41E-02

P18848, Q13557

ATF4, CAMK2D

Rolitetracycline

hsa04912

GnRH signaling pathway

5.11E-03

P18848, Q13557, P0DP24

ATF4, CAMK2D, CALM2

Rolitetracycline

hsa04915

Estrogen signaling pathway

2.24E-02

P18848, P0DP24, Q15788

ATF4, CALM2, NCOA1

Rolitetracycline

hsa04916

Melanogenesis

2.41E-02

Q13557, P0DP24

CAMK2D, CALM2

Rolitetracycline

hsa04918

Thyroid hormone synthesis

4.48E-02

P18848, P05543

ATF4, SERPINA7

Rolitetracycline

hsa04922

Glucagon signaling pathway

5.11E-03

P18848, P0DP24, Q13557

ATF4, CALM2, CAMK2D

Rolitetracycline

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Rolitetracycline

hsa04925

Aldosterone synthesis and secretion

3.91E-03

P18848, P0DP24, Q13557

ATF4, CALM2, CAMK2D

Rolitetracycline

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Rolitetracycline

hsa04934

Cushing syndrome

3.73E-02

P18848, Q13557

ATF4, CAMK2D

Rolitetracycline

Type I diabetes mellitus

1.67E-03

P10747, P13765, P01889, P10321, P01375

CD28, HLA-DOB, HLA-B, HLA-C, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Rolitetracycline

Salivary secretion

4.92E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Rolitetracycline

hsa04971

Gastric acid secretion

2.41E-02

P0DP24, Q13557

CALM2, CAMK2D

Rolitetracycline

Parkinson disease

1.71E-02

P05141, P18848, P0DP24, Q13557

SLC25A5, ATF4, CALM2, CAMK2D

Rolitetracycline

hsa05031

Amphetamine addiction

1.41E-03

P0DP24, Q13557, P18848

CALM2, CAMK2D, ATF4

Rolitetracycline

Morphine addiction

2.41E-02

P62873, P48169

GNB1, GABRA4

Rolitetracycline

hsa05033

Nicotine addiction

3.19E-02

P48169

GABRA4

Rolitetracycline

Alcoholism

7.15E-05

P18848, P0DP24, P62873, Q93077, P62807, O60814, P68431

ATF4, CALM2, GNB1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P61769	B2M	Beta-2-microglobulin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.738
P61769	B2M	Beta-2-microglobulin	P0DP24	CALM2	Calmodulin-2	0.787
P61769	B2M	Beta-2-microglobulin	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Rolitetracycline

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963

Rolitetracycline

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Rolitetracycline

Amoebiasis

1.70E-03

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79

Rolitetracycline

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7

Rolitetracycline

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744

Rolitetracycline

hsa05163

Human cytomegalovirus infection

2.17E-04

P01889, P10321, P62873, P0DP24, P18848, P61769

HLA-B, HLA-C, GNB1, CALM2, ATF4, B2M

Rolitetracycline

hsa05166

Human T-cell leukemia virus 1 infection

5.66E-03

P01889, P10321, P05141, P18848, P61769

HLA-B, HLA-C, SLC25A5, ATF4, B2M

Rolitetracycline

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.27E-04

P01889, P10321, P62873, Q29983, P0DP24

HLA-B, HLA-C, GNB1, MICA, CALM2

Rolitetracycline

hsa05168

Herpes simplex virus 1 infection

2.09E-02

Q9UBU9, P01889, P10321, P61769

NXF1, HLA-B, HLA-C, B2M

Rolitetracycline

hsa05169

Epstein-Barr virus infection

3.28E-02

P01889, P10321, P61769

HLA-B, HLA-C, B2M

Rolitetracycline

hsa05170

Human immunodeficiency virus 1 infection

4.62E-04

P01889, P10321, P62873, P0DP24, P61769

HLA-B, HLA-C, GNB1, CALM2, B2M

Rolitetracycline

Transcriptional misregulation in cancer

2.97E-04

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Rolitetracycline

Viral carcinogenesis

2.77E-03

P18848, Q15283, P01889, P10321, P62807, O60814

ATF4, RASA2, HLA-B, HLA-C, HIST1H2BC, H2BC12

Rolitetracycline

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Rolitetracycline

hsa05214

Glioma

1.85E-02

P0DP24, Q13557

CALM2, CAMK2D

Rolitetracycline

Asthma

2.84E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Rolitetracycline

hsa05320

Autoimmune thyroid disease

2.41E-02

P01889, P10321

HLA-B, HLA-C

Rolitetracycline

Inflammatory bowel disease

3.13E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751

Rolitetracycline

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725

Rolitetracycline

Rheumatoid arthritis

1.58E-02

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772

Rolitetracycline

hsa05330

Allograft rejection

2.41E-02

P01889, P10321

HLA-B, HLA-C

Rolitetracycline

Graft-versus-host disease

6.35E-06

P13765, P01889, P10321, P10747, P01375, P26715, Q13241

HLA-DOB, HLA-B, HLA-C, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837

Rolitetracycline

hsa05416

Viral myocarditis

3.73E-02

P01889, P10321

HLA-B, HLA-C

Tetracycline

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Tetracycline

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Tetracycline

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Tetracycline

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Tetracycline

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Tetracycline

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Tetracycline

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Tetracycline

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Tetracycline

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Tetracycline

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Tetracycline

hsa04015

Rap1 signaling pathway

4.78E-02

P09603, Q9GZP0, P11215, Q86WV1, P19174

CSF1, PDGFD, ITGAM, SKAP1, PLCG1

Tetracycline

NF-kappa B signaling pathway

9.28E-03

P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Tetracycline

Sphingolipid signaling pathway

4.78E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.729
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.734
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.775
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959

Tetracycline

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746

Tetracycline

Autophagy - animal

4.20E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P22894	MMP8	Neutrophil collagenase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.753
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.843
P22894	MMP8	Neutrophil collagenase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.856
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.776
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9H1Y0	ATG5	Autophagy protein 5	-0.712
P22894	MMP8	Neutrophil collagenase	Q9H1Y0	ATG5	Autophagy protein 5	-0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756

Tetracycline

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Tetracycline

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797

Tetracycline

hsa04151

PI3K-Akt signaling pathway

1.27E-02

P43657, P01106, P09603, Q9GZP0, P63218, P50151, P13612, Q13751, P14784

P2RY5, MYC, CSF1, PDGFD, GNG5, GNG10, ITGA4, LAMB3, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701

Tetracycline

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Tetracycline

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Tetracycline

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Tetracycline

Antigen processing and presentation

1.94E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P61769	B2M	Beta-2-microglobulin	P61769	B2M	Beta-2-microglobulin	1
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	Q06323	PSME1	Proteasome activator complex subunit 1	0.707
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P48382	RFX5	DNA-binding protein RFX5	-0.782
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.874
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13241	KLRD1	Natural killer cells antigen CD94	-0.906
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897

Tetracycline

Neutrophil extracellular trap formation

1.59E-05

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Tetracycline

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858

Tetracycline

Hematopoietic cell lineage

4.59E-03

P13612, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P09603

ITGA4, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, CSF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13612	ITGA4	Integrin alpha-4	-0.74
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P43250	GRK6	G protein-coupled receptor kinase 6	P11215	ITGAM	Integrin alpha-M	0.896
Q9UM07	PADI4	Protein-arginine deiminase type-4	P15144	ANPEP	Aminopeptidase N	0.76
Q9UM07	PADI4	Protein-arginine deiminase type-4	P25063	CD24	Signal transducer CD24	0.866
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P43250	GRK6	G protein-coupled receptor kinase 6	P09564	CD7	T-cell antigen CD7	-0.786
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73

Tetracycline

IL-17 signaling pathway

2.59E-03

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Tetracycline

Th1 and Th2 cell differentiation

2.06E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828

Tetracycline

T cell receptor signaling pathway

4.04E-05

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Tetracycline

hsa04664

Fc epsilon RI signaling pathway

3.15E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Tetracycline

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Tetracycline

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Tetracycline

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Tetracycline

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Tetracycline

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Tetracycline

Type I diabetes mellitus

2.91E-03

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P61769	B2M	Beta-2-microglobulin	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.714
P61769	B2M	Beta-2-microglobulin	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Tetracycline

Salivary secretion

4.92E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Tetracycline

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Tetracycline

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Tetracycline

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Tetracycline

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Tetracycline

Morphine addiction

1.27E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Tetracycline

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P61769	B2M	Beta-2-microglobulin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.738
P61769	B2M	Beta-2-microglobulin	P0DP24	CALM2	Calmodulin-2	0.787
P61769	B2M	Beta-2-microglobulin	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Tetracycline

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Tetracycline

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963

Tetracycline

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Tetracycline

Amoebiasis

1.70E-03

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05089	ARG1	Arginase-1	0.897
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q9UM07	PADI4	Protein-arginine deiminase type-4	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.809
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79

Tetracycline

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7

Tetracycline

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744

Tetracycline

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Tetracycline

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Tetracycline

Transcriptional misregulation in cancer

2.97E-04

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Tetracycline

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Tetracycline

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Tetracycline

Asthma

2.84E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12724	RNASE3	Eosinophil cationic protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P12724	RNASE3	Eosinophil cationic protein	0.767
P22894	MMP8	Neutrophil collagenase	P12724	RNASE3	Eosinophil cationic protein	0.783
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728

Tetracycline

Inflammatory bowel disease

3.13E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751

Tetracycline

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725

Tetracycline

Rheumatoid arthritis

1.58E-02

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09341	CXCL1	Growth-regulated alpha protein	0.868
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772

Tetracycline