PharmaCoNets of Testosterone-enanthate (SPCN: 56.65 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Testosterone-enanthatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Testosterone-enanthatehsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Testosterone-enanthatehsa00052Galactose metabolism2.91E-022P06280, O43451GLA, MGAMMore
Testosterone-enanthatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Testosterone-enanthatehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Testosterone-enanthatehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Testosterone-enanthatehsa00500Starch and sucrose metabolism4.62E-022O43451, P06737MGAM, PYGLMore
Testosterone-enanthatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Testosterone-enanthatehsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Testosterone-enanthatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Testosterone-enanthatehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Testosterone-enanthatehsa00730Thiamine metabolism1.53E-022P05186, P24666ALPL, ACP1More
Testosterone-enanthatehsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Testosterone-enanthatehsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Testosterone-enanthatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Testosterone-enanthatehsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Testosterone-enanthatehsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Testosterone-enanthatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Testosterone-enanthatehsa03013RNA transport8.18E-059P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Testosterone-enanthatehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Testosterone-enanthatehsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Testosterone-enanthatehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Testosterone-enanthatehsa04012ErbB signaling pathway2.98E-036P21860, P16333, Q13557, P19174, O14944, P01106ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYCMore
Testosterone-enanthatehsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Testosterone-enanthatehsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Testosterone-enanthatehsa04060Cytokine-cytokine receptor interaction3.20E-023P37173, P78552, P80075TGFBR2, IL13RA1, CCL8More
Testosterone-enanthatehsa04064NF-kappa B signaling pathway1.09E-0411P10415, Q13489, O00463, Q13546, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1, EDARMore
Testosterone-enanthatehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Testosterone-enanthatehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Testosterone-enanthatehsa04110Cell cycle1.79E-038Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Testosterone-enanthatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Testosterone-enanthatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Testosterone-enanthatehsa04141Protein processing in endoplasmic reticulum2.01E-038P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2More
Testosterone-enanthatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Testosterone-enanthatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Testosterone-enanthatehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Testosterone-enanthatehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Testosterone-enanthatehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Testosterone-enanthatehsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Testosterone-enanthatehsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Testosterone-enanthatehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Testosterone-enanthatehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Testosterone-enanthatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Testosterone-enanthatehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Testosterone-enanthatehsa04530Tight junction2.17E-033P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Testosterone-enanthatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Testosterone-enanthatehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Testosterone-enanthatehsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Testosterone-enanthatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Testosterone-enanthatehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Testosterone-enanthatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Testosterone-enanthatehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Testosterone-enanthatehsa04650Natural killer cell mediated cytotoxicity2.02E-039P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KLRC1More
Testosterone-enanthatehsa04658Th1 and Th2 cell differentiation7.34E-0714Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Testosterone-enanthatehsa04659Th17 cell differentiation3.21E-0412Q04759, P19174, P01730, P06239, P42224, P14784, P13765, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, CD3E, CD3G, CD247More
Testosterone-enanthatehsa04660T cell receptor signaling pathway1.22E-0312Q9UDY8, Q04759, P10747, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, P06239MALT1, PRKCQ, CD28, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, LCKMore
Testosterone-enanthatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Testosterone-enanthatehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Testosterone-enanthatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Testosterone-enanthatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Testosterone-enanthatehsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Testosterone-enanthatehsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Testosterone-enanthatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Testosterone-enanthatehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Testosterone-enanthatehsa04920Adipocytokine signaling pathway2.62E-033Q06124, Q9Y478, Q96RR4PTPN11, PRKAB1, CAMKK2More
Testosterone-enanthatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Testosterone-enanthatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Testosterone-enanthatehsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Testosterone-enanthatehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Testosterone-enanthatehsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Testosterone-enanthatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Testosterone-enanthatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Testosterone-enanthatehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Testosterone-enanthatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Testosterone-enanthatehsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Testosterone-enanthatehsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Testosterone-enanthatehsa05120Epithelial cell signaling in Helicobacter pylori infection3.14E-023Q16539, P25024, P25025MAPK14, CXCR1, CXCR2More
Testosterone-enanthatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Testosterone-enanthatehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Testosterone-enanthatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Testosterone-enanthatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Testosterone-enanthatehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Testosterone-enanthatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Testosterone-enanthatehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Testosterone-enanthatehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Testosterone-enanthatehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Testosterone-enanthatehsa05210Colorectal cancer3.43E-022Q9UKG1, P37173APPL1, TGFBR2More
Testosterone-enanthatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Testosterone-enanthatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Testosterone-enanthatehsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Testosterone-enanthatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Testosterone-enanthatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Testosterone-enanthatehsa05231Choline metabolism in cancer2.99E-033Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Testosterone-enanthatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.70E-0411P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q9HC35, P01730PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, EML4, CD4More
Testosterone-enanthatehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Testosterone-enanthatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Testosterone-enanthatehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Testosterone-enanthatehsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Testosterone-enanthatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Testosterone-enanthatehsa05415Diabetic cardiomyopathy7.55E-033P30405, P37173, P11413PPIF, TGFBR2, G6PDMore

Community members of Testosterone-enanthate (SDC: 5.25)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)