PharmaCoNets of Testosterone-cypionate (SPCN: 72.33 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Testosterone-cypionatehsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Testosterone-cypionatehsa00052Galactose metabolism2.91E-022P06280, O43451GLA, MGAMMore
Testosterone-cypionatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Testosterone-cypionatehsa00100Steroid biosynthesis4.70E-021P35610SOAT1More
Testosterone-cypionatehsa00190Oxidative phosphorylation2.21E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Testosterone-cypionatehsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Testosterone-cypionatehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Testosterone-cypionatehsa00500Starch and sucrose metabolism1.98E-034O43451, P46976, P35557, P06737MGAM, GYG1, GCK, PYGLMore
Testosterone-cypionatehsa00512Mucin type O-glycan biosynthesis1.31E-032O95395, Q8N4A0GCNT3, GALNT4More
Testosterone-cypionatehsa00524Neomycin, kanamycin and gentamicin biosynthesis4.70E-021P35557GCKMore
Testosterone-cypionatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Testosterone-cypionatehsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Testosterone-cypionatehsa00562Inositol phosphate metabolism3.69E-023P27987, P19174, P42338ITPKB, PLCG1, PIK3CBMore
Testosterone-cypionatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Testosterone-cypionatehsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Testosterone-cypionatehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Testosterone-cypionatehsa00730Thiamine metabolism1.53E-022P05186, P24666ALPL, ACP1More
Testosterone-cypionatehsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Testosterone-cypionatehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Testosterone-cypionatehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Testosterone-cypionatehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Testosterone-cypionatehsa00983Drug metabolism - other enzymes1.99E-035P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Testosterone-cypionatehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Testosterone-cypionatehsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Testosterone-cypionatehsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Testosterone-cypionatehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Testosterone-cypionatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Testosterone-cypionatehsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Testosterone-cypionatehsa03010Ribosome1.22E-022P46777, P50914RPL5, RPL14More
Testosterone-cypionatehsa03013RNA transport3.26E-0721O14980, P52298, Q09161, O14893, P61326, P38919, Q9GZY0, P37198, Q7Z3B4, P35658, P47813, Q14152, P55884, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114, Q53GS7XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NXF2; NXF2B, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1, GLE1More
Testosterone-cypionatehsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Testosterone-cypionatehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Testosterone-cypionatehsa04012ErbB signaling pathway3.69E-023Q13191, P19174, P42338CBLB, PLCG1, PIK3CBMore
Testosterone-cypionatehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Testosterone-cypionatehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Testosterone-cypionatehsa04060Cytokine-cytokine receptor interaction2.90E-0311P14784, P14778, P37173, Q06643, Q13651, Q9HBE5, P78552, P09341, P19875, P80075, Q93038IL2RB, IL1R1, TGFBR2, LTB, IL10RA, IL21R, IL13RA1, CXCL1, CXCL2, CCL8, TNFRSF25More
Testosterone-cypionatehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Testosterone-cypionatehsa04064NF-kappa B signaling pathway1.11E-0411Q13489, Q13546, P14778, P19174, Q04759, Q9UDY8, P06239, P09341, P19875, Q06643, Q9UNE0BIRC3, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, LCK, CXCL1, CXCL2, LTB, EDARMore
Testosterone-cypionatehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Testosterone-cypionatehsa04071Sphingolipid signaling pathway1.54E-039P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2More
Testosterone-cypionatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Testosterone-cypionatehsa04140Autophagy - animal1.56E-024Q9Y4H2, P42338, Q9NQL2, Q04759IRS2, PIK3CB, RRAGD, PRKCQMore
Testosterone-cypionatehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Testosterone-cypionatehsa04145Phagosome6.70E-0512P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Testosterone-cypionatehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Testosterone-cypionatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Testosterone-cypionatehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Testosterone-cypionatehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Testosterone-cypionatehsa04213Longevity regulating pathway - multiple species1.56E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Testosterone-cypionatehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Testosterone-cypionatehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Testosterone-cypionatehsa04360Axon guidance2.74E-038P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Testosterone-cypionatehsa04370VEGF signaling pathway3.46E-045P19174, P16298, P42338, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1More
Testosterone-cypionatehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Testosterone-cypionatehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Testosterone-cypionatehsa04530Tight junction2.17E-033P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Testosterone-cypionatehsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Testosterone-cypionatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Testosterone-cypionatehsa04612Antigen processing and presentation1.97E-025Q07444, Q13241, P01732, P30101, P11142KLRC3, KLRD1, CD8A, PDIA3, HSPA8More
Testosterone-cypionatehsa04613Neutrophil extracellular trap formation7.19E-0416P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Testosterone-cypionatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Testosterone-cypionatehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Testosterone-cypionatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Testosterone-cypionatehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Testosterone-cypionatehsa04640Hematopoietic cell lineage1.38E-026P14778, P11215, P25063, P07766, P01732, P09564IL1R1, ITGAM, CD24, CD3E, CD8A, CD7More
Testosterone-cypionatehsa04650Natural killer cell mediated cytotoxicity3.32E-0612P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, Q07444PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC3More
Testosterone-cypionatehsa04657IL-17 signaling pathway4.98E-026O00463, Q16539, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNFMore
Testosterone-cypionatehsa04658Th1 and Th2 cell differentiation3.01E-058Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Testosterone-cypionatehsa04659Th17 cell differentiation4.99E-0612Q04759, P19174, P06239, P14784, P14778, Q9HBE5, Q9UL17, P84022, Q13485, P08238, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, IL21R, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Testosterone-cypionatehsa04660T cell receptor signaling pathway5.50E-048Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Testosterone-cypionatehsa04662B cell receptor signaling pathway1.00E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Testosterone-cypionatehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Testosterone-cypionatehsa04666Fc gamma R-mediated phagocytosis9.96E-035P23528, P49006, P06396, P14598, P17252CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Testosterone-cypionatehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Testosterone-cypionatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Testosterone-cypionatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Testosterone-cypionatehsa04750Inflammatory mediator regulation of TRP channels2.19E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Testosterone-cypionatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Testosterone-cypionatehsa04920Adipocytokine signaling pathway2.62E-033Q06124, Q9Y478, Q96RR4PTPN11, PRKAB1, CAMKK2More
Testosterone-cypionatehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Testosterone-cypionatehsa04950Maturity onset diabetes of the young4.70E-021P35557GCKMore
Testosterone-cypionatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Testosterone-cypionatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Testosterone-cypionatehsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Testosterone-cypionatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Testosterone-cypionatehsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Testosterone-cypionatehsa05120Epithelial cell signaling in Helicobacter pylori infection3.70E-036Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Testosterone-cypionatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Testosterone-cypionatehsa05132Salmonella infection1.43E-0311Q9UJU2, P63261, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371LEF1, ACTG1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Testosterone-cypionatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Testosterone-cypionatehsa05134Legionellosis4.88E-034P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Testosterone-cypionatehsa05135Yersinia infection4.39E-024P06239, P19174, P42338, P01732LCK, PLCG1, PIK3CB, CD8AMore
Testosterone-cypionatehsa05140Leishmaniasis5.04E-038P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q15080NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, NCF4More
Testosterone-cypionatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Testosterone-cypionatehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Testosterone-cypionatehsa05146Amoebiasis3.01E-058P09341, P19875, P14778, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Testosterone-cypionatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Testosterone-cypionatehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Testosterone-cypionatehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Testosterone-cypionatehsa05202Transcriptional misregulation in cancer3.56E-0416Q12778, Q15532, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Testosterone-cypionatehsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Testosterone-cypionatehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Testosterone-cypionatehsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Testosterone-cypionatehsa05210Colorectal cancer3.43E-022Q9UKG1, P37173APPL1, TGFBR2More
Testosterone-cypionatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Testosterone-cypionatehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Testosterone-cypionatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Testosterone-cypionatehsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Testosterone-cypionatehsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Testosterone-cypionatehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Testosterone-cypionatehsa05221Acute myeloid leukemia4.95E-023P42338, Q15744, P11215PIK3CB, CEBPE, ITGAMMore
Testosterone-cypionatehsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Testosterone-cypionatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Testosterone-cypionatehsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Testosterone-cypionatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.09E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Testosterone-cypionatehsa05323Rheumatoid arthritis4.24E-036Q06643, P13765, P10747, P09341, P19875, O60603LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Testosterone-cypionatehsa05340Primary immunodeficiency4.95E-023P01732, P07766, P06239CD8A, CD3E, LCKMore
Testosterone-cypionatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Testosterone-cypionatehsa05415Diabetic cardiomyopathy8.09E-038P17252, P30405, P14598, Q15080, Q16718, O14521, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, TGFBR2, GAPDHMore
Testosterone-cypionatehsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More

Community members of Testosterone-cypionate (SDC: 5.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)