PharmaCoNets

Pentose phosphate pathway

3.67E-03

P60891, P11413, P37837

PRPS1, G6PD, TALDO1

Methyltestosterone

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Methyltestosterone

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Methyltestosterone

hsa00071

Fatty acid degradation

3.77E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Methyltestosterone

Oxidative phosphorylation

9.21E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8

Methyltestosterone

hsa00220

Arginine biosynthesis

4.88E-02

P49448

GLUD2

Methyltestosterone

hsa00250

Alanine, aspartate and glutamate metabolism

4.88E-02

P49448

GLUD2

Methyltestosterone

hsa00471

D-Glutamine and D-glutamate metabolism

1.65E-02

P49448

GLUD2

Methyltestosterone

Glutathione metabolism

1.35E-02

P11413

G6PD

Methyltestosterone

Starch and sucrose metabolism

1.00E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P43003	SLC1A3	Excitatory amino acid transporter 1	P46976	GYG1	Glycogenin-1	0.721
P43003	SLC1A3	Excitatory amino acid transporter 1	P35557	GCK	Hexokinase-4	-0.708
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799

Methyltestosterone

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Methyltestosterone

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Methyltestosterone

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Methyltestosterone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Methyltestosterone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Methyltestosterone

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Methyltestosterone

hsa00630

Glyoxylate and dicarboxylate metabolism

1.88E-05

P40925, P15104

MDH1, GLUL

Methyltestosterone

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Methyltestosterone

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Methyltestosterone

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Methyltestosterone

hsa00910

Nitrogen metabolism

4.88E-02

P49448

GLUD2

Methyltestosterone

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Methyltestosterone

Aminoacyl-tRNA biosynthesis

2.35E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Methyltestosterone

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Methyltestosterone

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Methyltestosterone

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Methyltestosterone

Carbon metabolism

2.91E-02

P11413

G6PD

Methyltestosterone

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Methyltestosterone

hsa01230

Biosynthesis of amino acids

3.27E-03

P51854, P60891, Q99707, P50213, P37837

TKTL1, PRPS1, MTR, IDH3A, TALDO1

Methyltestosterone

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Methyltestosterone

Endocrine resistance

2.16E-02

P08069

IGF1R

Methyltestosterone

hsa01523

Antifolate resistance

1.43E-03

Q92820, P04818

GGH, TYMS

Methyltestosterone

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Methyltestosterone

hsa03008

Ribosome biogenesis in eukaryotes

2.40E-03

P19784, P67870, O14980, O60832, Q9BVP2

CSNK2A2, CSNK2B, XPO1, DKC1, GNL3

Methyltestosterone

RNA transport

7.80E-06

P62826, O14980, P52298, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, Q14240, P23588, Q9Y6A5, Q14232

RAN, XPO1, NCBP2, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF4A2, EIF4B, TACC3, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14980	XPO1	Exportin-1	0.881
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.859
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14893	GEMIN2	Gem-associated protein 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q7Z3B4	NUP54	Nucleoporin p54	0.855
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.702
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.913
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.827
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.881
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q06787	FMR1	Synaptic functional regulator FMR1	0.817
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.908
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733

Methyltestosterone

hsa03020

RNA polymerase

6.21E-04

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Methyltestosterone

Spliceosome

4.48E-08

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Methyltestosterone

Protein export

3.28E-02

Q15070

OXA1L

Methyltestosterone

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Methyltestosterone

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Methyltestosterone

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Methyltestosterone

Ras signaling pathway

9.55E-04

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Methyltestosterone

Rap1 signaling pathway

9.79E-05

P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Methyltestosterone

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Methyltestosterone

cGMP-PKG signaling pathway

4.38E-03

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708

Methyltestosterone

hsa04024

cAMP signaling pathway

5.36E-04

P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P61586, Q13370, Q13009

GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RHOA, PDE3B, TIAM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P26678	PLN	Cardiac phospholamban	0.752
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.768
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P26678	PLN	Cardiac phospholamban	0.752
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.768

Methyltestosterone

Viral protein interaction with cytokine and cytokine receptor

4.79E-03

Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Methyltestosterone

Chemokine signaling pathway

5.65E-04

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Methyltestosterone

NF-kappa B signaling pathway

1.60E-05

Q13489, Q13546, P14778, P01584, P19174, Q04759, Q9UDY8, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7

BIRC3, RIPK1, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Methyltestosterone

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Methyltestosterone

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Methyltestosterone

Phosphatidylinositol signaling system

1.28E-03

P0DP23, P42338, O14986, Q16760, P48426, P27987

CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.708
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.702
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P23743	DGKA	Diacylglycerol kinase alpha	-0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P51955	NEK2	Serine/threonine-protein kinase Nek2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	-0.757

Methyltestosterone

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Methyltestosterone

hsa04072

Phospholipase D signaling pathway

5.40E-05

P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760

AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15438	PSCD1	Cytohesin-1	0.708
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15438	PSCD1	Cytohesin-1	0.708
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73

Methyltestosterone

Neuroactive ligand-receptor interaction

3.70E-02

P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318

CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Methyltestosterone

Cell cycle

1.97E-05

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P51955	NEK2	Serine/threonine-protein kinase Nek2	P30304	CDC25A	M-phase inducer phosphatase 1	0.93
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P51955	NEK2	Serine/threonine-protein kinase Nek2	P33981	TTK	Dual specificity protein kinase TTK	0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783

Methyltestosterone

Oocyte meiosis

1.78E-04

P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069

RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Methyltestosterone

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Methyltestosterone

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Methyltestosterone

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Methyltestosterone

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Methyltestosterone

Autophagy - animal

4.41E-03

P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9

IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Methyltestosterone

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871

Methyltestosterone

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Methyltestosterone

PI3K-Akt signaling pathway

1.89E-03

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Methyltestosterone

AMPK signaling pathway

2.07E-03

P08069, Q96EB6, P36956

IGF1R, SIRT1, SREBF1

Methyltestosterone

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Methyltestosterone

Longevity regulating pathway

1.96E-04

Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7

FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Methyltestosterone

Longevity regulating pathway - multiple species

1.50E-04

P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P11142, Q13547

AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P24723	PRKCH	Protein kinase C eta type	Q13547	HDAC1	Histone deacetylase 1	0.875
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Methyltestosterone

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Methyltestosterone

Necroptosis

2.34E-05

P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749

Methyltestosterone

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Methyltestosterone

Adrenergic signaling in cardiomyocytes

4.98E-04

Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23

ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Methyltestosterone

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Methyltestosterone

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Methyltestosterone

Axon guidance

1.58E-04

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Methyltestosterone

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q05397	PTK2	Focal adhesion kinase 1	0.898
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Methyltestosterone

Apelin signaling pathway

1.11E-03

P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Methyltestosterone

hsa04380

Osteoclast differentiation

1.88E-02

Q9NQC7, P23458, P31751, P01584

CYLD, JAK1, AKT2, IL1B

Methyltestosterone

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Methyltestosterone

Focal adhesion

8.84E-03

O14986, P61586, Q16363, P08069

PIP5K1B, RHOA, LAMA4, IGF1R

Methyltestosterone

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Methyltestosterone

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Methyltestosterone

Adherens junction

1.65E-05

P08069, P19784, P67870, P61586

IGF1R, CSNK2A2, CSNK2B, RHOA

Methyltestosterone

Tight junction

1.64E-06

Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727

Methyltestosterone

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Methyltestosterone

Complement and coagulation cascades

1.03E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Methyltestosterone

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Methyltestosterone

Neutrophil extracellular trap formation

1.07E-05

P16109, P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, P08514, P07359

SELP, ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772

Methyltestosterone

Toll-like receptor signaling pathway

4.30E-04

Q13546, P01568, P01584, P31751, Q8NHW4

RIPK1, IFNA21, IL1B, AKT2, CCL4L2

Methyltestosterone

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922

Methyltestosterone

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Methyltestosterone

Cytosolic DNA-sensing pathway

8.89E-08

P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727

Methyltestosterone

hsa04625

C-type lectin receptor signaling pathway

9.86E-03

P01584, Q9NQC7, P31751, P0DP23

IL1B, CYLD, AKT2, CALM1

Methyltestosterone

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Methyltestosterone

Hematopoietic cell lineage

1.15E-05

P13612, P21926, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564

ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777

Methyltestosterone

Natural killer cell mediated cytotoxicity

8.24E-07

P16298, P50591, P19174, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Methyltestosterone

IL-17 signaling pathway

3.31E-02

P49841, P14780, P01375

GSK3B, MMP9, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769

Methyltestosterone

Th1 and Th2 cell differentiation

9.26E-08

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P23771, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Methyltestosterone

Th17 cell differentiation

1.89E-09

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Methyltestosterone

T cell receptor signaling pathway

7.40E-06

Q04759, P42338, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Methyltestosterone

B cell receptor signaling pathway

9.03E-05

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878

Methyltestosterone

Fc epsilon RI signaling pathway

1.29E-03

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1

Methyltestosterone

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Methyltestosterone

hsa04713

Circadian entrainment

5.44E-03

P0DP23, P62873, Q08828, P51828, P63092

CALM1, GNB1, ADCY1, ADCY7, GNAS

Methyltestosterone

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Methyltestosterone

Long-term potentiation

1.71E-03

P16298, P0DP23, P51812, P18848, Q08828, Q02750

PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Methyltestosterone

hsa04721

Synaptic vesicle cycle

9.45E-04

Q13488, P31645

TCIRG1, SLC6A4

Methyltestosterone

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Methyltestosterone

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Methyltestosterone

hsa04724

Glutamatergic synapse

2.85E-03

P43003, P63092, P62873, P50151, P15104

SLC1A3, GNAS, GNB1, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928

Methyltestosterone

hsa04725

Cholinergic synapse

1.39E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Methyltestosterone

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Methyltestosterone

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Methyltestosterone

Long-term depression

1.16E-02

P08069

IGF1R

Methyltestosterone

Inflammatory mediator regulation of TRP channels

2.03E-04

P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Methyltestosterone

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Methyltestosterone

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Methyltestosterone

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Methyltestosterone

hsa04912

GnRH signaling pathway

1.39E-02

Q08828, P51828, P18848, P0DP23

ADCY1, ADCY7, ATF4, CALM1

Methyltestosterone

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Methyltestosterone

Progesterone-mediated oocyte maturation

9.67E-04

P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750

IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Methyltestosterone

Estrogen signaling pathway

2.13E-02

P18848, Q08828, P51828, P31751, P0DP23

ATF4, ADCY1, ADCY7, AKT2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Methyltestosterone

hsa04916

Melanogenesis

2.40E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Methyltestosterone

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Methyltestosterone

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Methyltestosterone

hsa04923

Regulation of lipolysis in adipocytes

6.16E-05

Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2

Methyltestosterone

Renin secretion

3.77E-02

Q13370, P0DP23

PDE3B, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Methyltestosterone

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Methyltestosterone

hsa04926

Relaxin signaling pathway

2.46E-02

P31751, P18848, Q08828, P51828

AKT2, ATF4, ADCY1, ADCY7

Methyltestosterone

hsa04927

Cortisol synthesis and secretion

1.59E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Methyltestosterone

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Methyltestosterone

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Methyltestosterone

Non-alcoholic fatty liver disease

5.87E-04

P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298

AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721

Methyltestosterone

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Methyltestosterone

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Methyltestosterone

hsa04935

Growth hormone synthesis, secretion and action

1.88E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Methyltestosterone

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Methyltestosterone

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Methyltestosterone

Proximal tubule bicarbonate reclamation

4.53E-03

P00918, P49448

CA2, GLUD2

Methyltestosterone

Collecting duct acid secretion

4.93E-02

P00918

CA2

Methyltestosterone

hsa04970

Salivary secretion

1.59E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Methyltestosterone

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Methyltestosterone

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Methyltestosterone

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Methyltestosterone

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Methyltestosterone

hsa04976

Bile secretion

7.23E-04

Q08828, P51828, P22694, P08183, Q14032

ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Methyltestosterone

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778

Methyltestosterone

hsa05016

Huntington disease

2.24E-02

O95298, P24928, P30876, P62487, P05141, O75460, P28070

NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Methyltestosterone

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Methyltestosterone

Pathways of neurodegeneration - multiple diseases

1.67E-02

O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070

NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738

Methyltestosterone

hsa05032

Morphine addiction

2.47E-03

P62873, P48169, P63092

GNB1, GABRA4, GNAS

Methyltestosterone

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Methyltestosterone

Epithelial cell signaling in Helicobacter pylori infection

3.32E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942

Methyltestosterone

Pathogenic Escherichia coli infection

2.02E-04

Q14247, P56750, O00501, Q92974, P63261, P25116, Q06124, O95487

CTTN, CLDN17, CLDN5, ARHGEF2, ACTG1, F2R, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Methyltestosterone

Salmonella infection

5.76E-04

P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371

NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Methyltestosterone

Pertussis

1.86E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Methyltestosterone

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Methyltestosterone

Yersinia infection

1.52E-02

P13612, P06239, Q16539, P49841, P01730, P01732

ITGA4, LCK, MAPK14, GSK3B, CD4, CD8A

Methyltestosterone

Leishmaniasis

2.18E-04

P14598, P42224, O60603, P25963, P29350, Q15080

NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Methyltestosterone

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Methyltestosterone

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Methyltestosterone

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Methyltestosterone

Amoebiasis

2.36E-05

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816

Methyltestosterone

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Methyltestosterone

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Methyltestosterone

Human cytomegalovirus infection

6.70E-06

P31751, P62873, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P18848, P63092, P61769

AKT2, GNB1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, ATF4, GNAS, B2M

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Methyltestosterone

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Methyltestosterone

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Methyltestosterone

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Methyltestosterone

hsa05168

Herpes simplex virus 1 infection

1.38E-04

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776

Methyltestosterone

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Methyltestosterone

Pathways in cancer

1.31E-03

Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Methyltestosterone

Transcriptional misregulation in cancer

8.55E-04

P27930, P11215, P08069, Q13547, P12980

IL1R2, ITGAM, IGF1R, HDAC1, LYL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Methyltestosterone

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Methyltestosterone

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Methyltestosterone

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Methyltestosterone

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Methyltestosterone

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Methyltestosterone

Pancreatic cancer

1.59E-05

P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293

PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Methyltestosterone

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Methyltestosterone

Glioma

1.88E-03

P08069, P0DP23, P42338, O75293

IGF1R, CALM1, PIK3CB, GADD45B

Methyltestosterone

Prostate cancer

1.33E-02

P08069

IGF1R

Methyltestosterone

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Methyltestosterone

Melanoma

6.63E-03

P08069

IGF1R

Methyltestosterone

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Methyltestosterone

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Methyltestosterone

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Methyltestosterone

Breast cancer

1.49E-02

P08069

IGF1R

Methyltestosterone

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Methyltestosterone

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Methyltestosterone

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Methyltestosterone

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.78
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772

Methyltestosterone

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.28E-06

P42338, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708

Methyltestosterone

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773

Methyltestosterone

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Methyltestosterone

Graft-versus-host disease

3.70E-02

P48023, P01375

FASLG, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Methyltestosterone

Primary immunodeficiency

2.90E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Methyltestosterone

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Methyltestosterone

Diabetic cardiomyopathy

7.96E-03

P17252, P14598, Q15080, Q16718, O14521, P04406, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1

Methyltestosterone

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.72
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711

Testosterone-cypionate

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Testosterone-cypionate

Galactose metabolism

2.91E-02

P06280, O43451

GLA, MGAM

Testosterone-cypionate

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Testosterone-cypionate

hsa00100

Steroid biosynthesis

4.70E-02

P35610

SOAT1

Testosterone-cypionate

Oxidative phosphorylation

2.21E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8

Testosterone-cypionate

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Testosterone-cypionate

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Testosterone-cypionate

Starch and sucrose metabolism

1.98E-03

O43451, P46976, P35557, P06737

MGAM, GYG1, GCK, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P43003	SLC1A3	Excitatory amino acid transporter 1	P46976	GYG1	Glycogenin-1	0.721
P43003	SLC1A3	Excitatory amino acid transporter 1	P35557	GCK	Hexokinase-4	-0.708
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799

Testosterone-cypionate

Mucin type O-glycan biosynthesis

1.31E-03

O95395, Q8N4A0

GCNT3, GALNT4

Testosterone-cypionate

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

4.70E-02

P35557

GCK

Testosterone-cypionate

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Testosterone-cypionate

hsa00561

Glycerolipid metabolism

2.21E-02

O14494, P06280, P23743

PLPP1, GLA, DGKA

Testosterone-cypionate

hsa00562

Inositol phosphate metabolism

3.69E-02

P27987, P19174, P42338

ITPKB, PLCG1, PIK3CB

Testosterone-cypionate

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Testosterone-cypionate

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Testosterone-cypionate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Testosterone-cypionate

Thiamine metabolism

1.53E-02

P05186, P24666

ALPL, ACP1

Testosterone-cypionate

Retinol metabolism

1.08E-02

Q9BPW9, O75911, P11712

DHRS9, DHRS3, CYP2C9

Testosterone-cypionate

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Testosterone-cypionate

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Testosterone-cypionate

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Testosterone-cypionate

Drug metabolism - other enzymes

1.99E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Testosterone-cypionate

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759

Testosterone-cypionate

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Testosterone-cypionate

Biosynthesis of cofactors

2.05E-02

P36551, O60701

CPOX, UGDH

Testosterone-cypionate

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Testosterone-cypionate

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Testosterone-cypionate

hsa03008

Ribosome biogenesis in eukaryotes

1.46E-02

Q9NYH9, P78345, Q9BVP2, Q9GZY0

UTP6, RPP38, GNL3, NXF2; NXF2B

Testosterone-cypionate

hsa03010

Ribosome

1.22E-02

P46777, P50914

RPL5, RPL14

Testosterone-cypionate

RNA transport

3.26E-07

O14980, P52298, Q09161, O14893, P61326, P38919, Q9GZY0, P37198, Q7Z3B4, P35658, P47813, Q14152, P55884, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114, Q53GS7

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NXF2; NXF2B, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1, GLE1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14980	XPO1	Exportin-1	0.881
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.859
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14893	GEMIN2	Gem-associated protein 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q7Z3B4	NUP54	Nucleoporin p54	0.855
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.702
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.913
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.827
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.881
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q06787	FMR1	Synaptic functional regulator FMR1	0.817
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.908
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733

Testosterone-cypionate

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Testosterone-cypionate

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-cypionate

hsa04012

ErbB signaling pathway

3.69E-02

Q13191, P19174, P42338

CBLB, PLCG1, PIK3CB

Testosterone-cypionate

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-cypionate

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-cypionate

Cytokine-cytokine receptor interaction

2.90E-03

P14784, P14778, P37173, Q06643, Q13651, Q9HBE5, P78552, P09341, P19875, P80075, Q93038

IL2RB, IL1R1, TGFBR2, LTB, IL10RA, IL21R, IL13RA1, CXCL1, CXCL2, CCL8, TNFRSF25

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P24723	PRKCH	Protein kinase C eta type	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.747
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P24723	PRKCH	Protein kinase C eta type	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.761
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787

Testosterone-cypionate

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Testosterone-cypionate

NF-kappa B signaling pathway

1.11E-04

Q13489, Q13546, P14778, P19174, Q04759, Q9UDY8, P06239, P09341, P19875, Q06643, Q9UNE0

BIRC3, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, LCK, CXCL1, CXCL2, LTB, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Testosterone-cypionate

Phosphatidylinositol signaling system

1.53E-02

Q86XP1, Q96DU7

DGKH, ITPKC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.708
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.702
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P23743	DGKA	Diacylglycerol kinase alpha	-0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P51955	NEK2	Serine/threonine-protein kinase Nek2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	-0.757

Testosterone-cypionate

Sphingolipid signaling pathway

1.54E-03

P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415

PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-cypionate

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-cypionate

Autophagy - animal

1.56E-02

Q9Y4H2, P42338, Q9NQL2, Q04759

IRS2, PIK3CB, RRAGD, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Testosterone-cypionate

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871

Testosterone-cypionate

Phagosome

6.70E-05

P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Testosterone-cypionate

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Testosterone-cypionate

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Testosterone-cypionate

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Testosterone-cypionate

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Testosterone-cypionate

Longevity regulating pathway - multiple species

1.56E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P24723	PRKCH	Protein kinase C eta type	Q13547	HDAC1	Histone deacetylase 1	0.875
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-cypionate

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749

Testosterone-cypionate

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Testosterone-cypionate

Axon guidance

2.74E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Testosterone-cypionate

VEGF signaling pathway

3.46E-04

P19174, P16298, P42338, Q05397, Q02750

PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q05397	PTK2	Focal adhesion kinase 1	0.898
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-cypionate

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Testosterone-cypionate

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Testosterone-cypionate

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727

Testosterone-cypionate

hsa04540

Gap junction

3.53E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Testosterone-cypionate

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Testosterone-cypionate

Antigen processing and presentation

1.97E-02

Q07444, Q13241, P01732, P30101, P11142

KLRC3, KLRD1, CD8A, PDIA3, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Testosterone-cypionate

Neutrophil extracellular trap formation

7.19E-04

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, P63261, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772

Testosterone-cypionate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Testosterone-cypionate

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922

Testosterone-cypionate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Testosterone-cypionate

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727

Testosterone-cypionate

Hematopoietic cell lineage

1.38E-02

P14778, P11215, P25063, P07766, P01732, P09564

IL1R1, ITGAM, CD24, CD3E, CD8A, CD7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777

Testosterone-cypionate

Natural killer cell mediated cytotoxicity

3.32E-06

P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, Q07444

PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Testosterone-cypionate

IL-17 signaling pathway

4.98E-02

O00463, Q16539, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769

Testosterone-cypionate

Th1 and Th2 cell differentiation

3.01E-05

Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Testosterone-cypionate

Th17 cell differentiation

4.99E-06

Q04759, P19174, P06239, P14784, P14778, Q9HBE5, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, IL21R, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Testosterone-cypionate

T cell receptor signaling pathway

5.50E-04

Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239

PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-cypionate

B cell receptor signaling pathway

1.00E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878

Testosterone-cypionate

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1

Testosterone-cypionate

hsa04666

Fc gamma R-mediated phagocytosis

9.96E-03

P23528, P49006, P06396, P14598, P17252

CFL1, MARCKSL1, GSN, NCF1, PRKCA

Testosterone-cypionate

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Testosterone-cypionate

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-cypionate

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-cypionate

Inflammatory mediator regulation of TRP channels

2.19E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Testosterone-cypionate

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-cypionate

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-cypionate

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Testosterone-cypionate

hsa04950

Maturity onset diabetes of the young

4.70E-02

P35557

GCK

Testosterone-cypionate

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Testosterone-cypionate

Collecting duct acid secretion

4.93E-02

P00918

CA2

Testosterone-cypionate

hsa04972

Pancreatic secretion

1.99E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Testosterone-cypionate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Testosterone-cypionate

hsa05110

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Testosterone-cypionate

Epithelial cell signaling in Helicobacter pylori infection

3.70E-03

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942

Testosterone-cypionate

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Testosterone-cypionate

Salmonella infection

1.43E-03

Q9UJU2, P63261, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

LEF1, ACTG1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Testosterone-cypionate

Pertussis

4.20E-02

P0C0L4

C4A

Testosterone-cypionate

hsa05134

Legionellosis

4.88E-03

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Testosterone-cypionate

Yersinia infection

4.39E-02

P06239, P19174, P42338, P01732

LCK, PLCG1, PIK3CB, CD8A

Testosterone-cypionate

Leishmaniasis

5.04E-03

P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q15080

NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Testosterone-cypionate

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Testosterone-cypionate

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Testosterone-cypionate

Amoebiasis

3.01E-05

P09341, P19875, P14778, P42338, P11215, P05089, P12814, P08311

CXCL1, CXCL2, IL1R1, PIK3CB, ITGAM, ARG1, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816

Testosterone-cypionate

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Testosterone-cypionate

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Testosterone-cypionate

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Testosterone-cypionate

Transcriptional misregulation in cancer

3.56E-04

Q12778, Q15532, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Testosterone-cypionate

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone-cypionate

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Testosterone-cypionate

Proteoglycans in cancer

2.66E-02

Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962

ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63

Testosterone-cypionate

Colorectal cancer

3.43E-02

Q9UKG1, P37173

APPL1, TGFBR2

Testosterone-cypionate

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Testosterone-cypionate

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Testosterone-cypionate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Testosterone-cypionate

hsa05216

Thyroid cancer

3.59E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Testosterone-cypionate

hsa05217

Basal cell carcinoma

1.46E-02

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Testosterone-cypionate

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Testosterone-cypionate

hsa05221

Acute myeloid leukemia

4.95E-02

P42338, Q15744, P11215

PIK3CB, CEBPE, ITGAM

Testosterone-cypionate

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Testosterone-cypionate

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Testosterone-cypionate

Choline metabolism in cancer

3.99E-02

P19174, P23743, O14494, P17252

PLCG1, DGKA, PLPP1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.78
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772

Testosterone-cypionate

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.09E-03

P42338, P19174, P07766, P20963, P06239, Q04759

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708

Testosterone-cypionate

Rheumatoid arthritis

4.24E-03

Q06643, P13765, P10747, P09341, P19875, O60603

LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.815
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P09341	CXCL1	Growth-regulated alpha protein	-0.737
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Testosterone-cypionate

Primary immunodeficiency

4.95E-02

P01732, P07766, P06239

CD8A, CD3E, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-cypionate

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Testosterone-cypionate

Diabetic cardiomyopathy

8.09E-03

P17252, P30405, P14598, Q15080, Q16718, O14521, P37173, P04406

PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, TGFBR2, GAPDH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1

Testosterone-cypionate

Fluid shear stress and atherosclerosis

4.26E-02

P14598, P14780, P63261, P04637, P10415, Q92974

NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.72
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711

Testosterone-enanthate

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Testosterone-enanthate

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Testosterone-enanthate

Galactose metabolism

2.91E-02

P06280, O43451

GLA, MGAM

Testosterone-enanthate

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Testosterone-enanthate

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Testosterone-enanthate

Glutathione metabolism

1.35E-02

P11413

G6PD

Testosterone-enanthate

Starch and sucrose metabolism

4.62E-02

O43451, P06737

MGAM, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P43003	SLC1A3	Excitatory amino acid transporter 1	P46976	GYG1	Glycogenin-1	0.721
P43003	SLC1A3	Excitatory amino acid transporter 1	P35557	GCK	Hexokinase-4	-0.708
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799

Testosterone-enanthate

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Testosterone-enanthate

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Testosterone-enanthate

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Testosterone-enanthate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Testosterone-enanthate

Thiamine metabolism

1.53E-02

P05186, P24666

ALPL, ACP1

Testosterone-enanthate

Retinol metabolism

1.08E-02

Q9BPW9, O75911, P11712

DHRS9, DHRS3, CYP2C9

Testosterone-enanthate

Metabolic pathways

2.25E-02

Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573

CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759

Testosterone-enanthate

Carbon metabolism

2.91E-02

P11413

G6PD

Testosterone-enanthate

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Testosterone-enanthate

Biosynthesis of cofactors

2.05E-02

P36551, O60701

CPOX, UGDH

Testosterone-enanthate

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Testosterone-enanthate

RNA transport

8.18E-05

P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042

EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14980	XPO1	Exportin-1	0.881
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.859
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14893	GEMIN2	Gem-associated protein 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q7Z3B4	NUP54	Nucleoporin p54	0.855
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.702
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.913
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.827
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.881
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q06787	FMR1	Synaptic functional regulator FMR1	0.817
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.908
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733

Testosterone-enanthate

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-enanthate

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Testosterone-enanthate

hsa03320

PPAR signaling pathway

1.62E-02

Q13133, Q02318

NR1H3, CYP27A1

Testosterone-enanthate

hsa04012

ErbB signaling pathway

2.98E-03

P21860, P16333, Q13557, P19174, O14944, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC

Testosterone-enanthate

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone-enanthate

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708

Testosterone-enanthate

Cytokine-cytokine receptor interaction

3.20E-02

P37173, P78552, P80075

TGFBR2, IL13RA1, CCL8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P24723	PRKCH	Protein kinase C eta type	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.747
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P24723	PRKCH	Protein kinase C eta type	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.761
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787

Testosterone-enanthate

NF-kappa B signaling pathway

1.09E-04

P10415, Q13489, O00463, Q13546, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341, Q9UNE0

BCL2, BIRC3, TRAF5, RIPK1, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Testosterone-enanthate

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-enanthate

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Testosterone-enanthate

Cell cycle

1.79E-03

Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547

ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P51955	NEK2	Serine/threonine-protein kinase Nek2	P30304	CDC25A	M-phase inducer phosphatase 1	0.93
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P51955	NEK2	Serine/threonine-protein kinase Nek2	P33981	TTK	Dual specificity protein kinase TTK	0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783

Testosterone-enanthate

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-enanthate

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Testosterone-enanthate

Protein processing in endoplasmic reticulum

2.01E-03

P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816

CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871

Testosterone-enanthate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Testosterone-enanthate

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Testosterone-enanthate

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-enanthate

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Testosterone-enanthate

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749

Testosterone-enanthate

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone-enanthate

Notch signaling pathway

2.46E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Testosterone-enanthate

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-enanthate

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Testosterone-enanthate

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q05397	PTK2	Focal adhesion kinase 1	0.898
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-enanthate

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Testosterone-enanthate

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727

Testosterone-enanthate

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Testosterone-enanthate

Antigen processing and presentation

4.48E-02

P13765, P26715, P26717, Q13241, P01732

HLA-DOB, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Testosterone-enanthate

Neutrophil extracellular trap formation

4.93E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772

Testosterone-enanthate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Testosterone-enanthate

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922

Testosterone-enanthate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Testosterone-enanthate

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727

Testosterone-enanthate

Natural killer cell mediated cytotoxicity

2.02E-03

P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, P26717, P26715

PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Testosterone-enanthate

Th1 and Th2 cell differentiation

7.34E-07

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Testosterone-enanthate

Th17 cell differentiation

3.21E-04

Q04759, P19174, P01730, P06239, P42224, P14784, P13765, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Testosterone-enanthate

T cell receptor signaling pathway

1.22E-03

Q9UDY8, Q04759, P10747, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, P06239

MALT1, PRKCQ, CD28, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-enanthate

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Testosterone-enanthate

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Testosterone-enanthate

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-enanthate

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-enanthate

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Testosterone-enanthate

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Testosterone-enanthate

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-enanthate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-enanthate

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-enanthate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-enanthate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-enanthate

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Testosterone-enanthate

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-enanthate

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Testosterone-enanthate

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Testosterone-enanthate

Collecting duct acid secretion

4.93E-02

P00918

CA2

Testosterone-enanthate

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Testosterone-enanthate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Testosterone-enanthate

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778

Testosterone-enanthate

hsa05020

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Testosterone-enanthate

Epithelial cell signaling in Helicobacter pylori infection

3.14E-02

Q16539, P25024, P25025

MAPK14, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942

Testosterone-enanthate

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Testosterone-enanthate

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Testosterone-enanthate

Pertussis

4.20E-02

P0C0L4

C4A

Testosterone-enanthate

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Testosterone-enanthate

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Testosterone-enanthate

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Testosterone-enanthate

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Testosterone-enanthate

Transcriptional misregulation in cancer

2.90E-02

Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Testosterone-enanthate

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Testosterone-enanthate

Colorectal cancer

3.43E-02

Q9UKG1, P37173

APPL1, TGFBR2

Testosterone-enanthate

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Testosterone-enanthate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Testosterone-enanthate

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Testosterone-enanthate

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Testosterone-enanthate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Testosterone-enanthate

Choline metabolism in cancer

2.99E-03

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.78
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772

Testosterone-enanthate

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.70E-04

P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q9HC35, P01730

PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708

Testosterone-enanthate

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85

Testosterone-enanthate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.815
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P09341	CXCL1	Growth-regulated alpha protein	-0.737
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Testosterone-enanthate

Graft-versus-host disease

3.45E-03

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Testosterone-enanthate

Primary immunodeficiency

4.24E-02

P01730, P07766, P06239

CD4, CD3E, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-enanthate

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Testosterone-enanthate

Diabetic cardiomyopathy

7.55E-03

P30405, P37173, P11413

PPIF, TGFBR2, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1

Testosterone-propionate

Pentose phosphate pathway

9.18E-05

P60891, P52209, P11413, P37837

PRPS1, PGD, G6PD, TALDO1

Testosterone-propionate

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Testosterone-propionate

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Testosterone-propionate

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8

Testosterone-propionate

hsa00220

Arginine biosynthesis

5.12E-03

P05089, P49448

ARG1, GLUD2

Testosterone-propionate

hsa00250

Alanine, aspartate and glutamate metabolism

4.88E-02

P49448

GLUD2

Testosterone-propionate

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Testosterone-propionate

hsa00471

D-Glutamine and D-glutamate metabolism

1.65E-02

P49448

GLUD2

Testosterone-propionate

Glutathione metabolism

1.35E-02

P11413

G6PD

Testosterone-propionate

Starch and sucrose metabolism

1.36E-06

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P43003	SLC1A3	Excitatory amino acid transporter 1	P46976	GYG1	Glycogenin-1	0.721
P43003	SLC1A3	Excitatory amino acid transporter 1	P35557	GCK	Hexokinase-4	-0.708
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799

Testosterone-propionate

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Testosterone-propionate

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Testosterone-propionate

hsa00590

Arachidonic acid metabolism

2.48E-03

P11712, P09917, P09960

CYP2C9, ALOX5, LTA4H

Testosterone-propionate

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Testosterone-propionate

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Testosterone-propionate

hsa00630

Glyoxylate and dicarboxylate metabolism

5.51E-05

P40925, P15104

MDH1, GLUL

Testosterone-propionate

Thiamine metabolism

2.39E-05

P05186, P24666

ALPL, ACP1

Testosterone-propionate

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Testosterone-propionate

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Testosterone-propionate

hsa00910

Nitrogen metabolism

4.88E-02

P49448

GLUD2

Testosterone-propionate

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Testosterone-propionate

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Testosterone-propionate

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Testosterone-propionate

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Testosterone-propionate

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Testosterone-propionate

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759

Testosterone-propionate

Carbon metabolism

2.00E-03

P11413, P52209, P37837

G6PD, PGD, TALDO1

Testosterone-propionate

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Testosterone-propionate

Biosynthesis of cofactors

1.34E-03

P13716, P36551, O60701, P14618

ALAD, CPOX, UGDH, PKM2

Testosterone-propionate

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Testosterone-propionate

Endocrine resistance

2.16E-02

P08069

IGF1R

Testosterone-propionate

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Testosterone-propionate

ABC transporters

4.48E-02

Q8IZY2

ABCA7

Testosterone-propionate

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14980	XPO1	Exportin-1	0.881
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.859
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14893	GEMIN2	Gem-associated protein 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q7Z3B4	NUP54	Nucleoporin p54	0.855
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.702
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.913
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.827
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.881
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q06787	FMR1	Synaptic functional regulator FMR1	0.817
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.908
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733

Testosterone-propionate

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Testosterone-propionate

Spliceosome

1.64E-09

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-propionate

Protein export

2.65E-03

Q15070, P37108, Q15005

OXA1L, SRP14, SPCS2

Testosterone-propionate

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Testosterone-propionate

hsa03460

Fanconi anemia pathway

1.85E-02

P40692, Q9UNA4

MLH1, POLI

Testosterone-propionate

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Testosterone-propionate

Ras signaling pathway

9.55E-04

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-propionate

Rap1 signaling pathway

9.79E-05

P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-propionate

Cytokine-cytokine receptor interaction

8.46E-04

P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, P09341, P80075, P01730

IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CCL8, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P24723	PRKCH	Protein kinase C eta type	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.747
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P24723	PRKCH	Protein kinase C eta type	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.761
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787

Testosterone-propionate

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Testosterone-propionate

Chemokine signaling pathway

2.28E-04

P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Testosterone-propionate

NF-kappa B signaling pathway

9.67E-09

P10415, Q13489, O00463, Q13546, P14778, P01584, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Testosterone-propionate

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Testosterone-propionate

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Testosterone-propionate

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.708
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.702
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P23743	DGKA	Diacylglycerol kinase alpha	-0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P51955	NEK2	Serine/threonine-protein kinase Nek2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	-0.757

Testosterone-propionate

Sphingolipid signaling pathway

1.06E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-propionate

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Testosterone-propionate

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P51955	NEK2	Serine/threonine-protein kinase Nek2	P30304	CDC25A	M-phase inducer phosphatase 1	0.93
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P51955	NEK2	Serine/threonine-protein kinase Nek2	P33981	TTK	Dual specificity protein kinase TTK	0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783

Testosterone-propionate

Oocyte meiosis

3.19E-03

P51812, Q02750, P16298, Q17RY0, P08069

RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-propionate

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Testosterone-propionate

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Testosterone-propionate

Autophagy - animal

2.95E-02

P08069, P22694, Q14643, P10415, Q04759

IGF1R, PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Testosterone-propionate

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871

Testosterone-propionate

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Testosterone-propionate

hsa04144

Endocytosis

1.13E-03

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Testosterone-propionate

Phagosome

2.82E-04

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Testosterone-propionate

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Testosterone-propionate

PI3K-Akt signaling pathway

3.02E-04

P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Testosterone-propionate

AMPK signaling pathway

2.07E-03

P08069, Q96EB6, P36956

IGF1R, SIRT1, SREBF1

Testosterone-propionate

Apoptosis

4.11E-03

Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-propionate

Longevity regulating pathway

1.34E-03

Q12778, P08069, Q9UEF7, Q96KQ7

FOXO1, IGF1R, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Testosterone-propionate

Longevity regulating pathway - multiple species

7.87E-04

P08069, Q9Y4H2, Q08828, P51828, P0DMV8, Q13547

IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P24723	PRKCH	Protein kinase C eta type	Q13547	HDAC1	Histone deacetylase 1	0.875
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-propionate

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Testosterone-propionate

Necroptosis

7.23E-05

P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, Q6FI13, Q99878, P10415, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749

Testosterone-propionate

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Testosterone-propionate

Adrenergic signaling in cardiomyocytes

2.84E-02

P09493, Q13362, P0DP23, P17252, P10415

TPM1, PPP2R5C, CALM1, PRKCA, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone-propionate

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Testosterone-propionate

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Testosterone-propionate

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Testosterone-propionate

Hedgehog signaling pathway

1.87E-04

P49841, P17612, P22694, Q13635, P10415

GSK3B, PRKACA, PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-propionate

Axon guidance

2.74E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Testosterone-propionate

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q05397	PTK2	Focal adhesion kinase 1	0.898
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-propionate

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Testosterone-propionate

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Testosterone-propionate

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Testosterone-propionate

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Testosterone-propionate

Focal adhesion

3.48E-02

P08069

IGF1R

Testosterone-propionate

hsa04512

ECM-receptor interaction

1.62E-03

P07359, P26012, P08514, P16070

GP1BA, ITGB8, ITGA2B, CD44

Testosterone-propionate

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Testosterone-propionate

Adherens junction

8.29E-03

P08069

IGF1R

Testosterone-propionate

Tight junction

1.64E-06

Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727

Testosterone-propionate

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Testosterone-propionate

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Testosterone-propionate

Complement and coagulation cascades

8.72E-04

P25116, P09871, P0C0L4

F2R, C1S, C4A

Testosterone-propionate

hsa04611

Platelet activation

2.96E-06

P25116, Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359

F2R, TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BA

Testosterone-propionate

Antigen processing and presentation

1.56E-04

P13765, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Testosterone-propionate

Neutrophil extracellular trap formation

1.42E-06

P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P21730, P08514, P21462, P07359

PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, C5AR1, ITGA2B, FPR1, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772

Testosterone-propionate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Testosterone-propionate

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922

Testosterone-propionate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Testosterone-propionate

Cytosolic DNA-sensing pathway

9.06E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727

Testosterone-propionate

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Testosterone-propionate

Hematopoietic cell lineage

1.51E-06

P13612, P21926, P14778, P27930, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, CD9, IL1R1, IL1R2, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777

Testosterone-propionate

Natural killer cell mediated cytotoxicity

8.57E-07

P16298, P50591, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Testosterone-propionate

IL-17 signaling pathway

2.18E-04

O00463, Q16539, P49841, P09341, P14780, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769

Testosterone-propionate

Th1 and Th2 cell differentiation

3.15E-11

Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Testosterone-propionate

Th17 cell differentiation

2.71E-11

P25963, Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Testosterone-propionate

T cell receptor signaling pathway

1.83E-06

Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-propionate

B cell receptor signaling pathway

1.21E-05

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878

Testosterone-propionate

Fc epsilon RI signaling pathway

1.36E-04

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1

Testosterone-propionate

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Testosterone-propionate

hsa04672

Intestinal immune network for IgA production

3.36E-04

P29965, P10747, P13765, P13612

CD40LG, CD28, HLA-DOB, ITGA4

Testosterone-propionate

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Testosterone-propionate

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-propionate

Long-term potentiation

1.95E-03

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-propionate

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Testosterone-propionate

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Testosterone-propionate

hsa04724

Glutamatergic synapse

1.82E-03

O15399, P43003, P63218, P50151, P15104

GRIN2D, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928

Testosterone-propionate

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Testosterone-propionate

hsa04727

GABAergic synapse

4.42E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Testosterone-propionate

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Testosterone-propionate

Long-term depression

1.16E-02

P08069

IGF1R

Testosterone-propionate

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Testosterone-propionate

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Testosterone-propionate

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Testosterone-propionate

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Testosterone-propionate

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Testosterone-propionate

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Testosterone-propionate

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Testosterone-propionate

Progesterone-mediated oocyte maturation

5.89E-03

P08069, Q17RY0, P51812, Q02750

IGF1R, CPEB4, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-propionate

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-propionate

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Testosterone-propionate

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-propionate

Glucagon signaling pathway

7.76E-04

P14618, P22694, P06737, Q12778, Q13370, P0DP23, Q14643

PKM2, PRKACB, PYGL, FOXO1, PDE3B, CALM1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-propionate

hsa04923

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Testosterone-propionate

Renin secretion

1.79E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-propionate

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-propionate

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Testosterone-propionate

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Testosterone-propionate

Non-alcoholic fatty liver disease

7.56E-04

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O95298

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721

Testosterone-propionate

AGE-RAGE signaling pathway in diabetic complications

8.03E-05

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Testosterone-propionate

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Testosterone-propionate

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Testosterone-propionate

Proximal tubule bicarbonate reclamation

4.03E-03

P00918, P49448

CA2, GLUD2

Testosterone-propionate

Collecting duct acid secretion

1.95E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Testosterone-propionate

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Testosterone-propionate

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Testosterone-propionate

hsa04976

Bile secretion

2.51E-03

Q08828, P51828, P22694, P08183, Q14032

ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Testosterone-propionate

Alzheimer disease

3.55E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778

Testosterone-propionate

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Testosterone-propionate

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Testosterone-propionate

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Testosterone-propionate

hsa05020

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Testosterone-propionate

Pathways of neurodegeneration - multiple diseases

4.00E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q06055, Q13561, P17252, Q08752, O15020, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PRKCA, PPID, SPTBN2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738

Testosterone-propionate

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone-propionate

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Testosterone-propionate

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942

Testosterone-propionate

Pathogenic Escherichia coli infection

2.02E-04

Q14247, P56750, O00501, Q92974, P63261, P25116, Q06124, O95487

CTTN, CLDN17, CLDN5, ARHGEF2, ACTG1, F2R, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Testosterone-propionate

hsa05131

Shigellosis

2.27E-02

P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Testosterone-propionate

Salmonella infection

3.94E-05

P25963, Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

NFKBIA, LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Testosterone-propionate

Pertussis

1.58E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Testosterone-propionate

hsa05134

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Testosterone-propionate

Leishmaniasis

2.04E-04

O75015, P14598, P42224, P13765, O60603, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Testosterone-propionate

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Testosterone-propionate

hsa05145

Toxoplasmosis

1.02E-03

P25963, P10415, Q13489, P42224, P13765, O60603, P29965

NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Testosterone-propionate

Amoebiasis

1.32E-03

P09341, P14778, P27930, O60603, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816

Testosterone-propionate

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Testosterone-propionate

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Testosterone-propionate

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Testosterone-propionate

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Testosterone-propionate

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Testosterone-propionate

Human cytomegalovirus infection

2.84E-04

P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Testosterone-propionate

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Testosterone-propionate

Kaposi sarcoma-associated herpesvirus infection

3.04E-03

P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Testosterone-propionate

hsa05169

Epstein-Barr virus infection

5.02E-04

P20023, P13765, P01106, Q13547, Q92769, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779

Testosterone-propionate

Human immunodeficiency virus 1 infection

8.44E-05

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Testosterone-propionate

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Testosterone-propionate

Transcriptional misregulation in cancer

2.13E-04

Q12778, Q13315, P14780, P27930, Q16548, P11215, O15550, P08069, P05164, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, ATM, MMP9, IL1R2, BCL2A1, ITGAM, UTX, IGF1R, MPO, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Testosterone-propionate

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone-propionate

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Testosterone-propionate

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Testosterone-propionate

Colorectal cancer

1.49E-03

Q9UKG1, P84022, Q13485, P10415, P37173

APPL1, SMAD3, SMAD4, BCL2, TGFBR2

Testosterone-propionate

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Testosterone-propionate

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Testosterone-propionate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Testosterone-propionate

Glioma

9.95E-03

P08069

IGF1R

Testosterone-propionate

Prostate cancer

1.33E-02

P08069

IGF1R

Testosterone-propionate

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Testosterone-propionate

hsa05217

Basal cell carcinoma

2.83E-02

Q13635, Q9UJU2, P24522

PTCH1, LEF1, GADD45A

Testosterone-propionate

Melanoma

6.63E-03

P08069

IGF1R

Testosterone-propionate

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Testosterone-propionate

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Testosterone-propionate

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Testosterone-propionate

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Testosterone-propionate

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Testosterone-propionate

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Testosterone-propionate

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Testosterone-propionate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Testosterone-propionate

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.72E-06

O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708

Testosterone-propionate

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Testosterone-propionate

Inflammatory bowel disease

1.44E-04

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85

Testosterone-propionate

Systemic lupus erythematosus

2.33E-07

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773

Testosterone-propionate

Rheumatoid arthritis

5.16E-04

P13765, Q13488, P10747, P09341, O60603

HLA-DOB, TCIRG1, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.815
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P09341	CXCL1	Growth-regulated alpha protein	-0.737
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Testosterone-propionate

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Testosterone-propionate

Graft-versus-host disease

1.95E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Testosterone-propionate

Primary immunodeficiency

1.31E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-propionate

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Testosterone-propionate

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Testosterone-propionate

Diabetic cardiomyopathy

3.09E-03

P17252, P30405, P14598, Q15080, Q16718, O14521, P37173, P11413

PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, TGFBR2, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1

Testosterone-propionate

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Testosterone-propionate

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.72
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711

Testosterone

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Testosterone

Pentose phosphate pathway

5.64E-03

P60891, P11413, P37837

PRPS1, G6PD, TALDO1

Testosterone

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Testosterone

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Testosterone

hsa00071

Fatty acid degradation

3.77E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Testosterone

Oxidative phosphorylation

9.21E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8

Testosterone

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Testosterone

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Testosterone

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Testosterone

Starch and sucrose metabolism

1.00E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P43003	SLC1A3	Excitatory amino acid transporter 1	P46976	GYG1	Glycogenin-1	0.721
P43003	SLC1A3	Excitatory amino acid transporter 1	P35557	GCK	Hexokinase-4	-0.708
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	O43451	MGAM	Maltase-glucoamylase	-0.709
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P06737	PYGL	Glycogen phosphorylase, liver form	-0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P49841	GSK3B	Glycogen synthase kinase-3 beta	O43451	MGAM	Maltase-glucoamylase	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P49841	GSK3B	Glycogen synthase kinase-3 beta	P46976	GYG1	Glycogenin-1	0.813
Q02763	TEK	Angiopoietin-1 receptor	P35573	AGL	Glycogen debranching enzyme	0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P49841	GSK3B	Glycogen synthase kinase-3 beta	P06737	PYGL	Glycogen phosphorylase, liver form	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799

Testosterone

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Testosterone

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Testosterone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Testosterone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Testosterone

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Testosterone

hsa00630

Glyoxylate and dicarboxylate metabolism

2.44E-07

P40925, P15104

MDH1, GLUL

Testosterone

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Testosterone

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Testosterone

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Testosterone

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Testosterone

Aminoacyl-tRNA biosynthesis

2.35E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Testosterone

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Testosterone

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Testosterone

Drug metabolism - other enzymes

1.28E-04

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Testosterone

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759

Testosterone

Carbon metabolism

2.91E-02

P11413

G6PD

Testosterone

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Testosterone

hsa01230

Biosynthesis of amino acids

3.91E-02

P51854, Q99707, P50213

TKTL1, MTR, IDH3A

Testosterone

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Testosterone

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Testosterone

Endocrine resistance

2.16E-02

P08069

IGF1R

Testosterone

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Testosterone

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Testosterone

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Testosterone

hsa03008

Ribosome biogenesis in eukaryotes

4.94E-02

P19784, P67870

CSNK2A2, CSNK2B

Testosterone

RNA transport

4.49E-02

P62826, Q9UBU9, P63279, P68104, Q14232

RAN, NXF1, UBE2I, EEF1A1, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14980	XPO1	Exportin-1	0.881
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.859
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14893	GEMIN2	Gem-associated protein 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q7Z3B4	NUP54	Nucleoporin p54	0.855
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.702
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.913
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.827
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.881
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q06787	FMR1	Synaptic functional regulator FMR1	0.817
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.908
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733

Testosterone

hsa03020

RNA polymerase

6.21E-04

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Testosterone

Spliceosome

4.31E-11

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Testosterone

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Testosterone

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Testosterone

Ras signaling pathway

9.55E-04

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone

Rap1 signaling pathway

9.79E-05

P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone

cGMP-PKG signaling pathway

4.38E-03

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708

Testosterone

hsa04024

cAMP signaling pathway

5.36E-04

P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P61586, Q13370, Q13009

GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RHOA, PDE3B, TIAM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P26678	PLN	Cardiac phospholamban	0.752
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.768
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P26678	PLN	Cardiac phospholamban	0.752
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.768

Testosterone

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P24723	PRKCH	Protein kinase C eta type	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.747
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P24723	PRKCH	Protein kinase C eta type	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.761
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787

Testosterone

Viral protein interaction with cytokine and cytokine receptor

1.28E-03

Q8NHW4, P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CCL4L2, CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Testosterone

Chemokine signaling pathway

2.28E-04

P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Testosterone

NF-kappa B signaling pathway

4.79E-09

P10415, Q13489, O00463, Q13546, P14778, P01584, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Testosterone

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Testosterone

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Testosterone

Phosphatidylinositol signaling system

1.28E-03

P0DP23, P42338, O14986, Q16760, P48426, P27987

CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.708
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.702
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P23743	DGKA	Diacylglycerol kinase alpha	-0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P51955	NEK2	Serine/threonine-protein kinase Nek2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	-0.757

Testosterone

Sphingolipid signaling pathway

7.86E-05

P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone

hsa04072

Phospholipase D signaling pathway

1.90E-04

P31751, P61586, O14986, Q15438, P63092, Q08828, P51828, Q16760

AKT2, RHOA, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q13547	HDAC1	Histone deacetylase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.804
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15438	PSCD1	Cytohesin-1	0.708
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15438	PSCD1	Cytohesin-1	0.708
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73

Testosterone

Neuroactive ligand-receptor interaction

1.31E-04

P08311, P48058, Q15722, P21453, Q9H228, P43657, O00398, P21730, Q16581, P07550, P35318

CTSG, GRIA4, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, C5AR1, C3AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Testosterone

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P51955	NEK2	Serine/threonine-protein kinase Nek2	P30304	CDC25A	M-phase inducer phosphatase 1	0.93
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P51955	NEK2	Serine/threonine-protein kinase Nek2	P33981	TTK	Dual specificity protein kinase TTK	0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783

Testosterone

Oocyte meiosis

1.78E-04

P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069

RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Testosterone

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Testosterone

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Testosterone

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Testosterone

Autophagy - animal

1.24E-03

P08069, P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9

IGF1R, AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Testosterone

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871

Testosterone

hsa04144

Endocytosis

2.81E-02

Q13191, P11142, P25024, P43250, P14784, Q9Y5X3

CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5

Testosterone

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Testosterone

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Testosterone

PI3K-Akt signaling pathway

1.89E-03

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Testosterone

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Testosterone

Apoptosis

5.62E-04

Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone

Longevity regulating pathway

1.96E-04

Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7

FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Testosterone

Longevity regulating pathway - multiple species

8.35E-04

P31751, P08069, Q9Y4H2, Q08828, P51828, Q13547

AKT2, IGF1R, IRS2, ADCY1, ADCY7, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P24723	PRKCH	Protein kinase C eta type	Q13547	HDAC1	Histone deacetylase 1	0.875
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone

Necroptosis

2.34E-05

P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749

Testosterone

Adrenergic signaling in cardiomyocytes

4.98E-04

Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23

ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Testosterone

Hedgehog signaling pathway

2.61E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone

Axon guidance

1.58E-04

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Testosterone

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q05397	PTK2	Focal adhesion kinase 1	0.898
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone

Apelin signaling pathway

1.11E-03

P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Testosterone

hsa04380

Osteoclast differentiation

1.88E-02

Q9NQC7, P23458, P31751, P01584

CYLD, JAK1, AKT2, IL1B

Testosterone

Focal adhesion

8.84E-03

O14986, P61586, Q16363, P08069

PIP5K1B, RHOA, LAMA4, IGF1R

Testosterone

hsa04512

ECM-receptor interaction

1.62E-03

P07359, P26012, P08514, P16070

GP1BA, ITGB8, ITGA2B, CD44

Testosterone

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Testosterone

Adherens junction

1.65E-05

P08069, P19784, P67870, P61586

IGF1R, CSNK2A2, CSNK2B, RHOA

Testosterone

Tight junction

1.64E-06

Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727

Testosterone

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Testosterone

Complement and coagulation cascades

1.03E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Testosterone

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Testosterone

Antigen processing and presentation

1.70E-05

P13765, P48382, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Testosterone

Neutrophil extracellular trap formation

7.68E-06

P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P21730, P08514, P07359

SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1, ITGA2B, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772

Testosterone

Toll-like receptor signaling pathway

4.30E-04

Q13546, P01568, P01584, P31751, Q8NHW4

RIPK1, IFNA21, IL1B, AKT2, CCL4L2

Testosterone

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922

Testosterone

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Testosterone

Cytosolic DNA-sensing pathway

8.89E-08

P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727

Testosterone

hsa04625

C-type lectin receptor signaling pathway

9.86E-03

P01584, Q9NQC7, P31751, P0DP23

IL1B, CYLD, AKT2, CALM1

Testosterone

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Testosterone

Hematopoietic cell lineage

1.15E-07

P13612, P14778, P27930, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765

ITGA4, IL1R1, IL1R2, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P07195	LDHB	L-lactate dehydrogenase B chain	P13612	ITGA4	Integrin alpha-4	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P11836	MS4A1	B-lymphocyte antigen CD20	0.822
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777

Testosterone

Natural killer cell mediated cytotoxicity

6.67E-09

P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Testosterone

IL-17 signaling pathway

3.31E-02

P49841, P14780, P01375

GSK3B, MMP9, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769

Testosterone

Th1 and Th2 cell differentiation

1.79E-14

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Testosterone

Th17 cell differentiation

3.30E-14

Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Testosterone

T cell receptor signaling pathway

5.20E-09

Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone

B cell receptor signaling pathway

1.21E-05

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P07948	LYN	Tyrosine-protein kinase Lyn	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P60033	CD81	CD81 antigen	0.723
P07948	LYN	Tyrosine-protein kinase Lyn	P60033	CD81	CD81 antigen	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P07948	LYN	Tyrosine-protein kinase Lyn	P07948	LYN	Tyrosine-protein kinase Lyn	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P35610	SOAT1	Sterol O-acyltransferase 1	P21854	CD72	B-cell differentiation antigen CD72	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
P35610	SOAT1	Sterol O-acyltransferase 1	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.727
P07948	LYN	Tyrosine-protein kinase Lyn	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.843
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878

Testosterone

Fc epsilon RI signaling pathway

1.29E-03

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1

Testosterone

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Testosterone

hsa04672

Intestinal immune network for IgA production

4.27E-02

P13765, P13612

HLA-DOB, ITGA4

Testosterone

hsa04713

Circadian entrainment

5.44E-03

P0DP23, P62873, Q08828, P51828, P63092

CALM1, GNB1, ADCY1, ADCY7, GNAS

Testosterone

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone

Long-term potentiation

1.71E-03

P16298, P0DP23, P51812, P18848, Q08828, Q02750

PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone

hsa04721

Synaptic vesicle cycle

9.45E-04

Q13488, P31645

TCIRG1, SLC6A4

Testosterone

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Testosterone

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Testosterone

hsa04724

Glutamatergic synapse

1.91E-04

O15399, P43003, P63092, P62873, P63218, P50151, P15104

GRIN2D, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928
P07948	LYN	Tyrosine-protein kinase Lyn	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	P43003	SLC1A3	Excitatory amino acid transporter 1	-0.796
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
P07948	LYN	Tyrosine-protein kinase Lyn	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.929
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P07948	LYN	Tyrosine-protein kinase Lyn	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.94
P35610	SOAT1	Sterol O-acyltransferase 1	P15104	GLUL	Glutamine synthetase	-0.843
P07948	LYN	Tyrosine-protein kinase Lyn	P15104	GLUL	Glutamine synthetase	0.928

Testosterone

hsa04725

Cholinergic synapse

2.34E-03

Q08828, P51828, P22694, Q14643, P18848, P31751, P10415

ADCY1, ADCY7, PRKACB, ITPR1, ATF4, AKT2, BCL2

Testosterone

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Testosterone

hsa04727

GABAergic synapse

4.42E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Testosterone

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Testosterone

Long-term depression

1.16E-02

P08069

IGF1R

Testosterone

Inflammatory mediator regulation of TRP channels

9.86E-03

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Testosterone

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Testosterone

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Testosterone

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Testosterone

hsa04912

GnRH signaling pathway

1.39E-02

Q08828, P51828, P18848, P0DP23

ADCY1, ADCY7, ATF4, CALM1

Testosterone

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Testosterone

Progesterone-mediated oocyte maturation

9.67E-04

P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750

IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone

Estrogen signaling pathway

2.83E-03

P14780, P22694, P18848, Q08828, P51828, P31751, Q14643, P0DP23, P10415

MMP9, PRKACB, ATF4, ADCY1, ADCY7, AKT2, ITPR1, CALM1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone

hsa04916

Melanogenesis

2.40E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Testosterone

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Testosterone

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Testosterone

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone

Glucagon signaling pathway

7.57E-03

P14618, P22694, P06737, Q12778, Q14643

PKM2, PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone

hsa04923

Regulation of lipolysis in adipocytes

7.59E-04

Q08828, P51828, P06213, P31751

ADCY1, ADCY7, INSR, AKT2

Testosterone

Renin secretion

8.19E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Testosterone

hsa04926

Relaxin signaling pathway

2.46E-02

P31751, P18848, Q08828, P51828

AKT2, ATF4, ADCY1, ADCY7

Testosterone

hsa04927

Cortisol synthesis and secretion

5.17E-04

Q14643, P18848, Q08828, P51828, P22694

ITPR1, ATF4, ADCY1, ADCY7, PRKACB

Testosterone

Parathyroid hormone synthesis, secretion and action

2.33E-03

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Testosterone

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Testosterone

Non-alcoholic fatty liver disease

5.87E-04

P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298

AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721

Testosterone

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Testosterone

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Testosterone

hsa04935

Growth hormone synthesis, secretion and action

1.88E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Testosterone

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Testosterone

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Testosterone

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Testosterone

Collecting duct acid secretion

4.93E-02

P00918

CA2

Testosterone

hsa04970

Salivary secretion

1.59E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Testosterone

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Testosterone

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Testosterone

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Testosterone

hsa04976

Bile secretion

7.23E-04

Q08828, P51828, P22694, P08183, Q14032

ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Testosterone

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778

Testosterone

hsa05016

Huntington disease

2.24E-02

O95298, P24928, P30876, P62487, P05141, O75460, P28070

NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Testosterone

hsa05017

Spinocerebellar ataxia

2.86E-03

Q92915, O75460, O15399, P42338, P31751, P28070, P05141, P21796

FGF14, ERN1, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1

Testosterone

Pathways of neurodegeneration - multiple diseases

1.67E-02

O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070

NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738

Testosterone

hsa05032

Morphine addiction

2.47E-03

P62873, P48169, P63092

GNB1, GABRA4, GNAS

Testosterone

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone

Epithelial cell signaling in Helicobacter pylori infection

3.76E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.832
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.76
P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.789
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942

Testosterone

Pathogenic Escherichia coli infection

2.02E-04

Q14247, P56750, O00501, Q92974, P63261, P25116, Q06124, O95487

CTTN, CLDN17, CLDN5, ARHGEF2, ACTG1, F2R, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Testosterone

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Testosterone

Pertussis

1.86E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Testosterone

Yersinia infection

1.52E-02

P13612, P06239, Q16539, P49841, P01730, P01732

ITGA4, LCK, MAPK14, GSK3B, CD4, CD8A

Testosterone

Leishmaniasis

2.18E-04

P14598, P42224, O60603, P25963, P29350, Q15080

NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Testosterone

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Testosterone

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Testosterone

Amoebiasis

6.00E-04

P09341, P14778, P27930, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816

Testosterone

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Testosterone

Human cytomegalovirus infection

6.70E-06

P31751, P62873, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P18848, P63092, P61769

AKT2, GNB1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, ATF4, GNAS, B2M

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Testosterone

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Testosterone

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Testosterone

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Testosterone

hsa05168

Herpes simplex virus 1 infection

1.38E-04

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776

Testosterone

hsa05169

Epstein-Barr virus infection

5.02E-04

P20023, P13765, P01106, Q13547, Q92769, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779

Testosterone

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Testosterone

Pathways in cancer

1.31E-03

Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Testosterone

Transcriptional misregulation in cancer

1.38E-05

Q12778, Q15532, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P08069, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, IGF1R, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Testosterone

Viral carcinogenesis

2.10E-04

Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Testosterone

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Testosterone

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Testosterone

Pancreatic cancer

1.45E-04

P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293

PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q15311	RALBP1	RalA-binding protein 1	0.72
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Testosterone

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Testosterone

Glioma

1.88E-03

P08069, P0DP23, P42338, O75293

IGF1R, CALM1, PIK3CB, GADD45B

Testosterone

Prostate cancer

1.33E-02

P08069

IGF1R

Testosterone

hsa05217

Basal cell carcinoma

2.83E-02

Q13635, Q9UJU2, P24522

PTCH1, LEF1, GADD45A

Testosterone

Melanoma

6.63E-03

P08069

IGF1R

Testosterone

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731

Testosterone

Breast cancer

1.49E-02

P08069

IGF1R

Testosterone

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Testosterone

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Testosterone

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Testosterone

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.78
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772

Testosterone

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.30E-05

P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730

CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708

Testosterone

Inflammatory bowel disease

1.03E-05

O60603, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85

Testosterone

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773

Testosterone

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.815
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P09341	CXCL1	Growth-regulated alpha protein	-0.737
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Testosterone

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Testosterone

Graft-versus-host disease

4.62E-08

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Testosterone

Primary immunodeficiency

2.04E-03

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Testosterone

Diabetic cardiomyopathy

7.96E-03

P17252, P14598, Q15080, Q16718, O14521, P04406, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P37173	TGFBR2	TGF-beta receptor type-2	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	-0.758
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1

Testosterone

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.72
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q14145	KEAP1	Kelch-like ECH-associated protein 1	-0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P49841	GSK3B	Glycogen synthase kinase-3 beta	P10599	TXN	Thioredoxin	0.836
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P49841	GSK3B	Glycogen synthase kinase-3 beta	P27930	IL1R2	Interleukin-1 receptor type 2	0.848
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P14598	NCF1	Neutrophil cytosol factor 1	0.792
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711

Testosterone-undecanoate

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Testosterone-undecanoate

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Testosterone-undecanoate

Oxidative phosphorylation

4.36E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.908
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8
P49336	CDK8	Cyclin-dependent kinase 8	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.767
P49336	CDK8	Cyclin-dependent kinase 8	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.883
P49336	CDK8	Cyclin-dependent kinase 8	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.8

Testosterone-undecanoate

hsa00340

Histidine metabolism

4.52E-02

O95954

FTCD

Testosterone-undecanoate

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Testosterone-undecanoate

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Testosterone-undecanoate

hsa00564

Glycerophospholipid metabolism

9.70E-03

Q9Y259, P49619

CHKB, DGKG

Testosterone-undecanoate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Testosterone-undecanoate

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Testosterone-undecanoate

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Testosterone-undecanoate

Metabolic pathways

2.25E-02

Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573

CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P11388	TOP2A	DNA topoisomerase 2-alpha	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.703
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P11388	TOP2A	DNA topoisomerase 2-alpha	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.879
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBX8	B4GALT6	Beta-1,4-galactosyltransferase 6	0.869
P11388	TOP2A	DNA topoisomerase 2-alpha	P35573	AGL	Glycogen debranching enzyme	0.759

Testosterone-undecanoate

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Testosterone-undecanoate

hsa01230

Biosynthesis of amino acids

3.91E-02

P51854, Q99707, P50213

TKTL1, MTR, IDH3A

Testosterone-undecanoate

Biosynthesis of cofactors

2.05E-02

P36551, O60701

CPOX, UGDH

Testosterone-undecanoate

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Testosterone-undecanoate

Endocrine resistance

2.16E-02

P08069

IGF1R

Testosterone-undecanoate

RNA transport

8.18E-05

P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042

EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14980	XPO1	Exportin-1	0.881
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.859
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O14893	GEMIN2	Gem-associated protein 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q7Z3B4	NUP54	Nucleoporin p54	0.855
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.702
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.913
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.827
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.881
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.722
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	Q06787	FMR1	Synaptic functional regulator FMR1	0.817
Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.908
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733

Testosterone-undecanoate

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-undecanoate

Protein export

1.13E-03

P37108, Q15005

SRP14, SPCS2

Testosterone-undecanoate

hsa03320

PPAR signaling pathway

2.42E-03

Q6PCB7, Q9UNU6, Q13133, Q02318

SLC27A1, CYP8B1, NR1H3, CYP27A1

Testosterone-undecanoate

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Testosterone-undecanoate

hsa04012

ErbB signaling pathway

2.98E-03

P21860, P16333, Q13557, P19174, O14944, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC

Testosterone-undecanoate

Ras signaling pathway

3.65E-02

P08069

IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-undecanoate

Rap1 signaling pathway

2.99E-02

P08069

IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P06213	INSR	Insulin receptor	P06213	INSR	Insulin receptor	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q96FS4	SIPA1	Signal-induced proliferation-associated protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11215	ITGAM	Integrin alpha-M	0.817
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P06213	INSR	Insulin receptor	O00522	KRIT1	Krev interaction trapped protein 1	0.741
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-undecanoate

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone-undecanoate

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708

Testosterone-undecanoate

Cytokine-cytokine receptor interaction

3.20E-02

P37173, P78552, P80075

TGFBR2, IL13RA1, CCL8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P24723	PRKCH	Protein kinase C eta type	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.747
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P24723	PRKCH	Protein kinase C eta type	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.761
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P37173	TGFBR2	TGF-beta receptor type-2	P37173	TGFBR2	TGF-beta receptor type-2	1
P37173	TGFBR2	TGF-beta receptor type-2	P78552	IL13RA1	Interleukin-13 receptor subunit alpha-1	0.785
P37173	TGFBR2	TGF-beta receptor type-2	P80075	CCL8	C-C motif chemokine 8	0.787

Testosterone-undecanoate

Viral protein interaction with cytokine and cytokine receptor

2.60E-02

Q8NHW4, P61073, Q13651

CCL4L2, CXCR4, IL10RA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Testosterone-undecanoate

NF-kappa B signaling pathway

4.06E-06

P10415, Q13489, O00463, Q13546, P01584, Q04759, Q9UDY8, P67870, Q16548, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1B, PRKCQ, MALT1, CSNK2B, BCL2A1, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Testosterone-undecanoate

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Testosterone-undecanoate

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Testosterone-undecanoate

Phosphatidylinositol signaling system

2.96E-02

P19174, P49619, P27987

PLCG1, DGKG, ITPKB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.708
Q9P1W9	PIM2	Serine/threonine-protein kinase pim-2	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.702
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P23743	DGKA	Diacylglycerol kinase alpha	-0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.73
P29375	JARID1A	Lysine-specific demethylase 5A	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.757
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P51955	NEK2	Serine/threonine-protein kinase Nek2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	-0.757

Testosterone-undecanoate

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, Q13362, Q9BX95, P10415

S1PR1, EDG8, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-undecanoate

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P05164	MPO	Myeloperoxidase	P08311	CTSG	Cathepsin G	0.956
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
P05164	MPO	Myeloperoxidase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.805
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
P05164	MPO	Myeloperoxidase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P05164	MPO	Myeloperoxidase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.711
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P05164	MPO	Myeloperoxidase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735

Testosterone-undecanoate

Cell cycle

1.65E-04

Q9UBD5, P06493, O75293, P30304, P33981, P42773, P01106, Q13547

ORC3, CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783
P52732	KIF11	Kinesin-like protein KIF11	P06493	CDK1	Cyclin-dependent kinase 1	0.869
P52732	KIF11	Kinesin-like protein KIF11	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.716
P52732	KIF11	Kinesin-like protein KIF11	P30304	CDC25A	M-phase inducer phosphatase 1	0.881
P52732	KIF11	Kinesin-like protein KIF11	P33981	TTK	Dual specificity protein kinase TTK	0.849
P52732	KIF11	Kinesin-like protein KIF11	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.793
P52732	KIF11	Kinesin-like protein KIF11	P01106	MYC	Myc proto-oncogene protein	-0.834
P06493	CDK1	Cyclin-dependent kinase 1	P06493	CDK1	Cyclin-dependent kinase 1	1
P06493	CDK1	Cyclin-dependent kinase 1	O60566	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	0.726
P06493	CDK1	Cyclin-dependent kinase 1	P30304	CDC25A	M-phase inducer phosphatase 1	0.724
P06493	CDK1	Cyclin-dependent kinase 1	P33981	TTK	Dual specificity protein kinase TTK	0.893
P06493	CDK1	Cyclin-dependent kinase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.722
P06493	CDK1	Cyclin-dependent kinase 1	P01106	MYC	Myc proto-oncogene protein	-0.733
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9UBD5	ORC3	Origin recognition complex subunit 3	0.718
P11388	TOP2A	DNA topoisomerase 2-alpha	P06493	CDK1	Cyclin-dependent kinase 1	0.861
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P30304	CDC25A	M-phase inducer phosphatase 1	P06493	CDK1	Cyclin-dependent kinase 1	0.724
P30304	CDC25A	M-phase inducer phosphatase 1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.791
P51955	NEK2	Serine/threonine-protein kinase Nek2	P30304	CDC25A	M-phase inducer phosphatase 1	0.93
P30304	CDC25A	M-phase inducer phosphatase 1	P30304	CDC25A	M-phase inducer phosphatase 1	1
P11388	TOP2A	DNA topoisomerase 2-alpha	P33981	TTK	Dual specificity protein kinase TTK	0.806
P51955	NEK2	Serine/threonine-protein kinase Nek2	P33981	TTK	Dual specificity protein kinase TTK	0.84
P30304	CDC25A	M-phase inducer phosphatase 1	P33981	TTK	Dual specificity protein kinase TTK	0.825
P30304	CDC25A	M-phase inducer phosphatase 1	P42773	CDKN2C	Cyclin-dependent kinase 4 inhibitor C	0.729
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P01106	MYC	Myc proto-oncogene protein	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P30304	CDC25A	M-phase inducer phosphatase 1	Q13547	HDAC1	Histone deacetylase 1	-0.783

Testosterone-undecanoate

Oocyte meiosis

6.20E-06

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-undecanoate

Autophagy - animal

2.95E-02

P08069, P22694, Q14643, P10415, Q04759

IGF1R, PRKACB, ITPR1, BCL2, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q96GC9	TMEM49	Vacuole membrane protein 1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Testosterone-undecanoate

Protein processing in endoplasmic reticulum

2.01E-03

P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816

CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871

Testosterone-undecanoate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Testosterone-undecanoate

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Testosterone-undecanoate

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Testosterone-undecanoate

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O76075	DFFB	DNA fragmentation factor subunit beta	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P05164	MPO	Myeloperoxidase	P43234	CTSO	Cathepsin O	-0.71
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-undecanoate

Longevity regulating pathway

1.34E-03

Q12778, P08069, Q9UEF7, Q96KQ7

FOXO1, IGF1R, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Testosterone-undecanoate

Longevity regulating pathway - multiple species

1.66E-02

P08069

IGF1R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q13547	HDAC1	Histone deacetylase 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.845
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.713
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q13547	HDAC1	Histone deacetylase 1	Q13547	HDAC1	Histone deacetylase 1	1
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P24723	PRKCH	Protein kinase C eta type	Q13547	HDAC1	Histone deacetylase 1	0.875
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q9Y4H2	IRS2	Insulin receptor substrate 2	0.852
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1

Testosterone-undecanoate

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749

Testosterone-undecanoate

hsa04260

Cardiac muscle contraction

4.49E-02

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Testosterone-undecanoate

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Testosterone-undecanoate

Notch signaling pathway

2.46E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Testosterone-undecanoate

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13635	PTCH1	Protein patched homolog 1	0.916
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-undecanoate

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P16333	NCK1	Cytoplasmic protein NCK1	-0.793
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
P29375	JARID1A	Lysine-specific demethylase 5A	P20827	EFNA1	Ephrin-A1	-0.821
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P29375	JARID1A	Lysine-specific demethylase 5A	O95631	NTN1	Netrin-1	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O95631	NTN1	Netrin-1	-0.702
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07332	FES	Tyrosine-protein kinase Fes/Fps	0.701
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
P29375	JARID1A	Lysine-specific demethylase 5A	P23528	CFL1	Cofilin-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P20827	EFNA1	Ephrin-A1	0.743
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P23528	CFL1	Cofilin-1	0.796
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1

Testosterone-undecanoate

VEGF signaling pathway

7.07E-07

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.927
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	Q05397	PTK2	Focal adhesion kinase 1	1
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q05397	PTK2	Focal adhesion kinase 1	0.898
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-undecanoate

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Testosterone-undecanoate

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Testosterone-undecanoate

Focal adhesion

3.48E-02

P08069

IGF1R

Testosterone-undecanoate

Adherens junction

8.29E-03

P08069

IGF1R

Testosterone-undecanoate

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q8TEU7	RAPGEF6	Rap guanine nucleotide exchange factor 6	-0.727
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P11712	CYP2C9	Cytochrome P450 2C9	P16989	CSDA	Y-box-binding protein 3	0.78
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16989	CSDA	Y-box-binding protein 3	0.722
P11712	CYP2C9	Cytochrome P450 2C9	P56750	CLDN17	Claudin-17	0.7
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
P11712	CYP2C9	Cytochrome P450 2C9	Q14247	CTTN	Src substrate cortactin	0.742
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
O14684	PTGES	Prostaglandin E synthase	P63261	ACTG1	Actin, cytoplasmic 2	0.771
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
O14684	PTGES	Prostaglandin E synthase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.727

Testosterone-undecanoate

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, Q02750, P08069, Q86SE9

BMPR2, MAP2K1, IGF1R, PCGF5

Testosterone-undecanoate

Antigen processing and presentation

5.83E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	P48382	RFX5	DNA-binding protein RFX5	-0.851
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.803
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1

Testosterone-undecanoate

Neutrophil extracellular trap formation

3.04E-03

P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P62807, Q16778, Q15080, P20160, P08311, P21730

PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2BC, HIST2H2BE, NCF4, AZU1, CTSG, C5AR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772

Testosterone-undecanoate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Testosterone-undecanoate

NOD-like receptor signaling pathway

4.48E-03

P01568, Q13489, Q9H1Y0, P43490, O00463, Q13546, Q05823, P01375, P49913, P59665, P59666, P12838

IFNA21, BIRC3, ATG5, PBEF1, TRAF5, RIPK1, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922

Testosterone-undecanoate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Testosterone-undecanoate

Cytosolic DNA-sensing pathway

8.25E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9Y535	POLR3H	DNA-directed RNA polymerase III subunit RPC8	0.737
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727

Testosterone-undecanoate

hsa04630

JAK-STAT signaling pathway

3.20E-02

P01106, P42224, P14784, Q13651

MYC, STAT1, IL2RB, IL10RA

Testosterone-undecanoate

Natural killer cell mediated cytotoxicity

6.65E-06

P16298, P50591, P01375, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P07195	LDHB	L-lactate dehydrogenase B chain	P26718	KLRK1	NKG2-D type II integral membrane protein	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07195	LDHB	L-lactate dehydrogenase B chain	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.739
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26717	KLRC2	NKG2-C type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Testosterone-undecanoate

Th1 and Th2 cell differentiation

5.56E-10

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Testosterone-undecanoate

Th17 cell differentiation

5.67E-06

Q04759, P19174, P01730, P06239, P42224, P14784, P13765, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Testosterone-undecanoate

T cell receptor signaling pathway

1.22E-03

Q9UDY8, Q04759, P10747, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, P06239

MALT1, PRKCQ, CD28, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P07195	LDHB	L-lactate dehydrogenase B chain	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P07195	LDHB	L-lactate dehydrogenase B chain	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P07195	LDHB	L-lactate dehydrogenase B chain	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.792
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P07195	LDHB	L-lactate dehydrogenase B chain	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.761
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-undecanoate

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Testosterone-undecanoate

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.825
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-undecanoate

Long-term potentiation

9.52E-04

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-undecanoate

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Testosterone-undecanoate

Long-term depression

1.16E-02

P08069

IGF1R

Testosterone-undecanoate

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Testosterone-undecanoate

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Testosterone-undecanoate

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Testosterone-undecanoate

Progesterone-mediated oocyte maturation

1.86E-05

P08069, Q17RY0, Q9Y6D9, P51812, Q02750

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q05397	PTK2	Focal adhesion kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.909
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.859
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
Q05397	PTK2	Focal adhesion kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.754
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q9Y6D9	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1	-0.764
Q05397	PTK2	Focal adhesion kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.932
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.93
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783

Testosterone-undecanoate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DMV8	HSPA1A	Heat shock 70 kDa protein 1A	0.753
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q15788	NCOA1	Nuclear receptor coactivator 1	0.86
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Testosterone-undecanoate

Thyroid hormone signaling pathway

1.64E-02

P19174, P42224, Q13547, P01106

PLCG1, STAT1, HDAC1, MYC

Testosterone-undecanoate

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
P10826	RARB	Retinoic acid receptor beta	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	-0.711
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
P10826	RARB	Retinoic acid receptor beta	Q96RR4	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.737
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q9Y478	PRKAB1	5'-AMP-activated protein kinase subunit beta-1	0.713

Testosterone-undecanoate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P07947	YES1	Tyrosine-protein kinase Yes	P14618	PKM2	Pyruvate kinase PKM	0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P07947	YES1	Tyrosine-protein kinase Yes	P06737	PYGL	Glycogen phosphorylase, liver form	0.808
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P06737	PYGL	Glycogen phosphorylase, liver form	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-undecanoate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P17252	PRKCA	Protein kinase C alpha type	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.832
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P29375	JARID1A	Lysine-specific demethylase 5A	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.737
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Testosterone-undecanoate

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Testosterone-undecanoate

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.818
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P05164	MPO	Myeloperoxidase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713

Testosterone-undecanoate

Non-alcoholic fatty liver disease

1.24E-02

O43521, O75460, P01584, P13073, P12074, O15239

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O43521	BCL2L11	Bcl-2-like protein 11	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721

Testosterone-undecanoate

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Testosterone-undecanoate

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Testosterone-undecanoate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Testosterone-undecanoate

Alzheimer disease

1.56E-03

Q92542, O15239, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, O15169, P67870, P45880, P28070

NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, AXIN1, CSNK2B, VDAC2, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.721
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	O95197	RTN3	Reticulon-3	0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P28070	PSMB4	Proteasome subunit beta type-4	0.778

Testosterone-undecanoate

hsa05020

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Testosterone-undecanoate

Pathways of neurodegeneration - multiple diseases

2.95E-02

Q06055, O15020

ATP5G2, SPTBN2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P30530	AXL	Tyrosine-protein kinase receptor UFO	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.735
P30530	AXL	Tyrosine-protein kinase receptor UFO	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.738

Testosterone-undecanoate

Alcoholism

4.79E-02

Q13547, P62807, Q16778

HDAC1, HIST1H2BC, HIST2H2BE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone-undecanoate

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Testosterone-undecanoate

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	Q14247	CTTN	Src substrate cortactin	0.93
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P56750	CLDN17	Claudin-17	0.713
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O00501	CLDN5	Claudin-5	0.819
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P25116	F2R	Proteinase-activated receptor 1	0.783
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.761
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P63261	ACTG1	Actin, cytoplasmic 2	0.936
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754

Testosterone-undecanoate

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Testosterone-undecanoate

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Testosterone-undecanoate

Leishmaniasis

4.50E-03

P14598, O60603, P25963, P29350, Q15080

NCF1, TLR2, NFKBIA, PTPN6, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Testosterone-undecanoate

Malaria

3.12E-02

P60033, P01375, P35443, P26718

CD81, TNF, THBS4, KLRK1

Testosterone-undecanoate

hsa05150

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Testosterone-undecanoate

Human cytomegalovirus infection

2.89E-02

P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651

CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.736
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61586	RHOA	Transforming protein RhoA	-0.769
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.709
P48169	GABRA4	Gamma-aminobutyric acid receptor subunit alpha-4	P61769	B2M	Beta-2-microglobulin	-0.711
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769

Testosterone-undecanoate

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Testosterone-undecanoate

hsa05169

Epstein-Barr virus infection

3.66E-02

P01106, Q13547, Q13761, P42224, P07766

MYC, HDAC1, RUNX3, STAT1, CD3E

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P07195	LDHB	L-lactate dehydrogenase B chain	P20023	CR2	Complement receptor type 2	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P07195	LDHB	L-lactate dehydrogenase B chain	Q92769	HDAC2	Histone deacetylase 2	0.759
P07195	LDHB	L-lactate dehydrogenase B chain	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07195	LDHB	L-lactate dehydrogenase B chain	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.935
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P07195	LDHB	L-lactate dehydrogenase B chain	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.706
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P51955	NEK2	Serine/threonine-protein kinase Nek2	P01106	MYC	Myc proto-oncogene protein	-0.788
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779

Testosterone-undecanoate

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Testosterone-undecanoate

Transcriptional misregulation in cancer

2.48E-03

Q12778, Q13315, P14780, Q16548, O15550, P08069, P05164, P08246, Q9C0K0, P24522

FOXO1, ATM, MMP9, BCL2A1, UTX, IGF1R, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Testosterone-undecanoate

Viral carcinogenesis

9.16E-03

Q13547, P12814, P06493, P62807, Q16778

HDAC1, ACTN1, CDK1, HIST1H2BC, HIST2H2BE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06493	CDK1	Cyclin-dependent kinase 1	0.72
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728

Testosterone-undecanoate

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Testosterone-undecanoate

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Testosterone-undecanoate

Colorectal cancer

3.43E-02

Q9UKG1, P37173

APPL1, TGFBR2

Testosterone-undecanoate

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Testosterone-undecanoate

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Testosterone-undecanoate

Glioma

9.95E-03

P08069

IGF1R

Testosterone-undecanoate

Prostate cancer

1.33E-02

P08069

IGF1R

Testosterone-undecanoate

Melanoma

6.63E-03

P08069

IGF1R

Testosterone-undecanoate

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Testosterone-undecanoate

Breast cancer

1.49E-02

P08069

IGF1R

Testosterone-undecanoate

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Testosterone-undecanoate

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Testosterone-undecanoate

Choline metabolism in cancer

1.14E-04

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.709
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P23743	DGKA	Diacylglycerol kinase alpha	0.705
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14494	PLPP1	Phospholipid phosphatase 1	-0.782
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q16760	DGKD	Diacylglycerol kinase delta	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.717
P11388	TOP2A	DNA topoisomerase 2-alpha	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.751
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.78
P30304	CDC25A	M-phase inducer phosphatase 1	Q9Y259	CHKB	Choline/ethanolamine kinase	-0.834
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11388	TOP2A	DNA topoisomerase 2-alpha	P49619	DGKG	Diacylglycerol kinase gamma	0.926
P51955	NEK2	Serine/threonine-protein kinase Nek2	P49619	DGKG	Diacylglycerol kinase gamma	0.792
P30304	CDC25A	M-phase inducer phosphatase 1	P49619	DGKG	Diacylglycerol kinase gamma	0.772

Testosterone-undecanoate

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.20E-06

P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q9HC35, P01730

PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.716
P30304	CDC25A	M-phase inducer phosphatase 1	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.737
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708

Testosterone-undecanoate

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P05164	MPO	Myeloperoxidase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P07195	LDHB	L-lactate dehydrogenase B chain	Q9UL17	TBX21	T-box transcription factor TBX21	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P05164	MPO	Myeloperoxidase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.871
P07195	LDHB	L-lactate dehydrogenase B chain	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P05164	MPO	Myeloperoxidase	Q9HBE5	IL21R	Interleukin-21 receptor	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85

Testosterone-undecanoate

Systemic lupus erythematosus

2.75E-02

P62807, Q16778, P12814

HIST1H2BC, HIST2H2BE, ACTN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P51955	NEK2	Serine/threonine-protein kinase Nek2	P12814	ACTN1	Alpha-actinin-1	0.773

Testosterone-undecanoate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.815
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P09341	CXCL1	Growth-regulated alpha protein	-0.737
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717

Testosterone-undecanoate

Graft-versus-host disease

3.45E-03

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P05164	MPO	Myeloperoxidase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.85
P07195	LDHB	L-lactate dehydrogenase B chain	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.733
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P05164	MPO	Myeloperoxidase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P05164	MPO	Myeloperoxidase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.82
P07195	LDHB	L-lactate dehydrogenase B chain	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P05164	MPO	Myeloperoxidase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.775
P07195	LDHB	L-lactate dehydrogenase B chain	Q13241	KLRD1	Natural killer cells antigen CD94	0.806
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Testosterone-undecanoate

Primary immunodeficiency

4.24E-02

P01730, P07766, P06239

CD4, CD3E, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P52732	KIF11	Kinesin-like protein KIF11	P11912	CD79A	B-cell antigen receptor complex-associated protein alpha chain	-0.749
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Testosterone-undecanoate