PharmaCoNets of Testolactone (SPCN: 10.35 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Testolactonehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Testolactonehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Testolactonehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Testolactonehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Testolactonehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Testolactonehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Testolactonehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Testolactonehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Testolactonehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Testolactonehsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Testolactonehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Testolactonehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Testolactonehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Testolactonehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Testolactonehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Testolactonehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Testolactonehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Testolactonehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Testolactonehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Testolactonehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Testolactonehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Testolactonehsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Testolactonehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Testolactonehsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Testolactonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Testolactonehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Testolactonehsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Testolactonehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Testolactonehsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Testolactonehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Testolactonehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Testolactone (SDC: 2.88)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromataseReported00.815610.15882.5666
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CYP19A1P11511Ki35000