PharmaCoNets of Terfenadine (SPCN: 31.11 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Terfenadinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Terfenadinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Terfenadinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Terfenadinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Terfenadinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Terfenadinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Terfenadinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Terfenadinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Terfenadinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Terfenadinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Terfenadinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Terfenadinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Terfenadinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Terfenadinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Terfenadinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Terfenadinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Terfenadinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Terfenadinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Terfenadinehsa03050Proteasome3.93E-021P62195PSMC5More
Terfenadinehsa04071Sphingolipid signaling pathway1.53E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Terfenadinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Terfenadinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Terfenadinehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Terfenadinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Terfenadinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Terfenadinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Terfenadinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Terfenadinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Terfenadinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Terfenadinehsa04613Neutrophil extracellular trap formation9.88E-0518O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Terfenadinehsa04657IL-17 signaling pathway6.64E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Terfenadinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Terfenadinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Terfenadinehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Terfenadinehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Terfenadinehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Terfenadinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Terfenadinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Terfenadinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Terfenadinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Terfenadinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Terfenadinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Terfenadinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Terfenadinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Terfenadinehsa05010Alzheimer disease2.27E-028O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796, P17861, P62195GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1, XBP1, PSMC5More
Terfenadinehsa05012Parkinson disease7.44E-032P17861, P62195XBP1, PSMC5More
Terfenadinehsa05014Amyotrophic lateral sclerosis2.32E-043P17861, P62195, Q53GS7XBP1, PSMC5, GLE1More
Terfenadinehsa05017Spinocerebellar ataxia1.95E-032P17861, P62195XBP1, PSMC5More
Terfenadinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Terfenadinehsa05022Pathways of neurodegeneration - multiple diseases3.76E-038P49841, Q16718, O14521, P17861, Q13561, Q16539, Q08752, P62195GSK3B, NDUFA5, SDHD, XBP1, DCTN2, MAPK14, PPID, PSMC5More
Terfenadinehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Terfenadinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Terfenadinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Terfenadinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Terfenadinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Terfenadinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Terfenadinehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Terfenadinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Terfenadinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Terfenadinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Terfenadinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Terfenadinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Terfenadinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Terfenadinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Terfenadine (SDC: 4.52)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)