PharmaCoNets

PharmaCoNets of Terconazole (S_PCN: 127.18 )

Terconazole regulated-network (S_DN: 18.73)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Terconazole

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Terconazole

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Terconazole

hsa00190

Oxidative phosphorylation

2.11E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Terconazole

hsa00220

Arginine biosynthesis

1.26E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Terconazole

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Terconazole

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Terconazole

hsa00500

Starch and sucrose metabolism

6.40E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Terconazole

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Terconazole

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Terconazole

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Terconazole

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Terconazole

hsa00630

Glyoxylate and dicarboxylate metabolism

1.32E-02

P40925, P15104

MDH1, GLUL

Terconazole

hsa00730

Thiamine metabolism

5.86E-04

P05186, P24666

ALPL, ACP1

Terconazole

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Terconazole

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Terconazole

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Terconazole

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Terconazole

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Terconazole

hsa00983

Drug metabolism - other enzymes

4.00E-04

P04183, P32320, P05164

TK1, CDA, MPO

Terconazole

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Terconazole

hsa01230

Biosynthesis of amino acids

2.16E-03

P51854, Q99707, P50213, P15104, P37837

TKTL1, MTR, IDH3A, GLUL, TALDO1

Terconazole

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Terconazole

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Terconazole

hsa03013

RNA transport

8.18E-05

P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042

EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Terconazole

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Terconazole

hsa03040

Spliceosome

4.49E-05

Q14562, O43143, O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Terconazole

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Terconazole

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Terconazole

hsa04012

ErbB signaling pathway

1.66E-03

P21860, P16333, Q13557, P19174, O14944, P42338, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYC

Terconazole

hsa04014

Ras signaling pathway

2.92E-04

P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Terconazole

hsa04015

Rap1 signaling pathway

4.83E-04

P20827, Q9NRA1, P49767, P11215, P25116, Q8TEU7, Q13009, P42338, P0DP23, P08514, P17252, P19174

EFNA1, PDGFC, VEGFC, ITGAM, F2R, RAPGEF6, TIAM1, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1

Terconazole

hsa04020

Calcium signaling pathway

1.09E-04

P27987, Q96DU7, P21796, P45880, Q13557, P21860, P19174, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Terconazole

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Terconazole

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Terconazole

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Terconazole

hsa04062

Chemokine signaling pathway

9.17E-06

P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711

Terconazole

hsa04064

NF-kappa B signaling pathway

7.03E-04

O00463, P14778, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P24522, P09341, Q06643

TRAF5, IL1R1, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, GADD45A, CXCL1, LTB

Terconazole

hsa04070

Phosphatidylinositol signaling system

1.12E-02

P19174, P0DP23, P42338, P23743, P27987

PLCG1, CALM1, PIK3CB, DGKA, ITPKB

Terconazole

hsa04071

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Terconazole

hsa04072

Phospholipase D signaling pathway

4.67E-02

P42338, P19174, Q14344, P23743, Q9NRA1

PIK3CB, PLCG1, GNA13, DGKA, PDGFC

Terconazole

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Terconazole

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Terconazole

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Terconazole

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Terconazole

hsa04142

Lysosome

3.80E-03

Q99437, P08311, P25774, Q9UPM8

ATP6V0B, CTSG, CTSS, AP4E1

Terconazole

hsa04145

Phagosome

3.11E-02

Q99437, P25774

ATP6V0B, CTSS

Terconazole

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Terconazole

hsa04151

PI3K-Akt signaling pathway

5.62E-03

P42338, P01106, P20827, Q9NRA1, P49767, P08238, P62873, P63218, P50151, O15335, P14784, P01568

PIK3CB, MYC, EFNA1, PDGFC, VEGFC, HSP90AB1, GNB1, GNG5, GNG10, CHAD, IL2RB, IFNA21

Terconazole

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Terconazole

hsa04213

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Terconazole

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Terconazole

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Terconazole

hsa04330

Notch signaling pathway

2.46E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Terconazole

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Terconazole

hsa04360

Axon guidance

2.87E-02

P16333, P20827, O95631, P42338, P19174

NCK1, EFNA1, NTN1, PIK3CB, PLCG1

Terconazole

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Terconazole

hsa04371

Apelin signaling pathway

2.41E-03

P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1

Terconazole

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Terconazole

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Terconazole

hsa04612

Antigen processing and presentation

1.75E-02

P13765, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A

Terconazole

hsa04613

Neutrophil extracellular trap formation

9.10E-07

P42338, P19174, P11215, P05164, Q13547, P04908, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, P20160, P08311, O43315, Q16539

PIK3CB, PLCG1, ITGAM, MPO, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, AZU1, CTSG, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
Q13231	CHIT1	Chitotriosidase-1	P05164	MPO	Myeloperoxidase	0.789
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
Q13231	CHIT1	Chitotriosidase-1	P20160	AZU1	Azurocidin	0.844
Q13231	CHIT1	Chitotriosidase-1	P08311	CTSG	Cathepsin G	0.733
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Terconazole

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Terconazole

hsa04623

Cytosolic DNA-sensing pathway

3.67E-02

P01568, P25963

IFNA21, NFKBIA

Terconazole

hsa04625

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Terconazole

hsa04640

Hematopoietic cell lineage

3.30E-05

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB

Terconazole

hsa04650

Natural killer cell mediated cytotoxicity

1.62E-04

P16298, P50591, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Terconazole

hsa04657

IL-17 signaling pathway

5.03E-03

O00463, Q16539, P49841, P09341, P14780, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF

Terconazole

hsa04658

Th1 and Th2 cell differentiation

2.74E-08

P25963, Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Terconazole

hsa04659

Th17 cell differentiation

8.09E-08

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Terconazole

hsa04660

T cell receptor signaling pathway

8.91E-04

Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Terconazole

hsa04662

B cell receptor signaling pathway

1.12E-02

P25963, P42338, P07948, P21854, Q8N149

NFKBIA, PIK3CB, LYN, CD72, LILRA2

Terconazole

hsa04664

Fc epsilon RI signaling pathway

1.34E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Terconazole

hsa04666

Fc gamma R-mediated phagocytosis

2.92E-02

P07948, P42338, P19174, P14598

LYN, PIK3CB, PLCG1, NCF1

Terconazole

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Terconazole

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Terconazole

hsa04713

Circadian entrainment

4.00E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Terconazole

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Terconazole

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Terconazole

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Terconazole

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Terconazole

hsa04724

Glutamatergic synapse

2.92E-02

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Terconazole

hsa04725

Cholinergic synapse

2.92E-02

P62873, P63218, P50151, P42338

GNB1, GNG5, GNG10, PIK3CB

Terconazole

hsa04727

GABAergic synapse

8.14E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Terconazole

hsa04744

Phototransduction

1.32E-02

P62873, P0DP23

GNB1, CALM1

Terconazole

hsa04750

Inflammatory mediator regulation of TRP channels

4.11E-03

P01584, P51828, Q13557, P19174, P42338, P24723, P0DP23

IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, CALM1

Terconazole

hsa04810

Regulation of actin cytoskeleton

2.61E-02

P12814, Q13009, P42338, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC

Terconazole

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Terconazole

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Terconazole

hsa04914

Progesterone-mediated oocyte maturation

4.29E-03

Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Terconazole

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Terconazole

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Terconazole

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Terconazole

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Terconazole

hsa04926

Relaxin signaling pathway

8.74E-03

P25963, P42338, P62873, P63218, P50151, P49767

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC

Terconazole

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Terconazole

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Terconazole

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Terconazole

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Terconazole

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Terconazole

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Terconazole

hsa05010

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Terconazole

hsa05012

Parkinson disease

4.01E-02

P21796, P60604, P19174, P0DP23, Q71U36, Q13509

VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3

Terconazole

hsa05020

Prion disease

1.37E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14

Terconazole

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Terconazole

hsa05032

Morphine addiction

7.60E-03

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Terconazole

hsa05034

Alcoholism

1.63E-06

Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Terconazole

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Terconazole

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Terconazole

hsa05132

Salmonella infection

2.36E-02

P25963, P08238, P01106, P42338, O75369, Q71U36, Q13509, P49754

NFKBIA, HSP90AB1, MYC, PIK3CB, FLNB, TUBA1A, TUBB3, VPS41

Terconazole

hsa05140

Leishmaniasis

4.21E-04

O75015, P14598, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Terconazole

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Terconazole

hsa05146

Amoebiasis

1.32E-03

P09341, P14778, P27930, O60603, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG

Terconazole

hsa05152

Tuberculosis

4.16E-02

Q99437, P25774

ATP6V0B, CTSS

Terconazole

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Terconazole

hsa05162

Measles

1.84E-02

P01568, P25963, P42224, P14784, P07766, P42338, P11142

IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8

Terconazole

hsa05163

Human cytomegalovirus infection

7.99E-05

P42338, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P01106, P14778, P25025, Q16539, P04637, O00463, P30101, P01568

PIK3CB, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, MYC, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Terconazole

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.21E-06

P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBB

Terconazole

hsa05168

Herpes simplex virus 1 infection

4.57E-02

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189

Terconazole

hsa05169

Epstein-Barr virus infection

1.94E-05

P13765, P01106, Q13547, O00463, P25963, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Terconazole

hsa05170

Human immunodeficiency virus 1 infection

5.72E-05

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1B

Terconazole

hsa05200

Pathways in cancer

1.82E-03

P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Terconazole

hsa05202

Transcriptional misregulation in cancer

1.24E-02

P27930, P11215, Q13547, P12980

IL1R2, ITGAM, HDAC1, LYL1

Terconazole

hsa05203

Viral carcinogenesis

2.90E-05

P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P58876, P62807, Q93079, Q16778, O60814

PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12

Terconazole

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Terconazole

hsa05205

Proteoglycans in cancer

4.46E-02

Q12955, Q14247, P17252, P08962

ANK3, CTTN, PRKCA, CD63

Terconazole

hsa05206

MicroRNAs in cancer

4.00E-04

P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174

CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1

Terconazole

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Terconazole

hsa05214

Glioma

1.34E-02

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Terconazole

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Terconazole

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Terconazole

hsa05220

Chronic myeloid leukemia

2.17E-02

Q13547, P01106, P25963, P42338, O75293

HDAC1, MYC, NFKBIA, PIK3CB, GADD45B

Terconazole

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Terconazole

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Terconazole

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Terconazole

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.49E-04

P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q04759, Q16539, P01730

NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, PRKCQ, MAPK14, CD4

Terconazole

hsa05310

Asthma

1.35E-02

P13765, P29965

HLA-DOB, CD40LG

Terconazole

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Terconazole

hsa05321

Inflammatory bowel disease

1.45E-02

P84022, Q9HBE5

SMAD3, IL21R

Terconazole

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Terconazole

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Terconazole

hsa05332

Graft-versus-host disease

3.75E-03

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Terconazole

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Terconazole

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.82E-02

P14923, P08514, Q9UJU2

JUP, ITGA2B, LEF1

Terconazole

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Terconazole

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Terconazole

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Terconazole (S_DC: 6.79)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P49336

CDK8

CyclinNonedependent kinase 8

Predicted

0.1356

0.647

1.3618

Q13231

CHIT1

ChitotriosidaseNone1

Predicted

0.0357

0.0429

0.1963

0.3

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

PharmaCoNets of Terconazole (SPCN: 127.18 )

Terconazole regulated-network (SDN: 18.73)

Community members of Terconazole (SDC: 6.79)

PharmaCoNets of Terconazole (S_PCN: 127.18 )

Terconazole regulated-network (S_DN: 18.73)

Community members of Terconazole (S_DC: 6.79)